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c_corpus

Id Subject Object Predicate Lexical cue
T1 47-62 GO:0006298 denotes mismatch repair
T2 69-73 PR:Q9ZRV4 denotes MLH1
T3 69-73 PR:P38920 denotes MLH1
T4 69-73 PR:Q54KD8 denotes MLH1
T6 69-73 PR:Q9JK91 denotes MLH1
T7 69-73 PR:P97679 denotes MLH1
T8 69-73 PR:Q9P7W6 denotes MLH1
T9 69-73 PR:000010442 denotes MLH1
T10 69-73 PR:P40692 denotes MLH1
T5 69-73 CVCL_G669 denotes MLH1
T12 75-78 CHEBI:16768 denotes MSH
T16 75-78 D009074 denotes MSH
T17 75-78 D009074 denotes MSH
T18 75-79 PR:000010666 denotes MSH2
T19 75-79 PR:P25847 denotes MSH2
T20 75-79 PR:P43246 denotes MSH2
T21 75-79 P22711 denotes MSH2
T22 75-79 PR:P22711 denotes MSH2
T23 75-79 PR:P54275 denotes MSH2
T24 75-79 PR:O74773 denotes MSH2
T25 75-79 PR:P43247 denotes MSH2
T26 75-79 PR:Q553L4 denotes MSH2
T27 75-79 PR:O24617 denotes MSH2
T29 85-88 CHEBI:16768 denotes MSH
T33 85-88 D009074 denotes MSH
T34 85-88 D009074 denotes MSH
T35 85-89 PR:P52701 denotes MSH6
T36 85-89 PR:P54276 denotes MSH6
T37 85-89 PR:Q9VUM0 denotes MSH6
T38 85-89 PR:Q55GU9 denotes MSH6
T39 85-89 PR:O04716 denotes MSH6
T40 85-89 PR:Q03834 denotes MSH6
T41 85-89 PR:O74502 denotes MSH6
T42 85-89 PR:000010670 denotes MSH6
T43 162-167 UBERON:0001155 denotes colon
T44 162-174 D003110 denotes colon cancer
T45 162-174 D015179 denotes colon cancer
T46 162-174 D003110 denotes colon cancer
T47 195-210 GO:0006298 denotes mismatch repair
T48 212-215 GO:0006298 denotes MMR
T50 212-215 P22897 denotes MMR
T51 212-215 PR:000002972 denotes MMR
T52 212-215 Q61830 denotes MMR
T49 212-215 CVCL_E779 denotes MMR
T53 233-241 SO:0000109 denotes mutation
T54 242-250 CHEBI:78059 denotes carriers
T57 287-290 P22897 denotes MMR
T58 287-290 PR:000002972 denotes MMR
T59 287-290 Q61830 denotes MMR
T55 287-290 GO:0006298 denotes MMR
T56 287-290 CVCL_E779 denotes MMR
T60 291-295 SO:0000704 denotes gene
T61 296-302 SO:0001023 denotes allele
T64 362-365 P22897 denotes MMR
T65 362-365 PR:000002972 denotes MMR
T66 362-365 Q61830 denotes MMR
T62 362-365 GO:0006298 denotes MMR
T63 362-365 CVCL_E779 denotes MMR
T67 366-370 SO:0000704 denotes gene
T70 408-411 P22897 denotes MMR
T71 408-411 PR:000002972 denotes MMR
T72 408-411 Q61830 denotes MMR
T69 408-411 CVCL_E779 denotes MMR
T68 408-411 GO:0006298 denotes MMR
T73 412-416 SO:0000704 denotes gene
T76 436-439 P22897 denotes MMR
T77 436-439 PR:000002972 denotes MMR
T78 436-439 Q61830 denotes MMR
T75 436-439 CVCL_E779 denotes MMR
T74 436-439 GO:0006298 denotes MMR
T81 488-491 P22897 denotes MMR
T82 488-491 PR:000002972 denotes MMR
T83 488-491 Q61830 denotes MMR
T80 488-491 CVCL_E779 denotes MMR
T79 488-491 GO:0006298 denotes MMR
T86 546-549 P22897 denotes MMR
T87 546-549 PR:000002972 denotes MMR
T88 546-549 Q61830 denotes MMR
T85 546-549 CVCL_E779 denotes MMR
T84 546-549 GO:0006298 denotes MMR
T89 550-554 SO:0000704 denotes gene
T92 686-690 SO:0000234 denotes mRNA
T90 686-690 D012333 denotes mRNA
T91 686-690 CHEBI:33699 denotes mRNA
T93 755-760 D006801 denotes human
T94 832-846 D004198 denotes susceptibility
T95 832-846 D004198 denotes susceptibility
T96 853-857 PR:Q9ZRV4 denotes MLH1
T97 853-857 PR:P38920 denotes MLH1
T98 853-857 PR:Q54KD8 denotes MLH1
T100 853-857 PR:Q9JK91 denotes MLH1
T101 853-857 PR:P97679 denotes MLH1
T102 853-857 PR:Q9P7W6 denotes MLH1
T103 853-857 PR:000010442 denotes MLH1
T104 853-857 PR:P40692 denotes MLH1
T99 853-857 CVCL_G669 denotes MLH1
T106 859-862 CHEBI:16768 denotes MSH
T110 859-862 D009074 denotes MSH
T111 859-862 D009074 denotes MSH
T112 859-863 PR:000010666 denotes MSH2
T113 859-863 PR:P25847 denotes MSH2
T114 859-863 PR:P43246 denotes MSH2
T115 859-863 P22711 denotes MSH2
T116 859-863 PR:P22711 denotes MSH2
T117 859-863 PR:P54275 denotes MSH2
T118 859-863 PR:O74773 denotes MSH2
T119 859-863 PR:P43247 denotes MSH2
T120 859-863 PR:Q553L4 denotes MSH2
T121 859-863 PR:O24617 denotes MSH2
T123 868-871 CHEBI:16768 denotes MSH
T127 868-871 D009074 denotes MSH
T128 868-871 D009074 denotes MSH
T129 868-872 PR:P52701 denotes MSH6
T130 868-872 PR:P54276 denotes MSH6
T131 868-872 PR:Q9VUM0 denotes MSH6
T132 868-872 PR:Q55GU9 denotes MSH6
T133 868-872 PR:O04716 denotes MSH6
T134 868-872 PR:Q03834 denotes MSH6
T135 868-872 PR:O74502 denotes MSH6
T136 868-872 PR:000010670 denotes MSH6
T138 892-897 SO:0002031 denotes shRNA
T137 892-897 D034741 denotes shRNA
T139 931-940 MOP:0000569 denotes reduction
T142 944-948 SO:0000234 denotes mRNA
T140 944-948 D012333 denotes mRNA
T141 944-948 CHEBI:33699 denotes mRNA
T143 987-990 GO:0006298 denotes MMR
T145 987-990 P22897 denotes MMR
T146 987-990 PR:000002972 denotes MMR
T147 987-990 Q61830 denotes MMR
T144 987-990 CVCL_E779 denotes MMR
T148 1045-1049 PR:Q9ZRV4 denotes MLH1
T149 1045-1049 PR:P38920 denotes MLH1
T150 1045-1049 PR:Q54KD8 denotes MLH1
T152 1045-1049 PR:Q9JK91 denotes MLH1
T153 1045-1049 PR:P97679 denotes MLH1
T154 1045-1049 PR:Q9P7W6 denotes MLH1
T155 1045-1049 PR:000010442 denotes MLH1
T156 1045-1049 PR:P40692 denotes MLH1
T151 1045-1049 CVCL_G669 denotes MLH1
T158 1054-1057 CHEBI:16768 denotes MSH
T162 1054-1057 D009074 denotes MSH
T163 1054-1057 D009074 denotes MSH
T164 1054-1058 PR:000010666 denotes MSH2
T165 1054-1058 PR:P25847 denotes MSH2
T166 1054-1058 PR:P43246 denotes MSH2
T167 1054-1058 P22711 denotes MSH2
T168 1054-1058 PR:P22711 denotes MSH2
T169 1054-1058 PR:P54275 denotes MSH2
T170 1054-1058 PR:O74773 denotes MSH2
T171 1054-1058 PR:P43247 denotes MSH2
T172 1054-1058 PR:Q553L4 denotes MSH2
T173 1054-1058 PR:O24617 denotes MSH2
T174 1063-1067 PR:Q9ZRV4 denotes MLH1
T175 1063-1067 PR:P38920 denotes MLH1
T176 1063-1067 PR:Q54KD8 denotes MLH1
T178 1063-1067 PR:Q9JK91 denotes MLH1
T179 1063-1067 PR:P97679 denotes MLH1
T180 1063-1067 PR:Q9P7W6 denotes MLH1
T181 1063-1067 PR:000010442 denotes MLH1
T182 1063-1067 PR:P40692 denotes MLH1
T177 1063-1067 CVCL_G669 denotes MLH1
T185 1083-1086 P22897 denotes MMR
T186 1083-1086 PR:000002972 denotes MMR
T187 1083-1086 Q61830 denotes MMR
T184 1083-1086 CVCL_E779 denotes MMR
T183 1083-1086 GO:0006298 denotes MMR
T189 1132-1135 CHEBI:16768 denotes MSH
T193 1132-1135 D009074 denotes MSH
T194 1132-1135 D009074 denotes MSH
T195 1132-1136 PR:P52701 denotes MSH6
T196 1132-1136 PR:P54276 denotes MSH6
T197 1132-1136 PR:Q9VUM0 denotes MSH6
T198 1132-1136 PR:Q55GU9 denotes MSH6
T199 1132-1136 PR:O04716 denotes MSH6
T200 1132-1136 PR:Q03834 denotes MSH6
T201 1132-1136 PR:O74502 denotes MSH6
T202 1132-1136 PR:000010670 denotes MSH6
T204 1141-1144 CHEBI:16768 denotes MSH
T208 1141-1144 D009074 denotes MSH
T209 1141-1144 D009074 denotes MSH
T210 1141-1145 PR:000010666 denotes MSH2
T211 1141-1145 PR:P25847 denotes MSH2
T212 1141-1145 PR:P43246 denotes MSH2
T213 1141-1145 P22711 denotes MSH2
T214 1141-1145 PR:P22711 denotes MSH2
T215 1141-1145 PR:P54275 denotes MSH2
T216 1141-1145 PR:O74773 denotes MSH2
T217 1141-1145 PR:P43247 denotes MSH2
T218 1141-1145 PR:Q553L4 denotes MSH2
T219 1141-1145 PR:O24617 denotes MSH2
T220 1304-1313 SO:0000817 denotes wild-type
T223 1353-1356 P22897 denotes MMR
T224 1353-1356 PR:000002972 denotes MMR
T225 1353-1356 Q61830 denotes MMR
T222 1353-1356 CVCL_E779 denotes MMR
T221 1353-1356 GO:0006298 denotes MMR

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 162-174 HP_0003003 denotes colon cancer
T2 162-174 HP_0100273 denotes colon cancer
T3 168-174 HP_0002664 denotes cancer
T4 304-310 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_24924810_1_0 116-130 expanded denotes Lynch syndrome
SS2_24924810_1_0 132-134 abbr denotes LS
SS1_24924810_1_1 195-210 expanded denotes mismatch repair
SS2_24924810_1_1 212-215 abbr denotes MMR
AE1_24924810_1_0 SS1_24924810_1_0 SS2_24924810_1_0 abbreviatedTo Lynch syndrome,LS
AE1_24924810_1_1 SS1_24924810_1_1 SS2_24924810_1_1 abbreviatedTo mismatch repair,MMR

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-115 DRI_Challenge denotes Assessing how reduced expression levels of the mismatch repair genes MLH1, MSH2, and MSH6 affect repair efficiency.
T2 116-229 DRI_Background denotes Lynch syndrome (LS), the most common familial colon cancer, is associated with mismatch repair (MMR) malfunction.
T3 230-379 DRI_Background denotes As mutation carriers inherit one normal and one defected MMR gene allele, cancer risk can be considered as limited amount of normal MMR gene product.
T4 380-474 DRI_Outcome denotes How reductions in different MMR gene expressions affect MMR capability is, however, not known.
T5 475-691 DRI_Challenge denotes The in vitro MMR assay is a method for the pathogenicity assessment of MMR gene variants causing functional or expressional defects and thus also suitable to evaluate the effects of reduced expression of normal mRNA.
T6 692-873 DRI_Background denotes Here, the assay was applied to quantify repair efficiencies of human cells retaining varying expression levels (25%/50%/75%) of the main LS susceptibility genes MLH1, MSH2, or MSH6.
T7 874-1050 DRI_Outcome denotes Compared with the shRNA knockdown control, already a 50% reduction in mRNA levels could be detected as decreased MMR function although without statistical significance in MLH1.
T8 1051-1221 DRI_Background denotes In MSH2 and MLH1, total loss of MMR was achieved with 25% expression, whereas in MSH6 and MSH2, the repair capability decreased significantly already with 75% expression.
T9 1222-1425 DRI_Outcome denotes Our results provide a preliminary indication of relative expressions required for wild-type function and suggest that the in vitro MMR assay could be used to recognize expression levels indicative of LS.