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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 906-916 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T2 921-929 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T4 1022-1031 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T5 1065-1076 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T6 1090-1099 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T7 1235-1245 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T8 1350-1361 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T10 1440-1452 Cell denotes keratinocyte http://purl.obolibrary.org/obo/CL:0000312
T11 1744-1755 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T12 1757-1768 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 543-562 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.
T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 543-562 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1330-1341 http://purl.obolibrary.org/obo/MAT_0000084 denotes bone marrow
T2 1330-1334 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
TextSentencer_T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
TextSentencer_T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
TextSentencer_T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
TextSentencer_T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
TextSentencer_T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
TextSentencer_T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
TextSentencer_T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
TextSentencer_T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
TextSentencer_T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
TextSentencer_T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.
T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.
T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 543-562 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 703-708 HP_0011088 denotes dense

ICD10

Id Subject Object Predicate Lexical cue
T1 1197-1207 http://purl.bioontology.org/ontology/ICD10/K65.9 denotes peritoneal
T2 1197-1207 http://purl.bioontology.org/ontology/ICD10/K65 denotes peritoneal

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 209-217 FMAID:165447 denotes proteins
_T2 209-217 FMAID:67257 denotes proteins
_T3 543-562 FMAID:196780 denotes N-acetyllactosamine
_T4 543-562 FMAID:82786 denotes N-acetyllactosamine
_T5 642-651 FMAID:67745 denotes compounds
_T6 642-651 FMAID:165656 denotes compounds
_T7 685-692 FMAID:167257 denotes laminin
_T8 685-692 FMAID:62926 denotes laminin
_T9 709-729 FMAID:165194 denotes extracellular matrix
_T10 709-729 FMAID:265717 denotes extracellular matrix
_T11 709-739 FMAID:165193 denotes extracellular matrix component
_T12 709-739 FMAID:63890 denotes extracellular matrix component
_T13 790-803 FMAID:167256 denotes glycoproteins
_T14 790-803 FMAID:62925 denotes glycoproteins
_T15 906-916 FMAID:167158 denotes neutrophil
_T16 906-916 FMAID:62860 denotes neutrophil
_T17 906-916 FMAID:167159 denotes neutrophil
_T18 921-929 FMAID:167164 denotes monocyte
_T19 921-929 FMAID:62864 denotes monocyte
_T20 1022-1031 FMAID:167148 denotes leukocyte
_T21 1022-1031 FMAID:62852 denotes leukocyte
_T22 1065-1076 FMAID:167158 denotes neutrophils
_T23 1065-1076 FMAID:167159 denotes neutrophils
_T24 1065-1076 FMAID:62860 denotes neutrophils
_T25 1065-1099 FMAID:167155 denotes neutrophils and promoted leukocyte
_T26 1090-1099 FMAID:62852 denotes leukocyte
_T27 1090-1099 FMAID:167148 denotes leukocyte
_T28 1116-1128 FMAID:82737 denotes carbohydrate
_T29 1116-1128 FMAID:197276 denotes carbohydrate
_T30 1197-1214 FMAID:104526 denotes peritoneal cavity
_T31 1197-1214 FMAID:14704 denotes peritoneal cavity
_T32 1197-1214 FMAID:104486 denotes peritoneal cavity
_T33 1208-1214 FMAID:183397 denotes cavity
_T34 1235-1245 FMAID:62860 denotes neutrophil
_T35 1235-1245 FMAID:167159 denotes neutrophil
_T36 1235-1245 FMAID:167158 denotes neutrophil
_T37 1292-1301 FMAID:197972 denotes cytokines
_T38 1292-1301 FMAID:84050 denotes cytokines
_T39 1330-1334 FMAID:123537 denotes bone
_T40 1330-1334 FMAID:30317 denotes bone
_T41 1330-1334 FMAID:172618 denotes bone
_T42 1330-1341 FMAID:97498 denotes bone marrow
_T43 1330-1341 FMAID:9608 denotes bone marrow
_T44 1350-1361 FMAID:167685 denotes macrophages
_T45 1350-1361 FMAID:63261 denotes macrophages
_T46 1440-1452 FMAID:170966 denotes keratinocyte
_T47 1461-1470 FMAID:241980 denotes chemokine
_T48 1461-1470 FMAID:241981 denotes chemokine
_T49 1461-1470 FMAID:241982 denotes chemokine
_T50 1461-1470 FMAID:241983 denotes chemokine
_T51 1461-1470 FMAID:241984 denotes chemokine
_T52 1461-1470 FMAID:241985 denotes chemokine
_T53 1520-1532 FMAID:82737 denotes carbohydrate
_T54 1520-1532 FMAID:197276 denotes carbohydrate
_T55 1744-1755 FMAID:62860 denotes neutrophils
_T56 1744-1755 FMAID:167158 denotes neutrophils
_T57 1744-1755 FMAID:167159 denotes neutrophils
_T58 1757-1768 FMAID:167685 denotes macrophages
_T59 1757-1768 FMAID:63261 denotes macrophages
_T60 1773-1793 FMAID:165194 denotes extracellular matrix
_T61 1773-1793 FMAID:265717 denotes extracellular matrix
_T62 1794-1802 FMAID:67257 denotes proteins
_T63 1794-1802 FMAID:165447 denotes proteins

uniprot-human

Id Subject Object Predicate Lexical cue
T1 445-448 http://www.uniprot.org/uniprot/O75925 denotes GBP
T2 762-765 http://www.uniprot.org/uniprot/O75925 denotes GBP
T3 1312-1316 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T4 1423-1427 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T5 1426-1434 http://www.uniprot.org/uniprot/P98066 denotes 6, TNF-α
T6 1429-1434 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T7 1573-1577 http://www.uniprot.org/uniprot/Q5VZI8 denotes TLR4

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 1275-1278 http://www.uniprot.org/uniprot/Q08761 denotes pro
T2 1396-1399 http://www.uniprot.org/uniprot/Q08761 denotes pro
T3 1663-1666 http://www.uniprot.org/uniprot/Q08761 denotes pro
T4 1829-1832 http://www.uniprot.org/uniprot/Q08761 denotes pro
T5 1312-1316 http://www.uniprot.org/uniprot/P08505 denotes IL-6
T6 1423-1427 http://www.uniprot.org/uniprot/P08505 denotes IL-6
T7 1429-1434 http://www.uniprot.org/uniprot/P06804 denotes TNF-α

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 288-292 http://purl.bioontology.org/ontology/NCBITAXON/9973 denotes many

GO-BP

Id Subject Object Predicate Lexical cue
T1 128-140 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2 274-292 http://purl.obolibrary.org/obo/GO_0004571 denotes activities of many
T3 897-905 http://purl.obolibrary.org/obo/GO_0065007 denotes regulate
T4 1008-1018 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T5 921-938 http://purl.obolibrary.org/obo/GO_0042117 denotes monocyte activity
T6 1008-1040 http://purl.obolibrary.org/obo/GO_0002695 denotes regulation of leukocyte activity
T7 1008-1040 http://purl.obolibrary.org/obo/GO_0002696 denotes regulation of leukocyte activity
T8 1008-1040 http://purl.obolibrary.org/obo/GO_0002694 denotes regulation of leukocyte activity
T9 1022-1040 http://purl.obolibrary.org/obo/GO_0045321 denotes leukocyte activity
T10 1090-1110 http://purl.obolibrary.org/obo/GO_0030595 denotes leukocyte chemotaxis
T11 1100-1110 http://purl.obolibrary.org/obo/GO_0006935 denotes chemotaxis
T12 1235-1255 http://purl.obolibrary.org/obo/GO_1990266 denotes neutrophil migration
T13 1477-1486 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14 1603-1612 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15 1593-1620 http://purl.obolibrary.org/obo/GO_0038034 denotes dependent signaling pathway
T16 1593-1620 http://purl.obolibrary.org/obo/GO_0097192 denotes dependent signaling pathway
T17 1603-1620 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18 1773-1802 http://purl.obolibrary.org/obo/GO_1901148 denotes extracellular matrix proteins

GO-MF

Id Subject Object Predicate Lexical cue
T1 75-80 http://purl.obolibrary.org/obo/GO_0070026 denotes binds
T2 201-208 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 239-246 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 360-367 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 860-867 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 770-774 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T7 75-80 http://purl.obolibrary.org/obo/GO_0003680 denotes binds
T8 201-208 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 239-246 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T10 360-367 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T11 860-867 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T12 770-774 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T13 75-80 http://purl.obolibrary.org/obo/GO_0017091 denotes binds
T14 201-208 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T15 239-246 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T16 360-367 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T17 860-867 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T18 770-774 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T19 75-80 http://purl.obolibrary.org/obo/GO_0005488 denotes binds
T20 201-208 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T21 239-246 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22 360-367 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T23 860-867 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T24 770-774 http://purl.obolibrary.org/obo/GO_0005488 denotes bind
T25 201-217 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T26 1312-1316 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T27 1423-1427 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T28 1773-1802 http://purl.obolibrary.org/obo/GO_1990430 denotes extracellular matrix proteins

GO-CC

Id Subject Object Predicate Lexical cue
T1 709-722 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T2 1773-1786 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T3 709-729 http://purl.obolibrary.org/obo/GO_0031012 denotes extracellular matrix
T4 1773-1793 http://purl.obolibrary.org/obo/GO_0031012 denotes extracellular matrix
T5 709-739 http://purl.obolibrary.org/obo/GO_0044420 denotes extracellular matrix component

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 46-57 http://purl.obolibrary.org/obo/UBERON_0013076 denotes snake venom
T2 173-184 http://purl.obolibrary.org/obo/UBERON_0013076 denotes snake venom
T3 425-436 http://purl.obolibrary.org/obo/UBERON_0013076 denotes snake venom
T4 52-57 http://purl.obolibrary.org/obo/UBERON_0007113 denotes venom
T5 179-184 http://purl.obolibrary.org/obo/UBERON_0007113 denotes venom
T6 431-436 http://purl.obolibrary.org/obo/UBERON_0007113 denotes venom
T7 1197-1214 http://purl.obolibrary.org/obo/UBERON_0001179 denotes peritoneal cavity
T8 1330-1341 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1330-1334 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T2 1330-1341 http://purl.obolibrary.org/obo/MAT_0000084 denotes bone marrow

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1330-1341 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T2 46-57 http://purl.obolibrary.org/obo/UBERON_0013076 denotes snake venom
PD-UBERON-AE-B_T3 173-184 http://purl.obolibrary.org/obo/UBERON_0013076 denotes snake venom
PD-UBERON-AE-B_T4 425-436 http://purl.obolibrary.org/obo/UBERON_0013076 denotes snake venom
PD-UBERON-AE-B_T5 52-57 http://purl.obolibrary.org/obo/UBERON_0007113 denotes venom
PD-UBERON-AE-B_T6 179-184 http://purl.obolibrary.org/obo/UBERON_0007113 denotes venom
PD-UBERON-AE-B_T7 431-436 http://purl.obolibrary.org/obo/UBERON_0007113 denotes venom
PD-UBERON-AE-B_T8 1197-1214 http://purl.obolibrary.org/obo/UBERON_0001179 denotes peritoneal cavity

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 128-140 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 1235-1255 Disease denotes neutrophil migration http://purl.obolibrary.org/obo/MONDO_0008091

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1330-1341 Body_part denotes bone marrow http://purl.obolibrary.org/obo/MAT_0000084

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 81-87 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 564-570 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T3 696-702 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T4 775-781 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T5 868-874 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T6 1718-1724 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 128-140 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 1235-1255 Disease denotes neutrophil migration http://purl.obolibrary.org/obo/MONDO_0008091

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 31-45 OrganismTaxon denotes Bothrops atrox 8725
T2 410-424 OrganismTaxon denotes Bothrops atrox 8725
T3 1191-1196 OrganismTaxon denotes mouse 10088|10090

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 906-916 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T2 921-929 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T4 1022-1031 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T5 1065-1076 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T6 1090-1099 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T7 1235-1245 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T8 1350-1361 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T10 1440-1452 Cell denotes keratinocyte http://purl.obolibrary.org/obo/CL:0000312
T11 1744-1755 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T12 1757-1768 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 425-436 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076
T4 709-729 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T5 906-916 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T6 921-929 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T8 1022-1031 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T9 1065-1076 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T10 1090-1099 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T11 1197-1214 Body_part denotes peritoneal cavity http://purl.obolibrary.org/obo/UBERON_0001179
T12 1235-1245 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T13 1330-1341 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T14 1350-1361 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T15 1440-1452 Body_part denotes keratinocyte http://purl.obolibrary.org/obo/CL_0000312
T16 1744-1755 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T17 1757-1768 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T18 1773-1793 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T1 46-57 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076
T2 173-184 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1330-1341 Body_part denotes bone marrow http://purl.obolibrary.org/obo/MAT_0000084

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
TextSentencer_T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
TextSentencer_T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
TextSentencer_T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
TextSentencer_T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
TextSentencer_T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
TextSentencer_T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
TextSentencer_T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
TextSentencer_T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
TextSentencer_T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
TextSentencer_T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.
T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.
T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 81-87 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 564-570 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T3 696-702 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T4 775-781 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T5 868-874 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T6 1718-1724 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-141 Sentence denotes Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation.
T2 142-318 Sentence denotes Previous studies indicate that snake venom contains glycan-binding proteins (GBPs), although the binding specificity and biological activities of many of these GBPs is unclear.
T3 319-449 Sentence denotes Here we report our studies on the glycan binding specificity and activities of galatrox, a Bothrops atrox snake venom-derived GBP.
T4 450-652 Sentence denotes Glycan microarray analysis indicates that galatrox binds most strongly to glycans expressing N-acetyllactosamine (LacNAc), with a significant preference for Galβ1-4GlcNAcβ over Galβ1-3GlcNAcβ compounds.
T5 653-804 Sentence denotes Galatrox also bound immobilized laminin, a LacNAc-dense extracellular matrix component, suggesting that this GBP can bind LacNAc-bearing glycoproteins.
T6 805-1041 Sentence denotes As several endogenous mammalian GBPs utilize a similar binding LacNAc binding preference to regulate neutrophil and monocyte activity, we hypothesized that galatrox may mediate B. atrox toxicity through regulation of leukocyte activity.
T7 1042-1146 Sentence denotes Indeed, galatrox bound neutrophils and promoted leukocyte chemotaxis in a carbohydrate-dependent manner.
T8 1147-1317 Sentence denotes Similarly, galatrox administration into the mouse peritoneal cavity induced significant neutrophil migration and the release of pro-inflammatory cytokines IL-1α and IL-6.
T9 1318-1471 Sentence denotes Exposure of bone marrow-derived macrophages to galatrox induced generation of pro-inflammatory mediators IL-6, TNF-α, and keratinocyte-derived chemokine.
T10 1472-1621 Sentence denotes This signaling by galatrox was mediated via its carbohydrate recognition domain by activation of the TLR4-mediated MyD88-dependent signaling pathway.
T11 1622-1856 Sentence denotes These results indicate that galatrox has pro-inflammatory activity through its interaction with LacNAc-bearing glycans on neutrophils, macrophages and extracellular matrix proteins and induce the release of pro-inflammatory mediators.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 31-45 OrganismTaxon denotes Bothrops atrox 8725
T2 410-424 OrganismTaxon denotes Bothrops atrox 8725
T3 1191-1196 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 425-436 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076
T4 709-729 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T5 906-916 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T6 921-929 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T8 1022-1031 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T9 1065-1076 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T10 1090-1099 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T11 1197-1214 Body_part denotes peritoneal cavity http://purl.obolibrary.org/obo/UBERON_0001179
T12 1235-1245 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T13 1330-1341 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T14 1350-1361 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T15 1440-1452 Body_part denotes keratinocyte http://purl.obolibrary.org/obo/CL_0000312
T16 1744-1755 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T17 1757-1768 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T18 1773-1793 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T1 46-57 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076
T2 173-184 Body_part denotes snake venom http://purl.obolibrary.org/obo/UBERON_0013076