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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 0-6 OrganismTaxon denotes Sepsis NCBItxid:137507
T2 146-152 OrganismTaxon denotes sepsis NCBItxid:137507
T3 381-387 OrganismTaxon denotes Sepsis NCBItxid:137507
T4 402-406 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T7 670-676 OrganismTaxon denotes sepsis NCBItxid:137507
T8 678-684 OrganismTaxon denotes Sepsis NCBItxid:137507
T9 837-843 OrganismTaxon denotes sepsis NCBItxid:137507
T15 1640-1646 OrganismTaxon denotes sepsis NCBItxid:137507
T10 981-987 OrganismTaxon denotes sepsis NCBItxid:137507
T11 1318-1324 OrganismTaxon denotes sepsis NCBItxid:137507
T12 1536-1540 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
T2 101-380 Sentence denotes The present study tested the hypothesis that sepsis-induced leucine (Leu) resistance in skeletal muscle is associated with a down-regulation of amino acid transporters important in regulating Leu flux or an impairment in the formation of the Leu-sensitive mTOR-Ragulator complex.
T3 381-564 Sentence denotes Sepsis in adult male rats decreased basal protein synthesis in gastrocnemius, associated with a reduction in mTOR activation as indicated by decreased 4E-BP1 and S6K1 phosphorylation.
T4 565-677 Sentence denotes The ability of oral Leu to increase protein synthesis and mTOR kinase after 1 h was largely prevented in sepsis.
T5 678-824 Sentence denotes Sepsis increased CAT1, LAT2 and SNAT2 mRNA content two- to fourfold, but only the protein content for CAT1 (20 % decrease) differed significantly.
T6 825-967 Sentence denotes Conversely, sepsis decreased the proton-assisted amino acid transporter (PAT)-2 mRNA by 60 %, but without a coordinate change in PAT2 protein.
T7 968-1085 Sentence denotes There was no sepsis or Leu effect on the protein content for RagA-D, LAMTOR-1 and -2, raptor, Rheb or mTOR in muscle.
T8 1086-1325 Sentence denotes The binding of mTOR, PRAS40 and RagC to raptor did not differ for control and septic muscle in the basal condition; however, the Leu-induced decrease in PRAS40·raptor and increase in RagC·raptor seen in control muscle was absent in sepsis.
T9 1326-1541 Sentence denotes The intracellular Leu concentration was increased in septic muscle, compared to basal control conditions, and oral Leu further increased the intracellular Leu concentration similarly in both control and septic rats.
T10 1542-1886 Sentence denotes Hence, while alterations in select amino acid transporters are not associated with development of sepsis-induced Leu resistance, the Leu-stimulated binding of raptor with RagC and the recruitment of mTOR/raptor to the endosome-lysosomal compartment may partially explain the inability of Leu to fully activate mTOR and muscle protein synthesis.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
10236 0-6 DiseaseOrPhenotypicFeature denotes Sepsis MESH:D018805
10237 26-49 GeneOrGeneProduct denotes amino acid transporters NCBIGene:246235|NCBIGene:25648|NCBIGene:29642|NCBIGene:84551
10238 54-61 ChemicalEntity denotes leucine MESH:D007930
10239 76-80 GeneOrGeneProduct denotes mTOR NCBIGene:56718
10240 146-152 DiseaseOrPhenotypicFeature denotes sepsis MESH:D018805
10241 161-168 ChemicalEntity denotes leucine MESH:D007930
10242 170-173 ChemicalEntity denotes Leu MESH:D007930
10243 245-268 GeneOrGeneProduct denotes amino acid transporters NCBIGene:246235|NCBIGene:25648|NCBIGene:29642|NCBIGene:84551
10244 293-296 ChemicalEntity denotes Leu MESH:D007930
10245 343-346 ChemicalEntity denotes Leu MESH:D007930
10246 357-361 GeneOrGeneProduct denotes mTOR NCBIGene:56718
10247 362-379 GeneOrGeneProduct denotes Ragulator complex NCBIGene:295234|NCBIGene:308869
10248 381-387 DiseaseOrPhenotypicFeature denotes Sepsis MESH:D018805
10249 402-406 OrganismTaxon denotes rats NCBITaxon:10116
10250 490-494 GeneOrGeneProduct denotes mTOR NCBIGene:56718
10251 532-538 GeneOrGeneProduct denotes 4E-BP1 NCBIGene:116636
10252 543-547 GeneOrGeneProduct denotes S6K1 NCBIGene:83840
10253 585-588 ChemicalEntity denotes Leu MESH:D007930
10254 623-627 GeneOrGeneProduct denotes mTOR NCBIGene:56718
10255 670-676 DiseaseOrPhenotypicFeature denotes sepsis MESH:D018805
10256 678-684 DiseaseOrPhenotypicFeature denotes Sepsis MESH:D018805
10257 695-699 GeneOrGeneProduct denotes CAT1 NCBIGene:25648
10258 701-705 GeneOrGeneProduct denotes LAT2 NCBIGene:84551
10259 710-715 GeneOrGeneProduct denotes SNAT2 NCBIGene:29642
10260 780-784 GeneOrGeneProduct denotes CAT1 NCBIGene:25648
10261 837-843 DiseaseOrPhenotypicFeature denotes sepsis MESH:D018805
10262 858-904 GeneOrGeneProduct denotes proton-assisted amino acid transporter (PAT)-2 NCBIGene:246235
10263 954-958 GeneOrGeneProduct denotes PAT2 NCBIGene:246235
10264 981-987 DiseaseOrPhenotypicFeature denotes sepsis MESH:D018805
10265 991-994 ChemicalEntity denotes Leu MESH:D007930
10266 1029-1035 GeneOrGeneProduct denotes RagA-D NCBIGene:117043|NCBIGene:117044|NCBIGene:297960|NCBIGene:298514
10267 1037-1052 GeneOrGeneProduct denotes LAMTOR-1 and -2 NCBIGene:295234|NCBIGene:308869
10268 1054-1060 GeneOrGeneProduct denotes raptor NCBIGene:287871
10269 1062-1066 GeneOrGeneProduct denotes Rheb NCBIGene:26954
10270 1070-1074 GeneOrGeneProduct denotes mTOR NCBIGene:56718
10271 1101-1105 GeneOrGeneProduct denotes mTOR NCBIGene:56718
10272 1107-1113 GeneOrGeneProduct denotes PRAS40 NCBIGene:292887
10273 1118-1122 GeneOrGeneProduct denotes RagC NCBIGene:298514
10274 1126-1132 GeneOrGeneProduct denotes raptor NCBIGene:287871
10275 1215-1218 ChemicalEntity denotes Leu MESH:D007930
10276 1239-1245 GeneOrGeneProduct denotes PRAS40 NCBIGene:292887
10277 1246-1252 GeneOrGeneProduct denotes raptor NCBIGene:287871
10278 1269-1273 GeneOrGeneProduct denotes RagC NCBIGene:298514
10279 1274-1280 GeneOrGeneProduct denotes raptor NCBIGene:287871
10280 1318-1324 DiseaseOrPhenotypicFeature denotes sepsis MESH:D018805
10281 1344-1347 ChemicalEntity denotes Leu MESH:D007930
10282 1441-1444 ChemicalEntity denotes Leu MESH:D007930
10283 1481-1484 ChemicalEntity denotes Leu MESH:D007930
10284 1536-1540 OrganismTaxon denotes rats NCBITaxon:10116
10285 1577-1600 GeneOrGeneProduct denotes amino acid transporters NCBIGene:246235|NCBIGene:25648|NCBIGene:29642|NCBIGene:84551
10286 1640-1646 DiseaseOrPhenotypicFeature denotes sepsis MESH:D018805
10287 1655-1658 ChemicalEntity denotes Leu MESH:D007930
10288 1675-1678 ChemicalEntity denotes Leu MESH:D007930
10289 1701-1707 GeneOrGeneProduct denotes raptor NCBIGene:287871
10290 1713-1717 GeneOrGeneProduct denotes RagC NCBIGene:298514
10291 1741-1745 GeneOrGeneProduct denotes mTOR NCBIGene:56718
10292 1746-1752 GeneOrGeneProduct denotes raptor NCBIGene:287871
10293 1830-1833 ChemicalEntity denotes Leu MESH:D007930
10294 1852-1856 GeneOrGeneProduct denotes mTOR NCBIGene:56718

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 26-36 GeneOrGeneProduct denotes amino acid
T2 37-49 GeneOrGeneProduct denotes transporters
T3 76-80 GeneOrGeneProduct denotes mTOR
T4 84-99 GeneOrGeneProduct denotes skeletal muscle
T5 189-204 GeneOrGeneProduct denotes skeletal muscle
T6 245-255 GeneOrGeneProduct denotes amino acid
T7 256-268 GeneOrGeneProduct denotes transporters
T8 357-361 GeneOrGeneProduct denotes mTOR
T9 423-430 GeneOrGeneProduct denotes protein
T10 490-494 GeneOrGeneProduct denotes mTOR
T11 532-538 GeneOrGeneProduct denotes 4E-BP1
T12 543-547 GeneOrGeneProduct denotes S6K1
T13 601-608 GeneOrGeneProduct denotes protein
T14 623-627 GeneOrGeneProduct denotes mTOR
T15 628-634 GeneOrGeneProduct denotes kinase
T16 695-699 GeneOrGeneProduct denotes CAT1
T17 701-705 GeneOrGeneProduct denotes LAT2
T18 710-715 GeneOrGeneProduct denotes SNAT2
T19 716-720 GeneOrGeneProduct denotes mRNA
T20 760-767 GeneOrGeneProduct denotes protein
T21 780-784 GeneOrGeneProduct denotes CAT1
T22 874-896 GeneOrGeneProduct denotes amino acid transporter
T23 905-909 GeneOrGeneProduct denotes mRNA
T24 954-958 GeneOrGeneProduct denotes PAT2
T25 959-966 GeneOrGeneProduct denotes protein
T26 1009-1016 GeneOrGeneProduct denotes protein
T27 1029-1033 GeneOrGeneProduct denotes RagA
T28 1037-1045 GeneOrGeneProduct denotes LAMTOR-1
T29 1054-1060 GeneOrGeneProduct denotes raptor
T30 1062-1066 GeneOrGeneProduct denotes Rheb
T31 1070-1074 GeneOrGeneProduct denotes mTOR
T32 1078-1084 GeneOrGeneProduct denotes muscle
T33 1090-1097 GeneOrGeneProduct denotes binding
T34 1101-1105 GeneOrGeneProduct denotes mTOR
T35 1107-1113 GeneOrGeneProduct denotes PRAS40
T36 1118-1122 GeneOrGeneProduct denotes RagC
T37 1126-1132 GeneOrGeneProduct denotes raptor
T38 1171-1177 GeneOrGeneProduct denotes muscle
T39 1239-1245 GeneOrGeneProduct denotes PRAS40
T40 1246-1252 GeneOrGeneProduct denotes raptor
T41 1297-1303 GeneOrGeneProduct denotes muscle
T42 1386-1392 GeneOrGeneProduct denotes muscle
T43 1577-1587 GeneOrGeneProduct denotes amino acid
T44 1588-1600 GeneOrGeneProduct denotes transporters
T45 1690-1697 GeneOrGeneProduct denotes binding
T46 1701-1707 GeneOrGeneProduct denotes raptor
T47 1713-1717 GeneOrGeneProduct denotes RagC
T48 1741-1745 GeneOrGeneProduct denotes mTOR
T49 1746-1752 GeneOrGeneProduct denotes raptor
T50 1852-1856 GeneOrGeneProduct denotes mTOR
T51 1861-1867 GeneOrGeneProduct denotes muscle
T52 1868-1875 GeneOrGeneProduct denotes protein

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 7-14 GeneOrGeneProduct denotes induced
T2 26-36 GeneOrGeneProduct denotes amino acid
T3 37-49 GeneOrGeneProduct denotes transporters
T4 76-80 GeneOrGeneProduct denotes mTOR
T5 84-99 GeneOrGeneProduct denotes skeletal muscle
T6 119-125 GeneOrGeneProduct denotes tested
T7 153-160 GeneOrGeneProduct denotes induced
T8 189-204 GeneOrGeneProduct denotes skeletal muscle
T9 231-241 GeneOrGeneProduct denotes regulation
T10 245-255 GeneOrGeneProduct denotes amino acid
T11 256-268 GeneOrGeneProduct denotes transporters
T12 282-292 GeneOrGeneProduct denotes regulating
T13 326-335 GeneOrGeneProduct denotes formation
T14 357-361 GeneOrGeneProduct denotes mTOR
T15 397-401 GeneOrGeneProduct denotes male
T16 423-430 GeneOrGeneProduct denotes protein
T17 490-494 GeneOrGeneProduct denotes mTOR
T18 495-505 GeneOrGeneProduct denotes activation
T19 532-538 GeneOrGeneProduct denotes 4E-BP1
T20 543-547 GeneOrGeneProduct denotes S6K1
T21 601-608 GeneOrGeneProduct denotes protein
T22 623-627 GeneOrGeneProduct denotes mTOR
T23 628-634 GeneOrGeneProduct denotes kinase
T24 649-656 GeneOrGeneProduct denotes largely
T25 695-699 GeneOrGeneProduct denotes CAT1
T26 701-705 GeneOrGeneProduct denotes LAT2
T27 710-715 GeneOrGeneProduct denotes SNAT2
T28 716-720 GeneOrGeneProduct denotes mRNA
T29 760-767 GeneOrGeneProduct denotes protein
T30 780-784 GeneOrGeneProduct denotes CAT1
T31 874-896 GeneOrGeneProduct denotes amino acid transporter
T32 897-904 GeneOrGeneProduct denotes (PAT)-2
T33 905-909 GeneOrGeneProduct denotes mRNA
T34 954-958 GeneOrGeneProduct denotes PAT2
T35 959-966 GeneOrGeneProduct denotes protein
T36 1009-1016 GeneOrGeneProduct denotes protein
T37 1029-1033 GeneOrGeneProduct denotes RagA
T38 1037-1045 GeneOrGeneProduct denotes LAMTOR-1
T39 1054-1060 GeneOrGeneProduct denotes raptor
T40 1062-1066 GeneOrGeneProduct denotes Rheb
T41 1070-1074 GeneOrGeneProduct denotes mTOR
T42 1078-1084 GeneOrGeneProduct denotes muscle
T43 1090-1097 GeneOrGeneProduct denotes binding
T44 1101-1105 GeneOrGeneProduct denotes mTOR
T45 1107-1113 GeneOrGeneProduct denotes PRAS40
T46 1118-1122 GeneOrGeneProduct denotes RagC
T47 1126-1132 GeneOrGeneProduct denotes raptor
T48 1171-1177 GeneOrGeneProduct denotes muscle
T49 1219-1226 GeneOrGeneProduct denotes induced
T50 1239-1245 GeneOrGeneProduct denotes PRAS40
T51 1246-1252 GeneOrGeneProduct denotes raptor
T52 1297-1303 GeneOrGeneProduct denotes muscle
T53 1386-1392 GeneOrGeneProduct denotes muscle
T54 1499-1508 GeneOrGeneProduct denotes similarly
T55 1577-1587 GeneOrGeneProduct denotes amino acid
T56 1588-1600 GeneOrGeneProduct denotes transporters
T57 1647-1654 GeneOrGeneProduct denotes induced
T58 1690-1697 GeneOrGeneProduct denotes binding
T59 1701-1707 GeneOrGeneProduct denotes raptor
T60 1713-1717 GeneOrGeneProduct denotes RagC
T61 1741-1745 GeneOrGeneProduct denotes mTOR
T62 1746-1752 GeneOrGeneProduct denotes raptor
T63 1843-1851 GeneOrGeneProduct denotes activate
T64 1852-1856 GeneOrGeneProduct denotes mTOR
T65 1861-1867 GeneOrGeneProduct denotes muscle
T66 1868-1875 GeneOrGeneProduct denotes protein

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 0-6 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T2 146-152 DiseaseOrPhenotypicFeature denotes sepsis D018805
T3 381-387 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T4 670-676 DiseaseOrPhenotypicFeature denotes sepsis D018805
T5 678-684 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T6 837-843 DiseaseOrPhenotypicFeature denotes sepsis D018805
T7 981-987 DiseaseOrPhenotypicFeature denotes sepsis D018805
T8 1318-1324 DiseaseOrPhenotypicFeature denotes sepsis D018805
T9 1640-1646 DiseaseOrPhenotypicFeature denotes sepsis D018805

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 26-49 GeneOrGeneProduct denotes amino acid transporters
T2 76-80 GeneOrGeneProduct denotes mTOR
T3 245-268 GeneOrGeneProduct denotes amino acid transporters
T4 357-361 GeneOrGeneProduct denotes mTOR
T5 490-494 GeneOrGeneProduct denotes mTOR
T6 532-538 GeneOrGeneProduct denotes 4E-BP1
T7 543-547 GeneOrGeneProduct denotes S6K1
T8 623-627 GeneOrGeneProduct denotes mTOR
T9 695-699 GeneOrGeneProduct denotes CAT1
T10 701-705 GeneOrGeneProduct denotes LAT2
T11 710-715 GeneOrGeneProduct denotes SNAT2
T12 760-775 GeneOrGeneProduct denotes protein content
T13 780-784 GeneOrGeneProduct denotes CAT1
T14 874-896 GeneOrGeneProduct denotes amino acid transporter
T15 954-958 GeneOrGeneProduct denotes PAT2
T16 1009-1024 GeneOrGeneProduct denotes protein content
T17 1029-1033 GeneOrGeneProduct denotes RagA
T18 1037-1045 GeneOrGeneProduct denotes LAMTOR-1
T19 1054-1060 GeneOrGeneProduct denotes raptor
T20 1062-1066 GeneOrGeneProduct denotes Rheb
T21 1070-1074 GeneOrGeneProduct denotes mTOR
T22 1101-1105 GeneOrGeneProduct denotes mTOR
T23 1107-1113 GeneOrGeneProduct denotes PRAS40
T24 1118-1122 GeneOrGeneProduct denotes RagC
T25 1126-1132 GeneOrGeneProduct denotes raptor
T26 1239-1245 GeneOrGeneProduct denotes PRAS40
T27 1246-1252 GeneOrGeneProduct denotes raptor
T28 1577-1600 GeneOrGeneProduct denotes amino acid transporters
T29 1701-1707 GeneOrGeneProduct denotes raptor
T30 1713-1717 GeneOrGeneProduct denotes RagC
T31 1741-1745 GeneOrGeneProduct denotes mTOR
T32 1746-1752 GeneOrGeneProduct denotes raptor
T33 1852-1856 GeneOrGeneProduct denotes mTOR

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 347-356 DiseaseOrPhenotypicFeature denotes sensitive 0000605

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 0-6 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T2 146-152 DiseaseOrPhenotypicFeature denotes sepsis D018805
T3 381-387 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T4 670-676 DiseaseOrPhenotypicFeature denotes sepsis D018805
T5 678-684 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T6 837-843 DiseaseOrPhenotypicFeature denotes sepsis D018805
T7 981-987 DiseaseOrPhenotypicFeature denotes sepsis D018805
T8 1318-1324 DiseaseOrPhenotypicFeature denotes sepsis D018805
T9 1640-1646 DiseaseOrPhenotypicFeature denotes sepsis D018805

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 0-6 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T2 146-152 DiseaseOrPhenotypicFeature denotes sepsis D018805
T3 381-387 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T4 670-676 DiseaseOrPhenotypicFeature denotes sepsis D018805
T5 678-684 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T6 837-843 DiseaseOrPhenotypicFeature denotes sepsis D018805
T7 981-987 DiseaseOrPhenotypicFeature denotes sepsis D018805
T8 1318-1324 DiseaseOrPhenotypicFeature denotes sepsis D018805
T9 1640-1646 DiseaseOrPhenotypicFeature denotes sepsis D018805

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 54-61 ChemicalEntity denotes leucine http://purl.obolibrary.org/obo/CHEBI_25017
T2 161-168 ChemicalEntity denotes leucine http://purl.obolibrary.org/obo/CHEBI_25017
T3 170-173 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T6 293-296 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T9 343-346 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T12 585-588 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T15 858-864 ChemicalEntity denotes proton D011522|http://purl.obolibrary.org/obo/CHEBI_24636
T17 898-901 ChemicalEntity denotes PAT http://purl.obolibrary.org/obo/CHEBI_74926
T18 991-994 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T21 1215-1218 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T24 1344-1347 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T27 1441-1444 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T30 1481-1484 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T33 1655-1658 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T36 1675-1678 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T39 1830-1833 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 402-406 OrganismTaxon denotes rats
T2 1536-1540 OrganismTaxon denotes rats

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T39 1830-1833 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T36 1675-1678 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T33 1655-1658 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T30 1481-1484 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T27 1441-1444 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T24 1344-1347 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T21 1215-1218 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T18 991-994 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T17 898-901 ChemicalEntity denotes PAT http://purl.obolibrary.org/obo/CHEBI_74926
T15 858-864 ChemicalEntity denotes proton http://purl.obolibrary.org/obo/CHEBI_24636|D011522
T12 585-588 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T9 343-346 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T6 293-296 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T3 170-173 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T2 161-168 ChemicalEntity denotes leucine http://purl.obolibrary.org/obo/CHEBI_25017
T1 54-61 ChemicalEntity denotes leucine http://purl.obolibrary.org/obo/CHEBI_25017
T60560 1852-1856 GeneOrGeneProduct denotes mTOR
T32 1746-1752 GeneOrGeneProduct denotes raptor
T31 1741-1745 GeneOrGeneProduct denotes mTOR
T74466 1713-1717 GeneOrGeneProduct denotes RagC
T29 1701-1707 GeneOrGeneProduct denotes raptor
T28 1577-1600 GeneOrGeneProduct denotes amino acid transporters
T41173 1246-1252 GeneOrGeneProduct denotes raptor
T26 1239-1245 GeneOrGeneProduct denotes PRAS40
T25 1126-1132 GeneOrGeneProduct denotes raptor
T95061 1118-1122 GeneOrGeneProduct denotes RagC
T23 1107-1113 GeneOrGeneProduct denotes PRAS40
T22 1101-1105 GeneOrGeneProduct denotes mTOR
T37404 1070-1074 GeneOrGeneProduct denotes mTOR
T20 1062-1066 GeneOrGeneProduct denotes Rheb
T19 1054-1060 GeneOrGeneProduct denotes raptor
T17753 1037-1045 GeneOrGeneProduct denotes LAMTOR-1
T92578 1029-1033 GeneOrGeneProduct denotes RagA
T16 1009-1024 GeneOrGeneProduct denotes protein content
T96883 954-958 GeneOrGeneProduct denotes PAT2
T14 874-896 GeneOrGeneProduct denotes amino acid transporter
T13 780-784 GeneOrGeneProduct denotes CAT1
T92095 760-775 GeneOrGeneProduct denotes protein content
T11 710-715 GeneOrGeneProduct denotes SNAT2
T10 701-705 GeneOrGeneProduct denotes LAT2
T68465 695-699 GeneOrGeneProduct denotes CAT1
T8 623-627 GeneOrGeneProduct denotes mTOR
T7 543-547 GeneOrGeneProduct denotes S6K1
T37977 532-538 GeneOrGeneProduct denotes 4E-BP1
T5 490-494 GeneOrGeneProduct denotes mTOR
T4 357-361 GeneOrGeneProduct denotes mTOR
T5683 245-268 GeneOrGeneProduct denotes amino acid transporters
T27631 76-80 GeneOrGeneProduct denotes mTOR
T68999 26-49 GeneOrGeneProduct denotes amino acid transporters
T69607 1640-1646 DiseaseOrPhenotypicFeature denotes sepsis D018805
T85654 1318-1324 DiseaseOrPhenotypicFeature denotes sepsis D018805
T39283 981-987 DiseaseOrPhenotypicFeature denotes sepsis D018805
T5833 837-843 DiseaseOrPhenotypicFeature denotes sepsis D018805
T84896 678-684 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T65437 670-676 DiseaseOrPhenotypicFeature denotes sepsis D018805
T96600 381-387 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T16409 146-152 DiseaseOrPhenotypicFeature denotes sepsis D018805
T3922 0-6 DiseaseOrPhenotypicFeature denotes Sepsis D018805
T7596 1536-1540 OrganismTaxon denotes rats
T7046 402-406 OrganismTaxon denotes rats

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
T2 101-380 Sentence denotes The present study tested the hypothesis that sepsis-induced leucine (Leu) resistance in skeletal muscle is associated with a down-regulation of amino acid transporters important in regulating Leu flux or an impairment in the formation of the Leu-sensitive mTOR-Ragulator complex.
T3 381-564 Sentence denotes Sepsis in adult male rats decreased basal protein synthesis in gastrocnemius, associated with a reduction in mTOR activation as indicated by decreased 4E-BP1 and S6K1 phosphorylation.
T4 565-677 Sentence denotes The ability of oral Leu to increase protein synthesis and mTOR kinase after 1 h was largely prevented in sepsis.
T5 678-824 Sentence denotes Sepsis increased CAT1, LAT2 and SNAT2 mRNA content two- to fourfold, but only the protein content for CAT1 (20 % decrease) differed significantly.
T6 825-967 Sentence denotes Conversely, sepsis decreased the proton-assisted amino acid transporter (PAT)-2 mRNA by 60 %, but without a coordinate change in PAT2 protein.
T7 968-1085 Sentence denotes There was no sepsis or Leu effect on the protein content for RagA-D, LAMTOR-1 and -2, raptor, Rheb or mTOR in muscle.
T8 1086-1325 Sentence denotes The binding of mTOR, PRAS40 and RagC to raptor did not differ for control and septic muscle in the basal condition; however, the Leu-induced decrease in PRAS40·raptor and increase in RagC·raptor seen in control muscle was absent in sepsis.
T9 1326-1541 Sentence denotes The intracellular Leu concentration was increased in septic muscle, compared to basal control conditions, and oral Leu further increased the intracellular Leu concentration similarly in both control and septic rats.
T10 1542-1886 Sentence denotes Hence, while alterations in select amino acid transporters are not associated with development of sepsis-induced Leu resistance, the Leu-stimulated binding of raptor with RagC and the recruitment of mTOR/raptor to the endosome-lysosomal compartment may partially explain the inability of Leu to fully activate mTOR and muscle protein synthesis.
T1 0-100 Sentence denotes Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
T2 101-380 Sentence denotes The present study tested the hypothesis that sepsis-induced leucine (Leu) resistance in skeletal muscle is associated with a down-regulation of amino acid transporters important in regulating Leu flux or an impairment in the formation of the Leu-sensitive mTOR-Ragulator complex.
T3 381-564 Sentence denotes Sepsis in adult male rats decreased basal protein synthesis in gastrocnemius, associated with a reduction in mTOR activation as indicated by decreased 4E-BP1 and S6K1 phosphorylation.
T4 565-677 Sentence denotes The ability of oral Leu to increase protein synthesis and mTOR kinase after 1 h was largely prevented in sepsis.
T5 678-824 Sentence denotes Sepsis increased CAT1, LAT2 and SNAT2 mRNA content two- to fourfold, but only the protein content for CAT1 (20 % decrease) differed significantly.
T6 825-967 Sentence denotes Conversely, sepsis decreased the proton-assisted amino acid transporter (PAT)-2 mRNA by 60 %, but without a coordinate change in PAT2 protein.
T7 968-1085 Sentence denotes There was no sepsis or Leu effect on the protein content for RagA-D, LAMTOR-1 and -2, raptor, Rheb or mTOR in muscle.
T8 1086-1325 Sentence denotes The binding of mTOR, PRAS40 and RagC to raptor did not differ for control and septic muscle in the basal condition; however, the Leu-induced decrease in PRAS40·raptor and increase in RagC·raptor seen in control muscle was absent in sepsis.
T9 1326-1541 Sentence denotes The intracellular Leu concentration was increased in septic muscle, compared to basal control conditions, and oral Leu further increased the intracellular Leu concentration similarly in both control and septic rats.
T10 1542-1886 Sentence denotes Hence, while alterations in select amino acid transporters are not associated with development of sepsis-induced Leu resistance, the Leu-stimulated binding of raptor with RagC and the recruitment of mTOR/raptor to the endosome-lysosomal compartment may partially explain the inability of Leu to fully activate mTOR and muscle protein synthesis.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 146-152 HP_0100806 denotes sepsis
T2 381-387 HP_0100806 denotes Sepsis
T3 670-676 HP_0100806 denotes sepsis
T4 678-684 HP_0100806 denotes Sepsis
T5 837-843 HP_0100806 denotes sepsis
T6 981-987 HP_0100806 denotes sepsis
T7 1318-1324 HP_0100806 denotes sepsis
T8 1640-1646 HP_0100806 denotes sepsis