PubMed:25171055 / 121-815 JSONTXT

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T1","span":{"begin":0,"end":694},"obj":"OBJECTIVE"}],"text":"Renal denervation has recently become of great interest as a potential treatment for resistant hypertension. Denervation techniques using radio frequency (RF) or ultrasound energy sources have already been explored in literature. In this study, we investigate the use of lasers as a potential energy source for renal denervation. In vitro studies are performed in porcine/ovine renal arteries with focused laser beams at 980 nm, 1210 nm, and 1700 nm to study the ability to damage renal nerves without causing injury to non-target tissue structures like the endothelium. Then, a 980 nm laser catheter prototype is built and used to demonstrate in vivo renal denervation in ovine renal arteries."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T3","span":{"begin":18,"end":21},"obj":"CVCL_6758|Undefined_cell_line_type|Cricetulus griseus"},{"id":"T4","span":{"begin":18,"end":21},"obj":"CVCL_E689|Transformed_cell_line|Homo sapiens"},{"id":"T5","span":{"begin":59,"end":60},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T6","span":{"begin":245,"end":247},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"},{"id":"T7","span":{"begin":281,"end":282},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T8","span":{"begin":398,"end":405},"obj":"CVCL_7955|Cancer_cell_line|Homo sapiens"},{"id":"T9","span":{"begin":577,"end":578},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"}],"text":"Renal denervation has recently become of great interest as a potential treatment for resistant hypertension. Denervation techniques using radio frequency (RF) or ultrasound energy sources have already been explored in literature. In this study, we investigate the use of lasers as a potential energy source for renal denervation. In vitro studies are performed in porcine/ovine renal arteries with focused laser beams at 980 nm, 1210 nm, and 1700 nm to study the ability to damage renal nerves without causing injury to non-target tissue structures like the endothelium. Then, a 980 nm laser catheter prototype is built and used to demonstrate in vivo renal denervation in ovine renal arteries."}

{"project":"GoldHamster","denotations":[{"id":"T4","span":{"begin":95,"end":107},"obj":"D006973"},{"id":"T5","span":{"begin":95,"end":107},"obj":"D006973"},{"id":"T6","span":{"begin":372,"end":377},"obj":"D012757"},{"id":"T7","span":{"begin":372,"end":377},"obj":"D012757"},{"id":"T8","span":{"begin":378,"end":392},"obj":"UBERON:0001184"},{"id":"T10","span":{"begin":487,"end":493},"obj":"UBERON:0001021"},{"id":"T11","span":{"begin":531,"end":537},"obj":"UBERON:0000479"},{"id":"T12","span":{"begin":558,"end":569},"obj":"UBERON:0001986"},{"id":"T13","span":{"begin":673,"end":678},"obj":"D012757"},{"id":"T14","span":{"begin":673,"end":678},"obj":"D012757"},{"id":"T15","span":{"begin":679,"end":693},"obj":"UBERON:0001184"}],"text":"Renal denervation has recently become of great interest as a potential treatment for resistant hypertension. Denervation techniques using radio frequency (RF) or ultrasound energy sources have already been explored in literature. In this study, we investigate the use of lasers as a potential energy source for renal denervation. In vitro studies are performed in porcine/ovine renal arteries with focused laser beams at 980 nm, 1210 nm, and 1700 nm to study the ability to damage renal nerves without causing injury to non-target tissue structures like the endothelium. Then, a 980 nm laser catheter prototype is built and used to demonstrate in vivo renal denervation in ovine renal arteries."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":95,"end":107},"obj":"HP_0000822"}],"text":"Renal denervation has recently become of great interest as a potential treatment for resistant hypertension. Denervation techniques using radio frequency (RF) or ultrasound energy sources have already been explored in literature. In this study, we investigate the use of lasers as a potential energy source for renal denervation. In vitro studies are performed in porcine/ovine renal arteries with focused laser beams at 980 nm, 1210 nm, and 1700 nm to study the ability to damage renal nerves without causing injury to non-target tissue structures like the endothelium. Then, a 980 nm laser catheter prototype is built and used to demonstrate in vivo renal denervation in ovine renal arteries."}