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PubMed:25174649 JSONTXT

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test-210614

Id Subject Object Predicate Lexical cue proteinmutation
25174649_0 100-106 ProteinMutation denotes G2019S rs34637584
25174649_1 840-846 ProteinMutation denotes G2019S rs34637584
25174649_2 676-682 ProteinMutation denotes G2019S rs34637584
25174649_3 626-632 ProteinMutation denotes G2019S rs34637584
25174649_4 489-495 ProteinMutation denotes G2019S rs34637584
25174649_5 389-395 ProteinMutation denotes G2019S rs34637584
25174649_6 266-272 ProteinMutation denotes G2019S rs34637584

PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
25174649_0 100-106 ProteinMutation denotes G2019S rs34637584
25174649_1 840-846 ProteinMutation denotes G2019S rs34637584
25174649_2 676-682 ProteinMutation denotes G2019S rs34637584
25174649_3 626-632 ProteinMutation denotes G2019S rs34637584
25174649_4 489-495 ProteinMutation denotes G2019S rs34637584
25174649_5 389-395 ProteinMutation denotes G2019S rs34637584
25174649_6 266-272 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 57-88 SO:0000153 denotes bacterial artificial chromosome
T2 67-77 32630 denotes artificial
T3 78-88 GO:0005694 denotes chromosome
T5 89-99 SO:0000781 denotes transgenic
T6 105-114 CHEBI:15603 denotes S leucine
T8 107-114 6308 denotes leucine
T9 107-114 SO:0001437 denotes leucine
T13 138-142 10118 denotes rats
T14 138-142 10116 denotes rats
T15 138-142 D051381 denotes rats
T17 157-164 6308 denotes leucine
T18 157-164 SO:0001437 denotes leucine
T16 157-164 CHEBI:15603 denotes leucine
T19 157-164 D007930 denotes leucine
T20 157-164 CHEBI:25017 denotes leucine
T21 157-164 D007930 denotes leucine
T22 189-194 PR:Q5S006 denotes LRRK2
T23 189-194 PR:000003033 denotes LRRK2
T24 189-194 PR:Q5S007 denotes LRRK2
T25 202-220 C566739 denotes autosomal dominant
T26 221-231 D000067562 denotes late-onset
T27 221-231 D000067562 denotes late-onset
T32 232-251 D010300 denotes Parkinson's disease
T33 232-251 D010300 denotes Parkinson's disease
T36 273-281 SO:0000109 denotes mutation
T37 296-302 SO:0000417 denotes domain
T38 306-311 PR:Q5S006 denotes LRRK2
T39 306-311 PR:000003033 denotes LRRK2
T40 306-311 PR:Q5S007 denotes LRRK2
T41 370-385 GO:0016301 denotes kinase activity
T42 396-401 PR:Q5S006 denotes LRRK2
T43 396-401 PR:000003033 denotes LRRK2
T44 396-401 PR:Q5S007 denotes LRRK2
T45 431-439 CHEBI:78059 denotes carriers
T46 496-501 PR:Q5S006 denotes LRRK2
T47 496-501 PR:000003033 denotes LRRK2
T48 496-501 PR:Q5S007 denotes LRRK2
T49 573-604 SO:0000153 denotes bacterial artificial chromosome
T50 583-593 32630 denotes artificial
T51 594-604 GO:0005694 denotes chromosome
T53 605-608 10116 denotes rat
T57 605-608 D051381 denotes rat
T54 605-608 PR:P63003-1 denotes rat
T55 605-608 PR:Q2G0B1 denotes rat
T56 605-608 PR:Q8VHJ4 denotes rat
T58 620-625 D006801 denotes human
T59 633-638 PR:Q5S006 denotes LRRK2
T60 633-638 PR:000003033 denotes LRRK2
T61 633-638 PR:Q5S007 denotes LRRK2
T62 683-688 PR:Q5S006 denotes LRRK2
T63 683-688 PR:000003033 denotes LRRK2
T64 683-688 PR:Q5S007 denotes LRRK2
T65 740-749 SO:0000817 denotes wild-type
T67 750-753 PR:P63003-1 denotes rat
T68 750-753 PR:Q2G0B1 denotes rat
T69 750-753 PR:Q8VHJ4 denotes rat
T66 750-753 10116 denotes rat
T70 750-753 D051381 denotes rat
T71 754-759 PR:Q5S006 denotes LRRK2
T72 754-759 PR:000003033 denotes LRRK2
T73 754-759 PR:Q5S007 denotes LRRK2
T74 847-852 PR:Q5S006 denotes LRRK2
T75 847-852 PR:000003033 denotes LRRK2
T76 847-852 PR:Q5S007 denotes LRRK2
T77 881-889 UBERON:0002435 denotes striatum
T78 881-889 UBERON:0005383 denotes striatum
T79 894-910 UBERON:0002038 denotes substantia nigra
T80 922-953 D052247 denotes inducible nitric oxide synthase
T84 932-944 7442 denotes nitric oxide
T85 932-953 O61309 denotes nitric oxide synthase
T86 932-953 Q8T8C0 denotes nitric oxide synthase
T87 932-953 Q9I9M2 denotes nitric oxide synthase
T88 932-953 Q27571 denotes nitric oxide synthase
T90 932-953 O61608 denotes nitric oxide synthase
T97 975-983 3628 denotes dopamine
T93 975-983 CHEBI:59905 denotes dopamine
T94 975-983 CHEBI:18243 denotes dopamine
T95 975-983 D004298 denotes dopamine
T96 975-983 D004298 denotes dopamine
T98 1051-1061 SO:0000781 denotes transgenic
T99 1051-1066 D055647 denotes transgenic rats
T103 1081-1090 SO:0000817 denotes wild-type
T104 1306-1313 D004194 denotes disease
T105 1306-1313 D004194 denotes disease
T106 1393-1397 SO:0000704 denotes gene

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.
T2 144-360 Sentence denotes Mutations in leucine-rich repeated kinase 2 (LRRK2) cause autosomal dominant late-onset Parkinson's disease (PD), and the G2019S mutation in the kinase domain of LRRK2 is the most common genetic cause of familial PD.
T3 361-515 Sentence denotes Enhanced kinase activity of G2019S LRRK2 is a suspected mechanism for carriers to develop PD but pathophysiological function of G2019S LRRK2 is not clear.
T4 516-639 Sentence denotes The objective of the present study was to characterize a bacterial artificial chromosome rat expressing human G2019S LRRK2.
T5 640-760 Sentence denotes Immunoblotting analysis showed that G2019S LRRK2 expression was approximately 5-8 times higher than wild-type rat LRRK2.
T6 761-1171 Sentence denotes At ages of 4, 8, and 12 months, our characterization showed that expression of G2019S LRRK2 induced oxidative stress in striatum and substantia nigra, increased inducible nitric oxide synthase expression in nigral dopamine neurons, and abnormal morphology of nigral dopaminergic neurons in transgenic rats compared with wild-type, without inducing overt neurodegeneration in nigrostriatal dopaminergic neurons.
T7 1172-1430 Sentence denotes Thus, we conclude that although this model does not reproduce the key features of end-stage PD, important preclinical features of the disease are evident, which may be useful in studying the earliest stages of PD and for gene-environment interaction studies.
T1 0-143 Sentence denotes Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.
T2 144-360 Sentence denotes Mutations in leucine-rich repeated kinase 2 (LRRK2) cause autosomal dominant late-onset Parkinson's disease (PD), and the G2019S mutation in the kinase domain of LRRK2 is the most common genetic cause of familial PD.
T3 361-515 Sentence denotes Enhanced kinase activity of G2019S LRRK2 is a suspected mechanism for carriers to develop PD but pathophysiological function of G2019S LRRK2 is not clear.
T4 516-639 Sentence denotes The objective of the present study was to characterize a bacterial artificial chromosome rat expressing human G2019S LRRK2.
T5 640-760 Sentence denotes Immunoblotting analysis showed that G2019S LRRK2 expression was approximately 5-8 times higher than wild-type rat LRRK2.
T6 761-1171 Sentence denotes At ages of 4, 8, and 12 months, our characterization showed that expression of G2019S LRRK2 induced oxidative stress in striatum and substantia nigra, increased inducible nitric oxide synthase expression in nigral dopamine neurons, and abnormal morphology of nigral dopaminergic neurons in transgenic rats compared with wild-type, without inducing overt neurodegeneration in nigrostriatal dopaminergic neurons.
T7 1172-1430 Sentence denotes Thus, we conclude that although this model does not reproduce the key features of end-stage PD, important preclinical features of the disease are evident, which may be useful in studying the earliest stages of PD and for gene-environment interaction studies.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 202-220 HP_0000006 denotes autosomal dominant
T2 202-225 HP_0000006 denotes autosomal dominant late
T3 232-241 HP_0001300 denotes Parkinson
T4 1115-1132 HP_0002180 denotes neurodegeneration

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-143 DRI_Background denotes Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.
T2 144-360 DRI_Background denotes Mutations in leucine-rich repeated kinase 2 (LRRK2) cause autosomal dominant late-onset Parkinson's disease (PD), and the G2019S mutation in the kinase domain of LRRK2 is the most common genetic cause of familial PD.
T3 361-388 DRI_Background denotes Enhanced kinase activity of
T4 389-401 Token_Label.OUTSIDE denotes G2019S LRRK2
T5 402-488 DRI_Background denotes is a suspected mechanism for carriers to develop PD but pathophysiological function of
T6 489-501 Token_Label.OUTSIDE denotes G2019S LRRK2
T7 502-515 DRI_Background denotes is not clear.
T8 516-625 DRI_Background denotes The objective of the present study was to characterize a bacterial artificial chromosome rat expressing human
T9 626-638 Token_Label.OUTSIDE denotes G2019S LRRK2
T10 638-639 DRI_Background denotes .
T11 640-675 DRI_Outcome denotes Immunoblotting analysis showed that
T12 676-688 Token_Label.OUTSIDE denotes G2019S LRRK2
T13 689-760 DRI_Outcome denotes expression was approximately 5-8 times higher than wild-type rat LRRK2.
T14 761-839 DRI_Outcome denotes At ages of 4, 8, and 12 months, our characterization showed that expression of
T15 840-852 Token_Label.OUTSIDE denotes G2019S LRRK2
T16 853-1171 DRI_Outcome denotes induced oxidative stress in striatum and substantia nigra, increased inducible nitric oxide synthase expression in nigral dopamine neurons, and abnormal morphology of nigral dopaminergic neurons in transgenic rats compared with wild-type, without inducing overt neurodegeneration in nigrostriatal dopaminergic neurons.
T17 1172-1430 DRI_Challenge denotes Thus, we conclude that although this model does not reproduce the key features of end-stage PD, important preclinical features of the disease are evident, which may be useful in studying the earliest stages of PD and for gene-environment interaction studies.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 144-360 DRI_Background denotes Mutations in leucine-rich repeated kinase 2 (LRRK2) cause autosomal dominant late-onset Parkinson's disease (PD), and the G2019S mutation in the kinase domain of LRRK2 is the most common genetic cause of familial PD.
T2 361-388 DRI_Background denotes Enhanced kinase activity of
T3 402-488 DRI_Background denotes is a suspected mechanism for carriers to develop PD but pathophysiological function of
T4 502-515 DRI_Background denotes is not clear.
T5 516-625 DRI_Background denotes The objective of the present study was to characterize a bacterial artificial chromosome rat expressing human
T6 638-639 DRI_Background denotes .
T7 640-675 DRI_Outcome denotes Immunoblotting analysis showed that
T8 689-760 DRI_Outcome denotes expression was approximately 5-8 times higher than wild-type rat LRRK2.
T9 761-839 DRI_Outcome denotes At ages of 4, 8, and 12 months, our characterization showed that expression of
T10 853-1171 DRI_Outcome denotes induced oxidative stress in striatum and substantia nigra, increased inducible nitric oxide synthase expression in nigral dopamine neurons, and abnormal morphology of nigral dopaminergic neurons in transgenic rats compared with wild-type, without inducing overt neurodegeneration in nigrostriatal dopaminergic neurons.
T11 1172-1430 DRI_Challenge denotes Thus, we conclude that although this model does not reproduce the key features of end-stage PD, important preclinical features of the disease are evident, which may be useful in studying the earliest stages of PD and for gene-environment interaction studies.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
25174649-2#28#34#geners34637584 389-395 geners34637584 denotes G2019S
25174649-2#128#134#geners34637584 489-495 geners34637584 denotes G2019S
25174649-2#90#92#diseaseC4274355 451-453 diseaseC4274355 denotes PD
28#34#geners3463758490#92#diseaseC4274355 25174649-2#28#34#geners34637584 25174649-2#90#92#diseaseC4274355 associated_with G2019S,PD
128#134#geners3463758490#92#diseaseC4274355 25174649-2#128#134#geners34637584 25174649-2#90#92#diseaseC4274355 associated_with G2019S,PD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25174649-2#35#40#gene120892 396-401 gene120892 denotes LRRK2
25174649-2#135#140#gene120892 496-501 gene120892 denotes LRRK2
25174649-2#90#92#diseaseC4274355 451-453 diseaseC4274355 denotes PD
35#40#gene12089290#92#diseaseC4274355 25174649-2#35#40#gene120892 25174649-2#90#92#diseaseC4274355 associated_with LRRK2,PD
135#140#gene12089290#92#diseaseC4274355 25174649-2#135#140#gene120892 25174649-2#90#92#diseaseC4274355 associated_with LRRK2,PD