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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-151 Sentence denotes Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model.
TextSentencer_T2 152-333 Sentence denotes Although great advances have been made in the treatment of pediatric acute lymphoblastic leukemia, up to one of five patients will relapse, and their prognosis thereafter is dismal.
TextSentencer_T3 334-511 Sentence denotes We have previously identified recurrent deletions in TBL1XR1, which encodes for an F-box like protein responsible for regulating the nuclear hormone repressor complex stability.
TextSentencer_T4 512-814 Sentence denotes Here we model TBL1XR1 deletions in B-precursor ALL cell lines and show that TBL1XR1 knockdown results in reduced glucocorticoid receptor recruitment to glucocorticoid responsive genes and ultimately decreased glucocorticoid signaling caused by increased levels of nuclear hormone repressor 1 and HDAC3.
TextSentencer_T5 815-971 Sentence denotes Reduction in glucocorticoid signaling in TBL1XR1-depleted lines resulted in resistance to glucocorticoid agonists, but not to other chemotherapeutic agents.
TextSentencer_T6 972-1100 Sentence denotes Importantly, we show that treatment with the HDAC inhibitor SAHA restores sensitivity to prednisolone in TBL1XR1-depleted cells.
TextSentencer_T7 1101-1303 Sentence denotes Altogether, our data indicate that loss of TBL1XR1 is a novel driver of glucocorticoid resistance in ALL and that epigenetic therapy may have future application in restoring drug sensitivity at relapse.
T1 0-151 Sentence denotes Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model.
T2 152-333 Sentence denotes Although great advances have been made in the treatment of pediatric acute lymphoblastic leukemia, up to one of five patients will relapse, and their prognosis thereafter is dismal.
T3 334-511 Sentence denotes We have previously identified recurrent deletions in TBL1XR1, which encodes for an F-box like protein responsible for regulating the nuclear hormone repressor complex stability.
T4 512-814 Sentence denotes Here we model TBL1XR1 deletions in B-precursor ALL cell lines and show that TBL1XR1 knockdown results in reduced glucocorticoid receptor recruitment to glucocorticoid responsive genes and ultimately decreased glucocorticoid signaling caused by increased levels of nuclear hormone repressor 1 and HDAC3.
T5 815-971 Sentence denotes Reduction in glucocorticoid signaling in TBL1XR1-depleted lines resulted in resistance to glucocorticoid agonists, but not to other chemotherapeutic agents.
T6 972-1100 Sentence denotes Importantly, we show that treatment with the HDAC inhibitor SAHA restores sensitivity to prednisolone in TBL1XR1-depleted cells.
T7 1101-1303 Sentence denotes Altogether, our data indicate that loss of TBL1XR1 is a novel driver of glucocorticoid resistance in ALL and that epigenetic therapy may have future application in restoring drug sensitivity at relapse.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 8-15 gene:79718 denotes TBL1XR1
T1 122-144 disease:C0023449 denotes lymphoblastic leukemia
T2 25-48 gene:2908 denotes glucocorticoid receptor
T3 122-144 disease:C1961102 denotes lymphoblastic leukemia
T4 25-48 gene:2908 denotes glucocorticoid receptor
T5 122-144 disease:C0023449 denotes lymphoblastic leukemia
T6 25-48 gene:2908 denotes glucocorticoid receptor
T7 122-144 disease:C0023448 denotes lymphoblastic leukemia
T8 8-15 gene:79718 denotes TBL1XR1
T9 89-114 disease:C1841972 denotes glucocorticoid resistance
T10 8-15 gene:79718 denotes TBL1XR1
T11 122-144 disease:C0023448 denotes lymphoblastic leukemia
T12 25-48 gene:2908 denotes glucocorticoid receptor
T13 89-114 disease:C1841972 denotes glucocorticoid resistance
T14 8-15 gene:79718 denotes TBL1XR1
T15 122-144 disease:C1961102 denotes lymphoblastic leukemia
T16 526-533 gene:79718 denotes TBL1XR1
T17 547-562 disease:C1292769 denotes B-precursor ALL
T18 808-813 gene:8841 denotes HDAC3
T19 547-562 disease:C1292769 denotes B-precursor ALL
T20 625-648 gene:2908 denotes glucocorticoid receptor
T21 547-562 disease:C1292769 denotes B-precursor ALL
T22 588-595 gene:79718 denotes TBL1XR1
T23 547-562 disease:C1292769 denotes B-precursor ALL
T24 1144-1151 gene:79718 denotes TBL1XR1
T25 1173-1198 disease:C1841972 denotes glucocorticoid resistance
R1 T0 T1 associated_with TBL1XR1,lymphoblastic leukemia
R2 T2 T3 associated_with glucocorticoid receptor,lymphoblastic leukemia
R3 T4 T5 associated_with glucocorticoid receptor,lymphoblastic leukemia
R4 T6 T7 associated_with glucocorticoid receptor,lymphoblastic leukemia
R5 T8 T9 associated_with TBL1XR1,glucocorticoid resistance
R6 T10 T11 associated_with TBL1XR1,lymphoblastic leukemia
R7 T12 T13 associated_with glucocorticoid receptor,glucocorticoid resistance
R8 T14 T15 associated_with TBL1XR1,lymphoblastic leukemia
R9 T16 T17 associated_with TBL1XR1,B-precursor ALL
R10 T18 T19 associated_with HDAC3,B-precursor ALL
R11 T20 T21 associated_with glucocorticoid receptor,B-precursor ALL
R12 T22 T23 associated_with TBL1XR1,B-precursor ALL
R13 T24 T25 associated_with TBL1XR1,glucocorticoid resistance

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 221-249 HP_0006721 denotes acute lymphoblastic leukemia
T2 241-249 HP_0001909 denotes leukemia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24895125-0#8#15#gene79718 8-15 gene79718 denotes TBL1XR1
24895125-0#25#48#gene2908 25-48 gene2908 denotes glucocorticoid receptor
24895125-0#8#15#gene79718 8-15 gene79718 denotes TBL1XR1
24895125-0#25#48#gene2908 25-48 gene2908 denotes glucocorticoid receptor
24895125-0#122#144#diseaseC0023448 122-144 diseaseC0023448 denotes lymphoblastic leukemia
24895125-0#122#144#diseaseC0023449 122-144 diseaseC0023449 denotes lymphoblastic leukemia
24895125-0#122#144#diseaseC1961102 122-144 diseaseC1961102 denotes lymphoblastic leukemia
24895125-0#122#144#diseaseC0023448 122-144 diseaseC0023448 denotes lymphoblastic leukemia
24895125-0#122#144#diseaseC0023449 122-144 diseaseC0023449 denotes lymphoblastic leukemia
24895125-0#122#144#diseaseC1961102 122-144 diseaseC1961102 denotes lymphoblastic leukemia
24895125-0#89#114#diseaseC1841972 89-114 diseaseC1841972 denotes glucocorticoid resistance
24895125-3#14#21#gene79718 526-533 gene79718 denotes TBL1XR1
24895125-3#76#83#gene79718 588-595 gene79718 denotes TBL1XR1
24895125-3#113#136#gene2908 625-648 gene2908 denotes glucocorticoid receptor
24895125-3#296#301#gene8841 808-813 gene8841 denotes HDAC3
24895125-3#35#50#diseaseC1292769 547-562 diseaseC1292769 denotes B-precursor ALL
8#15#gene79718122#144#diseaseC0023448 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC0023448 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC0023449 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC0023449 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC1961102 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC1961102 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC0023448 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC0023448 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC0023449 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC0023449 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC1961102 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC1961102 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene7971889#114#diseaseC1841972 24895125-0#8#15#gene79718 24895125-0#89#114#diseaseC1841972 associated_with TBL1XR1,glucocorticoid resistance
25#48#gene2908122#144#diseaseC0023448 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC0023448 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC0023449 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC0023449 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC1961102 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC1961102 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC0023448 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC0023448 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC0023449 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC0023449 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC1961102 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC1961102 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene290889#114#diseaseC1841972 24895125-0#25#48#gene2908 24895125-0#89#114#diseaseC1841972 associated_with glucocorticoid receptor,glucocorticoid resistance
8#15#gene79718122#144#diseaseC0023448 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC0023448 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC0023449 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC0023449 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC1961102 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC1961102 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC0023448 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC0023448 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC0023449 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC0023449 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene79718122#144#diseaseC1961102 24895125-0#8#15#gene79718 24895125-0#122#144#diseaseC1961102 associated_with TBL1XR1,lymphoblastic leukemia
8#15#gene7971889#114#diseaseC1841972 24895125-0#8#15#gene79718 24895125-0#89#114#diseaseC1841972 associated_with TBL1XR1,glucocorticoid resistance
25#48#gene2908122#144#diseaseC0023448 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC0023448 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC0023449 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC0023449 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC1961102 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC1961102 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC0023448 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC0023448 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC0023449 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC0023449 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene2908122#144#diseaseC1961102 24895125-0#25#48#gene2908 24895125-0#122#144#diseaseC1961102 associated_with glucocorticoid receptor,lymphoblastic leukemia
25#48#gene290889#114#diseaseC1841972 24895125-0#25#48#gene2908 24895125-0#89#114#diseaseC1841972 associated_with glucocorticoid receptor,glucocorticoid resistance
14#21#gene7971835#50#diseaseC1292769 24895125-3#14#21#gene79718 24895125-3#35#50#diseaseC1292769 associated_with TBL1XR1,B-precursor ALL
76#83#gene7971835#50#diseaseC1292769 24895125-3#76#83#gene79718 24895125-3#35#50#diseaseC1292769 associated_with TBL1XR1,B-precursor ALL
113#136#gene290835#50#diseaseC1292769 24895125-3#113#136#gene2908 24895125-3#35#50#diseaseC1292769 associated_with glucocorticoid receptor,B-precursor ALL
296#301#gene884135#50#diseaseC1292769 24895125-3#296#301#gene8841 24895125-3#35#50#diseaseC1292769 associated_with HDAC3,B-precursor ALL

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T105 8-15 gene:79718 denotes TBL1XR1
T106 122-144 disease:C0023448 denotes lymphoblastic leukemia
T107 25-48 gene:2908 denotes glucocorticoid receptor
R1 T105 T106 associated_with TBL1XR1,lymphoblastic leukemia
R2 T105 T106 associated_with TBL1XR1,lymphoblastic leukemia
R3 T105 T106 associated_with TBL1XR1,lymphoblastic leukemia
R4 T107 T106 associated_with glucocorticoid receptor,lymphoblastic leukemia
R5 T107 T106 associated_with glucocorticoid receptor,lymphoblastic leukemia
R6 T107 T106 associated_with glucocorticoid receptor,lymphoblastic leukemia

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 136-144 Phenotype denotes leukemia HP:0001909
T2 221-249 Phenotype denotes acute lymphoblastic leukemia HP:0006721

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 89-114 Disease denotes glucocorticoid resistance http://purl.obolibrary.org/obo/MONDO_0014421
T2 122-144 Disease denotes lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0001018|http://purl.obolibrary.org/obo/MONDO_0004967
T4 211-249 Disease denotes pediatric acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0000870
T5 547-562 Disease denotes B-precursor ALL http://purl.obolibrary.org/obo/MONDO_0020511
T6 1173-1198 Disease denotes glucocorticoid resistance http://purl.obolibrary.org/obo/MONDO_0014421

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 120-135 Cell denotes B-lymphoblastic http://purl.obolibrary.org/obo/CL:0017006
T2 227-240 Cell denotes lymphoblastic http://purl.obolibrary.org/obo/CL:0017005