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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-94 Sentence denotes Esophageal cancer stem cells express PLGF to increase cancer invasion through MMP9 activation.
TextSentencer_T2 95-196 Sentence denotes Cancer stem cells (CSCs) are a distinct population in tumors and cause cancer relapse and metastasis.
TextSentencer_T3 197-300 Sentence denotes Thus, treating CSCs are believed to be potential to cure rapidly growing and highly metastatic cancers.
TextSentencer_T4 301-364 Sentence denotes To date, CSCs in esophageal cancer have not been characterized.
TextSentencer_T5 365-662 Sentence denotes In the current study, we detected significant higher levels of placental growth factor (PLGF) and matrix metalloproteinase 9 (MMP9) in the esophageal cancers with metastasis, compared to those without metastasis, in which the expression levels of PLGF and MMP9 strongly correlated with each other.
TextSentencer_T6 663-763 Sentence denotes Thus, we used a human esophageal cancer cell line, TE-1, to examine the cross talk of PLGF and MMP9.
TextSentencer_T7 764-979 Sentence denotes We found that the levels of PLGF in TE-1 cells positively affected the levels of MMP9, while the levels of MMP9 did not affected the levels of PLGF, suggesting that PLGF may activate MMP9 in esophageal cancer cells.
TextSentencer_T8 980-1128 Sentence denotes Then, we separated PLGF-positive and PLGF-negative TE-1 cells that had been transfected with a GFP reporter under a PLGF promoter by flow cytometry.
TextSentencer_T9 1129-1353 Sentence denotes We found that PLGF-positive cells grew significantly faster than PLGF-negative cells both in vitro and in vivo in a stereotactical implantation model, suggesting that PLGF-positive cells are likely CSCs in esophageal cancer.
TextSentencer_T10 1354-1529 Sentence denotes Taken together, we demonstrate that PLGF-positive cells appear to be CSCs in esophageal cancer, and they may release PLGF to promote cancer metastasis through MMP9 activation.
T1 0-94 Sentence denotes Esophageal cancer stem cells express PLGF to increase cancer invasion through MMP9 activation.
T2 95-196 Sentence denotes Cancer stem cells (CSCs) are a distinct population in tumors and cause cancer relapse and metastasis.
T3 197-300 Sentence denotes Thus, treating CSCs are believed to be potential to cure rapidly growing and highly metastatic cancers.
T4 301-364 Sentence denotes To date, CSCs in esophageal cancer have not been characterized.
T5 365-662 Sentence denotes In the current study, we detected significant higher levels of placental growth factor (PLGF) and matrix metalloproteinase 9 (MMP9) in the esophageal cancers with metastasis, compared to those without metastasis, in which the expression levels of PLGF and MMP9 strongly correlated with each other.
T6 663-763 Sentence denotes Thus, we used a human esophageal cancer cell line, TE-1, to examine the cross talk of PLGF and MMP9.
T7 764-979 Sentence denotes We found that the levels of PLGF in TE-1 cells positively affected the levels of MMP9, while the levels of MMP9 did not affected the levels of PLGF, suggesting that PLGF may activate MMP9 in esophageal cancer cells.
T8 980-1128 Sentence denotes Then, we separated PLGF-positive and PLGF-negative TE-1 cells that had been transfected with a GFP reporter under a PLGF promoter by flow cytometry.
T9 1129-1353 Sentence denotes We found that PLGF-positive cells grew significantly faster than PLGF-negative cells both in vitro and in vivo in a stereotactical implantation model, suggesting that PLGF-positive cells are likely CSCs in esophageal cancer.
T10 1354-1529 Sentence denotes Taken together, we demonstrate that PLGF-positive cells appear to be CSCs in esophageal cancer, and they may release PLGF to promote cancer metastasis through MMP9 activation.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 95-101 HP_0002664 denotes Cancer
T2 149-155 HP_0002664 denotes tumors
T3 166-172 HP_0002664 denotes cancer
T4 292-299 HP_0002664 denotes cancers
T5 318-335 HP_0100751 denotes esophageal cancer
T6 329-335 HP_0002664 denotes cancer
T7 504-522 HP_0100751 denotes esophageal cancers
T8 515-522 HP_0002664 denotes cancers
T9 685-702 HP_0100751 denotes esophageal cancer
T10 696-702 HP_0002664 denotes cancer
T11 955-972 HP_0100751 denotes esophageal cancer
T12 966-972 HP_0002664 denotes cancer
T13 1335-1352 HP_0100751 denotes esophageal cancer
T14 1346-1352 HP_0002664 denotes cancer
T15 1431-1448 HP_0100751 denotes esophageal cancer
T16 1442-1448 HP_0002664 denotes cancer
T17 1487-1493 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25213700-0#37#41#gene5228 37-41 gene5228 denotes PLGF
25213700-0#0#17#diseaseC0014859 0-17 diseaseC0014859 denotes Esophageal cancer
25213700-0#0#17#diseaseC0152018 0-17 diseaseC0152018 denotes Esophageal cancer
25213700-0#0#17#diseaseC0546837 0-17 diseaseC0546837 denotes Esophageal cancer
25213700-6#81#85#gene4318 845-849 gene4318 denotes MMP9
25213700-6#107#111#gene4318 871-875 gene4318 denotes MMP9
25213700-6#183#187#gene4318 947-951 gene4318 denotes MMP9
25213700-6#191#208#diseaseC0014859 955-972 diseaseC0014859 denotes esophageal cancer
25213700-6#191#208#diseaseC0152018 955-972 diseaseC0152018 denotes esophageal cancer
25213700-6#191#208#diseaseC0546837 955-972 diseaseC0546837 denotes esophageal cancer
25213700-6#191#208#diseaseC0014859 955-972 diseaseC0014859 denotes esophageal cancer
25213700-6#191#208#diseaseC0152018 955-972 diseaseC0152018 denotes esophageal cancer
25213700-6#191#208#diseaseC0546837 955-972 diseaseC0546837 denotes esophageal cancer
25213700-6#191#208#diseaseC0014859 955-972 diseaseC0014859 denotes esophageal cancer
25213700-6#191#208#diseaseC0152018 955-972 diseaseC0152018 denotes esophageal cancer
25213700-6#191#208#diseaseC0546837 955-972 diseaseC0546837 denotes esophageal cancer
25213700-9#117#121#gene5228 1471-1475 gene5228 denotes PLGF
25213700-9#159#163#gene4318 1513-1517 gene4318 denotes MMP9
25213700-9#140#150#diseaseC0027627 1494-1504 diseaseC0027627 denotes metastasis
37#41#gene52280#17#diseaseC0014859 25213700-0#37#41#gene5228 25213700-0#0#17#diseaseC0014859 associated_with PLGF,Esophageal cancer
37#41#gene52280#17#diseaseC0152018 25213700-0#37#41#gene5228 25213700-0#0#17#diseaseC0152018 associated_with PLGF,Esophageal cancer
37#41#gene52280#17#diseaseC0546837 25213700-0#37#41#gene5228 25213700-0#0#17#diseaseC0546837 associated_with PLGF,Esophageal cancer
81#85#gene4318191#208#diseaseC0014859 25213700-6#81#85#gene4318 25213700-6#191#208#diseaseC0014859 associated_with MMP9,esophageal cancer
81#85#gene4318191#208#diseaseC0152018 25213700-6#81#85#gene4318 25213700-6#191#208#diseaseC0152018 associated_with MMP9,esophageal cancer
81#85#gene4318191#208#diseaseC0546837 25213700-6#81#85#gene4318 25213700-6#191#208#diseaseC0546837 associated_with MMP9,esophageal cancer
81#85#gene4318191#208#diseaseC0014859 25213700-6#81#85#gene4318 25213700-6#191#208#diseaseC0014859 associated_with MMP9,esophageal cancer
81#85#gene4318191#208#diseaseC0152018 25213700-6#81#85#gene4318 25213700-6#191#208#diseaseC0152018 associated_with MMP9,esophageal cancer
81#85#gene4318191#208#diseaseC0546837 25213700-6#81#85#gene4318 25213700-6#191#208#diseaseC0546837 associated_with MMP9,esophageal cancer
81#85#gene4318191#208#diseaseC0014859 25213700-6#81#85#gene4318 25213700-6#191#208#diseaseC0014859 associated_with MMP9,esophageal cancer
81#85#gene4318191#208#diseaseC0152018 25213700-6#81#85#gene4318 25213700-6#191#208#diseaseC0152018 associated_with MMP9,esophageal cancer
81#85#gene4318191#208#diseaseC0546837 25213700-6#81#85#gene4318 25213700-6#191#208#diseaseC0546837 associated_with MMP9,esophageal cancer
107#111#gene4318191#208#diseaseC0014859 25213700-6#107#111#gene4318 25213700-6#191#208#diseaseC0014859 associated_with MMP9,esophageal cancer
107#111#gene4318191#208#diseaseC0152018 25213700-6#107#111#gene4318 25213700-6#191#208#diseaseC0152018 associated_with MMP9,esophageal cancer
107#111#gene4318191#208#diseaseC0546837 25213700-6#107#111#gene4318 25213700-6#191#208#diseaseC0546837 associated_with MMP9,esophageal cancer
107#111#gene4318191#208#diseaseC0014859 25213700-6#107#111#gene4318 25213700-6#191#208#diseaseC0014859 associated_with MMP9,esophageal cancer
107#111#gene4318191#208#diseaseC0152018 25213700-6#107#111#gene4318 25213700-6#191#208#diseaseC0152018 associated_with MMP9,esophageal cancer
107#111#gene4318191#208#diseaseC0546837 25213700-6#107#111#gene4318 25213700-6#191#208#diseaseC0546837 associated_with MMP9,esophageal cancer
107#111#gene4318191#208#diseaseC0014859 25213700-6#107#111#gene4318 25213700-6#191#208#diseaseC0014859 associated_with MMP9,esophageal cancer
107#111#gene4318191#208#diseaseC0152018 25213700-6#107#111#gene4318 25213700-6#191#208#diseaseC0152018 associated_with MMP9,esophageal cancer
107#111#gene4318191#208#diseaseC0546837 25213700-6#107#111#gene4318 25213700-6#191#208#diseaseC0546837 associated_with MMP9,esophageal cancer
183#187#gene4318191#208#diseaseC0014859 25213700-6#183#187#gene4318 25213700-6#191#208#diseaseC0014859 associated_with MMP9,esophageal cancer
183#187#gene4318191#208#diseaseC0152018 25213700-6#183#187#gene4318 25213700-6#191#208#diseaseC0152018 associated_with MMP9,esophageal cancer
183#187#gene4318191#208#diseaseC0546837 25213700-6#183#187#gene4318 25213700-6#191#208#diseaseC0546837 associated_with MMP9,esophageal cancer
183#187#gene4318191#208#diseaseC0014859 25213700-6#183#187#gene4318 25213700-6#191#208#diseaseC0014859 associated_with MMP9,esophageal cancer
183#187#gene4318191#208#diseaseC0152018 25213700-6#183#187#gene4318 25213700-6#191#208#diseaseC0152018 associated_with MMP9,esophageal cancer
183#187#gene4318191#208#diseaseC0546837 25213700-6#183#187#gene4318 25213700-6#191#208#diseaseC0546837 associated_with MMP9,esophageal cancer
183#187#gene4318191#208#diseaseC0014859 25213700-6#183#187#gene4318 25213700-6#191#208#diseaseC0014859 associated_with MMP9,esophageal cancer
183#187#gene4318191#208#diseaseC0152018 25213700-6#183#187#gene4318 25213700-6#191#208#diseaseC0152018 associated_with MMP9,esophageal cancer
183#187#gene4318191#208#diseaseC0546837 25213700-6#183#187#gene4318 25213700-6#191#208#diseaseC0546837 associated_with MMP9,esophageal cancer
117#121#gene5228140#150#diseaseC0027627 25213700-9#117#121#gene5228 25213700-9#140#150#diseaseC0027627 associated_with PLGF,metastasis
159#163#gene4318140#150#diseaseC0027627 25213700-9#159#163#gene4318 25213700-9#140#150#diseaseC0027627 associated_with MMP9,metastasis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T251 37-41 gene:5228 denotes PLGF
T252 0-17 disease:C0014859 denotes Esophageal cancer
T253 845-849 gene:4318 denotes MMP9
T254 955-972 disease:C0014859 denotes esophageal cancer
T255 871-875 gene:4318 denotes MMP9
T256 947-951 gene:4318 denotes MMP9
T257 1471-1475 gene:5228 denotes PLGF
T258 1494-1504 disease:C0027627 denotes metastasis
T259 1513-1517 gene:4318 denotes MMP9
R1 T251 T252 associated_with PLGF,Esophageal cancer
R2 T251 T252 associated_with PLGF,Esophageal cancer
R3 T251 T252 associated_with PLGF,Esophageal cancer
R4 T253 T254 associated_with MMP9,esophageal cancer
R5 T253 T254 associated_with MMP9,esophageal cancer
R6 T253 T254 associated_with MMP9,esophageal cancer
R7 T255 T254 associated_with MMP9,esophageal cancer
R8 T255 T254 associated_with MMP9,esophageal cancer
R9 T255 T254 associated_with MMP9,esophageal cancer
R10 T256 T254 associated_with MMP9,esophageal cancer
R11 T256 T254 associated_with MMP9,esophageal cancer
R12 T256 T254 associated_with MMP9,esophageal cancer
R13 T257 T258 associated_with PLGF,metastasis
R14 T259 T258 associated_with MMP9,metastasis

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 428-437 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placental