> top > docs > PubMed:24998848 > annotations

PubMed:24998848 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist.
T2 129-198 Sentence denotes The TP53 tumor-suppressor gene is frequently mutated in human cancer.
T3 199-296 Sentence denotes Missense mutations can add novel functions (gain-of-function, GOF) that promote tumor malignancy.
T4 297-505 Sentence denotes Here we report that mutant (mut) p53 promotes tumor malignancy by suppressing the expression of a natural occurring anti-inflammatory cytokine, the secreted interleukin-1 receptor antagonist (sIL-1Ra, IL1RN).
T5 506-624 Sentence denotes We show that mutp53 but not wild-type (wt) p53 suppresses the sIL-1Ra production in conditioned media of cancer cells.
T6 625-893 Sentence denotes Moreover, mutp53, but not wtp53, binds physically the sIL-1Ra promoter and the protein-protein interaction with the transcriptional co-repressor MAFF (v-MAF musculoaponeurotic fibrosarcoma oncogene family, protein F) is required for mutp53-induced sIL-1Ra suppression.
T7 894-1077 Sentence denotes Remarkably, when exposed to IL-1 beta (IL-1β) inflammatory stimuli, mutp53 sustains a ready-to-be-activated in vitro and in vivo cancer cells' response through the sIL-1Ra repression.
T8 1078-1301 Sentence denotes Taken together, these results identify sIL-1Ra as a novel mutp53 target gene, whose suppression might be required to generate a chronic pro-inflammatory tumor microenvironment through which mutp53 promotes tumor malignancy.
T1 0-128 Sentence denotes Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist.
T2 129-198 Sentence denotes The TP53 tumor-suppressor gene is frequently mutated in human cancer.
T3 199-296 Sentence denotes Missense mutations can add novel functions (gain-of-function, GOF) that promote tumor malignancy.
T4 297-505 Sentence denotes Here we report that mutant (mut) p53 promotes tumor malignancy by suppressing the expression of a natural occurring anti-inflammatory cytokine, the secreted interleukin-1 receptor antagonist (sIL-1Ra, IL1RN).
T5 506-624 Sentence denotes We show that mutp53 but not wild-type (wt) p53 suppresses the sIL-1Ra production in conditioned media of cancer cells.
T6 625-893 Sentence denotes Moreover, mutp53, but not wtp53, binds physically the sIL-1Ra promoter and the protein-protein interaction with the transcriptional co-repressor MAFF (v-MAF musculoaponeurotic fibrosarcoma oncogene family, protein F) is required for mutp53-induced sIL-1Ra suppression.
T7 894-1077 Sentence denotes Remarkably, when exposed to IL-1 beta (IL-1β) inflammatory stimuli, mutp53 sustains a ready-to-be-activated in vitro and in vivo cancer cells' response through the sIL-1Ra repression.
T8 1078-1301 Sentence denotes Taken together, these results identify sIL-1Ra as a novel mutp53 target gene, whose suppression might be required to generate a chronic pro-inflammatory tumor microenvironment through which mutp53 promotes tumor malignancy.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 138-143 HP_0002664 denotes tumor
T2 191-197 HP_0002664 denotes cancer
T3 279-284 HP_0002664 denotes tumor
T4 343-348 HP_0002664 denotes tumor
T5 611-617 HP_0002664 denotes cancer
T6 801-813 HP_0100244 denotes fibrosarcoma
T7 1023-1029 HP_0002664 denotes cancer
T8 1231-1236 HP_0002664 denotes tumor
T9 1284-1289 HP_0002664 denotes tumor

kaiyin_test

Id Subject Object Predicate Lexical cue
T2 133-159 Gene denotes TP53 tumor-suppressor gene
T1 199-217 Var denotes Missense mutations
T3 271-278 PosReg denotes promote
T4 279-295 CPA denotes tumor malignancy
T5 317-323 Var denotes mutant
T6 330-333 Gene denotes p53
T7 334-342 PosReg denotes promotes
T8 343-359 CPA denotes tumor malignancy
T9 363-374 NegReg denotes suppressing
T10 379-439 MPA denotes expression of a natural occurring anti-inflammatory cytokine
T11 519-525 Var denotes mutp53
T12 553-563 NegReg denotes suppresses
T13 568-586 MPA denotes sIL-1Ra production
R1 T2 T1 ThemeOf TP53 tumor-suppressor gene,Missense mutations
R10 T13 T12 ThemeOf sIL-1Ra production,suppresses
R2 T1 T3 CauseOf Missense mutations,promote
R3 T4 T3 ThemeOf tumor malignancy,promote
R4 T6 T5 ThemeOf p53,mutant
R5 T5 T9 CauseOf mutant,suppressing
R6 T10 T9 ThemeOf expression of a natural occurring anti-inflammatory cytokine,suppressing
R7 T9 T7 CauseOf suppressing,promotes
R8 T8 T7 ThemeOf tumor malignancy,promotes
R9 T11 T12 CauseOf mutp53,suppresses

name_no

Id Subject Object Predicate Lexical cue
T2 133-159 Gene denotes TP53 tumor-suppressor gene
T1 199-217 Var denotes Missense mutations
T3 271-278 PosReg denotes promote
T4 279-295 CPA denotes tumor malignancy
T5 317-323 Var denotes mutant
T6 330-333 Gene denotes p53
T7 334-342 PosReg denotes promotes
T8 343-359 CPA denotes tumor malignancy
T9 363-374 NegReg denotes suppressing
T10 379-439 MPA denotes expression of a natural occurring anti-inflammatory cytokine
T11 519-525 Var denotes mutp53
T12 553-563 NegReg denotes suppresses
T13 568-586 MPA denotes sIL-1Ra production
R1 T2 T1 ThemeOf TP53 tumor-suppressor gene,Missense mutations
R10 T13 T12 ThemeOf sIL-1Ra production,suppresses
R2 T1 T3 CauseOf Missense mutations,promote
R3 T4 T3 ThemeOf tumor malignancy,promote
R4 T6 T5 ThemeOf p53,mutant
R5 T5 T9 CauseOf mutant,suppressing
R6 T10 T9 ThemeOf expression of a natural occurring anti-inflammatory cytokine,suppressing
R7 T9 T7 CauseOf suppressing,promotes
R8 T8 T7 ThemeOf tumor malignancy,promotes
R9 T11 T12 CauseOf mutp53,suppresses