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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
T2 119-223 Sentence denotes Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing immune/inflammatory cells.
T3 224-380 Sentence denotes The exact contribution of each immune cell subset and cytokine in the activation of the intracellular pathways sustaining CRC cell growth is not understood.
T4 381-890 Sentence denotes Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria mononuclear cells (LPMCs) from the tumor area and the macroscopically unaffected, adjacent, colonic mucosa of patients who underwent resection for sporadic CRC and show that the culture supernatants of TILs, but not of LPMCs, potently enhance the growth of human CRC cell lines through the activation of the oncogenic transcription factors signal transducer and activator of transcription 3 (STAT3) and nuclear factor-kappa B (NF-kB).
T5 891-1081 Sentence denotes Characterization of immune cell complexity of TILs and LPMCs reveals no differences in the percentages of T cells, natural killer T cells, natural killer (NK) cells, macrophages and B cells.
T6 1082-1338 Sentence denotes However, T cells from TILs show a functional switch compared with those from LPMCs to produce large amounts of T helper type 17 (Th17)-related cytokines (that is, interleukin-17A (IL-17A), IL-17F, IL-21 and IL-22), tumor necrosis factor-α (TNF-α) and IL-6.
T7 1339-1541 Sentence denotes Individual neutralization of IL-17A, IL-17F, IL-21, IL-22, TNF-α or IL-6 does not change TIL-derived supernatant-driven STAT3 and NF-kB activation, as well as their proproliferative effect in CRC cells.
T8 1542-1753 Sentence denotes In contrast, simultaneous neutralization of both IL-17A and TNF-α, which abrogates NF-kB signaling, and IL-22 and IL-6, which abrogates STAT3 signaling, reduces the mitogenic effect of supernatants in CRC cells.
T9 1754-1930 Sentence denotes IL-17A, IL-21, IL-22, TNF-α and IL-6 are also produced in excess in the early colonic lesions in a mouse model of sporadic CRC, associated with enhanced STAT3/NF-kB activation.
T10 1931-2171 Sentence denotes Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas.
T11 2172-2350 Sentence denotes These data suggest that strategies aimed at the cotargeting of STAT3/NF-kB activation and interaction between them might represent an attractive and novel approach to combat CRC.
T1 0-118 Sentence denotes Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
T2 119-223 Sentence denotes Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing immune/inflammatory cells.
T3 224-380 Sentence denotes The exact contribution of each immune cell subset and cytokine in the activation of the intracellular pathways sustaining CRC cell growth is not understood.
T4 381-890 Sentence denotes Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria mononuclear cells (LPMCs) from the tumor area and the macroscopically unaffected, adjacent, colonic mucosa of patients who underwent resection for sporadic CRC and show that the culture supernatants of TILs, but not of LPMCs, potently enhance the growth of human CRC cell lines through the activation of the oncogenic transcription factors signal transducer and activator of transcription 3 (STAT3) and nuclear factor-kappa B (NF-kB).
T5 891-1081 Sentence denotes Characterization of immune cell complexity of TILs and LPMCs reveals no differences in the percentages of T cells, natural killer T cells, natural killer (NK) cells, macrophages and B cells.
T6 1082-1338 Sentence denotes However, T cells from TILs show a functional switch compared with those from LPMCs to produce large amounts of T helper type 17 (Th17)-related cytokines (that is, interleukin-17A (IL-17A), IL-17F, IL-21 and IL-22), tumor necrosis factor-α (TNF-α) and IL-6.
T7 1339-1541 Sentence denotes Individual neutralization of IL-17A, IL-17F, IL-21, IL-22, TNF-α or IL-6 does not change TIL-derived supernatant-driven STAT3 and NF-kB activation, as well as their proproliferative effect in CRC cells.
T8 1542-1753 Sentence denotes In contrast, simultaneous neutralization of both IL-17A and TNF-α, which abrogates NF-kB signaling, and IL-22 and IL-6, which abrogates STAT3 signaling, reduces the mitogenic effect of supernatants in CRC cells.
T9 1754-1930 Sentence denotes IL-17A, IL-21, IL-22, TNF-α and IL-6 are also produced in excess in the early colonic lesions in a mouse model of sporadic CRC, associated with enhanced STAT3/NF-kB activation.
T10 1931-2171 Sentence denotes Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas.
T11 2172-2350 Sentence denotes These data suggest that strategies aimed at the cotargeting of STAT3/NF-kB activation and interaction between them might represent an attractive and novel approach to combat CRC.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 119-177 DRI_Background denotes Colorectal cancers (CRCs) often show a dense infiltrate of
T2 217-223 DRI_Background denotes cells.
T3 224-380 DRI_Outcome denotes The exact contribution of each immune cell subset and cytokine in the activation of the intracellular pathways sustaining CRC cell growth is not understood.
T4 381-890 DRI_Background denotes Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria mononuclear cells (LPMCs) from the tumor area and the macroscopically unaffected, adjacent, colonic mucosa of patients who underwent resection for sporadic CRC and show that the culture supernatants of TILs, but not of LPMCs, potently enhance the growth of human CRC cell lines through the activation of the oncogenic transcription factors signal transducer and activator of transcription 3 (STAT3) and nuclear factor-kappa B (NF-kB).
T5 891-1081 DRI_Approach denotes Characterization of immune cell complexity of TILs and LPMCs reveals no differences in the percentages of T cells, natural killer T cells, natural killer (NK) cells, macrophages and B cells.
T6 1082-1338 DRI_Outcome denotes However, T cells from TILs show a functional switch compared with those from LPMCs to produce large amounts of T helper type 17 (Th17)-related cytokines (that is, interleukin-17A (IL-17A), IL-17F, IL-21 and IL-22), tumor necrosis factor-α (TNF-α) and IL-6.
T7 1339-1427 DRI_Background denotes Individual neutralization of IL-17A, IL-17F, IL-21, IL-22, TNF-α or IL-6 does not change
T8 1459-1541 DRI_Background denotes STAT3 and NF-kB activation, as well as their proproliferative effect in CRC cells.
T9 1542-1753 DRI_Outcome denotes In contrast, simultaneous neutralization of both IL-17A and TNF-α, which abrogates NF-kB signaling, and IL-22 and IL-6, which abrogates STAT3 signaling, reduces the mitogenic effect of supernatants in CRC cells.
T10 1754-1930 DRI_Background denotes IL-17A, IL-21, IL-22, TNF-α and IL-6 are also produced in excess in the early colonic lesions in a mouse model of sporadic CRC, associated with enhanced STAT3/NF-kB activation.
T11 1931-2171 DRI_Background denotes Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas.
T12 2172-2350 DRI_Background denotes These data suggest that strategies aimed at the cotargeting of STAT3/NF-kB activation and interaction between them might represent an attractive and novel approach to combat CRC.

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-118 Sentence denotes Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
TextSentencer_T2 119-223 Sentence denotes Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing immune/inflammatory cells.
TextSentencer_T3 224-380 Sentence denotes The exact contribution of each immune cell subset and cytokine in the activation of the intracellular pathways sustaining CRC cell growth is not understood.
TextSentencer_T4 381-890 Sentence denotes Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria mononuclear cells (LPMCs) from the tumor area and the macroscopically unaffected, adjacent, colonic mucosa of patients who underwent resection for sporadic CRC and show that the culture supernatants of TILs, but not of LPMCs, potently enhance the growth of human CRC cell lines through the activation of the oncogenic transcription factors signal transducer and activator of transcription 3 (STAT3) and nuclear factor-kappa B (NF-kB).
TextSentencer_T5 891-1081 Sentence denotes Characterization of immune cell complexity of TILs and LPMCs reveals no differences in the percentages of T cells, natural killer T cells, natural killer (NK) cells, macrophages and B cells.
TextSentencer_T6 1082-1338 Sentence denotes However, T cells from TILs show a functional switch compared with those from LPMCs to produce large amounts of T helper type 17 (Th17)-related cytokines (that is, interleukin-17A (IL-17A), IL-17F, IL-21 and IL-22), tumor necrosis factor-α (TNF-α) and IL-6.
TextSentencer_T7 1339-1541 Sentence denotes Individual neutralization of IL-17A, IL-17F, IL-21, IL-22, TNF-α or IL-6 does not change TIL-derived supernatant-driven STAT3 and NF-kB activation, as well as their proproliferative effect in CRC cells.
TextSentencer_T8 1542-1753 Sentence denotes In contrast, simultaneous neutralization of both IL-17A and TNF-α, which abrogates NF-kB signaling, and IL-22 and IL-6, which abrogates STAT3 signaling, reduces the mitogenic effect of supernatants in CRC cells.
TextSentencer_T9 1754-1930 Sentence denotes IL-17A, IL-21, IL-22, TNF-α and IL-6 are also produced in excess in the early colonic lesions in a mouse model of sporadic CRC, associated with enhanced STAT3/NF-kB activation.
TextSentencer_T10 1931-2171 Sentence denotes Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas.
TextSentencer_T11 2172-2350 Sentence denotes These data suggest that strategies aimed at the cotargeting of STAT3/NF-kB activation and interaction between them might represent an attractive and novel approach to combat CRC.
T1 0-118 Sentence denotes Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
T2 119-223 Sentence denotes Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing immune/inflammatory cells.
T3 224-380 Sentence denotes The exact contribution of each immune cell subset and cytokine in the activation of the intracellular pathways sustaining CRC cell growth is not understood.
T4 381-890 Sentence denotes Herein, we isolate tumor-infiltrating leukocytes (TILs) and lamina propria mononuclear cells (LPMCs) from the tumor area and the macroscopically unaffected, adjacent, colonic mucosa of patients who underwent resection for sporadic CRC and show that the culture supernatants of TILs, but not of LPMCs, potently enhance the growth of human CRC cell lines through the activation of the oncogenic transcription factors signal transducer and activator of transcription 3 (STAT3) and nuclear factor-kappa B (NF-kB).
T5 891-1081 Sentence denotes Characterization of immune cell complexity of TILs and LPMCs reveals no differences in the percentages of T cells, natural killer T cells, natural killer (NK) cells, macrophages and B cells.
T6 1082-1338 Sentence denotes However, T cells from TILs show a functional switch compared with those from LPMCs to produce large amounts of T helper type 17 (Th17)-related cytokines (that is, interleukin-17A (IL-17A), IL-17F, IL-21 and IL-22), tumor necrosis factor-α (TNF-α) and IL-6.
T7 1339-1541 Sentence denotes Individual neutralization of IL-17A, IL-17F, IL-21, IL-22, TNF-α or IL-6 does not change TIL-derived supernatant-driven STAT3 and NF-kB activation, as well as their proproliferative effect in CRC cells.
T8 1542-1753 Sentence denotes In contrast, simultaneous neutralization of both IL-17A and TNF-α, which abrogates NF-kB signaling, and IL-22 and IL-6, which abrogates STAT3 signaling, reduces the mitogenic effect of supernatants in CRC cells.
T9 1754-1930 Sentence denotes IL-17A, IL-21, IL-22, TNF-α and IL-6 are also produced in excess in the early colonic lesions in a mouse model of sporadic CRC, associated with enhanced STAT3/NF-kB activation.
T10 1931-2171 Sentence denotes Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas.
T11 2172-2350 Sentence denotes These data suggest that strategies aimed at the cotargeting of STAT3/NF-kB activation and interaction between them might represent an attractive and novel approach to combat CRC.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25174402-0#21#25#gene3569 21-25 gene3569 denotes IL-6
25174402-0#30#35#gene7124 30-35 gene7124 denotes TNF-α
25174402-0#61#66#gene6774 61-66 gene6774 denotes STAT3
25174402-0#88#105#diseaseC0009402 88-105 diseaseC0009402 denotes colorectal cancer
25174402-0#88#105#diseaseC1527249 88-105 diseaseC1527249 denotes colorectal cancer
25174402-0#88#105#diseaseC0009402 88-105 diseaseC0009402 denotes colorectal cancer
25174402-0#88#105#diseaseC1527249 88-105 diseaseC1527249 denotes colorectal cancer
25174402-0#88#105#diseaseC0009402 88-105 diseaseC0009402 denotes colorectal cancer
25174402-0#88#105#diseaseC1527249 88-105 diseaseC1527249 denotes colorectal cancer
25174402-9#183#188#gene6774 2114-2119 gene6774 denotes STAT3
25174402-9#140#153#diseaseC0596263 2071-2084 diseaseC0596263 denotes tumorigenesis
21#25#gene356988#105#diseaseC0009402 25174402-0#21#25#gene3569 25174402-0#88#105#diseaseC0009402 associated_with IL-6,colorectal cancer
21#25#gene356988#105#diseaseC1527249 25174402-0#21#25#gene3569 25174402-0#88#105#diseaseC1527249 associated_with IL-6,colorectal cancer
21#25#gene356988#105#diseaseC0009402 25174402-0#21#25#gene3569 25174402-0#88#105#diseaseC0009402 associated_with IL-6,colorectal cancer
21#25#gene356988#105#diseaseC1527249 25174402-0#21#25#gene3569 25174402-0#88#105#diseaseC1527249 associated_with IL-6,colorectal cancer
21#25#gene356988#105#diseaseC0009402 25174402-0#21#25#gene3569 25174402-0#88#105#diseaseC0009402 associated_with IL-6,colorectal cancer
21#25#gene356988#105#diseaseC1527249 25174402-0#21#25#gene3569 25174402-0#88#105#diseaseC1527249 associated_with IL-6,colorectal cancer
30#35#gene712488#105#diseaseC0009402 25174402-0#30#35#gene7124 25174402-0#88#105#diseaseC0009402 associated_with TNF-α,colorectal cancer
30#35#gene712488#105#diseaseC1527249 25174402-0#30#35#gene7124 25174402-0#88#105#diseaseC1527249 associated_with TNF-α,colorectal cancer
30#35#gene712488#105#diseaseC0009402 25174402-0#30#35#gene7124 25174402-0#88#105#diseaseC0009402 associated_with TNF-α,colorectal cancer
30#35#gene712488#105#diseaseC1527249 25174402-0#30#35#gene7124 25174402-0#88#105#diseaseC1527249 associated_with TNF-α,colorectal cancer
30#35#gene712488#105#diseaseC0009402 25174402-0#30#35#gene7124 25174402-0#88#105#diseaseC0009402 associated_with TNF-α,colorectal cancer
30#35#gene712488#105#diseaseC1527249 25174402-0#30#35#gene7124 25174402-0#88#105#diseaseC1527249 associated_with TNF-α,colorectal cancer
61#66#gene677488#105#diseaseC0009402 25174402-0#61#66#gene6774 25174402-0#88#105#diseaseC0009402 associated_with STAT3,colorectal cancer
61#66#gene677488#105#diseaseC1527249 25174402-0#61#66#gene6774 25174402-0#88#105#diseaseC1527249 associated_with STAT3,colorectal cancer
61#66#gene677488#105#diseaseC0009402 25174402-0#61#66#gene6774 25174402-0#88#105#diseaseC0009402 associated_with STAT3,colorectal cancer
61#66#gene677488#105#diseaseC1527249 25174402-0#61#66#gene6774 25174402-0#88#105#diseaseC1527249 associated_with STAT3,colorectal cancer
61#66#gene677488#105#diseaseC0009402 25174402-0#61#66#gene6774 25174402-0#88#105#diseaseC0009402 associated_with STAT3,colorectal cancer
61#66#gene677488#105#diseaseC1527249 25174402-0#61#66#gene6774 25174402-0#88#105#diseaseC1527249 associated_with STAT3,colorectal cancer
183#188#gene6774140#153#diseaseC0596263 25174402-9#183#188#gene6774 25174402-9#140#153#diseaseC0596263 associated_with STAT3,tumorigenesis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2036 21-25 gene:3569 denotes IL-6
T2037 88-105 disease:C0009402 denotes colorectal cancer
T2038 30-35 gene:7124 denotes TNF-α
T2039 61-66 gene:6774 denotes STAT3
R1 T2036 T2037 associated_with IL-6,colorectal cancer
R2 T2036 T2037 associated_with IL-6,colorectal cancer
R3 T2038 T2037 associated_with TNF-α,colorectal cancer
R4 T2038 T2037 associated_with TNF-α,colorectal cancer
R5 T2039 T2037 associated_with STAT3,colorectal cancer
R6 T2039 T2037 associated_with STAT3,colorectal cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 441-447 http://purl.obolibrary.org/obo/UBERON_0000957 denotes lamina
PD-UBERON-AE-B_T2 441-455 http://purl.obolibrary.org/obo/UBERON_0000030 denotes lamina propria
PD-UBERON-AE-B_T3 548-555 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
PD-UBERON-AE-B_T4 1832-1839 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
PD-UBERON-AE-B_T5 2065-2070 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T6 548-562 http://purl.obolibrary.org/obo/UBERON_0000317 denotes colonic mucosa
PD-UBERON-AE-B_T7 556-562 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 441-447 http://purl.obolibrary.org/obo/UBERON_0000957 denotes lamina
PD-UBERON-AE-B_T2 441-455 http://purl.obolibrary.org/obo/UBERON_0000030 denotes lamina propria
PD-UBERON-AE-B_T3 548-555 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
PD-UBERON-AE-B_T4 1832-1839 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
PD-UBERON-AE-B_T5 2065-2070 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T6 548-562 http://purl.obolibrary.org/obo/UBERON_0000317 denotes colonic mucosa
PD-UBERON-AE-B_T7 556-562 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa