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PubMed:24942733 JSONTXT

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test-210614

Id Subject Object Predicate Lexical cue proteinmutation
24942733_0 934-940 ProteinMutation denotes G2019S rs34637584

PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
24942733_0 934-940 ProteinMutation denotes G2019S rs34637584

sentences

Id Subject Object Predicate Lexical cue
T1 0-162 Sentence denotes Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.
T2 163-338 Sentence denotes Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a common genetic cause of Parkinson disease, but the mechanisms whereby LRRK2 is regulated are unknown.
T3 339-418 Sentence denotes Phosphorylation of LRRK2 at Ser(910)/Ser(935) mediates interaction with 14-3-3.
T4 419-590 Sentence denotes Pharmacological inhibition of its kinase activity abolishes Ser(910)/Ser(935) phosphorylation and 14-3-3 binding, and this effect is also mimicked by pathogenic mutations.
T5 591-678 Sentence denotes However, physiological situations where dephosphorylation occurs have not been defined.
T6 679-827 Sentence denotes Here, we show that arsenite or H2O2-induced stresses promote loss of Ser(910)/Ser(935) phosphorylation, which is reversed by phosphatase inhibition.
T7 828-971 Sentence denotes Arsenite-induced dephosphorylation is accompanied by loss of 14-3-3 binding and is observed in wild type, G2019S, and kinase-dead D2017A LRRK2.
T8 972-1169 Sentence denotes Arsenite stress stimulates LRRK2 self-association and association with protein phosphatase 1α, decreases kinase activity and GTP binding in vitro, and induces translocation of LRRK2 to centrosomes.
T9 1170-1279 Sentence denotes Our data indicate that signaling events induced by arsenite and oxidative stress may regulate LRRK2 function.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 261-270 HP_0001300 denotes Parkinson
T2 953-957 HP_0000365 denotes dead

Allie

Id Subject Object Predicate Lexical cue
SS1_24942733_0_0 69-97 expanded denotes leucine-rich repeat kinase 2
SS2_24942733_0_0 99-104 abbr denotes LRRK2
SS1_24942733_1_0 194-222 expanded denotes leucine-rich repeat kinase 2
SS2_24942733_1_0 224-229 abbr denotes LRRK2
AE1_24942733_0_0 SS1_24942733_0_0 SS2_24942733_0_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_24942733_1_0 SS1_24942733_1_0 SS2_24942733_1_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 163-338 DRI_Approach denotes Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a common genetic cause of Parkinson disease, but the mechanisms whereby LRRK2 is regulated are unknown.
T2 339-418 DRI_Background denotes Phosphorylation of LRRK2 at Ser(910)/Ser(935) mediates interaction with 14-3-3.
T3 419-590 DRI_Background denotes Pharmacological inhibition of its kinase activity abolishes Ser(910)/Ser(935) phosphorylation and 14-3-3 binding, and this effect is also mimicked by pathogenic mutations.
T4 591-678 DRI_Background denotes However, physiological situations where dephosphorylation occurs have not been defined.
T5 679-827 DRI_Outcome denotes Here, we show that arsenite or H2O2-induced stresses promote loss of Ser(910)/Ser(935) phosphorylation, which is reversed by phosphatase inhibition.
T6 828-945 DRI_Background denotes Arsenite-induced dephosphorylation is accompanied by loss of 14-3-3 binding and is observed in wild type, G2019S, and
T7 970-971 DRI_Background denotes .
T8 972-998 DRI_Background denotes Arsenite stress stimulates
T9 1022-1169 DRI_Background denotes and association with protein phosphatase 1α, decreases kinase activity and GTP binding in vitro, and induces translocation of LRRK2 to centrosomes.
T10 1170-1279 DRI_Approach denotes Our data indicate that signaling events induced by arsenite and oxidative stress may regulate LRRK2 function.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 261-278 Disease denotes Parkinson disease http://purl.obolibrary.org/obo/MONDO_0005180

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 261-270 Phenotype denotes Parkinson HP:0001300
T2 1234-1250 Phenotype denotes oxidative stress HP:0025464