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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 121-815 OBJECTIVE denotes Renal denervation has recently become of great interest as a potential treatment for resistant hypertension. Denervation techniques using radio frequency (RF) or ultrasound energy sources have already been explored in literature. In this study, we investigate the use of lasers as a potential energy source for renal denervation. In vitro studies are performed in porcine/ovine renal arteries with focused laser beams at 980 nm, 1210 nm, and 1700 nm to study the ability to damage renal nerves without causing injury to non-target tissue structures like the endothelium. Then, a 980 nm laser catheter prototype is built and used to demonstrate in vivo renal denervation in ovine renal arteries.
T2 838-1697 METHODS denotes This study utilizes fiber coupled infrared lasers at 980 nm, 1210 nm, and 1700 nm. In vitro laser denervation studies at 980 nm are performed in both porcine and ovine renal arteries to study the ability of focused laser beams to damage renal nerves without injuring the endothelium. In vitro studies using lasers close to the lipid absorption lines at 1210 nm and 1700 nm are also performed in porcine renal arteries to study the possibility of selectively damaging the renal nerves by targeting the lipid myelin sheaths surrounding the nerves. Then, a laser catheter prototype is designed and built for in vivo renal denervation in ovine renal arteries using the 980 nm laser (powers ranging from 2 to 4 W, 5 seconds per exposure). Histochemical evaluations of the frozen sections are performed using methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay.
T3 1707-2384 RESULTS denotes Histochemical analysis of in vitro laser treatments at 980 nm in porcine and ovine renal arteries show clear evidence of laser-induced renal nerve damage without injury to the endothelium and part of the media. No evidence of selective nerve damage is observed using the 1210 nm and 1700 nm lasers with the current treatment parameters. Histochemical analysis of in vivo laser treatments in ovine renal arteries using a focused 980 nm laser show clear evidence of renal nerve damage with depths of damage extending > 1.5 mm from the artery wall. Sections with laser-induced damage to the media/adventitia at depths of > 1 mm without injury to the endothelium are also observed.
T4 2398-2711 CONCLUSIONS denotes We demonstrate the use of focused lasers as an attractive energy source for causing renal nerve damage without injury to the artery wall and thus, may have potential therapeutic applications for conditions such as resistant hypertension, where renal denervation has been shown to be a promising form of treatment.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 24-31 CVCL_7955|Cancer_cell_line|Homo sapiens denotes focused
T2 55-56 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 139-142 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T4 139-142 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T5 180-181 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 366-368 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T7 402-403 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 519-526 CVCL_7955|Cancer_cell_line|Homo sapiens denotes focused
T9 698-699 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T10 1045-1052 CVCL_7955|Cancer_cell_line|Homo sapiens denotes focused
T11 1390-1391 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 1537-1541 CVCL_R880|Spontaneously_immortalized_cell_line|Oreochromis mossambicus x Oreochromis niloticus denotes 2 to
T13 1544-1548 CVCL_Y635|Embryonic_stem_cell|Mus musculus denotes W, 5
T14 2125-2126 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T15 2127-2134 CVCL_7955|Cancer_cell_line|Homo sapiens denotes focused
T16 2398-2400 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T17 2424-2431 CVCL_7955|Cancer_cell_line|Homo sapiens denotes focused
T18 2442-2444 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T19 2442-2444 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T20 2545-2548 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T21 2660-2663 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T22 2660-2663 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T23 2681-2682 CVCL_6479|Finite_cell_line|Mus musculus denotes a

GoldHamster

Id Subject Object Predicate Lexical cue
T1 81-93 D006973 denotes hypertension
T2 81-93 D006973 denotes hypertension
T3 106-109 1481724 denotes AND
T4 216-228 D006973 denotes hypertension
T5 216-228 D006973 denotes hypertension
T6 493-498 D012757 denotes ovine
T7 493-498 D012757 denotes ovine
T8 499-513 UBERON:0001184 denotes renal arteries
T10 608-614 UBERON:0001021 denotes nerves
T11 652-658 UBERON:0000479 denotes tissue
T12 679-690 UBERON:0001986 denotes endothelium
T13 794-799 D012757 denotes ovine
T14 794-799 D012757 denotes ovine
T15 800-814 UBERON:0001184 denotes renal arteries
T17 825-828 1481724 denotes AND
T18 1000-1005 D012757 denotes ovine
T19 1000-1005 D012757 denotes ovine
T20 1006-1020 UBERON:0001184 denotes renal arteries
T22 1081-1087 UBERON:0001021 denotes nerves
T23 1109-1120 UBERON:0001986 denotes endothelium
T24 1165-1170 CHEBI:18059 denotes lipid
T25 1241-1255 UBERON:0001184 denotes renal arteries
T27 1315-1321 UBERON:0001021 denotes nerves
T28 1339-1344 CHEBI:18059 denotes lipid
T29 1345-1351 UBERON:0000345 denotes myelin
T30 1376-1382 UBERON:0001021 denotes nerves
T31 1472-1477 D012757 denotes ovine
T32 1472-1477 D012757 denotes ovine
T33 1478-1492 UBERON:0001184 denotes renal arteries
T35 1677-1684 CHEBI:15858 denotes bromide
T36 1686-1689 CHEBI:53233 denotes MTT
T37 1784-1789 D012757 denotes ovine
T38 1784-1789 D012757 denotes ovine
T39 1790-1804 UBERON:0001184 denotes renal arteries
T41 1842-1853 UBERON:0001964 denotes renal nerve
T43 1883-1894 UBERON:0001986 denotes endothelium
T44 1943-1948 UBERON:0001021 denotes nerve
T45 2098-2103 D012757 denotes ovine
T46 2098-2103 D012757 denotes ovine
T47 2104-2118 UBERON:0001184 denotes renal arteries
T49 2171-2182 UBERON:0001964 denotes renal nerve
T52 2240-2251 UBERON:0000415 denotes artery wall
T54 2301-2311 UBERON:0005742 denotes adventitia
T55 2354-2365 UBERON:0001986 denotes endothelium
T56 2482-2493 UBERON:0001964 denotes renal nerve
T59 2523-2534 UBERON:0000415 denotes artery wall
T61 2622-2634 D006973 denotes hypertension
T62 2622-2634 D006973 denotes hypertension

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 216-228 HP_0000822 denotes hypertension