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PubMed:25056937 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 103-109 HP_0002664 denotes Cancer
T2 442-448 HP_0002664 denotes cancer
T3 656-671 HP_0012125 denotes prostate cancer
T4 665-671 HP_0002664 denotes cancer
T5 836-841 HP_0002664 denotes tumor
T6 1150-1160 HP_0000718 denotes aggressive
T7 1181-1187 HP_0002664 denotes cancer
T8 1435-1450 HP_0012125 denotes prostate cancer
T9 1444-1450 HP_0002664 denotes cancer
T10 1974-1980 HP_0002664 denotes cancer
T11 2134-2153 HP_0012125 denotes cancer of prostatic
T12 2134-2140 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
25056937-0#26#48#gene1803 26-48 gene1803 denotes dipeptidyl peptidase 4
25056937-0#75#101#diseaseC0936223 75-101 diseaseC0936223 denotes metastatic prostate cancer
25056937-0#75#101#diseaseC1282496 75-101 diseaseC1282496 denotes metastatic prostate cancer
25056937-12#58#62#gene1803 2047-2051 gene1803 denotes DPP4
25056937-12#134#151#diseaseC0027627 2123-2140 diseaseC0027627 denotes metastatic cancer
25056937-12#134#151#diseaseC0346957 2123-2140 diseaseC0346957 denotes metastatic cancer
26#48#gene180375#101#diseaseC0936223 25056937-0#26#48#gene1803 25056937-0#75#101#diseaseC0936223 associated_with dipeptidyl peptidase 4,metastatic prostate cancer
26#48#gene180375#101#diseaseC1282496 25056937-0#26#48#gene1803 25056937-0#75#101#diseaseC1282496 associated_with dipeptidyl peptidase 4,metastatic prostate cancer
58#62#gene1803134#151#diseaseC0027627 25056937-12#58#62#gene1803 25056937-12#134#151#diseaseC0027627 associated_with DPP4,metastatic cancer
58#62#gene1803134#151#diseaseC0346957 25056937-12#58#62#gene1803 25056937-12#134#151#diseaseC0346957 associated_with DPP4,metastatic cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1996 26-48 gene:1803 denotes dipeptidyl peptidase 4
T1997 75-101 disease:C0936223 denotes metastatic prostate cancer
R1 T1996 T1997 associated_with dipeptidyl peptidase 4,metastatic prostate cancer
R2 T1996 T1997 associated_with dipeptidyl peptidase 4,metastatic prostate cancer

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-102 Sentence denotes Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.
TextSentencer_T2 103-190 Sentence denotes Cancer is responsible for many deaths and is a major source of healthcare expenditures.
TextSentencer_T3 191-340 Sentence denotes The identification of new, non-invasive biomarkers might allow improvement of the direct diagnostic or prognostic ability of already available tools.
TextSentencer_T4 341-598 Sentence denotes Here, we took the innovative approach of interrogating the activity of exopeptidases in the serum of cancer patients with the aim of establishing a distinction based on enzymatic function, instead of simple protein levels, as a means to biomarker discovery.
TextSentencer_T5 599-854 Sentence denotes We first analyzed two well-characterized mouse models of prostate cancer, each with a distinct genetic lesion, and established that broad exopeptidase and targeted aminopeptidase activity tests reveal proteolytic changes associated with tumor development.
TextSentencer_T6 855-1084 Sentence denotes We also describe new peptide-based freeze-frame reagents uniquely suited to probe the altered balance of selected aminopeptidases, as opposed to the full array of exopeptidases, and/or their modulators in patient serum or plasma.
TextSentencer_T7 1085-1205 Sentence denotes One particular proteolytic activity was impaired in animals with aggressive disease relative to cancer-free littermates.
TextSentencer_T8 1206-1363 Sentence denotes We identified the protease in question as dipeptidyl peptidase 4 (DPP4) by analyzing selected knockout mice and evaluating the effect of specific inhibitors.
TextSentencer_T9 1364-1515 Sentence denotes DPP4 activity was also reduced in the sera of patients with metastatic prostate cancer relative to patients with localized disease or healthy controls.
TextSentencer_T10 1516-1672 Sentence denotes However, no significant differences in DPP4 serum levels were observed, which established the loss of activity as the result of impaired enzymatic function.
TextSentencer_T11 1673-1852 Sentence denotes Biochemical analysis indicated that reduced activity was the result not of post-translational modifications or allosteric changes, but instead of a low-molecular-weight inhibitor.
TextSentencer_T12 1853-1988 Sentence denotes After we adjusted for age and total prostate-specific antigen, reduced DPP4 activity remained a significant predictor of cancer status.
TextSentencer_T13 1989-2270 Sentence denotes The results of this proof-of-principle study suggest that DPP4 activity might be a potential blood-based indicator of the presence of metastatic cancer of prostatic origin, either by itself or, more likely, as a means to improve the sensitivity and specificity of existing markers.
T1 0-102 Sentence denotes Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.
T2 103-190 Sentence denotes Cancer is responsible for many deaths and is a major source of healthcare expenditures.
T3 191-340 Sentence denotes The identification of new, non-invasive biomarkers might allow improvement of the direct diagnostic or prognostic ability of already available tools.
T4 341-598 Sentence denotes Here, we took the innovative approach of interrogating the activity of exopeptidases in the serum of cancer patients with the aim of establishing a distinction based on enzymatic function, instead of simple protein levels, as a means to biomarker discovery.
T5 599-854 Sentence denotes We first analyzed two well-characterized mouse models of prostate cancer, each with a distinct genetic lesion, and established that broad exopeptidase and targeted aminopeptidase activity tests reveal proteolytic changes associated with tumor development.
T6 855-1084 Sentence denotes We also describe new peptide-based freeze-frame reagents uniquely suited to probe the altered balance of selected aminopeptidases, as opposed to the full array of exopeptidases, and/or their modulators in patient serum or plasma.
T7 1085-1205 Sentence denotes One particular proteolytic activity was impaired in animals with aggressive disease relative to cancer-free littermates.
T8 1206-1363 Sentence denotes We identified the protease in question as dipeptidyl peptidase 4 (DPP4) by analyzing selected knockout mice and evaluating the effect of specific inhibitors.
T9 1364-1515 Sentence denotes DPP4 activity was also reduced in the sera of patients with metastatic prostate cancer relative to patients with localized disease or healthy controls.
T10 1516-1672 Sentence denotes However, no significant differences in DPP4 serum levels were observed, which established the loss of activity as the result of impaired enzymatic function.
T11 1673-1852 Sentence denotes Biochemical analysis indicated that reduced activity was the result not of post-translational modifications or allosteric changes, but instead of a low-molecular-weight inhibitor.
T12 1853-1988 Sentence denotes After we adjusted for age and total prostate-specific antigen, reduced DPP4 activity remained a significant predictor of cancer status.
T13 1989-2270 Sentence denotes The results of this proof-of-principle study suggest that DPP4 activity might be a potential blood-based indicator of the presence of metastatic cancer of prostatic origin, either by itself or, more likely, as a means to improve the sensitivity and specificity of existing markers.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 433-438 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 1068-1073 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 1560-1565 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T4 2082-2087 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 433-438 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 1068-1073 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 1560-1565 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T4 2082-2087 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 86-101 Phenotype denotes prostate cancer HP:0012125
T2 103-109 Phenotype denotes Cancer HP:0002664
T3 442-448 Phenotype denotes cancer HP:0002664
T4 656-671 Phenotype denotes prostate cancer HP:0012125
T5 836-841 Phenotype denotes tumor HP:0002664
T6 1150-1160 Phenotype denotes aggressive HP:0000718
T7 1181-1187 Phenotype denotes cancer HP:0002664
T8 1435-1450 Phenotype denotes prostate cancer HP:0012125
T9 1974-1980 Phenotype denotes cancer HP:0002664
T10 2134-2140 Phenotype denotes cancer HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 75-101 Disease denotes metastatic prostate cancer http://purl.obolibrary.org/obo/MONDO_0004956
T2 103-109 Disease denotes Cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 442-448 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 656-671 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315
T5 836-841 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 1181-1187 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T7 1424-1450 Disease denotes metastatic prostate cancer http://purl.obolibrary.org/obo/MONDO_0004956
T8 1974-1980 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T9 2123-2140 Disease denotes metastatic cancer http://purl.obolibrary.org/obo/MONDO_0024880

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 640-645 OrganismTaxon denotes mouse 10088|10090
T3 1060-1067 OrganismTaxon denotes patient 9606
T4 1309-1313 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 86-94 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T2 656-664 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T3 1077-1083 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T4 1435-1443 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T5 1889-1897 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T6 2082-2087 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 86-94 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T2 656-664 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T3 1435-1443 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T4 1889-1897 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T5 2082-2087 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T7 2144-2153 Body_part denotes prostatic http://purl.obolibrary.org/obo/MAT_0000078