PubMed:2514982 JSONTXT

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":333,"end":341},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G22535ZZ"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"Glycosmos6-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":333,"end":341},"obj":"http://www.glycoepitope.jp/epitopes/EP0508"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":333,"end":341},"obj":"https://glytoucan.org/Structures/Glycans/G22535ZZ"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":131},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":132,"end":354},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":355,"end":410},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":411,"end":494},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":495,"end":661},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":662,"end":907},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":908,"end":992},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":993,"end":1140},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":1141,"end":1272},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1273,"end":1461},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":131},"obj":"Sentence"},{"id":"T2","span":{"begin":132,"end":354},"obj":"Sentence"},{"id":"T3","span":{"begin":355,"end":410},"obj":"Sentence"},{"id":"T4","span":{"begin":411,"end":494},"obj":"Sentence"},{"id":"T5","span":{"begin":495,"end":661},"obj":"Sentence"},{"id":"T6","span":{"begin":662,"end":907},"obj":"Sentence"},{"id":"T7","span":{"begin":908,"end":992},"obj":"Sentence"},{"id":"T8","span":{"begin":993,"end":1140},"obj":"Sentence"},{"id":"T9","span":{"begin":1141,"end":1272},"obj":"Sentence"},{"id":"T10","span":{"begin":1273,"end":1461},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T1","span":{"begin":333,"end":341},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G22535ZZ"},{"id":"A2","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G22535ZZ"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T1","span":{"begin":333,"end":341},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G22535ZZ"},{"id":"A2","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G22535ZZ"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"GlyCosmos-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":333,"end":341},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"}],"attributes":[{"id":"A1","pred":"glycoepitope_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0508"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"GlyCosmos15-Taxon","denotations":[{"id":"T1","span":{"begin":103,"end":121},"obj":"Organism"},{"id":"T2","span":{"begin":208,"end":226},"obj":"Organism"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"55605"},{"id":"A2","pred":"db_id","subj":"T2","obj":"55605"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"GlyCosmos15-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":333,"end":341},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"}],"attributes":[{"id":"A1","pred":"glycoepitope_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0508"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T1","span":{"begin":0,"end":131},"obj":"Sentence"},{"id":"T2","span":{"begin":132,"end":354},"obj":"Sentence"},{"id":"T3","span":{"begin":355,"end":410},"obj":"Sentence"},{"id":"T4","span":{"begin":411,"end":494},"obj":"Sentence"},{"id":"T5","span":{"begin":495,"end":907},"obj":"Sentence"},{"id":"T6","span":{"begin":908,"end":992},"obj":"Sentence"},{"id":"T7","span":{"begin":993,"end":1140},"obj":"Sentence"},{"id":"T8","span":{"begin":1141,"end":1272},"obj":"Sentence"},{"id":"T9","span":{"begin":1273,"end":1461},"obj":"Sentence"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":103,"end":121},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":208,"end":226},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"55605"},{"id":"A2","pred":"db_id","subj":"T2","obj":"55605"}],"text":"Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa.\nAn anti-complementary arabinogalactan (AGIIb-1), isolated from the roots of Angelica acutiloba Kitagawa, comprised one neutral (N-I) and two acidic arabinogalactan (A-I and A-II) units and one neutral arabinan unit (N-II). N-I showed the most potent anti-complementary activity. AGIIb-1, A-I, and A-II had similar moderate activities, but N-II had weak activity. The product (AF-AGIIb-1) of digestion of AGIIb-1 with exo-alpha-L-arabinofuranosidase had markedly increased anti-complementary activity, as did that (AF-N-I) of N-I. Degradation of the rhamnogalacturonan core in AGIIb-1 slightly decreased the anti-complementary activity, whereas the high-molecular-weight neutral arabinogalactan and galacto-oligosaccharide side-chains in A-I and A-II showed potent activities. When AF-AGIIb-1 was digested with endo-arabinanase, the activity decreased slightly. Partial elimination of the (1--6)-beta-D-galactosyl side-chains from AF-N-I by digestion with exo-beta-D-galactosidase did not affect the activity. AGIIb-1 reacted weakly with the beta-D-glucosyl-Yariv antigen, but AF-AGIIb-1 and AF-N-1 had increased reactivity with the antigen. The anti-complementary activity of AGIIb-1 was expressed mainly through the classical pathway, whereas AF-AGIIb-1 and AF-N-I had markedly increased activity through the alterative pathway."}