PubMed:24968752
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 828-831 | Disease | denotes | FAS | http://purl.obolibrary.org/obo/MONDO_0016011 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 286-302 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 523-539 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T3 | 877-893 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T4 | 949-965 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T5 | 1571-1587 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 828-831 | Disease | denotes | FAS | http://purl.obolibrary.org/obo/MONDO_0016011 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 264-269 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 66-76 | Cell | denotes | phagocytes | http://purl.obolibrary.org/obo/CL:0000234 |
| T2 | 128-137 | Cell | denotes | leukocyte | http://purl.obolibrary.org/obo/CL:0000738 |
| T3 | 270-281 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T4 | 333-342 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T6 | 347-362 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T8 | 375-386 | Cell | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL:0000542 |
| T9 | 446-457 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T10 | 586-597 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T11 | 661-671 | Cell | denotes | neutrophil | http://purl.obolibrary.org/obo/CL:0000775 |
| T12 | 784-796 | Cell | denotes | neutrophilic | http://purl.obolibrary.org/obo/CL:0000775 |
| T13 | 842-852 | Cell | denotes | neutrophil | http://purl.obolibrary.org/obo/CL:0000775 |
| T14 | 916-934 | Cell | denotes | mature neutrophils | http://purl.obolibrary.org/obo/CL:0000096 |
| T15 | 1070-1080 | Cell | denotes | neutrophil | http://purl.obolibrary.org/obo/CL:0000775 |
| T16 | 1504-1514 | Cell | denotes | phagocytes | http://purl.obolibrary.org/obo/CL:0000234 |
| T17 | 1591-1602 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 66-76 | Body_part | denotes | phagocytes | http://purl.obolibrary.org/obo/CL_0000234 |
| T2 | 128-137 | Body_part | denotes | leukocyte | http://purl.obolibrary.org/obo/CL_0000738 |
| T3 | 270-281 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T4 | 333-342 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T6 | 347-362 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T7 | 375-386 | Body_part | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL_0000542 |
| T8 | 446-457 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T9 | 566-582 | Body_part | denotes | plasma membranes | http://purl.obolibrary.org/obo/GO_0005886 |
| T10 | 586-597 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T11 | 661-671 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
| T12 | 784-796 | Body_part | denotes | neutrophilic | http://purl.obolibrary.org/obo/CL_0000775 |
| T13 | 842-852 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
| T14 | 923-934 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T15 | 1001-1009 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T18 | 1040-1048 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T21 | 1070-1080 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
| T22 | 1504-1514 | Body_part | denotes | phagocytes | http://purl.obolibrary.org/obo/CL_0000234 |
| T23 | 1591-1602 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-77 | Sentence | denotes | Organization and functions of glycolipid-enriched microdomains in phagocytes. |
| T2 | 78-224 | Sentence | denotes | Populations of glycolipids change markedly during leukocyte differentiation, suggesting that these molecules are involved in biological functions. |
| T3 | 225-387 | Sentence | denotes | About 70% of the glycosphingolipids in human neutrophils are lactosylceramide, a molecule also expressed on monocytes and dendritic cells, but not on lymphocytes. |
| T4 | 388-458 | Sentence | denotes | In contrast, phosphatidylglucoside is mainly expressed on neutrophils. |
| T5 | 459-696 | Sentence | denotes | STED microscopic analysis showed that phosphatidylglucoside and lactosylceramide form different domains on plasma membranes of neutrophils, with phosphatidylglucoside preferentially expressed along the neutrophil differentiation pathway. |
| T6 | 697-863 | Sentence | denotes | Phosphatidylglucoside was found to mediate the differentiation of HL-60 cells into the neutrophilic lineage, and to be involved in FAS-dependent neutrophil apoptosis. |
| T7 | 864-935 | Sentence | denotes | In contrast, lactosylceramide was only expressed on mature neutrophils. |
| T8 | 936-1023 | Sentence | denotes | Complexes of lactosylceramide and the Src family kinase Lyn form membrane microdomains. |
| T9 | 1024-1163 | Sentence | denotes | LacCer-enriched membrane microdomains mediate neutrophil innate immune responses; e.g. chemotaxis, phagocytosis, and superoxide generation. |
| T10 | 1164-1291 | Sentence | denotes | C24 fatty acid chains of LacCer are indispensable for the formation of LacCer-Lyn complexes and for LacCer-dependent functions. |
| T11 | 1292-1422 | Sentence | denotes | Moreover, Lyn-coupled LacCer-enriched microdomains serve as signal transduction platforms for αMβ2 integrin-mediated phagocytosis. |
| T12 | 1423-1603 | Sentence | denotes | This review describes the organization and potential functions of glycolipids in phagocytes, as well as the roles of both phosphatidylglucoside and lactosylceramide in neutrophils. |
| T13 | 1604-1703 | Sentence | denotes | This article is part of a Special Issue entitled Linking transcription to physiology in lipidomics. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 286-302 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 523-539 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T3 | 877-893 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T4 | 949-965 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T5 | 1571-1587 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 286-302 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T2 | 523-539 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T3 | 877-893 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T4 | 949-965 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T5 | 1571-1587 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 264-269 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 286-302 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T2 | 523-539 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T3 | 877-893 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T4 | 949-965 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T5 | 1571-1587 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 66-76 | Body_part | denotes | phagocytes | http://purl.obolibrary.org/obo/CL_0000234 |
| T2 | 128-137 | Body_part | denotes | leukocyte | http://purl.obolibrary.org/obo/CL_0000738 |
| T3 | 270-281 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T4 | 333-342 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T6 | 347-362 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T7 | 375-386 | Body_part | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL_0000542 |
| T8 | 446-457 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T9 | 566-582 | Body_part | denotes | plasma membranes | http://purl.obolibrary.org/obo/GO_0005886 |
| T10 | 586-597 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T11 | 661-671 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
| T12 | 784-796 | Body_part | denotes | neutrophilic | http://purl.obolibrary.org/obo/CL_0000775 |
| T13 | 842-852 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
| T14 | 923-934 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T15 | 1001-1009 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T18 | 1040-1048 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T21 | 1070-1080 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
| T22 | 1504-1514 | Body_part | denotes | phagocytes | http://purl.obolibrary.org/obo/CL_0000234 |
| T23 | 1591-1602 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 66-76 | Cell | denotes | phagocytes | http://purl.obolibrary.org/obo/CL:0000234 |
| T2 | 128-137 | Cell | denotes | leukocyte | http://purl.obolibrary.org/obo/CL:0000738 |
| T3 | 270-281 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T4 | 333-342 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T6 | 347-362 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T8 | 375-386 | Cell | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL:0000542 |
| T9 | 446-457 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T10 | 586-597 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T11 | 661-671 | Cell | denotes | neutrophil | http://purl.obolibrary.org/obo/CL:0000775 |
| T12 | 784-796 | Cell | denotes | neutrophilic | http://purl.obolibrary.org/obo/CL:0000775 |
| T13 | 842-852 | Cell | denotes | neutrophil | http://purl.obolibrary.org/obo/CL:0000775 |
| T14 | 916-934 | Cell | denotes | mature neutrophils | http://purl.obolibrary.org/obo/CL:0000096 |
| T15 | 1070-1080 | Cell | denotes | neutrophil | http://purl.obolibrary.org/obo/CL:0000775 |
| T16 | 1504-1514 | Cell | denotes | phagocytes | http://purl.obolibrary.org/obo/CL:0000234 |
| T17 | 1591-1602 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |