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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
10065 0-26 GeneOrGeneProduct denotes Thyroid hormone receptor α NCBIGene:21833
10066 56-65 ChemicalEntity denotes thyroxine MESH:D013974
10067 76-94 DiseaseOrPhenotypicFeature denotes skeletal dysplasia MESH:D001848
10068 105-109 OrganismTaxon denotes mice NCBITaxon:10090
10069 184-188 GeneOrGeneProduct denotes THRA NCBIGene:7067
10070 199-226 GeneOrGeneProduct denotes thyroid hormone receptor α1 NCBIGene:7067
10071 228-232 GeneOrGeneProduct denotes TRα1 NCBIGene:7067
10072 271-273 ChemicalEntity denotes T3 MESH:D014284
10073 274-276 ChemicalEntity denotes T4 MESH:D013974
10074 307-327 DiseaseOrPhenotypicFeature denotes intellectual deficit MESH:D008607
10075 332-344 DiseaseOrPhenotypicFeature denotes constipation MESH:D003248
10076 379-397 DiseaseOrPhenotypicFeature denotes skeletal dysplasia MESH:D001848
10077 424-443 DiseaseOrPhenotypicFeature denotes developmental delay MESH:D002658
10078 470-484 DiseaseOrPhenotypicFeature denotes hypothyroidism MESH:D007037
10079 486-494 OrganismTaxon denotes patients NCBITaxon:9606
10080 540-542 ChemicalEntity denotes T4 MESH:D013974
10081 599-604 GeneOrGeneProduct denotes Thra1 NCBIGene:21833
10082 611-615 OrganismTaxon denotes mice NCBITaxon:10090
10083 666-670 GeneOrGeneProduct denotes TRα1 NCBIGene:21833
10084 764-769 GeneOrGeneProduct denotes Thra1 NCBIGene:21833
10085 776-780 OrganismTaxon denotes mice NCBITaxon:10090
10086 830-835 OrganismTaxon denotes human NCBITaxon:9606
10087 836-840 GeneOrGeneProduct denotes THRA NCBIGene:7067
10088 927-929 ChemicalEntity denotes T4 MESH:D013974
10089 946-968 DiseaseOrPhenotypicFeature denotes skeletal abnormalities MESH:D001847
10090 983-988 GeneOrGeneProduct denotes Thra1 NCBIGene:21833
10091 995-999 OrganismTaxon denotes mice NCBITaxon:10090
10092 1004-1017 DiseaseOrPhenotypicFeature denotes short stature MESH:D006130
10093 1110-1112 ChemicalEntity denotes T4 MESH:D013974
10094 1134-1137 GeneOrGeneProduct denotes TSH NCBIGene:12640|NCBIGene:22094
10095 1264-1293 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone MESH:D018382
10096 1319-1321 ChemicalEntity denotes T4 MESH:D013974
10097 1481-1485 GeneOrGeneProduct denotes TRα1 NCBIGene:7067
10098 1562-1570 OrganismTaxon denotes patients NCBITaxon:9606
10099 1586-1590 GeneOrGeneProduct denotes THRA NCBIGene:7067
10100 1636-1638 ChemicalEntity denotes T4 MESH:D013974

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 105-109 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T3 611-615 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T5 776-780 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T7 830-835 OrganismTaxon denotes human NCBItxid:9606
T8 995-999 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.
T2 111-234 Sentence denotes A new genetic disorder has been identified that results from mutation of THRA, encoding thyroid hormone receptor α1 (TRα1).
T3 235-398 Sentence denotes Affected children have a high serum T3:T4 ratio and variable degrees of intellectual deficit and constipation but exhibit a consistently severe skeletal dysplasia.
T4 399-598 Sentence denotes In an attempt to improve developmental delay and alleviate symptoms of hypothyroidism, patients are receiving varying doses and durations of T4 treatment, but responses have been inconsistent so far.
T5 599-742 Sentence denotes Thra1(PV/+) mice express a similar potent dominant-negative mutant TRα1 to affected individuals, and thus represent an excellent disease model.
T6 743-969 Sentence denotes We hypothesized that Thra1(PV/+) mice could be used to predict the skeletal outcome of human THRA mutations and determine whether prolonged treatment with a supraphysiological dose of T4 ameliorates the skeletal abnormalities.
T7 970-1100 Sentence denotes Adult female Thra1(PV/+) mice had short stature, grossly abnormal bone morphology but normal bone strength despite high bone mass.
T8 1101-1294 Sentence denotes Although T4 treatment suppressed TSH secretion, it had no effect on skeletal maturation, linear growth, or bone mineralization, thus demonstrating profound tissue resistance to thyroid hormone.
T9 1295-1453 Sentence denotes Despite this, prolonged T4 treatment abnormally increased bone stiffness and strength, suggesting the potential for detrimental consequences in the long term.
T10 1454-1705 Sentence denotes Our studies establish that TRα1 has an essential role in the developing and adult skeleton and predict that patients with different THRA mutations will display variable responses to T4 treatment, which depend on the severity of the causative mutation.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 0-7 DiseaseOrPhenotypicFeature denotes Thyroid 0004126
T2 199-206 DiseaseOrPhenotypicFeature denotes thyroid 0004126
T3 470-484 DiseaseOrPhenotypicFeature denotes hypothyroidism 0005420
T4 1278-1285 DiseaseOrPhenotypicFeature denotes thyroid 0004126

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 8-24 GeneOrGeneProduct denotes hormone receptor
T2 27-35 GeneOrGeneProduct denotes mutation
T3 105-109 GeneOrGeneProduct denotes mice
T4 172-180 GeneOrGeneProduct denotes mutation
T5 184-188 GeneOrGeneProduct denotes THRA
T6 199-223 GeneOrGeneProduct denotes thyroid hormone receptor
T7 260-264 GeneOrGeneProduct denotes high
T8 271-276 GeneOrGeneProduct denotes T3:T4
T9 509-516 GeneOrGeneProduct denotes varying
T10 599-604 GeneOrGeneProduct denotes Thra1
T11 611-615 GeneOrGeneProduct denotes mice
T12 626-633 GeneOrGeneProduct denotes similar
T13 659-665 GeneOrGeneProduct denotes mutant
T14 764-769 GeneOrGeneProduct denotes Thra1
T15 776-780 GeneOrGeneProduct denotes mice
T16 798-805 GeneOrGeneProduct denotes predict
T17 836-840 GeneOrGeneProduct denotes THRA
T18 841-850 GeneOrGeneProduct denotes mutations
T19 855-864 GeneOrGeneProduct denotes determine
T20 983-988 GeneOrGeneProduct denotes Thra1
T21 995-999 GeneOrGeneProduct denotes mice
T22 1010-1017 GeneOrGeneProduct denotes stature
T23 1036-1040 GeneOrGeneProduct denotes bone
T24 1063-1067 GeneOrGeneProduct denotes bone
T25 1068-1076 GeneOrGeneProduct denotes strength
T26 1085-1089 GeneOrGeneProduct denotes high
T27 1090-1094 GeneOrGeneProduct denotes bone
T28 1095-1099 GeneOrGeneProduct denotes mass
T29 1138-1151 GeneOrGeneProduct denotes secretion, it
T30 1178-1188 GeneOrGeneProduct denotes maturation
T31 1197-1203 GeneOrGeneProduct denotes growth
T32 1208-1212 GeneOrGeneProduct denotes bone
T33 1278-1293 GeneOrGeneProduct denotes thyroid hormone
T34 1353-1357 GeneOrGeneProduct denotes bone
T35 1358-1367 GeneOrGeneProduct denotes stiffness
T36 1372-1380 GeneOrGeneProduct denotes strength
T37 1443-1447 GeneOrGeneProduct denotes long
T38 1448-1452 GeneOrGeneProduct denotes term
T39 1545-1556 GeneOrGeneProduct denotes and predict
T40 1586-1590 GeneOrGeneProduct denotes THRA
T41 1591-1600 GeneOrGeneProduct denotes mutations
T42 1696-1704 GeneOrGeneProduct denotes mutation

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 8-24 GeneOrGeneProduct denotes hormone receptor
T2 184-188 GeneOrGeneProduct denotes THRA
T3 199-223 GeneOrGeneProduct denotes thyroid hormone receptor
T4 260-264 GeneOrGeneProduct denotes high
T5 271-276 GeneOrGeneProduct denotes T3:T4
T6 599-604 GeneOrGeneProduct denotes Thra1
T7 626-633 GeneOrGeneProduct denotes similar
T8 659-665 GeneOrGeneProduct denotes mutant
T9 764-769 GeneOrGeneProduct denotes Thra1
T10 836-840 GeneOrGeneProduct denotes THRA
T11 983-988 GeneOrGeneProduct denotes Thra1
T12 1010-1017 GeneOrGeneProduct denotes stature
T13 1068-1076 GeneOrGeneProduct denotes strength
T14 1085-1089 GeneOrGeneProduct denotes high
T15 1178-1188 GeneOrGeneProduct denotes maturation
T16 1197-1203 GeneOrGeneProduct denotes growth
T17 1278-1293 GeneOrGeneProduct denotes thyroid hormone
T18 1358-1367 GeneOrGeneProduct denotes stiffness
T19 1372-1380 GeneOrGeneProduct denotes strength
T20 1448-1452 GeneOrGeneProduct denotes term
T21 1586-1590 GeneOrGeneProduct denotes THRA

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 117-133 DiseaseOrPhenotypicFeature denotes genetic disorder D030342
T2 332-344 DiseaseOrPhenotypicFeature denotes constipation D003248
T3 424-443 DiseaseOrPhenotypicFeature denotes developmental delay DISEASE
T4 470-484 DiseaseOrPhenotypicFeature denotes hypothyroidism D007037
T5 728-735 DiseaseOrPhenotypicFeature denotes disease D004194
T6 1264-1293 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone D018382

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 8-24 GeneOrGeneProduct denotes hormone receptor
T2 184-188 GeneOrGeneProduct denotes THRA
T3 199-223 GeneOrGeneProduct denotes thyroid hormone receptor
T4 271-276 GeneOrGeneProduct denotes T3:T4
T5 599-604 GeneOrGeneProduct denotes Thra1
T6 764-769 GeneOrGeneProduct denotes Thra1
T7 836-840 GeneOrGeneProduct denotes THRA
T8 983-988 GeneOrGeneProduct denotes Thra1
T9 1010-1017 GeneOrGeneProduct denotes stature
T10 1068-1076 GeneOrGeneProduct denotes strength
T11 1358-1367 GeneOrGeneProduct denotes stiffness
T12 1372-1380 GeneOrGeneProduct denotes strength
T13 1586-1590 GeneOrGeneProduct denotes THRA

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 76-94 DiseaseOrPhenotypicFeature denotes skeletal dysplasia 0005516
T2 117-133 DiseaseOrPhenotypicFeature denotes genetic disorder 0003847
T3 332-344 DiseaseOrPhenotypicFeature denotes constipation 0002203
T4 379-397 DiseaseOrPhenotypicFeature denotes skeletal dysplasia 0005516
T5 470-484 DiseaseOrPhenotypicFeature denotes hypothyroidism 0005420
T6 605-607 DiseaseOrPhenotypicFeature denotes PV 0009891
T7 770-772 DiseaseOrPhenotypicFeature denotes PV 0009891
T8 989-991 DiseaseOrPhenotypicFeature denotes PV 0009891

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 76-94 DiseaseOrPhenotypicFeature denotes skeletal dysplasia DISEASE
T2 117-133 DiseaseOrPhenotypicFeature denotes genetic disorder D030342
T3 307-327 DiseaseOrPhenotypicFeature denotes intellectual deficit DISEASE
T4 332-344 DiseaseOrPhenotypicFeature denotes constipation D003248
T5 379-397 DiseaseOrPhenotypicFeature denotes skeletal dysplasia DISEASE
T6 424-443 DiseaseOrPhenotypicFeature denotes developmental delay DISEASE
T7 470-484 DiseaseOrPhenotypicFeature denotes hypothyroidism D007037
T8 728-735 DiseaseOrPhenotypicFeature denotes disease D004194
T9 946-968 DiseaseOrPhenotypicFeature denotes skeletal abnormalities DISEASE
T10 1004-1017 DiseaseOrPhenotypicFeature denotes short stature DISEASE
T11 1264-1293 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone D018382

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 76-94 DiseaseOrPhenotypicFeature denotes skeletal dysplasia DISEASE
T2 307-327 DiseaseOrPhenotypicFeature denotes intellectual deficit DISEASE
T3 332-344 DiseaseOrPhenotypicFeature denotes constipation D003248
T4 379-397 DiseaseOrPhenotypicFeature denotes skeletal dysplasia DISEASE
T5 424-443 DiseaseOrPhenotypicFeature denotes developmental delay DISEASE
T6 470-484 DiseaseOrPhenotypicFeature denotes hypothyroidism D007037
T7 946-968 DiseaseOrPhenotypicFeature denotes skeletal abnormalities DISEASE
T8 1004-1017 DiseaseOrPhenotypicFeature denotes short stature DISEASE
T9 1264-1293 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone D018382

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-15 ChemicalEntity denotes Thyroid hormone D013963
T2 56-65 ChemicalEntity denotes thyroxine http://purl.obolibrary.org/obo/CHEBI_30660|http://purl.obolibrary.org/obo/CHEBI_305790
T4 199-214 ChemicalEntity denotes thyroid hormone D013963
T5 1134-1137 ChemicalEntity denotes TSH http://purl.obolibrary.org/obo/CHEBI_17842|http://purl.obolibrary.org/obo/CHEBI_137741
T7 1278-1293 ChemicalEntity denotes thyroid hormone D013963

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 105-109 OrganismTaxon denotes mice
T2 486-494 OrganismTaxon denotes patients
T3 611-615 OrganismTaxon denotes mice
T4 776-780 OrganismTaxon denotes mice
T5 830-835 OrganismTaxon denotes human
T6 995-999 OrganismTaxon denotes mice
T7 1562-1570 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T7 1278-1293 ChemicalEntity denotes thyroid hormone D013963
T5 1134-1137 ChemicalEntity denotes TSH http://purl.obolibrary.org/obo/CHEBI_137741|http://purl.obolibrary.org/obo/CHEBI_17842
T4 199-214 ChemicalEntity denotes thyroid hormone D013963
T2 56-65 ChemicalEntity denotes thyroxine http://purl.obolibrary.org/obo/CHEBI_305790|http://purl.obolibrary.org/obo/CHEBI_30660
T1 0-15 ChemicalEntity denotes Thyroid hormone D013963
T13 1586-1590 GeneOrGeneProduct denotes THRA
T12 1372-1380 GeneOrGeneProduct denotes strength
T11 1358-1367 GeneOrGeneProduct denotes stiffness
T10 1068-1076 GeneOrGeneProduct denotes strength
T9 1010-1017 GeneOrGeneProduct denotes stature
T8 983-988 GeneOrGeneProduct denotes Thra1
T51264 836-840 GeneOrGeneProduct denotes THRA
T6 764-769 GeneOrGeneProduct denotes Thra1
T90899 599-604 GeneOrGeneProduct denotes Thra1
T50076 271-276 GeneOrGeneProduct denotes T3:T4
T3 199-223 GeneOrGeneProduct denotes thyroid hormone receptor
T26478 184-188 GeneOrGeneProduct denotes THRA
T71274 8-24 GeneOrGeneProduct denotes hormone receptor
T85265 1264-1293 DiseaseOrPhenotypicFeature denotes resistance to thyroid hormone D018382
T5218 1004-1017 DiseaseOrPhenotypicFeature denotes short stature DISEASE
T12299 946-968 DiseaseOrPhenotypicFeature denotes skeletal abnormalities DISEASE
T574 470-484 DiseaseOrPhenotypicFeature denotes hypothyroidism D007037
T78347 424-443 DiseaseOrPhenotypicFeature denotes developmental delay DISEASE
T177 379-397 DiseaseOrPhenotypicFeature denotes skeletal dysplasia DISEASE
T80375 332-344 DiseaseOrPhenotypicFeature denotes constipation D003248
T11184 307-327 DiseaseOrPhenotypicFeature denotes intellectual deficit DISEASE
T65118 76-94 DiseaseOrPhenotypicFeature denotes skeletal dysplasia DISEASE
T22901 1562-1570 OrganismTaxon denotes patients
T82959 995-999 OrganismTaxon denotes mice
T69093 830-835 OrganismTaxon denotes human
T36879 776-780 OrganismTaxon denotes mice
T31783 611-615 OrganismTaxon denotes mice
T10962 486-494 OrganismTaxon denotes patients
T29646 105-109 OrganismTaxon denotes mice

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-26 gene:7067 denotes Thyroid hormone receptor α
T1 76-94 disease:C0410528 denotes skeletal dysplasia
T2 184-188 gene:7067 denotes THRA
T3 117-133 disease:C0019247 denotes genetic disorder
T4 983-988 gene:9572 denotes Thra1
T5 1004-1017 disease:C0013336 denotes short stature
T6 983-988 gene:7067 denotes Thra1
T7 1004-1017 disease:C0013336 denotes short stature
R1 T0 T1 associated_with Thyroid hormone receptor α,skeletal dysplasia
R2 T2 T3 associated_with THRA,genetic disorder
R3 T4 T5 associated_with Thra1,short stature
R4 T6 T7 associated_with Thra1,short stature

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 332-344 HP_0002019 denotes constipation
T2 379-397 HP_0002652 denotes skeletal dysplasia
T3 424-443 HP_0001263 denotes developmental delay
T4 470-484 HP_0000821 denotes hypothyroidism
T5 946-968 HP_0000924 denotes skeletal abnormalities
T6 1004-1017 HP_0004322 denotes short stature
T7 1264-1293 HP_0002930 denotes resistance to thyroid hormone

Allie

Id Subject Object Predicate Lexical cue
SS1_24914936_1_0 199-226 expanded denotes thyroid hormone receptor α1
SS2_24914936_1_0 228-232 abbr denotes TRα1
AE1_24914936_1_0 SS1_24914936_1_0 SS2_24914936_1_0 abbreviatedTo thyroid hormone receptor α1,TRα1

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24914936-0#0#26#gene105371807 0-26 gene105371807 denotes Thyroid hormone receptor α
24914936-0#0#26#gene7067 0-26 gene7067 denotes Thyroid hormone receptor α
24914936-0#76#94#diseaseC0029422 76-94 diseaseC0029422 denotes skeletal dysplasia
24914936-0#76#94#diseaseC0410528 76-94 diseaseC0410528 denotes skeletal dysplasia
24914936-0#76#94#diseaseC0029422 76-94 diseaseC0029422 denotes skeletal dysplasia
24914936-0#76#94#diseaseC0410528 76-94 diseaseC0410528 denotes skeletal dysplasia
24914936-5#21#26#gene9572 764-769 gene9572 denotes Thra1
24914936-5#21#26#gene7067 764-769 gene7067 denotes Thra1
24914936-5#93#97#gene7067 836-840 gene7067 denotes THRA
24914936-5#203#225#diseaseC4021790 946-968 diseaseC4021790 denotes skeletal abnormalities
24914936-6#13#18#gene9572 983-988 gene9572 denotes Thra1
24914936-6#13#18#gene7067 983-988 gene7067 denotes Thra1
24914936-6#34#47#diseaseC0013336 1004-1017 diseaseC0013336 denotes short stature
0#26#gene10537180776#94#diseaseC0029422 24914936-0#0#26#gene105371807 24914936-0#76#94#diseaseC0029422 associated_with Thyroid hormone receptor α,skeletal dysplasia
0#26#gene10537180776#94#diseaseC0410528 24914936-0#0#26#gene105371807 24914936-0#76#94#diseaseC0410528 associated_with Thyroid hormone receptor α,skeletal dysplasia
0#26#gene10537180776#94#diseaseC0029422 24914936-0#0#26#gene105371807 24914936-0#76#94#diseaseC0029422 associated_with Thyroid hormone receptor α,skeletal dysplasia
0#26#gene10537180776#94#diseaseC0410528 24914936-0#0#26#gene105371807 24914936-0#76#94#diseaseC0410528 associated_with Thyroid hormone receptor α,skeletal dysplasia
0#26#gene706776#94#diseaseC0029422 24914936-0#0#26#gene7067 24914936-0#76#94#diseaseC0029422 associated_with Thyroid hormone receptor α,skeletal dysplasia
0#26#gene706776#94#diseaseC0410528 24914936-0#0#26#gene7067 24914936-0#76#94#diseaseC0410528 associated_with Thyroid hormone receptor α,skeletal dysplasia
0#26#gene706776#94#diseaseC0029422 24914936-0#0#26#gene7067 24914936-0#76#94#diseaseC0029422 associated_with Thyroid hormone receptor α,skeletal dysplasia
0#26#gene706776#94#diseaseC0410528 24914936-0#0#26#gene7067 24914936-0#76#94#diseaseC0410528 associated_with Thyroid hormone receptor α,skeletal dysplasia
21#26#gene9572203#225#diseaseC4021790 24914936-5#21#26#gene9572 24914936-5#203#225#diseaseC4021790 associated_with Thra1,skeletal abnormalities
21#26#gene7067203#225#diseaseC4021790 24914936-5#21#26#gene7067 24914936-5#203#225#diseaseC4021790 associated_with Thra1,skeletal abnormalities
93#97#gene7067203#225#diseaseC4021790 24914936-5#93#97#gene7067 24914936-5#203#225#diseaseC4021790 associated_with THRA,skeletal abnormalities
13#18#gene957234#47#diseaseC0013336 24914936-6#13#18#gene9572 24914936-6#34#47#diseaseC0013336 associated_with Thra1,short stature
13#18#gene706734#47#diseaseC0013336 24914936-6#13#18#gene7067 24914936-6#34#47#diseaseC0013336 associated_with Thra1,short stature