PubMed:25286407 / 1131-1801 JSONTXT

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T3","span":{"begin":0,"end":670},"obj":"RESULTS"}],"text":"In the organotypic culture model, both anesthetic agents induced time-dependent NP cell death; when compared with injected saline solution, significant effects were detected within 7 days. Compared with the saline group, TUNEL-positive NP cells were significantly increased in the bupivacaine group. In the in vivo study, MRI analysis did not show any significant difference. Histological analysis revealed that IVD degeneration occurred to a significantly level in the saline- and local anesthetics-injected groups compared with the untreated control or puncture-only groups. However, there was no significant difference between the saline and anesthetic agents groups."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T9","span":{"begin":65,"end":69},"obj":"CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens"},{"id":"T10","span":{"begin":441,"end":442},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"}],"text":"In the organotypic culture model, both anesthetic agents induced time-dependent NP cell death; when compared with injected saline solution, significant effects were detected within 7 days. Compared with the saline group, TUNEL-positive NP cells were significantly increased in the bupivacaine group. In the in vivo study, MRI analysis did not show any significant difference. Histological analysis revealed that IVD degeneration occurred to a significantly level in the saline- and local anesthetics-injected groups compared with the untreated control or puncture-only groups. However, there was no significant difference between the saline and anesthetic agents groups."}

{"project":"GoldHamster","denotations":[{"id":"T107","span":{"begin":39,"end":56},"obj":"D000777"},{"id":"T108","span":{"begin":39,"end":56},"obj":"D000777"},{"id":"T109","span":{"begin":83,"end":93},"obj":"GO:0008219"},{"id":"T110","span":{"begin":123,"end":138},"obj":"D000077330"},{"id":"T113","span":{"begin":281,"end":292},"obj":"1815"},{"id":"T112","span":{"begin":281,"end":292},"obj":"D002045"},{"id":"T114","span":{"begin":281,"end":292},"obj":"CHEBI:3215"},{"id":"T115","span":{"begin":281,"end":292},"obj":"CHEBI:60790"},{"id":"T116","span":{"begin":281,"end":292},"obj":"CHEBI:6149"},{"id":"T117","span":{"begin":281,"end":292},"obj":"D002045"},{"id":"T118","span":{"begin":322,"end":325},"obj":"PR:000010565"},{"id":"T119","span":{"begin":322,"end":325},"obj":"PR:Q6AYH4"},{"id":"T120","span":{"begin":322,"end":325},"obj":"PR:Q8BHZ5"},{"id":"T121","span":{"begin":322,"end":325},"obj":"PR:Q9BWK5"},{"id":"T122","span":{"begin":412,"end":415},"obj":"Q9FS87"},{"id":"T123","span":{"begin":412,"end":415},"obj":"Q9SWG0"},{"id":"T124","span":{"begin":412,"end":415},"obj":"P12007"},{"id":"T125","span":{"begin":412,"end":415},"obj":"P26440"},{"id":"T126","span":{"begin":412,"end":415},"obj":"Q3SZI8"},{"id":"T127","span":{"begin":412,"end":415},"obj":"PR:P12007"},{"id":"T128","span":{"begin":412,"end":415},"obj":"P34275"},{"id":"T129","span":{"begin":412,"end":415},"obj":"Q9JHI5"},{"id":"T130","span":{"begin":412,"end":415},"obj":"PR:Q9SWG0"},{"id":"T131","span":{"begin":412,"end":415},"obj":"Q75IM9"},{"id":"T132","span":{"begin":412,"end":415},"obj":"PR:P26440"},{"id":"T133","span":{"begin":412,"end":415},"obj":"Q5RBD5"},{"id":"T134","span":{"begin":412,"end":415},"obj":"PR:000009166"},{"id":"T135","span":{"begin":412,"end":415},"obj":"PR:Q9JHI5"},{"id":"T137","span":{"begin":482,"end":499},"obj":"CHEBI:36333"},{"id":"T138","span":{"begin":482,"end":499},"obj":"D000779"},{"id":"T139","span":{"begin":482,"end":499},"obj":"D000779"},{"id":"T143","span":{"begin":645,"end":662},"obj":"D000777"},{"id":"T144","span":{"begin":645,"end":662},"obj":"D000777"}],"text":"In the organotypic culture model, both anesthetic agents induced time-dependent NP cell death; when compared with injected saline solution, significant effects were detected within 7 days. Compared with the saline group, TUNEL-positive NP cells were significantly increased in the bupivacaine group. In the in vivo study, MRI analysis did not show any significant difference. Histological analysis revealed that IVD degeneration occurred to a significantly level in the saline- and local anesthetics-injected groups compared with the untreated control or puncture-only groups. However, there was no significant difference between the saline and anesthetic agents groups."}