PubMed:2516764 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":289,"end":305},"obj":"HP_0002721"}],"text":"[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].\nOligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance."}

{"project":"QFMC_MEDLINE","denotations":[{"id":"T1","span":{"begin":10,"end":16},"obj":"PROC"},{"id":"T1c","span":{"begin":10,"end":16},"obj":"UMLS:C1510425"},{"id":"T2","span":{"begin":63,"end":84},"obj":"CHEM"},{"id":"T2c","span":{"begin":63,"end":84},"obj":"UMLS:C0028948"},{"id":"T3","span":{"begin":139,"end":212},"obj":"CHEM"},{"id":"T3c","span":{"begin":139,"end":212},"obj":"UMLS:C0599533"}],"relations":[{"id":"#1","pred":"Normalization","subj":"T1","obj":"T1c"},{"id":"#2","pred":"Normalization","subj":"T2","obj":"T2c"},{"id":"#3","pred":"Normalization","subj":"T3","obj":"T3c"}],"namespaces":[{"prefix":"UMLS","uri":"https://uts.nlm.nih.gov/metathesaurus.html#"}],"text":"[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].\nOligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance."}