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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 145-1423 UNLABELLED denotes The snail Bithynia siamensis goniomphalos acts as the first intermediate host for the human liver fluke Opisthorchis viverrini, the major cause of cholangiocarcinoma (CCA) in Northeast Thailand. The undisputed link between CCA and O. viverrini infection has precipitated efforts to understand the molecular basis of host-parasite interactions with a view to ultimately developing new control strategies to combat this carcinogenic infection. To date most effort has focused on the interactions between the parasite and its human host, and little is known about the molecular relationships between the liver fluke and its snail intermediate host. In the present study we analyse the protein expression changes in different tissues of B. siamensis goniomphalos induced by infection with larval O. viverrini using iTRAQ labelling technology. We show that O. viverrini infection downregulates the expression of oxidoreductases and catalytic enzymes, while stress-related and motor proteins are upregulated. The present work could serve as a basis for future studies on the proteins implicated in the susceptibility/resistance of B. siamensis goniomphalos to O. viverrini, as well as studies on other pulmonate snail intermediate hosts of various parasitic flukes that infect humans.
T2 1449-2226 UNASSIGNED denotes Despite the importance and high prevalence of opisthorchiasis in some regions of Southeast Asia and the direct relationship between infection by Opisthorchis viverrini and the incidence of cholangiocarcinoma, little is known of the modifications induced by this parasite in its snail intermediate hosts. This time-course study provides the first in-depth quantitative proteomic analysis of experimentally infected Bithynia siamensis goniomphalos. We show how motor and stress-related proteins are upregulated in infected snails, while O. viverrini infection downregulates the expression of oxidoreductases and catalytic enzymes. This work serves as a basis for the development of new strategies, focused on the invertebrate intermediate hosts, to control parasite transmission.

sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Proteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrini.
T2 133-144 Sentence denotes UNLABELLED:
T3 145-339 Sentence denotes The snail Bithynia siamensis goniomphalos acts as the first intermediate host for the human liver fluke Opisthorchis viverrini, the major cause of cholangiocarcinoma (CCA) in Northeast Thailand.
T4 340-586 Sentence denotes The undisputed link between CCA and O. viverrini infection has precipitated efforts to understand the molecular basis of host-parasite interactions with a view to ultimately developing new control strategies to combat this carcinogenic infection.
T5 587-790 Sentence denotes To date most effort has focused on the interactions between the parasite and its human host, and little is known about the molecular relationships between the liver fluke and its snail intermediate host.
T6 791-983 Sentence denotes In the present study we analyse the protein expression changes in different tissues of B. siamensis goniomphalos induced by infection with larval O. viverrini using iTRAQ labelling technology.
T7 984-1147 Sentence denotes We show that O. viverrini infection downregulates the expression of oxidoreductases and catalytic enzymes, while stress-related and motor proteins are upregulated.
T8 1148-1423 Sentence denotes The present work could serve as a basis for future studies on the proteins implicated in the susceptibility/resistance of B. siamensis goniomphalos to O. viverrini, as well as studies on other pulmonate snail intermediate hosts of various parasitic flukes that infect humans.
T9 1424-1448 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T10 1449-1752 Sentence denotes Despite the importance and high prevalence of opisthorchiasis in some regions of Southeast Asia and the direct relationship between infection by Opisthorchis viverrini and the incidence of cholangiocarcinoma, little is known of the modifications induced by this parasite in its snail intermediate hosts.
T11 1753-1895 Sentence denotes This time-course study provides the first in-depth quantitative proteomic analysis of experimentally infected Bithynia siamensis goniomphalos.
T12 1896-2077 Sentence denotes We show how motor and stress-related proteins are upregulated in infected snails, while O. viverrini infection downregulates the expression of oxidoreductases and catalytic enzymes.
T13 2078-2226 Sentence denotes This work serves as a basis for the development of new strategies, focused on the invertebrate intermediate hosts, to control parasite transmission.
T1 0-132 Sentence denotes Proteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrini.
T2 133-144 Sentence denotes UNLABELLED:
T3 145-339 Sentence denotes The snail Bithynia siamensis goniomphalos acts as the first intermediate host for the human liver fluke Opisthorchis viverrini, the major cause of cholangiocarcinoma (CCA) in Northeast Thailand.
T4 340-586 Sentence denotes The undisputed link between CCA and O. viverrini infection has precipitated efforts to understand the molecular basis of host-parasite interactions with a view to ultimately developing new control strategies to combat this carcinogenic infection.
T5 587-790 Sentence denotes To date most effort has focused on the interactions between the parasite and its human host, and little is known about the molecular relationships between the liver fluke and its snail intermediate host.
T6 791-983 Sentence denotes In the present study we analyse the protein expression changes in different tissues of B. siamensis goniomphalos induced by infection with larval O. viverrini using iTRAQ labelling technology.
T7 984-1147 Sentence denotes We show that O. viverrini infection downregulates the expression of oxidoreductases and catalytic enzymes, while stress-related and motor proteins are upregulated.
T8 1148-1423 Sentence denotes The present work could serve as a basis for future studies on the proteins implicated in the susceptibility/resistance of B. siamensis goniomphalos to O. viverrini, as well as studies on other pulmonate snail intermediate hosts of various parasitic flukes that infect humans.
T9 1424-1448 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T10 1449-1752 Sentence denotes Despite the importance and high prevalence of opisthorchiasis in some regions of Southeast Asia and the direct relationship between infection by Opisthorchis viverrini and the incidence of cholangiocarcinoma, little is known of the modifications induced by this parasite in its snail intermediate hosts.
T11 1753-1895 Sentence denotes This time-course study provides the first in-depth quantitative proteomic analysis of experimentally infected Bithynia siamensis goniomphalos.
T12 1896-2077 Sentence denotes We show how motor and stress-related proteins are upregulated in infected snails, while O. viverrini infection downregulates the expression of oxidoreductases and catalytic enzymes.
T13 2078-2226 Sentence denotes This work serves as a basis for the development of new strategies, focused on the invertebrate intermediate hosts, to control parasite transmission.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 97-102 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 237-242 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T3 746-751 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T4 2160-2172 http://purl.obolibrary.org/obo/MAT_0000374 denotes invertebrate

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 292-310 HP_0030153 denotes cholangiocarcinoma

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 97-102 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 237-242 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T3 746-751 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T4 2160-2172 Body_part denotes invertebrate http://purl.obolibrary.org/obo/MAT_0000374

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 292-310 Phenotype denotes cholangiocarcinoma HP:0030153
T2 312-315 Phenotype denotes CCA HP:0030153
T3 368-371 Phenotype denotes CCA HP:0030153
T4 1638-1656 Phenotype denotes cholangiocarcinoma HP:0030153

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 65-74 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T2 97-108 Disease denotes liver fluke http://purl.obolibrary.org/obo/MONDO_0004668
T3 237-248 Disease denotes liver fluke http://purl.obolibrary.org/obo/MONDO_0004668
T4 292-310 Disease denotes cholangiocarcinoma http://purl.obolibrary.org/obo/MONDO_0019087
T5 312-315 Disease denotes CCA http://purl.obolibrary.org/obo/MONDO_0019087
T6 368-371 Disease denotes CCA http://purl.obolibrary.org/obo/MONDO_0019087
T7 389-398 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T8 576-585 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T9 746-757 Disease denotes liver fluke http://purl.obolibrary.org/obo/MONDO_0004668
T10 915-924 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T11 1010-1019 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 1495-1510 Disease denotes opisthorchiasis http://purl.obolibrary.org/obo/MONDO_0005884
T13 1581-1606 Disease denotes infection by Opisthorchis http://purl.obolibrary.org/obo/MONDO_0005884
T14 1638-1656 Disease denotes cholangiocarcinoma http://purl.obolibrary.org/obo/MONDO_0019087
T15 1997-2006 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 21-52 OrganismTaxon denotes Bithynia siamensis goniomphalos 479249
T2 109-131 OrganismTaxon denotes Opisthorchis viverrini 6198
T3 155-186 OrganismTaxon denotes Bithynia siamensis goniomphalos 479249
T4 231-236 OrganismTaxon denotes human 9606
T5 249-271 OrganismTaxon denotes Opisthorchis viverrini 6198
T6 668-673 OrganismTaxon denotes human 9606
T7 1594-1616 OrganismTaxon denotes Opisthorchis viverrini 6198
T8 1863-1894 OrganismTaxon denotes Bithynia siamensis goniomphalos 479249

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 97-102 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 103-108 Body_part denotes fluke http://purl.obolibrary.org/obo/UBERON_0013131
T3 237-242 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T4 243-248 Body_part denotes fluke http://purl.obolibrary.org/obo/UBERON_0013131
T5 746-751 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T6 752-757 Body_part denotes fluke http://purl.obolibrary.org/obo/UBERON_0013131