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PubMed:24996823 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-71 Sentence denotes Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6.
TextSentencer_T2 72-160 Sentence denotes Galectin-3 has been reported to regulate the functions of a number of immune cell types.
TextSentencer_T3 161-346 Sentence denotes We previously reported that galectin-3 is translocated to immunological synapses in T cells upon T-cell receptor engagement, where it associates with ALG-2-interacting protein X (Alix).
TextSentencer_T4 347-504 Sentence denotes Alix is known to coordinate with the endosomal sorting complex required for transport (ESCRT) to promote human immunodeficiency virus (HIV)-1 virion release.
TextSentencer_T5 505-573 Sentence denotes We hypothesized that galectin-3 plays a role in HIV-1 viral budding.
TextSentencer_T6 574-803 Sentence denotes Cotransfection of cells of the Jurkat T line with galectin-3 and HIV-1 plasmids resulted in increased HIV-1 budding, and suppression of galectin-3 expression by RNAi in Hut78 and primary CD4+ T cells led to reduced HIV-1 budding.
TextSentencer_T7 804-932 Sentence denotes We used immunofluorescence microscopy to observe the partial colocalization of galectin-3, Alix and Gag in HIV-1-infected cells.
TextSentencer_T8 933-1149 Sentence denotes Results from co-immunoprecipitation experiments indicate that galectin-3 expression promotes Alix-Gag p6 association, whereas the results of Alix knockdown suggest that galectin-3 promotes HIV-1 budding through Alix.
TextSentencer_T9 1150-1320 Sentence denotes HIV-1 particles released from galectin-3-expressing cells acquire the galectin-3 protein in an Alix-dependent manner, with proteins primarily residing inside the virions.
TextSentencer_T10 1321-1420 Sentence denotes We also found that the galectin-3 N-terminal domain interacts with the proline-rich region of Alix.
TextSentencer_T11 1421-1551 Sentence denotes Collectively, these results suggest that endogenous galectin-3 facilitates HIV-1 budding by promoting the Alix-Gag p6 association.
T1 0-71 Sentence denotes Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6.
T2 72-160 Sentence denotes Galectin-3 has been reported to regulate the functions of a number of immune cell types.
T3 161-346 Sentence denotes We previously reported that galectin-3 is translocated to immunological synapses in T cells upon T-cell receptor engagement, where it associates with ALG-2-interacting protein X (Alix).
T4 347-504 Sentence denotes Alix is known to coordinate with the endosomal sorting complex required for transport (ESCRT) to promote human immunodeficiency virus (HIV)-1 virion release.
T5 505-573 Sentence denotes We hypothesized that galectin-3 plays a role in HIV-1 viral budding.
T6 574-803 Sentence denotes Cotransfection of cells of the Jurkat T line with galectin-3 and HIV-1 plasmids resulted in increased HIV-1 budding, and suppression of galectin-3 expression by RNAi in Hut78 and primary CD4+ T cells led to reduced HIV-1 budding.
T7 804-932 Sentence denotes We used immunofluorescence microscopy to observe the partial colocalization of galectin-3, Alix and Gag in HIV-1-infected cells.
T8 933-1320 Sentence denotes Results from co-immunoprecipitation experiments indicate that galectin-3 expression promotes Alix-Gag p6 association, whereas the results of Alix knockdown suggest that galectin-3 promotes HIV-1 budding through Alix. HIV-1 particles released from galectin-3-expressing cells acquire the galectin-3 protein in an Alix-dependent manner, with proteins primarily residing inside the virions.
T9 1321-1551 Sentence denotes We also found that the galectin-3 N-terminal domain interacts with the proline-rich region of Alix. Collectively, these results suggest that endogenous galectin-3 facilitates HIV-1 budding by promoting the Alix-Gag p6 association.
T1 0-71 Sentence denotes Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6.
T2 72-160 Sentence denotes Galectin-3 has been reported to regulate the functions of a number of immune cell types.
T3 161-346 Sentence denotes We previously reported that galectin-3 is translocated to immunological synapses in T cells upon T-cell receptor engagement, where it associates with ALG-2-interacting protein X (Alix).
T4 347-504 Sentence denotes Alix is known to coordinate with the endosomal sorting complex required for transport (ESCRT) to promote human immunodeficiency virus (HIV)-1 virion release.
T5 505-573 Sentence denotes We hypothesized that galectin-3 plays a role in HIV-1 viral budding.
T6 574-803 Sentence denotes Cotransfection of cells of the Jurkat T line with galectin-3 and HIV-1 plasmids resulted in increased HIV-1 budding, and suppression of galectin-3 expression by RNAi in Hut78 and primary CD4+ T cells led to reduced HIV-1 budding.
T7 804-932 Sentence denotes We used immunofluorescence microscopy to observe the partial colocalization of galectin-3, Alix and Gag in HIV-1-infected cells.
T8 933-1149 Sentence denotes Results from co-immunoprecipitation experiments indicate that galectin-3 expression promotes Alix-Gag p6 association, whereas the results of Alix knockdown suggest that galectin-3 promotes HIV-1 budding through Alix.
T9 1150-1320 Sentence denotes HIV-1 particles released from galectin-3-expressing cells acquire the galectin-3 protein in an Alix-dependent manner, with proteins primarily residing inside the virions.
T10 1321-1420 Sentence denotes We also found that the galectin-3 N-terminal domain interacts with the proline-rich region of Alix.
T11 1421-1551 Sentence denotes Collectively, these results suggest that endogenous galectin-3 facilitates HIV-1 budding by promoting the Alix-Gag p6 association.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 458-474 HP_0002721 denotes immunodeficiency

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T1 452-485 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC512 denotes human immunodeficiency virus (HIV

ICD10

Id Subject Object Predicate Lexical cue
T1 452-485 http://purl.bioontology.org/ontology/ICD10/B24 denotes human immunodeficiency virus (HIV
T2 452-485 http://purl.bioontology.org/ontology/ICD10/Z71.7 denotes human immunodeficiency virus (HIV
T3 452-485 http://purl.bioontology.org/ontology/ICD10/B20-B24.9 denotes human immunodeficiency virus (HIV
T4 458-474 http://purl.bioontology.org/ontology/ICD10/D84.9 denotes immunodeficiency

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 64-67 FMAID:167404 denotes Gag
_T2 233-241 FMAID:67408 denotes synapses
_T3 233-241 FMAID:165330 denotes synapses
_T4 247-252 FMAID:68646 denotes cells
_T5 247-252 FMAID:169002 denotes cells
_T6 329-336 FMAID:165447 denotes protein
_T7 329-336 FMAID:67257 denotes protein
_T8 384-393 FMAID:165070 denotes endosomal
_T9 384-393 FMAID:67180 denotes endosomal
_T10 592-597 FMAID:169002 denotes cells
_T11 592-597 FMAID:68646 denotes cells
_T12 768-773 FMAID:68646 denotes cells
_T13 768-773 FMAID:169002 denotes cells
_T14 904-907 FMAID:167404 denotes Gag
_T15 926-931 FMAID:68646 denotes cells
_T16 926-931 FMAID:169002 denotes cells
_T17 1031-1034 FMAID:167404 denotes Gag
_T18 1202-1207 FMAID:68646 denotes cells
_T19 1202-1207 FMAID:169002 denotes cells
_T20 1231-1238 FMAID:165447 denotes protein
_T21 1231-1238 FMAID:67257 denotes protein
_T22 1273-1281 FMAID:165447 denotes proteins
_T23 1273-1281 FMAID:67257 denotes proteins
_T24 1392-1399 FMAID:196750 denotes proline
_T25 1392-1399 FMAID:82761 denotes proline
_T26 1532-1535 FMAID:167404 denotes Gag

uniprot-human

Id Subject Object Predicate Lexical cue
T1 0-10 http://www.uniprot.org/uniprot/P17931 denotes Galectin-3
T2 72-82 http://www.uniprot.org/uniprot/P17931 denotes Galectin-3
T3 189-199 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T4 526-536 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T5 624-634 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T6 710-720 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T7 883-893 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T8 995-1005 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T9 1102-1112 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T10 1180-1190 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T11 1220-1230 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T12 1344-1354 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T13 1473-1483 http://www.uniprot.org/uniprot/P17931 denotes galectin-3
T14 68-70 http://www.uniprot.org/uniprot/P80511 denotes p6
T15 1035-1037 http://www.uniprot.org/uniprot/P80511 denotes p6
T16 1536-1538 http://www.uniprot.org/uniprot/P80511 denotes p6
T17 311-328 http://www.uniprot.org/uniprot/Q8WUM4 denotes ALG-2-interacting
T18 315-336 http://www.uniprot.org/uniprot/Q9BWK7 denotes 2-interacting protein
T19 761-764 http://www.uniprot.org/uniprot/P01730 denotes CD4
T20 1220-1238 http://www.uniprot.org/uniprot/Q08380 denotes galectin-3 protein

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 0-10 http://www.uniprot.org/uniprot/P16110 denotes Galectin-3
T2 72-82 http://www.uniprot.org/uniprot/P16110 denotes Galectin-3
T3 189-199 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T4 526-536 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T5 624-634 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T6 710-720 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T7 883-893 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T8 995-1005 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T9 1102-1112 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T10 1180-1190 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T11 1220-1230 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T12 1344-1354 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T13 1473-1483 http://www.uniprot.org/uniprot/P16110 denotes galectin-3
T14 55-59 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T15 340-344 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T16 347-351 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T17 895-899 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T18 1026-1030 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T19 1074-1078 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T20 1144-1148 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T21 1245-1249 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T22 1415-1419 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T23 1527-1531 http://www.uniprot.org/uniprot/Q9WU78 denotes Alix
T24 761-764 http://www.uniprot.org/uniprot/P06332 denotes CD4

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 247-252 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T2 452-480 http://purl.bioontology.org/ontology/NCBITAXON/11709 denotes human immunodeficiency virus
T3 452-480 http://purl.bioontology.org/ontology/NCBITAXON/11723 denotes human immunodeficiency virus
T4 452-480 http://purl.bioontology.org/ontology/NCBITAXON/11676 denotes human immunodeficiency virus
T5 452-480 http://purl.bioontology.org/ontology/NCBITAXON/12721 denotes human immunodeficiency virus
T6 458-480 http://purl.bioontology.org/ontology/NCBITAXON/11673 denotes immunodeficiency virus
T7 475-480 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus
T8 592-597 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T9 768-773 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 926-931 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T11 946-948 http://purl.bioontology.org/ontology/NCBITAXON/13893 denotes co
T12 1202-1207 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 26-33 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T2 565-572 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T3 682-689 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T4 795-802 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T5 1128-1135 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T6 1502-1509 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T7 104-112 http://purl.obolibrary.org/obo/GO_0065007 denotes regulate
T8 258-273 http://purl.obolibrary.org/obo/GO_0032393 denotes T-cell receptor
T9 258-273 http://purl.obolibrary.org/obo/GO_0032394 denotes T-cell receptor
T10 258-273 http://purl.obolibrary.org/obo/GO_0032395 denotes T-cell receptor
T11 423-432 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T12 559-572 http://purl.obolibrary.org/obo/GO_0046755 denotes viral budding
T13 735-739 http://purl.obolibrary.org/obo/GO_0016246 denotes RNAi

GO-CC

Id Subject Object Predicate Lexical cue
T1 149-153 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 247-252 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 592-597 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 768-773 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 926-931 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 1202-1207 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 219-241 http://purl.obolibrary.org/obo/GO_0001772 denotes immunological synapses
T8 233-241 http://purl.obolibrary.org/obo/GO_0045202 denotes synapses
T9 384-393 http://purl.obolibrary.org/obo/GO_0005768 denotes endosomal
T10 384-401 http://purl.obolibrary.org/obo/GO_0097443 denotes endosomal sorting
T11 489-495 http://purl.obolibrary.org/obo/GO_0019012 denotes virion
T12 1312-1319 http://purl.obolibrary.org/obo/GO_0019012 denotes virions

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 11-19 http://edamontology.org/topic_0749 denotes promotes
T2 11-19 http://edamontology.org/topic_0111 denotes promotes
T3 11-19 http://edamontology.org/topic_1312 denotes promotes
T4 219-232 http://edamontology.org/topic_0804 denotes immunological
T5 317-328 http://edamontology.org/topic_0602 denotes interacting
T6 329-336 http://edamontology.org/topic_0078 denotes protein
T7 444-451 http://edamontology.org/topic_1312 denotes promote
T8 444-451 http://edamontology.org/topic_0111 denotes promote
T9 444-451 http://edamontology.org/topic_0749 denotes promote
T10 452-457 http://edamontology.org/topic_2815 denotes human
T11 831-841 http://edamontology.org/topic_3382 denotes microscopy
T12 949-980 http://edamontology.org/topic_3656 denotes immunoprecipitation experiments
T13 1017-1025 http://edamontology.org/topic_1312 denotes promotes
T14 1017-1025 http://edamontology.org/topic_0111 denotes promotes
T15 1017-1025 http://edamontology.org/topic_0749 denotes promotes
T16 1113-1121 http://edamontology.org/topic_0749 denotes promotes
T17 1113-1121 http://edamontology.org/topic_1312 denotes promotes
T18 1113-1121 http://edamontology.org/topic_0111 denotes promotes
T19 1231-1238 http://edamontology.org/topic_0078 denotes protein
T20 1273-1281 http://edamontology.org/topic_0078 denotes proteins
T21 1357-1365 http://edamontology.org/topic_0749 denotes terminal
T22 1373-1382 http://edamontology.org/topic_0602 denotes interacts
T23 1513-1522 http://edamontology.org/topic_0749 denotes promoting
T24 1513-1522 http://edamontology.org/topic_1312 denotes promoting
T25 1513-1522 http://edamontology.org/topic_0111 denotes promoting

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 92-100 http://edamontology.org/data_2048 denotes reported
T2 117-126 http://edamontology.org/operation_0004 denotes functions
T3 154-159 http://edamontology.org/data_2100 denotes types
T4 175-183 http://edamontology.org/data_2048 denotes reported
T5 329-336 http://edamontology.org/format_1208 denotes protein
T6 329-336 http://edamontology.org/data_1467 denotes protein
T7 1231-1238 http://edamontology.org/format_1208 denotes protein
T8 1231-1238 http://edamontology.org/data_1467 denotes protein
T9 1273-1281 http://edamontology.org/data_1467 denotes proteins
T10 1273-1281 http://edamontology.org/format_1208 denotes proteins
T11 1292-1300 http://edamontology.org/data_2619 denotes residing
T12 1366-1382 http://edamontology.org/data_2359 denotes domain interacts

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 0-8 https://acgg.asia/db/lfdb/LfDB0270 denotes Galectin
Lectin_T2 72-80 https://acgg.asia/db/lfdb/LfDB0270 denotes Galectin
Lectin_T3 0-8 https://acgg.asia/db/lfdb/LfDB0272 denotes Galectin
Lectin_T4 72-80 https://acgg.asia/db/lfdb/LfDB0272 denotes Galectin
Lectin_T5 0-8 https://acgg.asia/db/lfdb/LfDB0274 denotes Galectin
Lectin_T6 72-80 https://acgg.asia/db/lfdb/LfDB0274 denotes Galectin

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 458-474 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 458-474 Phenotype denotes immunodeficiency HP:0002721

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 452-488 OrganismTaxon denotes human immunodeficiency virus (HIV)-1 11676

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 142-153 Body_part denotes immune cell http://purl.obolibrary.org/obo/CL_0000738
T2 233-241 Body_part denotes synapses http://purl.obolibrary.org/obo/GO_0045202
T3 258-264 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 142-153 Cell denotes immune cell http://purl.obolibrary.org/obo/CL:0000738
T2 245-252 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 258-264 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T4 766-773 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084