> top > docs > PubMed:25239884 > annotations

PubMed:25239884 JSONTXT

Annnotations TAB JSON ListView MergeView

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 198-211 HP_0003002 denotes breast tumors
T2 198-211 HP_0100013 denotes breast tumors
T3 205-211 HP_0002664 denotes tumors
T4 265-282 HP_0003002 denotes breast carcinomas
T5 403-408 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25239884-0#29#34#gene54971 29-34 gene54971 denotes SMAR1
25239884-0#45#50#gene4790 45-50 gene4790 denotes NF-κB
25239884-0#61#74#gene3576 61-74 gene3576 denotes Interleukin-8
25239884-0#92#105#diseaseC0006142 92-105 diseaseC0006142 denotes breast cancer
25239884-0#92#105#diseaseC0678222 92-105 diseaseC0678222 denotes breast cancer
25239884-0#92#105#diseaseC0006142 92-105 diseaseC0006142 denotes breast cancer
25239884-0#92#105#diseaseC0678222 92-105 diseaseC0678222 denotes breast cancer
25239884-0#92#105#diseaseC0006142 92-105 diseaseC0006142 denotes breast cancer
25239884-0#92#105#diseaseC0678222 92-105 diseaseC0678222 denotes breast cancer
25239884-1#0#13#gene3576 107-120 gene3576 denotes Interleukin-8
25239884-1#15#19#gene3576 122-126 gene3576 denotes IL-8
25239884-1#0#13#gene3576 107-120 gene3576 denotes Interleukin-8
25239884-1#15#19#gene3576 122-126 gene3576 denotes IL-8
25239884-1#60#70#diseaseC0027627 167-177 diseaseC0027627 denotes metastasis
25239884-1#91#104#diseaseC1458155 198-211 diseaseC1458155 denotes breast tumors
29#34#gene5497192#105#diseaseC0006142 25239884-0#29#34#gene54971 25239884-0#92#105#diseaseC0006142 associated_with SMAR1,breast cancer
29#34#gene5497192#105#diseaseC0678222 25239884-0#29#34#gene54971 25239884-0#92#105#diseaseC0678222 associated_with SMAR1,breast cancer
29#34#gene5497192#105#diseaseC0006142 25239884-0#29#34#gene54971 25239884-0#92#105#diseaseC0006142 associated_with SMAR1,breast cancer
29#34#gene5497192#105#diseaseC0678222 25239884-0#29#34#gene54971 25239884-0#92#105#diseaseC0678222 associated_with SMAR1,breast cancer
29#34#gene5497192#105#diseaseC0006142 25239884-0#29#34#gene54971 25239884-0#92#105#diseaseC0006142 associated_with SMAR1,breast cancer
29#34#gene5497192#105#diseaseC0678222 25239884-0#29#34#gene54971 25239884-0#92#105#diseaseC0678222 associated_with SMAR1,breast cancer
45#50#gene479092#105#diseaseC0006142 25239884-0#45#50#gene4790 25239884-0#92#105#diseaseC0006142 associated_with NF-κB,breast cancer
45#50#gene479092#105#diseaseC0678222 25239884-0#45#50#gene4790 25239884-0#92#105#diseaseC0678222 associated_with NF-κB,breast cancer
45#50#gene479092#105#diseaseC0006142 25239884-0#45#50#gene4790 25239884-0#92#105#diseaseC0006142 associated_with NF-κB,breast cancer
45#50#gene479092#105#diseaseC0678222 25239884-0#45#50#gene4790 25239884-0#92#105#diseaseC0678222 associated_with NF-κB,breast cancer
45#50#gene479092#105#diseaseC0006142 25239884-0#45#50#gene4790 25239884-0#92#105#diseaseC0006142 associated_with NF-κB,breast cancer
45#50#gene479092#105#diseaseC0678222 25239884-0#45#50#gene4790 25239884-0#92#105#diseaseC0678222 associated_with NF-κB,breast cancer
61#74#gene357692#105#diseaseC0006142 25239884-0#61#74#gene3576 25239884-0#92#105#diseaseC0006142 associated_with Interleukin-8,breast cancer
61#74#gene357692#105#diseaseC0678222 25239884-0#61#74#gene3576 25239884-0#92#105#diseaseC0678222 associated_with Interleukin-8,breast cancer
61#74#gene357692#105#diseaseC0006142 25239884-0#61#74#gene3576 25239884-0#92#105#diseaseC0006142 associated_with Interleukin-8,breast cancer
61#74#gene357692#105#diseaseC0678222 25239884-0#61#74#gene3576 25239884-0#92#105#diseaseC0678222 associated_with Interleukin-8,breast cancer
61#74#gene357692#105#diseaseC0006142 25239884-0#61#74#gene3576 25239884-0#92#105#diseaseC0006142 associated_with Interleukin-8,breast cancer
61#74#gene357692#105#diseaseC0678222 25239884-0#61#74#gene3576 25239884-0#92#105#diseaseC0678222 associated_with Interleukin-8,breast cancer
0#13#gene357660#70#diseaseC0027627 25239884-1#0#13#gene3576 25239884-1#60#70#diseaseC0027627 associated_with Interleukin-8,metastasis
0#13#gene357691#104#diseaseC1458155 25239884-1#0#13#gene3576 25239884-1#91#104#diseaseC1458155 associated_with Interleukin-8,breast tumors
15#19#gene357660#70#diseaseC0027627 25239884-1#15#19#gene3576 25239884-1#60#70#diseaseC0027627 associated_with IL-8,metastasis
15#19#gene357691#104#diseaseC1458155 25239884-1#15#19#gene3576 25239884-1#91#104#diseaseC1458155 associated_with IL-8,breast tumors
0#13#gene357660#70#diseaseC0027627 25239884-1#0#13#gene3576 25239884-1#60#70#diseaseC0027627 associated_with Interleukin-8,metastasis
0#13#gene357691#104#diseaseC1458155 25239884-1#0#13#gene3576 25239884-1#91#104#diseaseC1458155 associated_with Interleukin-8,breast tumors
15#19#gene357660#70#diseaseC0027627 25239884-1#15#19#gene3576 25239884-1#60#70#diseaseC0027627 associated_with IL-8,metastasis
15#19#gene357691#104#diseaseC1458155 25239884-1#15#19#gene3576 25239884-1#91#104#diseaseC1458155 associated_with IL-8,breast tumors

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 107-212 DRI_Background denotes Interleukin-8 (IL-8) is a pleiotropic chemokine involved in metastasis and angiogenesis of breast tumors.
T2 213-374 DRI_Background denotes The expression of IL-8 is deregulated in metastatic breast carcinomas owing to aberrant NF-κB activity, which is known to positively regulate IL-8 transcription.
T3 375-496 DRI_Outcome denotes Earlier, we have shown that tumor suppressor SMAR1 suppresses NF-κB transcriptional activity by modulating IκBα function.
T4 497-584 DRI_Outcome denotes Here, we show that NF-κB target gene IL-8, is a direct transcriptional target of SMAR1.
T5 585-772 DRI_Approach denotes Using chromatin immunoprecipitation and reporter assays, we demonstrate that SMAR1 binds to IL-8 promoter MAR (matrix attachment region) and recruits HDAC1 dependent co-repressor complex.
T6 773-930 DRI_Outcome denotes Further, we also show that SMAR1 antagonizes p300-mediated acetylation of RelA/p65, a post-translational modification indispensable for IL-8 transactivation.
T7 931-1048 DRI_Approach denotes Thus, we decipher a new role of SMAR1 in NF-κB dependent transcriptional regulation of pro-angiogenic chemokine IL-8.