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PubMed:25234496 JSONTXT

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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 45-51 http://purl.obolibrary.org/obo/MAT_0000034 denotes artery
T2 782-788 http://purl.obolibrary.org/obo/MAT_0000034 denotes artery
T3 962-968 http://purl.obolibrary.org/obo/MAT_0000034 denotes artery
T4 1202-1223 http://purl.obolibrary.org/obo/MAT_0000016 denotes cardiovascular system
T5 1982-1988 http://purl.obolibrary.org/obo/MAT_0000034 denotes artery
T6 2175-2196 http://purl.obolibrary.org/obo/MAT_0000016 denotes cardiovascular system
T7 2296-2301 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T8 2296-2301 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T9 2420-2425 http://purl.obolibrary.org/obo/MAT_0000488 denotes later

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-134 Sentence denotes Differential proteomic analysis of umbilical artery tissue from preeclampsia patients, using iTRAQ isobaric tags and 2D nano LC-MS/MS.
TextSentencer_T2 135-146 Sentence denotes UNLABELLED:
TextSentencer_T3 147-265 Sentence denotes Epidemiological studies suggest that the impact of preeclampsia does not only affect the mother but also the children.
TextSentencer_T4 266-414 Sentence denotes We know that adverse events in utero may predispose individuals to premature cardiovascular disease in adulthood, but we do not know the mechanisms.
TextSentencer_T5 415-625 Sentence denotes To gain insights into the mechanisms of cardiovascular dysfunction in the offspring of preeclampsia, we employed a global stable isotope labeled profiling strategy using iTRAQ reagents, followed by 2D-LC-MS/MS.
TextSentencer_T6 626-703 Sentence denotes We identified 1521 non-redundant proteins, and 1496 of these were quantified.
TextSentencer_T7 704-856 Sentence denotes Further analysis identified 53 differentially expressed proteins in umbilical artery; 22 proteins were up-regulated and 31 proteins were down-regulated.
TextSentencer_T8 857-1034 Sentence denotes K-means clustering analysis showed that there was a specific protein expression profile in the umbilical artery which could distinguish between normal and preeclampsia patients.
TextSentencer_T9 1035-1224 Sentence denotes These 53 proteins were analyzed by Ingenuity Pathway Analysis (IPA) and were found to play important roles in the angiogenesis, vasculogenesis, and development of the cardiovascular system.
TextSentencer_T10 1225-1401 Sentence denotes In addition, the differential expression of three cardiovascular relative proteins (aldose reductase, fibronectin-1, fibrillin-1) was independently verified using western blot.
TextSentencer_T11 1402-1526 Sentence denotes These results may supply new insights into the mechanisms of vascular dysfunction in the offspring of preeclampsia patients.
TextSentencer_T12 1527-1551 Sentence denotes BIOLOGICAL SIGNIFICANCE:
TextSentencer_T13 1552-1758 Sentence denotes Increasing evidence suggests that the children who were exposed to preeclampsia in utero have an increased cardiovascular risk, and vascular dysfunction has been found in some children born of preeclampsia.
TextSentencer_T14 1759-1806 Sentence denotes However, the mechanism remains largely unknown.
TextSentencer_T15 1807-1899 Sentence denotes In this study, we identified 1521 non-redundant proteins, and 1496 of these were quantified.
TextSentencer_T16 1900-2083 Sentence denotes Further analysis identified 53 differentially expressed proteins in the umbilical artery from preeclampsia patients; 22 proteins were up-regulated and 31 proteins were down-regulated.
TextSentencer_T17 2084-2209 Sentence denotes Some of these differentially expressed proteins have been shown to play important roles in cardiovascular system development.
TextSentencer_T18 2210-2431 Sentence denotes Our results provide new insights into the potential mechanisms underlying the changed blood pressure of offspring of mothers with preeclampsia, and, the elevation of their risk of cardiovascular abnormality in later life.
T1 0-134 Sentence denotes Differential proteomic analysis of umbilical artery tissue from preeclampsia patients, using iTRAQ isobaric tags and 2D nano LC-MS/MS.
T2 135-146 Sentence denotes UNLABELLED:
T3 147-265 Sentence denotes Epidemiological studies suggest that the impact of preeclampsia does not only affect the mother but also the children.
T4 266-414 Sentence denotes We know that adverse events in utero may predispose individuals to premature cardiovascular disease in adulthood, but we do not know the mechanisms.
T5 415-625 Sentence denotes To gain insights into the mechanisms of cardiovascular dysfunction in the offspring of preeclampsia, we employed a global stable isotope labeled profiling strategy using iTRAQ reagents, followed by 2D-LC-MS/MS.
T6 626-703 Sentence denotes We identified 1521 non-redundant proteins, and 1496 of these were quantified.
T7 704-856 Sentence denotes Further analysis identified 53 differentially expressed proteins in umbilical artery; 22 proteins were up-regulated and 31 proteins were down-regulated.
T8 857-1034 Sentence denotes K-means clustering analysis showed that there was a specific protein expression profile in the umbilical artery which could distinguish between normal and preeclampsia patients.
T9 1035-1224 Sentence denotes These 53 proteins were analyzed by Ingenuity Pathway Analysis (IPA) and were found to play important roles in the angiogenesis, vasculogenesis, and development of the cardiovascular system.
T10 1225-1401 Sentence denotes In addition, the differential expression of three cardiovascular relative proteins (aldose reductase, fibronectin-1, fibrillin-1) was independently verified using western blot.
T11 1402-1526 Sentence denotes These results may supply new insights into the mechanisms of vascular dysfunction in the offspring of preeclampsia patients.
T12 1527-1551 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T13 1552-1758 Sentence denotes Increasing evidence suggests that the children who were exposed to preeclampsia in utero have an increased cardiovascular risk, and vascular dysfunction has been found in some children born of preeclampsia.
T14 1759-1806 Sentence denotes However, the mechanism remains largely unknown.
T15 1807-1899 Sentence denotes In this study, we identified 1521 non-redundant proteins, and 1496 of these were quantified.
T16 1900-2083 Sentence denotes Further analysis identified 53 differentially expressed proteins in the umbilical artery from preeclampsia patients; 22 proteins were up-regulated and 31 proteins were down-regulated.
T17 2084-2209 Sentence denotes Some of these differentially expressed proteins have been shown to play important roles in cardiovascular system development.
T18 2210-2431 Sentence denotes Our results provide new insights into the potential mechanisms underlying the changed blood pressure of offspring of mothers with preeclampsia, and, the elevation of their risk of cardiovascular abnormality in later life.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 198-210 HP_0100602 denotes preeclampsia
T2 502-514 HP_0100602 denotes preeclampsia
T3 1012-1024 HP_0100602 denotes preeclampsia
T4 1504-1516 HP_0100602 denotes preeclampsia

Preeclampsia

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 64-76 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 198-210 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 502-514 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T4 1012-1024 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T5 1504-1516 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T6 1619-1631 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T7 1745-1757 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T8 1994-2006 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T9 2340-2352 ORPHA:275555 denotes preeclampsia

Preeclampsia-compare

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 64-76 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 198-210 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 502-514 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T4 1012-1024 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T5 1504-1516 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T6 1619-1631 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T7 1745-1757 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T8 1994-2006 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T9 2340-2352 ORPHA:275555 denotes preeclampsia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 35-51 http://purl.obolibrary.org/obo/UBERON_0001310 denotes umbilical artery
PD-UBERON-AE-B_T2 772-788 http://purl.obolibrary.org/obo/UBERON_0001310 denotes umbilical artery
PD-UBERON-AE-B_T3 952-968 http://purl.obolibrary.org/obo/UBERON_0001310 denotes umbilical artery
PD-UBERON-AE-B_T4 1972-1988 http://purl.obolibrary.org/obo/UBERON_0001310 denotes umbilical artery
PD-UBERON-AE-B_T5 45-51 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T6 782-788 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T7 962-968 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T8 1982-1988 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T9 52-58 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T10 1202-1223 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
PD-UBERON-AE-B_T11 2175-2196 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
PD-UBERON-AE-B_T12 2296-2301 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

preeclampsia_genes

Id Subject Object Predicate Lexical cue
PD-PreeclampsiaGenes-B_T1 1327-1340 HGNC:FN1 denotes fibronectin-1
PD-PreeclampsiaGenes-B_T2 1342-1353 HGNC:FBN1 denotes fibrillin-1

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 2296-2301 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 45-51 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T3 782-788 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T4 962-968 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T5 1982-1988 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T6 52-58 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T7 35-51 http://purl.obolibrary.org/obo/UBERON_0001310 denotes umbilical artery
PD-UBERON-AE-B_T8 772-788 http://purl.obolibrary.org/obo/UBERON_0001310 denotes umbilical artery
PD-UBERON-AE-B_T9 952-968 http://purl.obolibrary.org/obo/UBERON_0001310 denotes umbilical artery
PD-UBERON-AE-B_T10 1972-1988 http://purl.obolibrary.org/obo/UBERON_0001310 denotes umbilical artery
PD-UBERON-AE-B_T11 1202-1223 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
PD-UBERON-AE-B_T12 2175-2196 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 64-76 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T2 198-210 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T3 343-365 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T4 502-514 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T5 1012-1024 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T6 1504-1516 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T7 1619-1631 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T8 1745-1757 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T9 1994-2006 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081
T10 2340-2352 Disease denotes preeclampsia http://purl.obolibrary.org/obo/MONDO_0005081

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 343-365 Phenotype denotes cardiovascular disease HP:0001626
T2 2390-2416 Phenotype denotes cardiovascular abnormality HP:0001626

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 35-51 Body_part denotes umbilical artery http://purl.obolibrary.org/obo/UBERON_0001310
T2 52-58 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 772-788 Body_part denotes umbilical artery http://purl.obolibrary.org/obo/UBERON_0001310
T4 952-968 Body_part denotes umbilical artery http://purl.obolibrary.org/obo/UBERON_0001310
T5 1202-1223 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T6 1972-1988 Body_part denotes umbilical artery http://purl.obolibrary.org/obo/UBERON_0001310
T7 2175-2196 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T8 2296-2301 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 45-51 Body_part denotes artery http://purl.obolibrary.org/obo/MAT_0000034
T2 782-788 Body_part denotes artery http://purl.obolibrary.org/obo/MAT_0000034
T3 962-968 Body_part denotes artery http://purl.obolibrary.org/obo/MAT_0000034
T4 1202-1223 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/MAT_0000016
T5 1982-1988 Body_part denotes artery http://purl.obolibrary.org/obo/MAT_0000034
T6 2175-2196 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/MAT_0000016
T7 2296-2301 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T9 2420-2425 Body_part denotes later http://purl.obolibrary.org/obo/MAT_0000488