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PubMed:25060537 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 613-633 HP_0001370 denotes rheumatoid arthritis
T2 624-633 HP_0001369 denotes arthritis
T3 643-653 HP_0002960 denotes autoimmune
T4 643-661 HP_0002960 denotes autoimmune disease

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis.
T2 116-354 Sentence denotes Although we have obtained comprehensive catalogues of genetic risk loci that are linked to human diseases, little is known regarding how to devise a systematic strategy to integrate genetic study results with diverse biological resources.
T3 355-487 Sentence denotes Such strategies will be crucial for providing novel insights into disease biology and for aiding drug discovery as an ultimate goal.
T4 488-718 Sentence denotes Here we describe the current progress in this field using a pioneering example of large-scale genetic association studies on rheumatoid arthritis (RA), an autoimmune disease characterized by inflammation and destruction of joints.
T5 719-937 Sentence denotes Through functional and bioinformatic annotations of risk SNPs and genes from >100 RA risk loci identified by genome-wide association study (GWAS) meta-analysis, we found novel biological insights into RA pathogenicity.
T6 938-1315 Sentence denotes Further, by integrating RA genetic findings with the complete catalogue of approved drugs for RA and other diseases, we provide empirical data to indicate that human genetic-based approaches may be useful for supporting "genetics-driven genomic drug discovery" efforts in complex human traits and suggest that further development of integrative approaches should be undertaken.
T1 0-115 Sentence denotes From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis.
T2 116-354 Sentence denotes Although we have obtained comprehensive catalogues of genetic risk loci that are linked to human diseases, little is known regarding how to devise a systematic strategy to integrate genetic study results with diverse biological resources.
T3 355-487 Sentence denotes Such strategies will be crucial for providing novel insights into disease biology and for aiding drug discovery as an ultimate goal.
T4 488-718 Sentence denotes Here we describe the current progress in this field using a pioneering example of large-scale genetic association studies on rheumatoid arthritis (RA), an autoimmune disease characterized by inflammation and destruction of joints.
T5 719-937 Sentence denotes Through functional and bioinformatic annotations of risk SNPs and genes from >100 RA risk loci identified by genome-wide association study (GWAS) meta-analysis, we found novel biological insights into RA pathogenicity.
T6 938-1315 Sentence denotes Further, by integrating RA genetic findings with the complete catalogue of approved drugs for RA and other diseases, we provide empirical data to indicate that human genetic-based approaches may be useful for supporting "genetics-driven genomic drug discovery" efforts in complex human traits and suggest that further development of integrative approaches should be undertaken.