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PubMed:25192306 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1023-1034 HP_0001824 denotes weight loss

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Preventive effect of the microalga Chlamydomonas debaryana on the acute phase of experimental colitis in rats.
T2 111-221 Sentence denotes Inflammatory bowel diseases (IBD) are characterised by chronic uncontrolled inflammation of intestinal mucosa.
T3 222-298 Sentence denotes Diet and nutritional factors have emerged as possible interventions for IBD.
T4 299-361 Sentence denotes Microalgae are rich sources of n-3 PUFA and derived oxylipins.
T5 362-450 Sentence denotes Oxylipins are lipid mediators involved in the resolution of many inflammatory disorders.
T6 451-770 Sentence denotes The aim of the present study was to investigate the effects of the oxylipin-containing biomass of the microalga Chlamydomonas debaryana and its major oxylipin constituent, (9Z,11E,13S,15Z)-13-hydroxyoctadeca-9,11,15-trienoic acid ((13S)-HOTE), on acute 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats.
T7 771-948 Sentence denotes Lyophilised microalgal biomass and (13S)-HOTE were administered by oral route 48, 24 and 1 h before the induction of colitis and 24 h later, and the rats were killed after 48 h.
T8 949-1139 Sentence denotes The treatment with the lyophilised microalga and (13S)-HOTE improved body-weight loss and colon shortening, as well as attenuated the extent of colonic damage and increased mucus production.
T9 1140-1332 Sentence denotes Cellular neutrophil infiltration, with the subsequent increase in myeloperoxidase levels induced by TNBS, were also reduced after the administration of the lyophilised microalga or (13S)-HOTE.
T10 1333-1444 Sentence denotes The anti-inflammatory effects of these treatments were confirmed by the inhibition of colonic TNF-α production.
T11 1445-1571 Sentence denotes Moreover, lyophilised microalga or (13S)-HOTE down-regulated cyclo-oxygenase-2 and inducible nitric oxide synthase expression.
T12 1572-1765 Sentence denotes The present study was the first to show the prophylactic effects of a lyophilised biomass sample of the microalga C. debaryana and the oxylipin (13S)-HOTE on TNBS-induced acute colitis in rats.
T13 1766-1916 Sentence denotes Our findings suggest that the microalga C. debaryana or derived oxylipins could be used as nutraceuticals in the treatment of the active phase of IBD.
T1 0-110 Sentence denotes Preventive effect of the microalga Chlamydomonas debaryana on the acute phase of experimental colitis in rats.
T2 111-221 Sentence denotes Inflammatory bowel diseases (IBD) are characterised by chronic uncontrolled inflammation of intestinal mucosa.
T3 222-298 Sentence denotes Diet and nutritional factors have emerged as possible interventions for IBD.
T4 299-361 Sentence denotes Microalgae are rich sources of n-3 PUFA and derived oxylipins.
T5 362-450 Sentence denotes Oxylipins are lipid mediators involved in the resolution of many inflammatory disorders.
T6 451-770 Sentence denotes The aim of the present study was to investigate the effects of the oxylipin-containing biomass of the microalga Chlamydomonas debaryana and its major oxylipin constituent, (9Z,11E,13S,15Z)-13-hydroxyoctadeca-9,11,15-trienoic acid ((13S)-HOTE), on acute 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats.
T7 771-948 Sentence denotes Lyophilised microalgal biomass and (13S)-HOTE were administered by oral route 48, 24 and 1 h before the induction of colitis and 24 h later, and the rats were killed after 48 h.
T8 949-1139 Sentence denotes The treatment with the lyophilised microalga and (13S)-HOTE improved body-weight loss and colon shortening, as well as attenuated the extent of colonic damage and increased mucus production.
T9 1140-1332 Sentence denotes Cellular neutrophil infiltration, with the subsequent increase in myeloperoxidase levels induced by TNBS, were also reduced after the administration of the lyophilised microalga or (13S)-HOTE.
T10 1333-1444 Sentence denotes The anti-inflammatory effects of these treatments were confirmed by the inhibition of colonic TNF-α production.
T11 1445-1571 Sentence denotes Moreover, lyophilised microalga or (13S)-HOTE down-regulated cyclo-oxygenase-2 and inducible nitric oxide synthase expression.
T12 1572-1765 Sentence denotes The present study was the first to show the prophylactic effects of a lyophilised biomass sample of the microalga C. debaryana and the oxylipin (13S)-HOTE on TNBS-induced acute colitis in rats.
T13 1766-1916 Sentence denotes Our findings suggest that the microalga C. debaryana or derived oxylipins could be used as nutraceuticals in the treatment of the active phase of IBD.