PubMed:24971578 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/24971578","sourcedb":"PubMed","sourceid":"24971578","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/24971578","text":"MutLα heterodimers modify the molecular phenotype of Friedreich ataxia.\nBACKGROUND: Friedreich ataxia (FRDA), the most common autosomal recessive ataxia disorder, is caused by a dynamic GAA repeat expansion mutation within intron 1 of FXN gene, resulting in down-regulation of frataxin expression. Studies of cell and mouse models have revealed a role for the mismatch repair (MMR) MutS-heterodimer complexes and the PMS2 component of the MutLα complex in the dynamics of intergenerational and somatic GAA repeat expansions: MSH2, MSH3 and MSH6 promote GAA repeat expansions, while PMS2 inhibits GAA repeat expansions.\nMETHODOLOGY/PRINCIPAL FINDINGS: To determine the potential role of the other component of the MutLα complex, MLH1, in GAA repeat instability in FRDA, we have analyzed intergenerational and somatic GAA repeat expansions from FXN transgenic mice that have been crossed with Mlh1 deficient mice. We find that loss of Mlh1 activity reduces both intergenerational and somatic GAA repeat expansions. However, we also find that loss of either Mlh1 or Pms2 reduces FXN transcription, suggesting different mechanisms of action for Mlh1 and Pms2 on GAA repeat expansion dynamics and regulation of FXN transcription.\nCONCLUSIONS/SIGNIFICANCE: Both MutLα components, PMS2 and MLH1, have now been shown to modify the molecular phenotype of FRDA. We propose that upregulation of MLH1 or PMS2 could be potential FRDA therapeutic approaches to increase FXN transcription.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_24971578_2_0","span":{"begin":84,"end":101},"obj":"expanded"},{"id":"SS2_24971578_2_0","span":{"begin":103,"end":107},"obj":"abbr"},{"id":"SS1_24971578_3_0","span":{"begin":360,"end":375},"obj":"expanded"},{"id":"SS2_24971578_3_0","span":{"begin":377,"end":380},"obj":"abbr"}],"relations":[{"id":"AE1_24971578_2_0","pred":"abbreviatedTo","subj":"SS1_24971578_2_0","obj":"SS2_24971578_2_0"},{"id":"AE1_24971578_3_0","pred":"abbreviatedTo","subj":"SS1_24971578_3_0","obj":"SS2_24971578_3_0"}],"attributes":[{"subj":"SS1_24971578_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_24971578_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_24971578_3_0","pred":"source","obj":"Allie"},{"subj":"SS2_24971578_3_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":95,"end":101},"obj":"HP_0001251"},{"id":"T2","span":{"begin":126,"end":145},"obj":"HP_0000007"},{"id":"T3","span":{"begin":146,"end":152},"obj":"HP_0001251"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"24971578-1#102#105#gene2548","span":{"begin":186,"end":189},"obj":"gene2548"},{"id":"24971578-1#151#154#gene2395","span":{"begin":235,"end":238},"obj":"gene2395"},{"id":"24971578-1#193#201#gene2395","span":{"begin":277,"end":285},"obj":"gene2395"},{"id":"24971578-1#0#17#diseaseC0016719","span":{"begin":84,"end":101},"obj":"diseaseC0016719"},{"id":"24971578-3#86#89#gene2548","span":{"begin":737,"end":740},"obj":"gene2548"},{"id":"24971578-3#112#116#diseaseC1856689","span":{"begin":763,"end":767},"obj":"diseaseC1856689"},{"id":"24971578-7#32#36#gene4292","span":{"begin":1384,"end":1388},"obj":"gene4292"},{"id":"24971578-7#40#44#gene5395","span":{"begin":1392,"end":1396},"obj":"gene5395"},{"id":"24971578-7#104#107#gene2395","span":{"begin":1456,"end":1459},"obj":"gene2395"},{"id":"24971578-7#64#68#diseaseC1856689","span":{"begin":1416,"end":1420},"obj":"diseaseC1856689"}],"relations":[{"id":"102#105#gene25480#17#diseaseC0016719","pred":"associated_with","subj":"24971578-1#102#105#gene2548","obj":"24971578-1#0#17#diseaseC0016719"},{"id":"151#154#gene23950#17#diseaseC0016719","pred":"associated_with","subj":"24971578-1#151#154#gene2395","obj":"24971578-1#0#17#diseaseC0016719"},{"id":"193#201#gene23950#17#diseaseC0016719","pred":"associated_with","subj":"24971578-1#193#201#gene2395","obj":"24971578-1#0#17#diseaseC0016719"},{"id":"86#89#gene2548112#116#diseaseC1856689","pred":"associated_with","subj":"24971578-3#86#89#gene2548","obj":"24971578-3#112#116#diseaseC1856689"},{"id":"32#36#gene429264#68#diseaseC1856689","pred":"associated_with","subj":"24971578-7#32#36#gene4292","obj":"24971578-7#64#68#diseaseC1856689"},{"id":"40#44#gene539564#68#diseaseC1856689","pred":"associated_with","subj":"24971578-7#40#44#gene5395","obj":"24971578-7#64#68#diseaseC1856689"},{"id":"104#107#gene239564#68#diseaseC1856689","pred":"associated_with","subj":"24971578-7#104#107#gene2395","obj":"24971578-7#64#68#diseaseC1856689"}],"attributes":[{"subj":"24971578-1#102#105#gene2548","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24971578-1#151#154#gene2395","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24971578-1#193#201#gene2395","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24971578-1#0#17#diseaseC0016719","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24971578-3#86#89#gene2548","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24971578-3#112#116#diseaseC1856689","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24971578-7#32#36#gene4292","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24971578-7#40#44#gene5395","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24971578-7#104#107#gene2395","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24971578-7#64#68#diseaseC1856689","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T1","span":{"begin":84,"end":618},"obj":"BACKGROUND"},{"id":"T2","span":{"begin":651,"end":1224},"obj":"RESULTS"},{"id":"T3","span":{"begin":1251,"end":1474},"obj":"CONCLUSIONS"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_Structured_Abstracts"},{"subj":"T2","pred":"source","obj":"PubMed_Structured_Abstracts"},{"subj":"T3","pred":"source","obj":"PubMed_Structured_Abstracts"}]},{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"PR:000023324"},{"id":"T2","span":{"begin":0,"end":4},"obj":"PR:Q93T05"},{"id":"T3","span":{"begin":0,"end":4},"obj":"PR:P23367"},{"id":"T6","span":{"begin":53,"end":70},"obj":"D005621"},{"id":"T7","span":{"begin":53,"end":70},"obj":"D005621"},{"id":"T8","span":{"begin":53,"end":70},"obj":"C565561"},{"id":"T13","span":{"begin":84,"end":101},"obj":"D005621"},{"id":"T14","span":{"begin":84,"end":101},"obj":"D005621"},{"id":"T15","span":{"begin":84,"end":101},"obj":"C565561"},{"id":"T19","span":{"begin":103,"end":107},"obj":"PR:000007710"},{"id":"T20","span":{"begin":103,"end":107},"obj":"PR:000022686"},{"id":"T21","span":{"begin":103,"end":107},"obj":"PR:P00363"},{"id":"T22","span":{"begin":103,"end":107},"obj":"PR:Q16595"},{"id":"T23","span":{"begin":103,"end":107},"obj":"PR:O35943"},{"id":"T18","span":{"begin":103,"end":107},"obj":"C565561"},{"id":"T24","span":{"begin":146,"end":152},"obj":"D001259"},{"id":"T25","span":{"begin":146,"end":152},"obj":"D001259"},{"id":"T26","span":{"begin":186,"end":189},"obj":"PR:Q6P7A9"},{"id":"T27","span":{"begin":186,"end":189},"obj":"PR:000007752"},{"id":"T28","span":{"begin":186,"end":189},"obj":"PR:P10253"},{"id":"T29","span":{"begin":186,"end":189},"obj":"PR:P70699"},{"id":"T31","span":{"begin":186,"end":189},"obj":"PR:Q9MYM4"},{"id":"T30","span":{"begin":186,"end":189},"obj":"CHEBI:144460"},{"id":"T32","span":{"begin":190,"end":196},"obj":"SO:0001068"},{"id":"T33","span":{"begin":207,"end":215},"obj":"SO:0000109"},{"id":"T34","span":{"begin":223,"end":229},"obj":"SO:0000188"},{"id":"T35","span":{"begin":223,"end":229},"obj":"SO:0001627"},{"id":"T36","span":{"begin":235,"end":238},"obj":"PR:000007710"},{"id":"T37","span":{"begin":235,"end":238},"obj":"Q8HXX9"},{"id":"T38","span":{"begin":235,"end":238},"obj":"Q9TY03"},{"id":"T39","span":{"begin":235,"end":238},"obj":"Q05B87"},{"id":"T40","span":{"begin":235,"end":238},"obj":"PR:D3ZYW7"},{"id":"T41","span":{"begin":235,"end":238},"obj":"Q54C45"},{"id":"T42","span":{"begin":235,"end":238},"obj":"D3ZYW7"},{"id":"T43","span":{"begin":235,"end":238},"obj":"Q9ZR07"},{"id":"T44","span":{"begin":235,"end":238},"obj":"B0YLW8"},{"id":"T45","span":{"begin":235,"end":238},"obj":"O35943"},{"id":"T46","span":{"begin":235,"end":238},"obj":"Q16595"},{"id":"T47","span":{"begin":235,"end":238},"obj":"PR:Q54C45"},{"id":"T48","span":{"begin":235,"end":238},"obj":"PR:Q16595"},{"id":"T49","span":{"begin":235,"end":238},"obj":"PR:O35943"},{"id":"T50","span":{"begin":235,"end":238},"obj":"Q8SWI3"},{"id":"T51","span":{"begin":239,"end":243},"obj":"SO:0000704"},{"id":"T52","span":{"begin":263,"end":273},"obj":"GO:0065007"},{"id":"T53","span":{"begin":277,"end":285},"obj":"B0YLW8"},{"id":"T54","span":{"begin":277,"end":285},"obj":"C098527"},{"id":"T55","span":{"begin":277,"end":285},"obj":"C098527"},{"id":"T56","span":{"begin":318,"end":323},"obj":"10090"},{"id":"T57","span":{"begin":318,"end":323},"obj":"D051379"},{"id":"T58","span":{"begin":360,"end":375},"obj":"GO:0006298"},{"id":"T59","span":{"begin":377,"end":380},"obj":"GO:0006298"},{"id":"T60","span":{"begin":377,"end":380},"obj":"CVCL_E779"},{"id":"T61","span":{"begin":377,"end":380},"obj":"P22897"},{"id":"T62","span":{"begin":377,"end":380},"obj":"PR:000002972"},{"id":"T63","span":{"begin":377,"end":380},"obj":"Q61830"},{"id":"T64","span":{"begin":382,"end":386},"obj":"PR:000023326"},{"id":"T65","span":{"begin":382,"end":386},"obj":"PR:P23909"},{"id":"T66","span":{"begin":382,"end":386},"obj":"PR:Q2FYZ9"},{"id":"T67","span":{"begin":417,"end":420},"obj":"CHEBI:53396"},{"id":"T70","span":{"begin":417,"end":420},"obj":"CHEBI:53430"},{"id":"T72","span":{"begin":417,"end":420},"obj":"CHEBI:8055"},{"id":"T73","span":{"begin":417,"end":421},"obj":"PR:P54279"},{"id":"T74","span":{"begin":417,"end":421},"obj":"PR:F1NQJ3"},{"id":"T75","span":{"begin":417,"end":421},"obj":"PR:P38920"},{"id":"T76","span":{"begin":417,"end":421},"obj":"PR:000012914"},{"id":"T77","span":{"begin":417,"end":421},"obj":"PR:P54278"},{"id":"T78","span":{"begin":439,"end":443},"obj":"PR:000023324"},{"id":"T79","span":{"begin":439,"end":443},"obj":"PR:Q93T05"},{"id":"T80","span":{"begin":439,"end":443},"obj":"PR:P23367"},{"id":"T81","span":{"begin":502,"end":505},"obj":"PR:Q6P7A9"},{"id":"T82","span":{"begin":502,"end":505},"obj":"PR:000007752"},{"id":"T83","span":{"begin":502,"end":505},"obj":"PR:P10253"},{"id":"T84","span":{"begin":502,"end":505},"obj":"PR:P70699"},{"id":"T86","span":{"begin":502,"end":505},"obj":"PR:Q9MYM4"},{"id":"T85","span":{"begin":502,"end":505},"obj":"CHEBI:144460"},{"id":"T87","span":{"begin":506,"end":512},"obj":"SO:0001068"},{"id":"T89","span":{"begin":525,"end":528},"obj":"CHEBI:16768"},{"id":"T93","span":{"begin":525,"end":528},"obj":"D009074"},{"id":"T94","span":{"begin":525,"end":528},"obj":"D009074"},{"id":"T95","span":{"begin":525,"end":529},"obj":"PR:000010666"},{"id":"T96","span":{"begin":525,"end":529},"obj":"PR:P25847"},{"id":"T97","span":{"begin":525,"end":529},"obj":"PR:P43246"},{"id":"T98","span":{"begin":525,"end":529},"obj":"P22711"},{"id":"T99","span":{"begin":525,"end":529},"obj":"PR:P22711"},{"id":"T100","span":{"begin":525,"end":529},"obj":"PR:P54275"},{"id":"T101","span":{"begin":525,"end":529},"obj":"PR:O74773"},{"id":"T102","span":{"begin":525,"end":529},"obj":"PR:P43247"},{"id":"T103","span":{"begin":525,"end":529},"obj":"PR:Q553L4"},{"id":"T104","span":{"begin":525,"end":529},"obj":"PR:O24617"},{"id":"T106","span":{"begin":531,"end":534},"obj":"CHEBI:16768"},{"id":"T110","span":{"begin":531,"end":534},"obj":"D009074"},{"id":"T111","span":{"begin":531,"end":534},"obj":"D009074"},{"id":"T112","span":{"begin":531,"end":535},"obj":"PR:O65607"},{"id":"T113","span":{"begin":531,"end":535},"obj":"PR:000010667"},{"id":"T114","span":{"begin":531,"end":535},"obj":"PR:Q59Y41"},{"id":"T115","span":{"begin":531,"end":535},"obj":"PR:P25336"},{"id":"T116","span":{"begin":531,"end":535},"obj":"PR:P20585"},{"id":"T117","span":{"begin":531,"end":535},"obj":"PR:P26359"},{"id":"T118","span":{"begin":531,"end":535},"obj":"PR:P13705"},{"id":"T119","span":{"begin":531,"end":535},"obj":"PR:Q1ZXH0"},{"id":"T121","span":{"begin":540,"end":543},"obj":"CHEBI:16768"},{"id":"T125","span":{"begin":540,"end":543},"obj":"D009074"},{"id":"T126","span":{"begin":540,"end":543},"obj":"D009074"},{"id":"T127","span":{"begin":540,"end":544},"obj":"PR:P52701"},{"id":"T128","span":{"begin":540,"end":544},"obj":"PR:P54276"},{"id":"T129","span":{"begin":540,"end":544},"obj":"PR:Q9VUM0"},{"id":"T130","span":{"begin":540,"end":544},"obj":"PR:Q55GU9"},{"id":"T131","span":{"begin":540,"end":544},"obj":"PR:O04716"},{"id":"T132","span":{"begin":540,"end":544},"obj":"PR:Q03834"},{"id":"T133","span":{"begin":540,"end":544},"obj":"PR:O74502"},{"id":"T134","span":{"begin":540,"end":544},"obj":"PR:000010670"},{"id":"T135","span":{"begin":553,"end":556},"obj":"PR:Q6P7A9"},{"id":"T136","span":{"begin":553,"end":556},"obj":"PR:000007752"},{"id":"T137","span":{"begin":553,"end":556},"obj":"PR:P10253"},{"id":"T138","span":{"begin":553,"end":556},"obj":"PR:P70699"},{"id":"T140","span":{"begin":553,"end":556},"obj":"PR:Q9MYM4"},{"id":"T139","span":{"begin":553,"end":556},"obj":"CHEBI:144460"},{"id":"T141","span":{"begin":557,"end":563},"obj":"SO:0001068"},{"id":"T142","span":{"begin":582,"end":585},"obj":"CHEBI:53396"},{"id":"T145","span":{"begin":582,"end":585},"obj":"CHEBI:53430"},{"id":"T147","span":{"begin":582,"end":585},"obj":"CHEBI:8055"},{"id":"T148","span":{"begin":582,"end":586},"obj":"PR:P54279"},{"id":"T149","span":{"begin":582,"end":586},"obj":"PR:F1NQJ3"},{"id":"T150","span":{"begin":582,"end":586},"obj":"PR:P38920"},{"id":"T151","span":{"begin":582,"end":586},"obj":"PR:000012914"},{"id":"T152","span":{"begin":582,"end":586},"obj":"PR:P54278"},{"id":"T153","span":{"begin":596,"end":599},"obj":"PR:Q6P7A9"},{"id":"T154","span":{"begin":596,"end":599},"obj":"PR:000007752"},{"id":"T155","span":{"begin":596,"end":599},"obj":"PR:P10253"},{"id":"T156","span":{"begin":596,"end":599},"obj":"PR:P70699"},{"id":"T158","span":{"begin":596,"end":599},"obj":"PR:Q9MYM4"},{"id":"T157","span":{"begin":596,"end":599},"obj":"CHEBI:144460"},{"id":"T159","span":{"begin":600,"end":606},"obj":"SO:0001068"},{"id":"T160","span":{"begin":713,"end":717},"obj":"PR:000023324"},{"id":"T161","span":{"begin":713,"end":717},"obj":"PR:Q93T05"},{"id":"T162","span":{"begin":713,"end":717},"obj":"PR:P23367"},{"id":"T166","span":{"begin":728,"end":732},"obj":"CVCL_G669"},{"id":"T163","span":{"begin":728,"end":732},"obj":"PR:Q9ZRV4"},{"id":"T164","span":{"begin":728,"end":732},"obj":"PR:P38920"},{"id":"T165","span":{"begin":728,"end":732},"obj":"PR:Q54KD8"},{"id":"T167","span":{"begin":728,"end":732},"obj":"PR:Q9JK91"},{"id":"T168","span":{"begin":728,"end":732},"obj":"PR:P97679"},{"id":"T169","span":{"begin":728,"end":732},"obj":"PR:Q9P7W6"},{"id":"T170","span":{"begin":728,"end":732},"obj":"PR:000010442"},{"id":"T171","span":{"begin":728,"end":732},"obj":"PR:P40692"},{"id":"T172","span":{"begin":737,"end":740},"obj":"PR:Q6P7A9"},{"id":"T173","span":{"begin":737,"end":740},"obj":"PR:000007752"},{"id":"T174","span":{"begin":737,"end":740},"obj":"PR:P10253"},{"id":"T175","span":{"begin":737,"end":740},"obj":"PR:P70699"},{"id":"T177","span":{"begin":737,"end":740},"obj":"PR:Q9MYM4"},{"id":"T176","span":{"begin":737,"end":740},"obj":"CHEBI:144460"},{"id":"T178","span":{"begin":741,"end":747},"obj":"SO:0001068"},{"id":"T180","span":{"begin":763,"end":767},"obj":"PR:000007710"},{"id":"T181","span":{"begin":763,"end":767},"obj":"PR:000022686"},{"id":"T182","span":{"begin":763,"end":767},"obj":"PR:P00363"},{"id":"T183","span":{"begin":763,"end":767},"obj":"PR:Q16595"},{"id":"T184","span":{"begin":763,"end":767},"obj":"PR:O35943"},{"id":"T179","span":{"begin":763,"end":767},"obj":"C565561"},{"id":"T185","span":{"begin":816,"end":819},"obj":"PR:Q6P7A9"},{"id":"T186","span":{"begin":816,"end":819},"obj":"PR:000007752"},{"id":"T187","span":{"begin":816,"end":819},"obj":"PR:P10253"},{"id":"T188","span":{"begin":816,"end":819},"obj":"PR:P70699"},{"id":"T190","span":{"begin":816,"end":819},"obj":"PR:Q9MYM4"},{"id":"T189","span":{"begin":816,"end":819},"obj":"CHEBI:144460"},{"id":"T191","span":{"begin":820,"end":826},"obj":"SO:0001068"},{"id":"T192","span":{"begin":843,"end":846},"obj":"PR:000007710"},{"id":"T193","span":{"begin":843,"end":846},"obj":"Q8HXX9"},{"id":"T194","span":{"begin":843,"end":846},"obj":"Q9TY03"},{"id":"T195","span":{"begin":843,"end":846},"obj":"Q05B87"},{"id":"T196","span":{"begin":843,"end":846},"obj":"PR:D3ZYW7"},{"id":"T197","span":{"begin":843,"end":846},"obj":"Q54C45"},{"id":"T198","span":{"begin":843,"end":846},"obj":"D3ZYW7"},{"id":"T199","span":{"begin":843,"end":846},"obj":"Q9ZR07"},{"id":"T200","span":{"begin":843,"end":846},"obj":"B0YLW8"},{"id":"T201","span":{"begin":843,"end":846},"obj":"O35943"},{"id":"T202","span":{"begin":843,"end":846},"obj":"Q16595"},{"id":"T203","span":{"begin":843,"end":846},"obj":"PR:Q54C45"},{"id":"T204","span":{"begin":843,"end":846},"obj":"PR:Q16595"},{"id":"T205","span":{"begin":843,"end":846},"obj":"PR:O35943"},{"id":"T206","span":{"begin":843,"end":846},"obj":"Q8SWI3"},{"id":"T207","span":{"begin":847,"end":857},"obj":"SO:0000781"},{"id":"T208","span":{"begin":847,"end":862},"obj":"10090"},{"id":"T209","span":{"begin":847,"end":862},"obj":"D008822"},{"id":"T210","span":{"begin":858,"end":862},"obj":"PR:000005054"},{"id":"T212","span":{"begin":858,"end":862},"obj":"O89094"},{"id":"T217","span":{"begin":891,"end":895},"obj":"CVCL_G669"},{"id":"T214","span":{"begin":891,"end":895},"obj":"PR:Q9ZRV4"},{"id":"T215","span":{"begin":891,"end":895},"obj":"PR:P38920"},{"id":"T216","span":{"begin":891,"end":895},"obj":"PR:Q54KD8"},{"id":"T218","span":{"begin":891,"end":895},"obj":"PR:Q9JK91"},{"id":"T219","span":{"begin":891,"end":895},"obj":"PR:P97679"},{"id":"T220","span":{"begin":891,"end":895},"obj":"PR:Q9P7W6"},{"id":"T221","span":{"begin":891,"end":895},"obj":"PR:000010442"},{"id":"T222","span":{"begin":891,"end":895},"obj":"PR:P40692"},{"id":"T223","span":{"begin":906,"end":910},"obj":"PR:000005054"},{"id":"T225","span":{"begin":906,"end":910},"obj":"O89094"},{"id":"T224","span":{"begin":906,"end":910},"obj":"D051379"},{"id":"T226","span":{"begin":906,"end":910},"obj":"10095"},{"id":"T227","span":{"begin":933,"end":937},"obj":"PR:Q9ZRV4"},{"id":"T228","span":{"begin":933,"end":937},"obj":"PR:P38920"},{"id":"T229","span":{"begin":933,"end":937},"obj":"PR:Q54KD8"},{"id":"T231","span":{"begin":933,"end":937},"obj":"PR:Q9JK91"},{"id":"T232","span":{"begin":933,"end":937},"obj":"PR:P97679"},{"id":"T233","span":{"begin":933,"end":937},"obj":"PR:Q9P7W6"},{"id":"T234","span":{"begin":933,"end":937},"obj":"PR:000010442"},{"id":"T235","span":{"begin":933,"end":937},"obj":"PR:P40692"},{"id":"T230","span":{"begin":933,"end":937},"obj":"CVCL_G669"},{"id":"T236","span":{"begin":990,"end":993},"obj":"PR:Q6P7A9"},{"id":"T237","span":{"begin":990,"end":993},"obj":"PR:000007752"},{"id":"T238","span":{"begin":990,"end":993},"obj":"PR:P10253"},{"id":"T239","span":{"begin":990,"end":993},"obj":"PR:P70699"},{"id":"T241","span":{"begin":990,"end":993},"obj":"PR:Q9MYM4"},{"id":"T240","span":{"begin":990,"end":993},"obj":"CHEBI:144460"},{"id":"T242","span":{"begin":994,"end":1000},"obj":"SO:0001068"},{"id":"T243","span":{"begin":1055,"end":1059},"obj":"PR:Q9ZRV4"},{"id":"T244","span":{"begin":1055,"end":1059},"obj":"PR:P38920"},{"id":"T245","span":{"begin":1055,"end":1059},"obj":"PR:Q54KD8"},{"id":"T247","span":{"begin":1055,"end":1059},"obj":"PR:Q9JK91"},{"id":"T248","span":{"begin":1055,"end":1059},"obj":"PR:P97679"},{"id":"T249","span":{"begin":1055,"end":1059},"obj":"PR:Q9P7W6"},{"id":"T250","span":{"begin":1055,"end":1059},"obj":"PR:000010442"},{"id":"T251","span":{"begin":1055,"end":1059},"obj":"PR:P40692"},{"id":"T246","span":{"begin":1055,"end":1059},"obj":"CVCL_G669"},{"id":"T252","span":{"begin":1063,"end":1066},"obj":"CHEBI:53396"},{"id":"T255","span":{"begin":1063,"end":1066},"obj":"CHEBI:53430"},{"id":"T257","span":{"begin":1063,"end":1066},"obj":"CHEBI:8055"},{"id":"T258","span":{"begin":1063,"end":1067},"obj":"PR:P54279"},{"id":"T259","span":{"begin":1063,"end":1067},"obj":"PR:F1NQJ3"},{"id":"T260","span":{"begin":1063,"end":1067},"obj":"PR:P38920"},{"id":"T261","span":{"begin":1063,"end":1067},"obj":"PR:000012914"},{"id":"T262","span":{"begin":1063,"end":1067},"obj":"PR:P54278"},{"id":"T263","span":{"begin":1076,"end":1079},"obj":"PR:000007710"},{"id":"T264","span":{"begin":1076,"end":1079},"obj":"Q8HXX9"},{"id":"T265","span":{"begin":1076,"end":1079},"obj":"Q9TY03"},{"id":"T266","span":{"begin":1076,"end":1079},"obj":"Q05B87"},{"id":"T267","span":{"begin":1076,"end":1079},"obj":"PR:D3ZYW7"},{"id":"T268","span":{"begin":1076,"end":1079},"obj":"Q54C45"},{"id":"T269","span":{"begin":1076,"end":1079},"obj":"D3ZYW7"},{"id":"T270","span":{"begin":1076,"end":1079},"obj":"Q9ZR07"},{"id":"T271","span":{"begin":1076,"end":1079},"obj":"B0YLW8"},{"id":"T272","span":{"begin":1076,"end":1079},"obj":"O35943"},{"id":"T273","span":{"begin":1076,"end":1079},"obj":"Q16595"},{"id":"T274","span":{"begin":1076,"end":1079},"obj":"PR:Q54C45"},{"id":"T275","span":{"begin":1076,"end":1079},"obj":"PR:Q16595"},{"id":"T276","span":{"begin":1076,"end":1079},"obj":"PR:O35943"},{"id":"T277","span":{"begin":1076,"end":1079},"obj":"Q8SWI3"},{"id":"T278","span":{"begin":1080,"end":1093},"obj":"GO:0006351"},{"id":"T279","span":{"begin":1141,"end":1145},"obj":"PR:Q9ZRV4"},{"id":"T280","span":{"begin":1141,"end":1145},"obj":"PR:P38920"},{"id":"T281","span":{"begin":1141,"end":1145},"obj":"PR:Q54KD8"},{"id":"T283","span":{"begin":1141,"end":1145},"obj":"PR:Q9JK91"},{"id":"T284","span":{"begin":1141,"end":1145},"obj":"PR:P97679"},{"id":"T285","span":{"begin":1141,"end":1145},"obj":"PR:Q9P7W6"},{"id":"T286","span":{"begin":1141,"end":1145},"obj":"PR:000010442"},{"id":"T287","span":{"begin":1141,"end":1145},"obj":"PR:P40692"},{"id":"T282","span":{"begin":1141,"end":1145},"obj":"CVCL_G669"},{"id":"T288","span":{"begin":1150,"end":1153},"obj":"CHEBI:53396"},{"id":"T291","span":{"begin":1150,"end":1153},"obj":"CHEBI:53430"},{"id":"T293","span":{"begin":1150,"end":1153},"obj":"CHEBI:8055"},{"id":"T294","span":{"begin":1150,"end":1154},"obj":"PR:P54279"},{"id":"T295","span":{"begin":1150,"end":1154},"obj":"PR:F1NQJ3"},{"id":"T296","span":{"begin":1150,"end":1154},"obj":"PR:P38920"},{"id":"T297","span":{"begin":1150,"end":1154},"obj":"PR:000012914"},{"id":"T298","span":{"begin":1150,"end":1154},"obj":"PR:P54278"},{"id":"T299","span":{"begin":1158,"end":1161},"obj":"PR:Q6P7A9"},{"id":"T300","span":{"begin":1158,"end":1161},"obj":"PR:000007752"},{"id":"T301","span":{"begin":1158,"end":1161},"obj":"PR:P10253"},{"id":"T302","span":{"begin":1158,"end":1161},"obj":"PR:P70699"},{"id":"T304","span":{"begin":1158,"end":1161},"obj":"PR:Q9MYM4"},{"id":"T303","span":{"begin":1158,"end":1161},"obj":"CHEBI:144460"},{"id":"T305","span":{"begin":1162,"end":1168},"obj":"SO:0001068"},{"id":"T306","span":{"begin":1192,"end":1202},"obj":"GO:0065007"},{"id":"T307","span":{"begin":1206,"end":1209},"obj":"PR:000007710"},{"id":"T308","span":{"begin":1206,"end":1209},"obj":"Q8HXX9"},{"id":"T309","span":{"begin":1206,"end":1209},"obj":"Q9TY03"},{"id":"T310","span":{"begin":1206,"end":1209},"obj":"Q05B87"},{"id":"T311","span":{"begin":1206,"end":1209},"obj":"PR:D3ZYW7"},{"id":"T312","span":{"begin":1206,"end":1209},"obj":"Q54C45"},{"id":"T313","span":{"begin":1206,"end":1209},"obj":"D3ZYW7"},{"id":"T314","span":{"begin":1206,"end":1209},"obj":"Q9ZR07"},{"id":"T315","span":{"begin":1206,"end":1209},"obj":"B0YLW8"},{"id":"T316","span":{"begin":1206,"end":1209},"obj":"O35943"},{"id":"T317","span":{"begin":1206,"end":1209},"obj":"Q16595"},{"id":"T318","span":{"begin":1206,"end":1209},"obj":"PR:Q54C45"},{"id":"T319","span":{"begin":1206,"end":1209},"obj":"PR:Q16595"},{"id":"T320","span":{"begin":1206,"end":1209},"obj":"PR:O35943"},{"id":"T321","span":{"begin":1206,"end":1209},"obj":"Q8SWI3"},{"id":"T322","span":{"begin":1210,"end":1223},"obj":"GO:0006351"},{"id":"T323","span":{"begin":1256,"end":1260},"obj":"PR:000023324"},{"id":"T324","span":{"begin":1256,"end":1260},"obj":"PR:Q93T05"},{"id":"T325","span":{"begin":1256,"end":1260},"obj":"PR:P23367"},{"id":"T326","span":{"begin":1274,"end":1277},"obj":"CHEBI:53396"},{"id":"T329","span":{"begin":1274,"end":1277},"obj":"CHEBI:53430"},{"id":"T331","span":{"begin":1274,"end":1277},"obj":"CHEBI:8055"},{"id":"T332","span":{"begin":1274,"end":1278},"obj":"PR:P54279"},{"id":"T333","span":{"begin":1274,"end":1278},"obj":"PR:F1NQJ3"},{"id":"T334","span":{"begin":1274,"end":1278},"obj":"PR:P38920"},{"id":"T335","span":{"begin":1274,"end":1278},"obj":"PR:000012914"},{"id":"T336","span":{"begin":1274,"end":1278},"obj":"PR:P54278"},{"id":"T337","span":{"begin":1283,"end":1287},"obj":"PR:Q9ZRV4"},{"id":"T338","span":{"begin":1283,"end":1287},"obj":"PR:P38920"},{"id":"T339","span":{"begin":1283,"end":1287},"obj":"PR:Q54KD8"},{"id":"T341","span":{"begin":1283,"end":1287},"obj":"PR:Q9JK91"},{"id":"T342","span":{"begin":1283,"end":1287},"obj":"PR:P97679"},{"id":"T343","span":{"begin":1283,"end":1287},"obj":"PR:Q9P7W6"},{"id":"T344","span":{"begin":1283,"end":1287},"obj":"PR:000010442"},{"id":"T345","span":{"begin":1283,"end":1287},"obj":"PR:P40692"},{"id":"T340","span":{"begin":1283,"end":1287},"obj":"CVCL_G669"},{"id":"T347","span":{"begin":1346,"end":1350},"obj":"PR:000007710"},{"id":"T348","span":{"begin":1346,"end":1350},"obj":"PR:000022686"},{"id":"T349","span":{"begin":1346,"end":1350},"obj":"PR:P00363"},{"id":"T350","span":{"begin":1346,"end":1350},"obj":"PR:Q16595"},{"id":"T351","span":{"begin":1346,"end":1350},"obj":"PR:O35943"},{"id":"T346","span":{"begin":1346,"end":1350},"obj":"C565561"},{"id":"T352","span":{"begin":1384,"end":1388},"obj":"PR:Q9ZRV4"},{"id":"T353","span":{"begin":1384,"end":1388},"obj":"PR:P38920"},{"id":"T354","span":{"begin":1384,"end":1388},"obj":"PR:Q54KD8"},{"id":"T356","span":{"begin":1384,"end":1388},"obj":"PR:Q9JK91"},{"id":"T357","span":{"begin":1384,"end":1388},"obj":"PR:P97679"},{"id":"T358","span":{"begin":1384,"end":1388},"obj":"PR:Q9P7W6"},{"id":"T359","span":{"begin":1384,"end":1388},"obj":"PR:000010442"},{"id":"T360","span":{"begin":1384,"end":1388},"obj":"PR:P40692"},{"id":"T355","span":{"begin":1384,"end":1388},"obj":"CVCL_G669"},{"id":"T361","span":{"begin":1392,"end":1395},"obj":"CHEBI:53396"},{"id":"T364","span":{"begin":1392,"end":1395},"obj":"CHEBI:53430"},{"id":"T366","span":{"begin":1392,"end":1395},"obj":"CHEBI:8055"},{"id":"T367","span":{"begin":1392,"end":1396},"obj":"PR:P54279"},{"id":"T368","span":{"begin":1392,"end":1396},"obj":"PR:F1NQJ3"},{"id":"T369","span":{"begin":1392,"end":1396},"obj":"PR:P38920"},{"id":"T370","span":{"begin":1392,"end":1396},"obj":"PR:000012914"},{"id":"T371","span":{"begin":1392,"end":1396},"obj":"PR:P54278"},{"id":"T373","span":{"begin":1416,"end":1420},"obj":"PR:000007710"},{"id":"T374","span":{"begin":1416,"end":1420},"obj":"PR:000022686"},{"id":"T375","span":{"begin":1416,"end":1420},"obj":"PR:P00363"},{"id":"T376","span":{"begin":1416,"end":1420},"obj":"PR:Q16595"},{"id":"T377","span":{"begin":1416,"end":1420},"obj":"PR:O35943"},{"id":"T372","span":{"begin":1416,"end":1420},"obj":"C565561"},{"id":"T378","span":{"begin":1456,"end":1459},"obj":"PR:000007710"},{"id":"T379","span":{"begin":1456,"end":1459},"obj":"Q8HXX9"},{"id":"T380","span":{"begin":1456,"end":1459},"obj":"Q9TY03"},{"id":"T381","span":{"begin":1456,"end":1459},"obj":"Q05B87"},{"id":"T382","span":{"begin":1456,"end":1459},"obj":"PR:D3ZYW7"},{"id":"T383","span":{"begin":1456,"end":1459},"obj":"Q54C45"},{"id":"T384","span":{"begin":1456,"end":1459},"obj":"D3ZYW7"},{"id":"T385","span":{"begin":1456,"end":1459},"obj":"Q9ZR07"},{"id":"T386","span":{"begin":1456,"end":1459},"obj":"B0YLW8"},{"id":"T387","span":{"begin":1456,"end":1459},"obj":"O35943"},{"id":"T388","span":{"begin":1456,"end":1459},"obj":"Q16595"},{"id":"T389","span":{"begin":1456,"end":1459},"obj":"PR:Q54C45"},{"id":"T390","span":{"begin":1456,"end":1459},"obj":"PR:Q16595"},{"id":"T391","span":{"begin":1456,"end":1459},"obj":"PR:O35943"},{"id":"T392","span":{"begin":1456,"end":1459},"obj":"Q8SWI3"},{"id":"T393","span":{"begin":1460,"end":1473},"obj":"GO:0006351"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T19","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T110","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T149","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T151","pred":"source","obj":"c_corpus"},{"subj":"T152","pred":"source","obj":"c_corpus"},{"subj":"T153","pred":"source","obj":"c_corpus"},{"subj":"T154","pred":"source","obj":"c_corpus"},{"subj":"T155","pred":"source","obj":"c_corpus"},{"subj":"T156","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T159","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T168","pred":"source","obj":"c_corpus"},{"subj":"T169","pred":"source","obj":"c_corpus"},{"subj":"T170","pred":"source","obj":"c_corpus"},{"subj":"T171","pred":"source","obj":"c_corpus"},{"subj":"T172","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T182","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T184","pred":"source","obj":"c_corpus"},{"subj":"T179","pred":"source","obj":"c_corpus"},{"subj":"T185","pred":"source","obj":"c_corpus"},{"subj":"T186","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T190","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T191","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"},{"subj":"T193","pred":"source","obj":"c_corpus"},{"subj":"T194","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T196","pred":"source","obj":"c_corpus"},{"subj":"T197","pred":"source","obj":"c_corpus"},{"subj":"T198","pred":"source","obj":"c_corpus"},{"subj":"T199","pred":"source","obj":"c_corpus"},{"subj":"T200","pred":"source","obj":"c_corpus"},{"subj":"T201","pred":"source","obj":"c_corpus"},{"subj":"T202","pred":"source","obj":"c_corpus"},{"subj":"T203","pred":"source","obj":"c_corpus"},{"subj":"T204","pred":"source","obj":"c_corpus"},{"subj":"T205","pred":"source","obj":"c_corpus"},{"subj":"T206","pred":"source","obj":"c_corpus"},{"subj":"T207","pred":"source","obj":"c_corpus"},{"subj":"T208","pred":"source","obj":"c_corpus"},{"subj":"T209","pred":"source","obj":"c_corpus"},{"subj":"T210","pred":"source","obj":"c_corpus"},{"subj":"T212","pred":"source","obj":"c_corpus"},{"subj":"T217","pred":"source","obj":"c_corpus"},{"subj":"T214","pred":"source","obj":"c_corpus"},{"subj":"T215","pred":"source","obj":"c_corpus"},{"subj":"T216","pred":"source","obj":"c_corpus"},{"subj":"T218","pred":"source","obj":"c_corpus"},{"subj":"T219","pred":"source","obj":"c_corpus"},{"subj":"T220","pred":"source","obj":"c_corpus"},{"subj":"T221","pred":"source","obj":"c_corpus"},{"subj":"T222","pred":"source","obj":"c_corpus"},{"subj":"T223","pred":"source","obj":"c_corpus"},{"subj":"T225","pred":"source","obj":"c_corpus"},{"subj":"T224","pred":"source","obj":"c_corpus"},{"subj":"T226","pred":"source","obj":"c_corpus"},{"subj":"T227","pred":"source","obj":"c_corpus"},{"subj":"T228","pred":"source","obj":"c_corpus"},{"subj":"T229","pred":"source","obj":"c_corpus"},{"subj":"T231","pred":"source","obj":"c_corpus"},{"subj":"T232","pred":"source","obj":"c_corpus"},{"subj":"T233","pred":"source","obj":"c_corpus"},{"subj":"T234","pred":"source","obj":"c_corpus"},{"subj":"T235","pred":"source","obj":"c_corpus"},{"subj":"T230","pred":"source","obj":"c_corpus"},{"subj":"T236","pred":"source","obj":"c_corpus"},{"subj":"T237","pred":"source","obj":"c_corpus"},{"subj":"T238","pred":"source","obj":"c_corpus"},{"subj":"T239","pred":"source","obj":"c_corpus"},{"subj":"T241","pred":"source","obj":"c_corpus"},{"subj":"T240","pred":"source","obj":"c_corpus"},{"subj":"T242","pred":"source","obj":"c_corpus"},{"subj":"T243","pred":"source","obj":"c_corpus"},{"subj":"T244","pred":"source","obj":"c_corpus"},{"subj":"T245","pred":"source","obj":"c_corpus"},{"subj":"T247","pred":"source","obj":"c_corpus"},{"subj":"T248","pred":"source","obj":"c_corpus"},{"subj":"T249","pred":"source","obj":"c_corpus"},{"subj":"T250","pred":"source","obj":"c_corpus"},{"subj":"T251","pred":"source","obj":"c_corpus"},{"subj":"T246","pred":"source","obj":"c_corpus"},{"subj":"T252","pred":"source","obj":"c_corpus"},{"subj":"T255","pred":"source","obj":"c_corpus"},{"subj":"T257","pred":"source","obj":"c_corpus"},{"subj":"T258","pred":"source","obj":"c_corpus"},{"subj":"T259","pred":"source","obj":"c_corpus"},{"subj":"T260","pred":"source","obj":"c_corpus"},{"subj":"T261","pred":"source","obj":"c_corpus"},{"subj":"T262","pred":"source","obj":"c_corpus"},{"subj":"T263","pred":"source","obj":"c_corpus"},{"subj":"T264","pred":"source","obj":"c_corpus"},{"subj":"T265","pred":"source","obj":"c_corpus"},{"subj":"T266","pred":"source","obj":"c_corpus"},{"subj":"T267","pred":"source","obj":"c_corpus"},{"subj":"T268","pred":"source","obj":"c_corpus"},{"subj":"T269","pred":"source","obj":"c_corpus"},{"subj":"T270","pred":"source","obj":"c_corpus"},{"subj":"T271","pred":"source","obj":"c_corpus"},{"subj":"T272","pred":"source","obj":"c_corpus"},{"subj":"T273","pred":"source","obj":"c_corpus"},{"subj":"T274","pred":"source","obj":"c_corpus"},{"subj":"T275","pred":"source","obj":"c_corpus"},{"subj":"T276","pred":"source","obj":"c_corpus"},{"subj":"T277","pred":"source","obj":"c_corpus"},{"subj":"T278","pred":"source","obj":"c_corpus"},{"subj":"T279","pred":"source","obj":"c_corpus"},{"subj":"T280","pred":"source","obj":"c_corpus"},{"subj":"T281","pred":"source","obj":"c_corpus"},{"subj":"T283","pred":"source","obj":"c_corpus"},{"subj":"T284","pred":"source","obj":"c_corpus"},{"subj":"T285","pred":"source","obj":"c_corpus"},{"subj":"T286","pred":"source","obj":"c_corpus"},{"subj":"T287","pred":"source","obj":"c_corpus"},{"subj":"T282","pred":"source","obj":"c_corpus"},{"subj":"T288","pred":"source","obj":"c_corpus"},{"subj":"T291","pred":"source","obj":"c_corpus"},{"subj":"T293","pred":"source","obj":"c_corpus"},{"subj":"T294","pred":"source","obj":"c_corpus"},{"subj":"T295","pred":"source","obj":"c_corpus"},{"subj":"T296","pred":"source","obj":"c_corpus"},{"subj":"T297","pred":"source","obj":"c_corpus"},{"subj":"T298","pred":"source","obj":"c_corpus"},{"subj":"T299","pred":"source","obj":"c_corpus"},{"subj":"T300","pred":"source","obj":"c_corpus"},{"subj":"T301","pred":"source","obj":"c_corpus"},{"subj":"T302","pred":"source","obj":"c_corpus"},{"subj":"T304","pred":"source","obj":"c_corpus"},{"subj":"T303","pred":"source","obj":"c_corpus"},{"subj":"T305","pred":"source","obj":"c_corpus"},{"subj":"T306","pred":"source","obj":"c_corpus"},{"subj":"T307","pred":"source","obj":"c_corpus"},{"subj":"T308","pred":"source","obj":"c_corpus"},{"subj":"T309","pred":"source","obj":"c_corpus"},{"subj":"T310","pred":"source","obj":"c_corpus"},{"subj":"T311","pred":"source","obj":"c_corpus"},{"subj":"T312","pred":"source","obj":"c_corpus"},{"subj":"T313","pred":"source","obj":"c_corpus"},{"subj":"T314","pred":"source","obj":"c_corpus"},{"subj":"T315","pred":"source","obj":"c_corpus"},{"subj":"T316","pred":"source","obj":"c_corpus"},{"subj":"T317","pred":"source","obj":"c_corpus"},{"subj":"T318","pred":"source","obj":"c_corpus"},{"subj":"T319","pred":"source","obj":"c_corpus"},{"subj":"T320","pred":"source","obj":"c_corpus"},{"subj":"T321","pred":"source","obj":"c_corpus"},{"subj":"T322","pred":"source","obj":"c_corpus"},{"subj":"T323","pred":"source","obj":"c_corpus"},{"subj":"T324","pred":"source","obj":"c_corpus"},{"subj":"T325","pred":"source","obj":"c_corpus"},{"subj":"T326","pred":"source","obj":"c_corpus"},{"subj":"T329","pred":"source","obj":"c_corpus"},{"subj":"T331","pred":"source","obj":"c_corpus"},{"subj":"T332","pred":"source","obj":"c_corpus"},{"subj":"T333","pred":"source","obj":"c_corpus"},{"subj":"T334","pred":"source","obj":"c_corpus"},{"subj":"T335","pred":"source","obj":"c_corpus"},{"subj":"T336","pred":"source","obj":"c_corpus"},{"subj":"T337","pred":"source","obj":"c_corpus"},{"subj":"T338","pred":"source","obj":"c_corpus"},{"subj":"T339","pred":"source","obj":"c_corpus"},{"subj":"T341","pred":"source","obj":"c_corpus"},{"subj":"T342","pred":"source","obj":"c_corpus"},{"subj":"T343","pred":"source","obj":"c_corpus"},{"subj":"T344","pred":"source","obj":"c_corpus"},{"subj":"T345","pred":"source","obj":"c_corpus"},{"subj":"T340","pred":"source","obj":"c_corpus"},{"subj":"T347","pred":"source","obj":"c_corpus"},{"subj":"T348","pred":"source","obj":"c_corpus"},{"subj":"T349","pred":"source","obj":"c_corpus"},{"subj":"T350","pred":"source","obj":"c_corpus"},{"subj":"T351","pred":"source","obj":"c_corpus"},{"subj":"T346","pred":"source","obj":"c_corpus"},{"subj":"T352","pred":"source","obj":"c_corpus"},{"subj":"T353","pred":"source","obj":"c_corpus"},{"subj":"T354","pred":"source","obj":"c_corpus"},{"subj":"T356","pred":"source","obj":"c_corpus"},{"subj":"T357","pred":"source","obj":"c_corpus"},{"subj":"T358","pred":"source","obj":"c_corpus"},{"subj":"T359","pred":"source","obj":"c_corpus"},{"subj":"T360","pred":"source","obj":"c_corpus"},{"subj":"T355","pred":"source","obj":"c_corpus"},{"subj":"T361","pred":"source","obj":"c_corpus"},{"subj":"T364","pred":"source","obj":"c_corpus"},{"subj":"T366","pred":"source","obj":"c_corpus"},{"subj":"T367","pred":"source","obj":"c_corpus"},{"subj":"T368","pred":"source","obj":"c_corpus"},{"subj":"T369","pred":"source","obj":"c_corpus"},{"subj":"T370","pred":"source","obj":"c_corpus"},{"subj":"T371","pred":"source","obj":"c_corpus"},{"subj":"T373","pred":"source","obj":"c_corpus"},{"subj":"T374","pred":"source","obj":"c_corpus"},{"subj":"T375","pred":"source","obj":"c_corpus"},{"subj":"T376","pred":"source","obj":"c_corpus"},{"subj":"T377","pred":"source","obj":"c_corpus"},{"subj":"T372","pred":"source","obj":"c_corpus"},{"subj":"T378","pred":"source","obj":"c_corpus"},{"subj":"T379","pred":"source","obj":"c_corpus"},{"subj":"T380","pred":"source","obj":"c_corpus"},{"subj":"T381","pred":"source","obj":"c_corpus"},{"subj":"T382","pred":"source","obj":"c_corpus"},{"subj":"T383","pred":"source","obj":"c_corpus"},{"subj":"T384","pred":"source","obj":"c_corpus"},{"subj":"T385","pred":"source","obj":"c_corpus"},{"subj":"T386","pred":"source","obj":"c_corpus"},{"subj":"T387","pred":"source","obj":"c_corpus"},{"subj":"T388","pred":"source","obj":"c_corpus"},{"subj":"T389","pred":"source","obj":"c_corpus"},{"subj":"T390","pred":"source","obj":"c_corpus"},{"subj":"T391","pred":"source","obj":"c_corpus"},{"subj":"T392","pred":"source","obj":"c_corpus"},{"subj":"T393","pred":"source","obj":"c_corpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#93ecc2","default":true},{"id":"PubmedHPO","color":"#eca893"},{"id":"DisGeNET5_gene_disease","color":"#9397ec"},{"id":"PubMed_Structured_Abstracts","color":"#b1ec93"},{"id":"c_corpus","color":"#ec93cb"}]}]}}