PubMed:25064355 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/25064355","sourcedb":"PubMed","sourceid":"25064355","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/25064355","text":"A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis.\nOncogenic fusion of the RET (rearranged during transfection) gene was recently identified as a novel driver gene aberration not only for the development of thyroid carcinoma but also of lung adenocarcinoma, the most frequent histological type of lung cancer. This study constructed and analyzed transgenic mice expressing KIF5B-RET, the predominant form of RET fusion gene specific for lung adenocarcinoma, under the control of the SPC (surfactant protein C) gene promoter. The mice expressed the KIF5B-RET fusion gene specifically in lung alveolar epithelial cells, and developed multiple tumors in the lungs. Treatment of the transgenic mice with vandetanib, which is a RET tyrosine kinase inhibitor approved by the U.S. Food and Drug Administration for the treatment of thyroid carcinoma, for 8 or 20 weeks led to a marked reduction in the number of lung tumors (3.3 versus 0 and 6.5 versus 0.2 per tissue section, respectively; P \u003c 0.01, t-test). The results suggest that the RET fusion functions as a driver for the development of lung tumors, whose growth is inhibited by RET tyrosine kinase inhibitors.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":44,"end":48},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":250,"end":254},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":310,"end":314},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":450,"end":454},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":599,"end":603},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":668,"end":673},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":917,"end":921},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T8","span":{"begin":1100,"end":1104},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T9","span":{"begin":966,"end":972},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T6","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T7","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T8","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T9","pred":"source","obj":"performance-test"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":220,"end":237},"obj":"HP_0002890"},{"id":"T2","span":{"begin":250,"end":269},"obj":"HP_0030078"},{"id":"T3","span":{"begin":310,"end":321},"obj":"HP_0100526"},{"id":"T4","span":{"begin":315,"end":321},"obj":"HP_0002664"},{"id":"T5","span":{"begin":450,"end":469},"obj":"HP_0030078"},{"id":"T6","span":{"begin":654,"end":660},"obj":"HP_0002664"},{"id":"T7","span":{"begin":654,"end":673},"obj":"HP_0100526"},{"id":"T8","span":{"begin":837,"end":854},"obj":"HP_0002890"},{"id":"T9","span":{"begin":917,"end":928},"obj":"HP_0100526"},{"id":"T10","span":{"begin":922,"end":928},"obj":"HP_0002664"},{"id":"T11","span":{"begin":1100,"end":1111},"obj":"HP_0100526"},{"id":"T12","span":{"begin":1105,"end":1111},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"},{"subj":"T11","pred":"source","obj":"PubmedHPO"},{"subj":"T12","pred":"source","obj":"PubmedHPO"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":64,"end":322},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":323,"end":537},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":538,"end":674},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":675,"end":786},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":787,"end":1014},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":1015,"end":1173},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"T2","span":{"begin":64,"end":322},"obj":"Sentence"},{"id":"T3","span":{"begin":323,"end":537},"obj":"Sentence"},{"id":"T4","span":{"begin":538,"end":674},"obj":"Sentence"},{"id":"T5","span":{"begin":675,"end":786},"obj":"Sentence"},{"id":"T6","span":{"begin":787,"end":1014},"obj":"Sentence"},{"id":"T7","span":{"begin":1015,"end":1173},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":44,"end":48},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":250,"end":254},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":310,"end":314},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":450,"end":454},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":599,"end":603},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":917,"end":921},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":1100,"end":1104},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T8","span":{"begin":966,"end":972},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T6","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T7","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T8","pred":"source","obj":"UBERON-AE"}]},{"project":"DisGeNet-2017-sample","denotations":[{"id":"T2482","span":{"begin":88,"end":91},"obj":"gene:5979"},{"id":"T2483","span":{"begin":310,"end":321},"obj":"disease:C0242379"},{"id":"T2484","span":{"begin":93,"end":123},"obj":"gene:5979"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T2482","obj":"T2483"},{"id":"R2","pred":"associated_with","subj":"T2482","obj":"T2483"},{"id":"R3","pred":"associated_with","subj":"T2482","obj":"T2483"},{"id":"R4","pred":"associated_with","subj":"T2484","obj":"T2483"},{"id":"R5","pred":"associated_with","subj":"T2484","obj":"T2483"},{"id":"R6","pred":"associated_with","subj":"T2484","obj":"T2483"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T2482","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T2483","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T2484","pred":"source","obj":"DisGeNet-2017-sample"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"25064355-0#23#26#gene5979","span":{"begin":23,"end":26},"obj":"gene5979"},{"id":"25064355-0#49#62#diseaseC0596263","span":{"begin":49,"end":62},"obj":"diseaseC0596263"},{"id":"25064355-1#24#27#gene5979","span":{"begin":88,"end":91},"obj":"gene5979"},{"id":"25064355-1#29#59#gene5979","span":{"begin":93,"end":123},"obj":"gene5979"},{"id":"25064355-1#246#257#diseaseC0242379","span":{"begin":310,"end":321},"obj":"diseaseC0242379"},{"id":"25064355-1#246#257#diseaseC0684249","span":{"begin":310,"end":321},"obj":"diseaseC0684249"},{"id":"25064355-1#246#257#diseaseC1306460","span":{"begin":310,"end":321},"obj":"diseaseC1306460"},{"id":"25064355-1#246#257#diseaseC0242379","span":{"begin":310,"end":321},"obj":"diseaseC0242379"},{"id":"25064355-1#246#257#diseaseC0684249","span":{"begin":310,"end":321},"obj":"diseaseC0684249"},{"id":"25064355-1#246#257#diseaseC1306460","span":{"begin":310,"end":321},"obj":"diseaseC1306460"},{"id":"25064355-2#98#101#gene5979","span":{"begin":421,"end":424},"obj":"gene5979"},{"id":"25064355-2#127#146#diseaseC0152013","span":{"begin":450,"end":469},"obj":"diseaseC0152013"},{"id":"25064355-3#23#28#gene3799","span":{"begin":561,"end":566},"obj":"gene3799"},{"id":"25064355-3#29#32#gene5979","span":{"begin":567,"end":570},"obj":"gene5979"},{"id":"25064355-3#107#122#diseaseC0260037","span":{"begin":645,"end":660},"obj":"diseaseC0260037"},{"id":"25064355-4#61#64#gene5979","span":{"begin":736,"end":739},"obj":"gene5979"},{"id":"25064355-4#162#179#diseaseC0549473","span":{"begin":837,"end":854},"obj":"diseaseC0549473"},{"id":"25064355-5#29#32#gene5979","span":{"begin":1044,"end":1047},"obj":"gene5979"},{"id":"25064355-5#127#130#gene5979","span":{"begin":1142,"end":1145},"obj":"gene5979"},{"id":"25064355-5#85#96#diseaseC0024121","span":{"begin":1100,"end":1111},"obj":"diseaseC0024121"}],"relations":[{"id":"23#26#gene597949#62#diseaseC0596263","pred":"associated_with","subj":"25064355-0#23#26#gene5979","obj":"25064355-0#49#62#diseaseC0596263"},{"id":"24#27#gene5979246#257#diseaseC0242379","pred":"associated_with","subj":"25064355-1#24#27#gene5979","obj":"25064355-1#246#257#diseaseC0242379"},{"id":"24#27#gene5979246#257#diseaseC0684249","pred":"associated_with","subj":"25064355-1#24#27#gene5979","obj":"25064355-1#246#257#diseaseC0684249"},{"id":"24#27#gene5979246#257#diseaseC1306460","pred":"associated_with","subj":"25064355-1#24#27#gene5979","obj":"25064355-1#246#257#diseaseC1306460"},{"id":"24#27#gene5979246#257#diseaseC0242379","pred":"associated_with","subj":"25064355-1#24#27#gene5979","obj":"25064355-1#246#257#diseaseC0242379"},{"id":"24#27#gene5979246#257#diseaseC0684249","pred":"associated_with","subj":"25064355-1#24#27#gene5979","obj":"25064355-1#246#257#diseaseC0684249"},{"id":"24#27#gene5979246#257#diseaseC1306460","pred":"associated_with","subj":"25064355-1#24#27#gene5979","obj":"25064355-1#246#257#diseaseC1306460"},{"id":"29#59#gene5979246#257#diseaseC0242379","pred":"associated_with","subj":"25064355-1#29#59#gene5979","obj":"25064355-1#246#257#diseaseC0242379"},{"id":"29#59#gene5979246#257#diseaseC0684249","pred":"associated_with","subj":"25064355-1#29#59#gene5979","obj":"25064355-1#246#257#diseaseC0684249"},{"id":"29#59#gene5979246#257#diseaseC1306460","pred":"associated_with","subj":"25064355-1#29#59#gene5979","obj":"25064355-1#246#257#diseaseC1306460"},{"id":"29#59#gene5979246#257#diseaseC0242379","pred":"associated_with","subj":"25064355-1#29#59#gene5979","obj":"25064355-1#246#257#diseaseC0242379"},{"id":"29#59#gene5979246#257#diseaseC0684249","pred":"associated_with","subj":"25064355-1#29#59#gene5979","obj":"25064355-1#246#257#diseaseC0684249"},{"id":"29#59#gene5979246#257#diseaseC1306460","pred":"associated_with","subj":"25064355-1#29#59#gene5979","obj":"25064355-1#246#257#diseaseC1306460"},{"id":"98#101#gene5979127#146#diseaseC0152013","pred":"associated_with","subj":"25064355-2#98#101#gene5979","obj":"25064355-2#127#146#diseaseC0152013"},{"id":"23#28#gene3799107#122#diseaseC0260037","pred":"associated_with","subj":"25064355-3#23#28#gene3799","obj":"25064355-3#107#122#diseaseC0260037"},{"id":"29#32#gene5979107#122#diseaseC0260037","pred":"associated_with","subj":"25064355-3#29#32#gene5979","obj":"25064355-3#107#122#diseaseC0260037"},{"id":"61#64#gene5979162#179#diseaseC0549473","pred":"associated_with","subj":"25064355-4#61#64#gene5979","obj":"25064355-4#162#179#diseaseC0549473"},{"id":"29#32#gene597985#96#diseaseC0024121","pred":"associated_with","subj":"25064355-5#29#32#gene5979","obj":"25064355-5#85#96#diseaseC0024121"},{"id":"127#130#gene597985#96#diseaseC0024121","pred":"associated_with","subj":"25064355-5#127#130#gene5979","obj":"25064355-5#85#96#diseaseC0024121"}],"attributes":[{"subj":"25064355-0#23#26#gene5979","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-0#49#62#diseaseC0596263","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-1#24#27#gene5979","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-1#29#59#gene5979","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-1#246#257#diseaseC0242379","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-1#246#257#diseaseC0684249","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-1#246#257#diseaseC1306460","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-1#246#257#diseaseC0242379","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-1#246#257#diseaseC0684249","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-1#246#257#diseaseC1306460","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-2#98#101#gene5979","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-2#127#146#diseaseC0152013","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-3#23#28#gene3799","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-3#29#32#gene5979","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-3#107#122#diseaseC0260037","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-4#61#64#gene5979","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-4#162#179#diseaseC0549473","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-5#29#32#gene5979","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-5#127#130#gene5979","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"25064355-5#85#96#diseaseC0024121","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"performance-test","color":"#a7ec93","default":true},{"id":"PubmedHPO","color":"#ec93c1"},{"id":"sentences","color":"#93dbec"},{"id":"UBERON-AE","color":"#ece393"},{"id":"DisGeNet-2017-sample","color":"#c993ec"},{"id":"DisGeNET5_gene_disease","color":"#93ecaf"}]}]}}