> top > docs > PubMed:2521857 > annotations

PubMed:2521857 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-192 Sentence denotes Phorbol ester or epidermal growth factor (EGF) stimulates the concurrent accumulation of mRNA for the EGF receptor and its ligand transforming growth factor-alpha in a breast cancer cell line.
T2 193-358 Sentence denotes We have previously reported that both 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) can stimulate the synthesis rate of EGF receptors.
T3 359-591 Sentence denotes We now show that the MDA468 breast cancer cells express the mRNA for the EGF-like molecule, transforming growth factor-alpha (TGF-alpha), and demonstrate that TPA or EGF cause an accumulation of both EGF receptor and TGF-alpha mRNA.
T4 592-770 Sentence denotes The levels of EGF receptor mRNA paralleled our earlier protein data, with peak accumulations of 2-3-fold with 10(-9) M EGF and 3-5-fold with 100 ng/ml TPA seen between 6 and 8 h.
T5 771-911 Sentence denotes A 7-fold accumulation of TGF-alpha mRNA was seen following 4 h of treatment with TPA, and a 2-fold accumulation was seen after 8 h with EGF.
T6 912-1127 Sentence denotes These changes in EGF receptor and TGF-alpha mRNAs were observed in the absence of any change in the mRNA level of the alpha-subunit of hexosaminidase A (a lysosomal enzyme), demonstrating some degree of specificity.
T7 1128-1396 Sentence denotes Detectable quantities of immunoreactive TGF-alpha accumulated in the cell culture medium of MDA468 cell treated with the blocking anti-EGF receptor monoclonal antibody B1D8 while no immunoreactive TGF-alpha was detected in the medium of cells with unblocked receptors.
T8 1397-1630 Sentence denotes The concentration of B1D8 used was sufficient to block the binding of exogenously added 125I-EGF to undetectable levels but had only minor effects on cell growth and no effect on the expression of the TGF-alpha and EGF receptor mRNA.
T1 0-192 Sentence denotes Phorbol ester or epidermal growth factor (EGF) stimulates the concurrent accumulation of mRNA for the EGF receptor and its ligand transforming growth factor-alpha in a breast cancer cell line.
T2 193-358 Sentence denotes We have previously reported that both 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) can stimulate the synthesis rate of EGF receptors.
T3 359-591 Sentence denotes We now show that the MDA468 breast cancer cells express the mRNA for the EGF-like molecule, transforming growth factor-alpha (TGF-alpha), and demonstrate that TPA or EGF cause an accumulation of both EGF receptor and TGF-alpha mRNA.
T4 592-770 Sentence denotes The levels of EGF receptor mRNA paralleled our earlier protein data, with peak accumulations of 2-3-fold with 10(-9) M EGF and 3-5-fold with 100 ng/ml TPA seen between 6 and 8 h.
T5 771-911 Sentence denotes A 7-fold accumulation of TGF-alpha mRNA was seen following 4 h of treatment with TPA, and a 2-fold accumulation was seen after 8 h with EGF.
T6 912-1127 Sentence denotes These changes in EGF receptor and TGF-alpha mRNAs were observed in the absence of any change in the mRNA level of the alpha-subunit of hexosaminidase A (a lysosomal enzyme), demonstrating some degree of specificity.
T7 1128-1396 Sentence denotes Detectable quantities of immunoreactive TGF-alpha accumulated in the cell culture medium of MDA468 cell treated with the blocking anti-EGF receptor monoclonal antibody B1D8 while no immunoreactive TGF-alpha was detected in the medium of cells with unblocked receptors.
T8 1397-1630 Sentence denotes The concentration of B1D8 used was sufficient to block the binding of exogenously added 125I-EGF to undetectable levels but had only minor effects on cell growth and no effect on the expression of the TGF-alpha and EGF receptor mRNA.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 17-40 gene:1950 denotes epidermal growth factor
T1 168-181 disease:C0006142 denotes breast cancer
T2 17-40 gene:1950 denotes epidermal growth factor
T3 168-181 disease:C0678222 denotes breast cancer
T4 42-45 gene:1950 denotes EGF
T5 168-181 disease:C0006142 denotes breast cancer
T6 42-45 gene:1950 denotes EGF
T7 168-181 disease:C0678222 denotes breast cancer
T8 102-105 gene:1950 denotes EGF
T9 168-181 disease:C0006142 denotes breast cancer
T10 102-105 gene:1950 denotes EGF
T11 168-181 disease:C0678222 denotes breast cancer
T12 130-162 gene:7039 denotes transforming growth factor-alpha
T13 168-181 disease:C0006142 denotes breast cancer
T14 130-162 gene:7039 denotes transforming growth factor-alpha
T15 168-181 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with epidermal growth factor,breast cancer
R2 T2 T3 associated_with epidermal growth factor,breast cancer
R3 T4 T5 associated_with EGF,breast cancer
R4 T6 T7 associated_with EGF,breast cancer
R5 T8 T9 associated_with EGF,breast cancer
R6 T10 T11 associated_with EGF,breast cancer
R7 T12 T13 associated_with transforming growth factor-alpha,breast cancer
R8 T14 T15 associated_with transforming growth factor-alpha,breast cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 387-400 HP_0003002 denotes breast cancer
T2 387-400 HP_0100013 denotes breast cancer
T3 394-400 HP_0002664 denotes cancer

CoMAGC

Id Subject Object Predicate Lexical cue
T1 576-590 Gene denotes TGF-alpha mRNA
E2 538-550 Positive_regulation denotes accumulation
T2 387-400 breast cancer denotes breast cancer
R1 T1 E2 themeOf TGF-alpha mRNA,accumulation
R3 T1 T2 CGE-increased TGF-alpha mRNA,breast cancer
R4 T1 T2 CCS-normalTOcancer TGF-alpha mRNA,breast cancer
R5 T1 T2 PT-observation TGF-alpha mRNA,breast cancer
R3 T1 T2 IGE-unchanged TGF-alpha mRNA,breast cancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 168-181 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 387-400 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 17-33 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021
T2 168-174 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 278-294 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021
T4 387-393 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310