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PubMed:25183011 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 204-223 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T2 225-233 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T4 310-318 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 225-233 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 310-318 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 204-223 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T2 225-233 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T3 225-233 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T4 310-318 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T5 310-318 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc

sentences

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes MicroRNA-539 is up-regulated in failing heart, and suppresses O-GlcNAcase expression.
T2 86-175 Sentence denotes Derangements in metabolism and related signaling pathways characterize the failing heart.
T3 176-423 Sentence denotes One such signal, O-linked β-N-acetylglucosamine (O-GlcNAc), is an essential post-translational modification regulated by two enzymes, O-GlcNAc transferase and O-GlcNAcase (OGA), which modulate the function of many nuclear and cytoplasmic proteins.
T4 424-679 Sentence denotes We recently reported reduced OGA expression in the failing heart, which is consistent with the pro-adaptive role of increased O-GlcNAcylation during heart failure; however, molecular mechanisms regulating these enzymes during heart failure remain unknown.
T5 680-783 Sentence denotes Using miRNA microarray analysis, we observed acute and chronic changes in expression of several miRNAs.
T6 784-856 Sentence denotes Here, we focused on miR-539 because it was predicted to target OGA mRNA.
T7 857-1001 Sentence denotes Indeed, co-transfection of the OGA-3'UTR containing reporter plasmid and miR-539 overexpression plasmid significantly reduced reporter activity.
T8 1002-1237 Sentence denotes Overexpression of miR-539 in neonatal rat cardiomyocytes significantly suppressed OGA expression and consequently increased O-GlcNAcylation; conversely, the miR-539 inhibitor rescued OGA protein expression and restored O-GlcNAcylation.
T9 1238-1354 Sentence denotes In conclusion, this work identifies the first target of miR-539 in the heart and the first miRNA that regulates OGA.
T10 1355-1483 Sentence denotes Manipulation of miR-539 may represent a novel therapeutic target in the treatment of heart failure and other metabolic diseases.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 40-45 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T2 169-174 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T3 483-488 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T4 573-578 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T5 650-655 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T6 1309-1314 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T7 1440-1445 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart

DisGeNET

Id Subject Object Predicate Lexical cue
T0 453-456 gene:10724 denotes OGA
T1 650-663 disease:C0018802 denotes heart failure
T2 453-456 gene:10724 denotes OGA
T3 650-663 disease:C0018801 denotes heart failure
T4 453-456 gene:10724 denotes OGA
T5 573-586 disease:C0018802 denotes heart failure
T6 453-456 gene:10724 denotes OGA
T7 573-586 disease:C0018801 denotes heart failure
T8 1371-1378 gene:664612 denotes miR-539
T9 1464-1482 disease:C0025517 denotes metabolic diseases
T10 1371-1378 gene:664612 denotes miR-539
T11 1440-1453 disease:C0018802 denotes heart failure
T12 1371-1378 gene:664612 denotes miR-539
T13 1440-1453 disease:C0018801 denotes heart failure
R1 T0 T1 associated_with OGA,heart failure
R2 T2 T3 associated_with OGA,heart failure
R3 T4 T5 associated_with OGA,heart failure
R4 T6 T7 associated_with OGA,heart failure
R5 T8 T9 associated_with miR-539,metabolic diseases
R6 T10 T11 associated_with miR-539,heart failure
R7 T12 T13 associated_with miR-539,heart failure

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 573-586 HP_0001635 denotes heart failure
T2 650-663 HP_0001635 denotes heart failure
T3 1440-1453 HP_0001635 denotes heart failure

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 204-223 chem:24139 denotes N-acetylglucosamine
PD-NGLY1-deficiency-B_T2 227-233 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T3 312-318 chem:24139 denotes GlcNAc

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25183011-3#29#32#gene10724 453-456 gene10724 denotes OGA
25183011-3#149#162#diseaseC0018801 573-586 diseaseC0018801 denotes heart failure
25183011-3#149#162#diseaseC0018802 573-586 diseaseC0018802 denotes heart failure
25183011-3#226#239#diseaseC0018801 650-663 diseaseC0018801 denotes heart failure
25183011-3#226#239#diseaseC0018802 650-663 diseaseC0018802 denotes heart failure
25183011-9#16#23#gene664612 1371-1378 gene664612 denotes miR-539
25183011-9#16#23#gene664612 1371-1378 gene664612 denotes miR-539
25183011-9#85#98#diseaseC0018801 1440-1453 diseaseC0018801 denotes heart failure
25183011-9#85#98#diseaseC0018802 1440-1453 diseaseC0018802 denotes heart failure
25183011-9#109#127#diseaseC0025517 1464-1482 diseaseC0025517 denotes metabolic diseases
29#32#gene10724149#162#diseaseC0018801 25183011-3#29#32#gene10724 25183011-3#149#162#diseaseC0018801 associated_with OGA,heart failure
29#32#gene10724149#162#diseaseC0018802 25183011-3#29#32#gene10724 25183011-3#149#162#diseaseC0018802 associated_with OGA,heart failure
29#32#gene10724226#239#diseaseC0018801 25183011-3#29#32#gene10724 25183011-3#226#239#diseaseC0018801 associated_with OGA,heart failure
29#32#gene10724226#239#diseaseC0018802 25183011-3#29#32#gene10724 25183011-3#226#239#diseaseC0018802 associated_with OGA,heart failure
16#23#gene66461285#98#diseaseC0018801 25183011-9#16#23#gene664612 25183011-9#85#98#diseaseC0018801 associated_with miR-539,heart failure
16#23#gene66461285#98#diseaseC0018802 25183011-9#16#23#gene664612 25183011-9#85#98#diseaseC0018802 associated_with miR-539,heart failure
16#23#gene664612109#127#diseaseC0025517 25183011-9#16#23#gene664612 25183011-9#109#127#diseaseC0025517 associated_with miR-539,metabolic diseases
16#23#gene66461285#98#diseaseC0018801 25183011-9#16#23#gene664612 25183011-9#85#98#diseaseC0018801 associated_with miR-539,heart failure
16#23#gene66461285#98#diseaseC0018802 25183011-9#16#23#gene664612 25183011-9#85#98#diseaseC0018802 associated_with miR-539,heart failure
16#23#gene664612109#127#diseaseC0025517 25183011-9#16#23#gene664612 25183011-9#109#127#diseaseC0025517 associated_with miR-539,metabolic diseases

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 225-233 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 310-318 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 40-45 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T2 169-174 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T3 483-488 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T4 573-578 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T5 650-655 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T6 1309-1314 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T7 1440-1445 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 573-586 Phenotype denotes heart failure HP:0001635
T2 650-663 Phenotype denotes heart failure HP:0001635
T3 1440-1453 Phenotype denotes heart failure HP:0001635

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 573-586 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T2 650-663 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T3 1440-1453 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T4 1458-1482 Disease denotes other metabolic diseases http://purl.obolibrary.org/obo/MONDO_0019602

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 225-233 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 310-318 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 225-233 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 310-318 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 573-586 Phenotype denotes heart failure HP:0001635
T2 650-663 Phenotype denotes heart failure HP:0001635
T3 1440-1453 Phenotype denotes heart failure HP:0001635

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1044-1058 Cell denotes cardiomyocytes http://purl.obolibrary.org/obo/CL:0000746

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 40-45 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T5 169-174 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T9 402-413 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T10 483-488 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T14 573-578 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T18 650-655 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T22 1044-1058 Body_part denotes cardiomyocytes http://purl.obolibrary.org/obo/CL_0000746
T23 1309-1314 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T27 1440-1445 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 573-586 Disease denotes heart failure MONDO:0005252
T2 650-663 Disease denotes heart failure MONDO:0005252
T3 1440-1453 Disease denotes heart failure MONDO:0005252
T4 1464-1482 Disease denotes metabolic diseases MONDO:0005066

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 1040-1043 Organism denotes rat 10114|10116

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 225-233 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 310-318 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes MicroRNA-539 is up-regulated in failing heart, and suppresses O-GlcNAcase expression.
T2 86-175 Sentence denotes Derangements in metabolism and related signaling pathways characterize the failing heart.
T3 176-423 Sentence denotes One such signal, O-linked β-N-acetylglucosamine (O-GlcNAc), is an essential post-translational modification regulated by two enzymes, O-GlcNAc transferase and O-GlcNAcase (OGA), which modulate the function of many nuclear and cytoplasmic proteins.
T4 424-679 Sentence denotes We recently reported reduced OGA expression in the failing heart, which is consistent with the pro-adaptive role of increased O-GlcNAcylation during heart failure; however, molecular mechanisms regulating these enzymes during heart failure remain unknown.
T5 680-783 Sentence denotes Using miRNA microarray analysis, we observed acute and chronic changes in expression of several miRNAs.
T6 784-856 Sentence denotes Here, we focused on miR-539 because it was predicted to target OGA mRNA.
T7 857-1001 Sentence denotes Indeed, co-transfection of the OGA-3'UTR containing reporter plasmid and miR-539 overexpression plasmid significantly reduced reporter activity.
T8 1002-1237 Sentence denotes Overexpression of miR-539 in neonatal rat cardiomyocytes significantly suppressed OGA expression and consequently increased O-GlcNAcylation; conversely, the miR-539 inhibitor rescued OGA protein expression and restored O-GlcNAcylation.
T9 1238-1354 Sentence denotes In conclusion, this work identifies the first target of miR-539 in the heart and the first miRNA that regulates OGA.
T10 1355-1483 Sentence denotes Manipulation of miR-539 may represent a novel therapeutic target in the treatment of heart failure and other metabolic diseases.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 40-45 Body_part denotes heart FMA:7088
T2 169-174 Body_part denotes heart FMA:7088
T3 402-413 Body_part denotes cytoplasmic FMA:66835
T4 483-488 Body_part denotes heart FMA:7088
T5 573-578 Body_part denotes heart FMA:7088
T6 650-655 Body_part denotes heart FMA:7088
T7 1044-1058 Body_part denotes cardiomyocytes FMA:14067
T8 1309-1314 Body_part denotes heart FMA:7088
T9 1440-1445 Body_part denotes heart FMA:7088

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 40-45 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T2 169-174 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T3 483-488 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T4 573-578 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T5 650-655 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T6 1309-1314 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T7 1440-1445 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1040-1043 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 40-45 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T5 169-174 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T9 402-413 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T10 483-488 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T14 573-578 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T18 650-655 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T22 1044-1058 Body_part denotes cardiomyocytes http://purl.obolibrary.org/obo/CL_0000746
T23 1309-1314 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T27 1440-1445 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1044-1058 Cell denotes cardiomyocytes http://purl.obolibrary.org/obo/CL:0000746