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PubMed:25138305 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 989-998 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T2 989-998 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 989-998 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 989-998 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T2 989-998 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-42 Sentence denotes Galectin-3 in angiogenesis and metastasis.
TextSentencer_T2 43-242 Sentence denotes Galectin-3 is a member of the family of β-galactoside-binding lectins characterized by evolutionarily conserved sequences defined by structural similarities in their carbohydrate-recognition domains.
TextSentencer_T3 243-611 Sentence denotes Galectin-3 is a unique, chimeric protein consisting of three distinct structural motifs: (i) a short NH2 terminal domain containing a serine phosphorylation site; (ii) a repetitive proline-rich collagen-α-like sequence cleavable by matrix metalloproteases; and (iii) a globular COOH-terminal domain containing a carbohydrate-binding motif and an NWGR anti-death motif.
TextSentencer_T4 612-720 Sentence denotes It is ubiquitously expressed and has diverse biological functions depending on its subcellular localization.
TextSentencer_T5 721-848 Sentence denotes Galectin-3 is mainly found in the cytoplasm, also seen in the nucleus and can be secreted by non-classical, secretory pathways.
TextSentencer_T6 849-1044 Sentence denotes In general, secreted galectin-3 mediates cell migration, cell adhesion and cell-cell interactions through the binding with high affinity to galactose-containing glycoproteins on the cell surface.
TextSentencer_T7 1045-1243 Sentence denotes Cytoplasmic galectin-3 exhibits anti-apoptotic activity and regulates several signal transduction pathways, whereas nuclear galectin-3 has been associated with pre-mRNA splicing and gene expression.
TextSentencer_T8 1244-1529 Sentence denotes Its unique chimeric structure enables it to interact with a plethora of ligands and modulate diverse functions such as cell growth, adhesion, migration, invasion, angiogenesis, immune function, apoptosis and endocytosis emphasizing its significance in the process of tumor progression.
TextSentencer_T9 1530-1646 Sentence denotes In this review, we have focused on the role of galectin-3 in tumor metastasis with special emphasis on angiogenesis.
T1 0-42 Sentence denotes Galectin-3 in angiogenesis and metastasis.
T2 43-242 Sentence denotes Galectin-3 is a member of the family of β-galactoside-binding lectins characterized by evolutionarily conserved sequences defined by structural similarities in their carbohydrate-recognition domains.
T3 243-611 Sentence denotes Galectin-3 is a unique, chimeric protein consisting of three distinct structural motifs: (i) a short NH2 terminal domain containing a serine phosphorylation site; (ii) a repetitive proline-rich collagen-α-like sequence cleavable by matrix metalloproteases; and (iii) a globular COOH-terminal domain containing a carbohydrate-binding motif and an NWGR anti-death motif.
T4 612-720 Sentence denotes It is ubiquitously expressed and has diverse biological functions depending on its subcellular localization.
T5 721-848 Sentence denotes Galectin-3 is mainly found in the cytoplasm, also seen in the nucleus and can be secreted by non-classical, secretory pathways.
T6 849-1044 Sentence denotes In general, secreted galectin-3 mediates cell migration, cell adhesion and cell-cell interactions through the binding with high affinity to galactose-containing glycoproteins on the cell surface.
T7 1045-1243 Sentence denotes Cytoplasmic galectin-3 exhibits anti-apoptotic activity and regulates several signal transduction pathways, whereas nuclear galectin-3 has been associated with pre-mRNA splicing and gene expression.
T8 1244-1529 Sentence denotes Its unique chimeric structure enables it to interact with a plethora of ligands and modulate diverse functions such as cell growth, adhesion, migration, invasion, angiogenesis, immune function, apoptosis and endocytosis emphasizing its significance in the process of tumor progression.
T9 1530-1646 Sentence denotes In this review, we have focused on the role of galectin-3 in tumor metastasis with special emphasis on angiogenesis.
T1 0-42 Sentence denotes Galectin-3 in angiogenesis and metastasis.
T2 43-242 Sentence denotes Galectin-3 is a member of the family of β-galactoside-binding lectins characterized by evolutionarily conserved sequences defined by structural similarities in their carbohydrate-recognition domains.
T3 243-611 Sentence denotes Galectin-3 is a unique, chimeric protein consisting of three distinct structural motifs: (i) a short NH2 terminal domain containing a serine phosphorylation site; (ii) a repetitive proline-rich collagen-α-like sequence cleavable by matrix metalloproteases; and (iii) a globular COOH-terminal domain containing a carbohydrate-binding motif and an NWGR anti-death motif.
T4 612-720 Sentence denotes It is ubiquitously expressed and has diverse biological functions depending on its subcellular localization.
T5 721-848 Sentence denotes Galectin-3 is mainly found in the cytoplasm, also seen in the nucleus and can be secreted by non-classical, secretory pathways.
T6 849-1044 Sentence denotes In general, secreted galectin-3 mediates cell migration, cell adhesion and cell-cell interactions through the binding with high affinity to galactose-containing glycoproteins on the cell surface.
T7 1045-1243 Sentence denotes Cytoplasmic galectin-3 exhibits anti-apoptotic activity and regulates several signal transduction pathways, whereas nuclear galectin-3 has been associated with pre-mRNA splicing and gene expression.
T8 1244-1529 Sentence denotes Its unique chimeric structure enables it to interact with a plethora of ligands and modulate diverse functions such as cell growth, adhesion, migration, invasion, angiogenesis, immune function, apoptosis and endocytosis emphasizing its significance in the process of tumor progression.
T9 1530-1646 Sentence denotes In this review, we have focused on the role of galectin-3 in tumor metastasis with special emphasis on angiogenesis.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1304-1312 HP_0001050 denotes plethora
T2 1511-1516 HP_0002664 denotes tumor
T3 1591-1596 HP_0002664 denotes tumor

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 209-221 FMAID:82737 denotes carbohydrate
_T2 209-221 FMAID:197276 denotes carbohydrate
_T3 276-283 FMAID:67257 denotes protein
_T4 276-283 FMAID:165447 denotes protein
_T5 377-383 FMAID:67710 denotes serine
_T6 377-383 FMAID:82764 denotes serine
_T7 377-383 FMAID:165609 denotes serine
_T8 377-383 FMAID:196753 denotes serine
_T9 424-431 FMAID:196750 denotes proline
_T10 424-431 FMAID:82761 denotes proline
_T11 437-445 FMAID:63891 denotes collagen
_T12 437-445 FMAID:162361 denotes collagen
_T13 555-567 FMAID:82737 denotes carbohydrate
_T14 555-567 FMAID:197276 denotes carbohydrate
_T15 755-764 FMAID:66835 denotes cytoplasm
_T16 755-764 FMAID:165187 denotes cytoplasm
_T17 755-764 FMAID:164989 denotes cytoplasm
_T18 906-933 FMAID:62914 denotes cell adhesion and cell-cell
_T19 906-933 FMAID:167237 denotes cell adhesion and cell-cell
_T20 920-928 FMAID:86471 denotes and cell
_T21 920-928 FMAID:200932 denotes and cell
_T22 920-933 FMAID:83114 denotes and cell-cell
_T23 920-933 FMAID:197397 denotes and cell-cell
_T24 989-998 FMAID:82794 denotes galactose
_T25 989-998 FMAID:196789 denotes galactose
_T26 1010-1023 FMAID:62925 denotes glycoproteins
_T27 1010-1023 FMAID:167256 denotes glycoproteins
_T28 1031-1043 FMAID:212684 denotes cell surface
_T29 1031-1043 FMAID:200942 denotes cell surface
_T30 1036-1043 FMAID:146300 denotes surface
_T31 1036-1043 FMAID:50594 denotes surface
_T32 1045-1056 FMAID:66835 denotes Cytoplasmic
_T33 1045-1056 FMAID:165187 denotes Cytoplasmic
_T34 1045-1056 FMAID:164989 denotes Cytoplasmic
_T35 1227-1231 FMAID:198663 denotes gene

uniprot-human

Id Subject Object Predicate Lexical cue
T1 0-10 http://www.uniprot.org/uniprot/P17931 denotes Galectin-3
T2 43-53 http://www.uniprot.org/uniprot/P17931 denotes Galectin-3
T3 243-253 http://www.uniprot.org/uniprot/P17931 denotes Galectin-3
T4 721-731 http://www.uniprot.org/uniprot/P17931 denotes Galectin-3
T5 870-880 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T6 1057-1067 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T7 1169-1179 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T8 1577-1587 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T9 407-409 http://www.uniprot.org/uniprot/Q8SNA0 denotes ii

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 0-10 http://www.uniprot.org/uniprot/P16110 denotes Galectin-3
T2 43-53 http://www.uniprot.org/uniprot/P16110 denotes Galectin-3
T3 243-253 http://www.uniprot.org/uniprot/P16110 denotes Galectin-3
T4 721-731 http://www.uniprot.org/uniprot/P16110 denotes Galectin-3
T5 870-880 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T6 1057-1067 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T7 1169-1179 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T8 1577-1587 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T9 407-409 http://www.uniprot.org/uniprot/P04441 denotes ii
T10 1205-1208 http://www.uniprot.org/uniprot/Q99NH7 denotes pre

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 657-677 http://purl.bioontology.org/ontology/STY/T039 denotes biological functions
T2 814-817 http://purl.bioontology.org/ontology/NCBITAXON/604139 denotes non

GO-BP

Id Subject Object Predicate Lexical cue
T1 14-26 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T2 1407-1419 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T3 1633-1645 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T4 384-399 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T5 599-604 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T6 707-719 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T7 802-810 http://purl.obolibrary.org/obo/GO_0046903 denotes secreted
T8 861-869 http://purl.obolibrary.org/obo/GO_0046903 denotes secreted
T9 895-910 http://purl.obolibrary.org/obo/GO_0016477 denotes migration, cell
T10 911-928 http://purl.obolibrary.org/obo/GO_0007155 denotes adhesion and cell
T11 1092-1122 http://purl.obolibrary.org/obo/GO_1904526 denotes activity and regulates several
T12 1105-1114 http://purl.obolibrary.org/obo/GO_0065007 denotes regulates
T13 1123-1129 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T14 1123-1142 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T15 1123-1151 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathways
T16 1123-1151 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathways
T17 1123-1151 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathways
T18 1123-1151 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathways
T19 1130-1142 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T20 1205-1208 http://purl.obolibrary.org/obo/GO_0003904 denotes pre
T21 1205-1222 http://purl.obolibrary.org/obo/GO_0000398 denotes pre-mRNA splicing
T22 1205-1222 http://purl.obolibrary.org/obo/GO_0048024 denotes pre-mRNA splicing
T23 1209-1222 http://purl.obolibrary.org/obo/GO_0000372 denotes mRNA splicing
T24 1209-1222 http://purl.obolibrary.org/obo/GO_0000373 denotes mRNA splicing
T25 1209-1222 http://purl.obolibrary.org/obo/GO_0000374 denotes mRNA splicing
T26 1209-1222 http://purl.obolibrary.org/obo/GO_0000394 denotes mRNA splicing
T27 1209-1222 http://purl.obolibrary.org/obo/GO_0000398 denotes mRNA splicing
T28 1214-1222 http://purl.obolibrary.org/obo/GO_0045292 denotes splicing
T29 1227-1242 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T30 1363-1374 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T31 1368-1374 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T32 1438-1447 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T33 1438-1447 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T34 1452-1463 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

GO-MF

Id Subject Object Predicate Lexical cue
T1 85-104 http://purl.obolibrary.org/obo/GO_0016936 denotes galactoside-binding
T2 97-104 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 568-575 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 959-966 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 97-104 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T6 568-575 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 959-966 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 97-104 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T9 568-575 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 959-966 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T11 97-104 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12 568-575 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13 959-966 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14 555-575 http://purl.obolibrary.org/obo/GO_0030246 denotes carbohydrate-binding
T15 1316-1323 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands

GO-CC

Id Subject Object Predicate Lexical cue
T1 755-764 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T2 1045-1056 http://purl.obolibrary.org/obo/GO_0005737 denotes Cytoplasmic
T3 783-790 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T4 890-894 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 906-910 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 924-928 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7 929-933 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8 1031-1035 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9 1363-1367 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10 1031-1043 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 155-164 http://edamontology.org/topic_3168 denotes sequences
T2 155-164 http://edamontology.org/topic_0080 denotes sequences
T3 209-221 http://edamontology.org/topic_0152 denotes carbohydrate
T4 276-283 http://edamontology.org/topic_0078 denotes protein
T5 313-330 http://edamontology.org/topic_0166 denotes structural motifs
T6 324-330 http://edamontology.org/topic_0158 denotes motifs
T7 348-356 http://edamontology.org/topic_0749 denotes terminal
T8 384-404 http://edamontology.org/topic_0751 denotes phosphorylation site
T9 453-461 http://edamontology.org/topic_0080 denotes sequence
T10 453-461 http://edamontology.org/topic_3168 denotes sequence
T11 526-534 http://edamontology.org/topic_0749 denotes terminal
T12 555-567 http://edamontology.org/topic_0152 denotes carbohydrate
T13 576-581 http://edamontology.org/topic_0158 denotes motif
T14 605-610 http://edamontology.org/topic_0158 denotes motif
T15 755-764 http://edamontology.org/topic_0616 denotes cytoplasm
T16 783-790 http://edamontology.org/topic_0616 denotes nucleus
T17 839-847 http://edamontology.org/topic_0602 denotes pathways
T18 924-933 http://edamontology.org/topic_0612 denotes cell-cell
T19 934-946 http://edamontology.org/topic_0602 denotes interactions
T20 1045-1056 http://edamontology.org/topic_0616 denotes Cytoplasmic
T21 1123-1151 http://edamontology.org/topic_0602 denotes signal transduction pathways
T22 1143-1151 http://edamontology.org/topic_0602 denotes pathways
T23 1209-1222 http://edamontology.org/topic_3320 denotes mRNA splicing
T24 1227-1242 http://edamontology.org/topic_0203 denotes gene expression
T25 1288-1296 http://edamontology.org/topic_0602 denotes interact

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 155-164 http://edamontology.org/data_2044 denotes sequences
T2 155-164 http://edamontology.org/operation_3218 denotes sequences
T3 176-186 http://edamontology.org/data_0883 denotes structural
T4 176-199 http://edamontology.org/data_0888 denotes structural similarities
T5 222-233 http://edamontology.org/operation_2423 denotes recognition
T6 276-283 http://edamontology.org/data_1467 denotes protein
T7 276-283 http://edamontology.org/format_1208 denotes protein
T8 313-323 http://edamontology.org/data_0883 denotes structural
T9 453-461 http://edamontology.org/data_2044 denotes sequence
T10 453-461 http://edamontology.org/operation_3218 denotes sequence
T11 475-481 http://edamontology.org/data_2082 denotes matrix
T12 668-677 http://edamontology.org/operation_0004 denotes functions
T13 839-847 http://edamontology.org/data_2600 denotes pathways
T14 852-859 http://edamontology.org/operation_3429 denotes general
T15 1123-1151 http://edamontology.org/data_1659 denotes signal transduction pathways
T16 1143-1151 http://edamontology.org/data_2600 denotes pathways
T17 1264-1273 http://edamontology.org/data_0883 denotes structure
T18 1345-1354 http://edamontology.org/operation_0004 denotes functions
T19 1500-1507 http://edamontology.org/operation_0004 denotes process
T20 1500-1507 http://edamontology.org/operation_2409 denotes process

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25138305-0#0#10#gene3958 721-731 gene3958 denotes Galectin-3
25138305-0#31#41#diseaseC0027627 1209-1343 diseaseC0027627 denotes mRNA splicing and gene expression. Its unique chimeric structure enables it to interact with a plethora of ligands and modulate divers
0#10#gene395831#41#diseaseC0027627 25138305-0#0#10#gene3958 25138305-0#31#41#diseaseC0027627 associated_with Galectin-3,mRNA splicing and gene expression. Its unique chimeric structure enables it to interact with a plethora of ligands and modulate divers

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 924-933 http://purl.obolibrary.org/obo/MAT_0000083 denotes cell-cell

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 0-8 https://acgg.asia/db/lfdb/LfDB0270 denotes Galectin
Lectin_T2 43-51 https://acgg.asia/db/lfdb/LfDB0270 denotes Galectin
Lectin_T3 243-251 https://acgg.asia/db/lfdb/LfDB0270 denotes Galectin
Lectin_T4 721-729 https://acgg.asia/db/lfdb/LfDB0270 denotes Galectin
Lectin_T5 0-8 https://acgg.asia/db/lfdb/LfDB0272 denotes Galectin
Lectin_T6 43-51 https://acgg.asia/db/lfdb/LfDB0272 denotes Galectin
Lectin_T7 243-251 https://acgg.asia/db/lfdb/LfDB0272 denotes Galectin
Lectin_T8 721-729 https://acgg.asia/db/lfdb/LfDB0272 denotes Galectin
Lectin_T9 0-8 https://acgg.asia/db/lfdb/LfDB0274 denotes Galectin
Lectin_T10 43-51 https://acgg.asia/db/lfdb/LfDB0274 denotes Galectin
Lectin_T11 243-251 https://acgg.asia/db/lfdb/LfDB0274 denotes Galectin
Lectin_T12 721-729 https://acgg.asia/db/lfdb/LfDB0274 denotes Galectin

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 814-817 "http://rdf.glycoinfo.org/glycan/G02780QX" denotes non
GlycanIUPAC_T2 814-817 "http://rdf.glycoinfo.org/glycan/G18425DX" denotes non
GlycanIUPAC_T3 814-817 "http://rdf.glycoinfo.org/glycan/G18630JE" denotes non
GlycanIUPAC_T4 814-817 "http://rdf.glycoinfo.org/glycan/G01004IT" denotes non
GlycanIUPAC_T5 814-817 "http://rdf.glycoinfo.org/glycan/G87301QZ" denotes non
GlycanIUPAC_T6 814-817 "http://rdf.glycoinfo.org/glycan/G39790GW" denotes non
GlycanIUPAC_T7 814-817 "http://rdf.glycoinfo.org/glycan/G42928BB" denotes non
GlycanIUPAC_T8 814-817 "http://rdf.glycoinfo.org/glycan/G51134HC" denotes non
GlycanIUPAC_T9 814-817 "http://rdf.glycoinfo.org/glycan/G68183GR" denotes non
GlycanIUPAC_T10 814-817 "http://rdf.glycoinfo.org/glycan/G46883FA" denotes non
GlycanIUPAC_T11 814-817 "http://rdf.glycoinfo.org/glycan/G54702VY" denotes non

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1511-1516 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 1591-1596 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1304-1312 Phenotype denotes plethora HP:0001050
T2 1511-1516 Phenotype denotes tumor HP:0002664
T3 1591-1596 Phenotype denotes tumor HP:0002664

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 755-764 Body_part denotes cytoplasm http://purl.obolibrary.org/obo/GO_0005737
T2 783-790 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125