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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 558-562 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-151 Sentence denotes Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.
T2 152-330 Sentence denotes Acute treatment with metformin has a protective effect in myocardial infarction by suppression of inflammatory responses due to activation of AMP-activated protein kinase (AMPK).
T3 331-545 Sentence denotes In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation with AMPK were assessed.
T4 546-759 Sentence denotes Male Wistar rats were randomly assigned to one of 5 groups (n=6): normal control and groups were injected isoproterenol after chronic pre-treatment with 0, 25, 50, or 100mg/kg of metformin twice daily for 14 days.
T5 760-877 Sentence denotes Isoproterenol (100mg/kg) was injected subcutaneously on the 13th and 14th days to induce acute myocardial infarction.
T6 878-1009 Sentence denotes Isoproterenol alone decreased left ventricular systolic pressure and myocardial contractility indexed as LVdp/dtmax and LVdp/dtmin.
T7 1010-1122 Sentence denotes The left ventricular dysfunction was significantly lower in the groups treated with 25 and 50mg/kg of metformin.
T8 1123-1337 Sentence denotes Metfromin markedly lowered isoproterenol-induced elevation in the levels of TLR4 mRNA, myeloid differentiation protein 88 (MyD88), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) in the heart tissues.
T9 1338-1407 Sentence denotes Similar changes were also seen in the serum levels of TNF-α and IL-6.
T10 1408-1485 Sentence denotes However, the lower doses of 25 and 50mg/kg were more effective than 100mg/kg.
T11 1486-1627 Sentence denotes Phosphorylated AMPKα (p-AMPK) in the myocardium was significantly elevated by 25mg/kg of metformin, slightly by 50mg/kg, but not by 100mg/kg.
T12 1628-1806 Sentence denotes Chronic pre-treatment with metformin reduces post-myocardial infarction cardiac dysfunction and suppresses inflammatory responses, possibly through inhibition of TLR4 activities.
T13 1807-1884 Sentence denotes This mechanism can be considered as a target to protect infarcted myocardium.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9969 23-32 ChemicalEntity denotes metformin MESH:D008687
9970 44-64 GeneOrGeneProduct denotes toll-like receptor 4 NCBIGene:29260
9971 90-118 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction MESH:D018487
9972 129-150 DiseaseOrPhenotypicFeature denotes myocardial infarction MESH:D009203
9973 173-182 ChemicalEntity denotes metformin MESH:D008687
9974 210-231 DiseaseOrPhenotypicFeature denotes myocardial infarction MESH:D009203
9975 250-262 DiseaseOrPhenotypicFeature denotes inflammatory MESH:D007249
9976 294-322 GeneOrGeneProduct denotes AMP-activated protein kinase NCBIGene:65248
9977 324-328 GeneOrGeneProduct denotes AMPK NCBIGene:65248
9978 394-403 ChemicalEntity denotes metformin MESH:D008687
9979 407-426 DiseaseOrPhenotypicFeature denotes cardiac dysfunction MESH:D006331
9980 431-451 GeneOrGeneProduct denotes toll-like receptor 4 NCBIGene:29260
9981 453-457 GeneOrGeneProduct denotes TLR4 NCBIGene:29260
9982 480-501 DiseaseOrPhenotypicFeature denotes myocardial infarction MESH:D009203
9983 526-530 GeneOrGeneProduct denotes AMPK NCBIGene:65248
9984 558-562 OrganismTaxon denotes rats NCBITaxon:10116
9985 652-665 ChemicalEntity denotes isoproterenol MESH:D007545
9986 725-734 ChemicalEntity denotes metformin MESH:D008687
9987 760-773 ChemicalEntity denotes Isoproterenol MESH:D007545
9988 849-876 DiseaseOrPhenotypicFeature denotes acute myocardial infarction MESH:D009203
9989 878-891 ChemicalEntity denotes Isoproterenol MESH:D007545
9990 1014-1042 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction MESH:D018487
9991 1112-1121 ChemicalEntity denotes metformin MESH:D008687
9992 1123-1132 ChemicalEntity denotes Metfromin MESH:D008687
9993 1150-1163 ChemicalEntity denotes isoproterenol MESH:D007545
9994 1199-1203 GeneOrGeneProduct denotes TLR4 NCBIGene:29260
9995 1210-1244 GeneOrGeneProduct denotes myeloid differentiation protein 88 NCBIGene:301059
9996 1246-1251 GeneOrGeneProduct denotes MyD88 NCBIGene:301059
9997 1254-1281 GeneOrGeneProduct denotes tumor necrosis factor-alpha NCBIGene:24835
9998 1283-1288 GeneOrGeneProduct denotes TNF-α NCBIGene:24835
9999 1295-1308 GeneOrGeneProduct denotes interleukin 6 NCBIGene:24498
10000 1310-1314 GeneOrGeneProduct denotes IL-6 NCBIGene:24498
10001 1392-1397 GeneOrGeneProduct denotes TNF-α NCBIGene:24835
10002 1402-1406 GeneOrGeneProduct denotes IL-6 NCBIGene:24498
10003 1501-1506 GeneOrGeneProduct denotes AMPKα NCBIGene:65248
10004 1510-1514 GeneOrGeneProduct denotes AMPK NCBIGene:65248
10005 1575-1584 ChemicalEntity denotes metformin MESH:D008687
10006 1655-1664 ChemicalEntity denotes metformin MESH:D008687
10007 1678-1699 DiseaseOrPhenotypicFeature denotes myocardial infarction MESH:D009203
10008 1700-1719 DiseaseOrPhenotypicFeature denotes cardiac dysfunction MESH:D006331
10009 1735-1747 DiseaseOrPhenotypicFeature denotes inflammatory MESH:D007249
10010 1790-1794 GeneOrGeneProduct denotes TLR4 NCBIGene:29260
10011 1863-1883 DiseaseOrPhenotypicFeature denotes infarcted myocardium MESH:D009203

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 129-150 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T2 210-231 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T3 480-501 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T4 849-876 DiseaseOrPhenotypicFeature denotes acute myocardial infarction 0004781
T5 855-876 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T6 1678-1699 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T2 79-89 GeneOrGeneProduct denotes attenuates
T1 44-64 GeneOrGeneProduct denotes toll-like receptor 4
T3 183-188 GeneOrGeneProduct denotes has a
T4 280-290 GeneOrGeneProduct denotes activation
T5 294-322 GeneOrGeneProduct denotes AMP-activated protein kinase
T6 324-328 GeneOrGeneProduct denotes AMPK
T7 431-451 GeneOrGeneProduct denotes toll-like receptor 4
T8 453-457 GeneOrGeneProduct denotes TLR4
T9 459-469 GeneOrGeneProduct denotes activities
T10 526-530 GeneOrGeneProduct denotes AMPK
T11 546-550 GeneOrGeneProduct denotes Male
T12 706-712 GeneOrGeneProduct denotes 50, or
T13 747-753 GeneOrGeneProduct denotes for 14
T14 842-848 GeneOrGeneProduct denotes induce
T15 1133-1141 GeneOrGeneProduct denotes markedly
T16 1164-1171 GeneOrGeneProduct denotes induced
T17 1199-1203 GeneOrGeneProduct denotes TLR4
T18 1204-1208 GeneOrGeneProduct denotes mRNA
T19 1234-1241 GeneOrGeneProduct denotes protein
T20 1246-1251 GeneOrGeneProduct denotes MyD88
T21 1254-1281 GeneOrGeneProduct denotes tumor necrosis factor-alpha
T22 1295-1308 GeneOrGeneProduct denotes interleukin 6
T23 1310-1314 GeneOrGeneProduct denotes IL-6
T24 1323-1328 GeneOrGeneProduct denotes heart
T25 1338-1345 GeneOrGeneProduct denotes Similar
T26 1402-1406 GeneOrGeneProduct denotes IL-6
T27 1501-1505 GeneOrGeneProduct denotes AMPK
T28 1510-1514 GeneOrGeneProduct denotes AMPK
T29 1586-1594 GeneOrGeneProduct denotes slightly
T30 1665-1672 GeneOrGeneProduct denotes reduces
T31 1673-1677 GeneOrGeneProduct denotes post
T32 1790-1794 GeneOrGeneProduct denotes TLR4
T33 1795-1805 GeneOrGeneProduct denotes activities

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 44-64 GeneOrGeneProduct denotes toll-like receptor 4
T2 294-322 GeneOrGeneProduct denotes AMP-activated protein kinase
T3 324-328 GeneOrGeneProduct denotes AMPK
T4 431-451 GeneOrGeneProduct denotes toll-like receptor 4
T5 453-457 GeneOrGeneProduct denotes TLR4
T6 526-530 GeneOrGeneProduct denotes AMPK
T7 1199-1203 GeneOrGeneProduct denotes TLR4
T8 1204-1208 GeneOrGeneProduct denotes mRNA
T9 1234-1241 GeneOrGeneProduct denotes protein
T10 1246-1251 GeneOrGeneProduct denotes MyD88
T11 1254-1281 GeneOrGeneProduct denotes tumor necrosis factor-alpha
T12 1295-1308 GeneOrGeneProduct denotes interleukin 6
T13 1310-1314 GeneOrGeneProduct denotes IL-6
T14 1323-1328 GeneOrGeneProduct denotes heart
T15 1338-1345 GeneOrGeneProduct denotes Similar
T16 1402-1406 GeneOrGeneProduct denotes IL-6
T17 1501-1505 GeneOrGeneProduct denotes AMPK
T18 1510-1514 GeneOrGeneProduct denotes AMPK
T19 1673-1677 GeneOrGeneProduct denotes post
T20 1790-1794 GeneOrGeneProduct denotes TLR4

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 90-118 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction D018487
T2 129-150 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T3 210-231 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T4 250-262 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T5 407-426 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T6 480-501 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T7 855-876 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T8 1014-1042 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction D018487
T9 1254-1259 DiseaseOrPhenotypicFeature denotes tumor D009369
T10 1260-1268 DiseaseOrPhenotypicFeature denotes necrosis D009336
T11 1678-1699 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T12 1700-1719 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T13 1735-1747 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T14 1863-1872 DiseaseOrPhenotypicFeature denotes infarcted D007238

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 44-64 GeneOrGeneProduct denotes toll-like receptor 4
T2 294-322 GeneOrGeneProduct denotes AMP-activated protein kinase
T3 324-328 GeneOrGeneProduct denotes AMPK
T4 431-451 GeneOrGeneProduct denotes toll-like receptor 4
T5 453-457 GeneOrGeneProduct denotes TLR4
T6 526-530 GeneOrGeneProduct denotes AMPK
T7 1199-1203 GeneOrGeneProduct denotes TLR4
T8 1246-1251 GeneOrGeneProduct denotes MyD88
T9 1254-1281 GeneOrGeneProduct denotes tumor necrosis factor-alpha
T10 1295-1308 GeneOrGeneProduct denotes interleukin 6
T11 1310-1314 GeneOrGeneProduct denotes IL-6
T12 1402-1406 GeneOrGeneProduct denotes IL-6
T13 1501-1505 GeneOrGeneProduct denotes AMPK
T14 1510-1514 GeneOrGeneProduct denotes AMPK
T15 1790-1794 GeneOrGeneProduct denotes TLR4

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 129-150 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T2 210-231 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T3 480-501 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T4 849-876 DiseaseOrPhenotypicFeature denotes acute myocardial infarction 0004781
T5 1254-1259 DiseaseOrPhenotypicFeature denotes tumor 0005070
T6 1678-1699 DiseaseOrPhenotypicFeature denotes myocardial infarction 0005068
T7 1822-1825 DiseaseOrPhenotypicFeature denotes can 0012833

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 90-118 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction D018487
T2 129-150 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T3 210-231 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T4 250-262 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE
T5 407-426 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T6 480-501 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T7 855-876 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T8 1014-1042 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction D018487
T9 1254-1259 DiseaseOrPhenotypicFeature denotes tumor D009369
T10 1260-1268 DiseaseOrPhenotypicFeature denotes necrosis D009336
T11 1678-1699 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T12 1700-1719 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T13 1735-1747 DiseaseOrPhenotypicFeature denotes inflammatory DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 90-118 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction D018487
T2 129-150 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T3 210-231 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T4 407-426 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T5 480-501 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T6 855-876 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T7 1014-1042 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction D018487
T8 1254-1259 DiseaseOrPhenotypicFeature denotes tumor D009369
T9 1678-1699 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T10 1700-1719 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 558-562 OrganismTaxon denotes rats

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 23-32 ChemicalEntity denotes metformin D008687|http://purl.obolibrary.org/obo/CHEBI_6801
T3 173-182 ChemicalEntity denotes metformin D008687|http://purl.obolibrary.org/obo/CHEBI_6801
T5 294-297 ChemicalEntity denotes AMP http://purl.obolibrary.org/obo/CHEBI_456215|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_16027
T8 394-403 ChemicalEntity denotes metformin D008687|http://purl.obolibrary.org/obo/CHEBI_6801
T10 652-665 ChemicalEntity denotes isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T12 725-734 ChemicalEntity denotes metformin D008687|http://purl.obolibrary.org/obo/CHEBI_6801
T14 760-773 ChemicalEntity denotes Isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T16 878-891 ChemicalEntity denotes Isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T18 1112-1121 ChemicalEntity denotes metformin D008687|http://purl.obolibrary.org/obo/CHEBI_6801
T20 1123-1132 ChemicalEntity denotes Metfromin ChemicalEntity
T21 1150-1163 ChemicalEntity denotes isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T23 1575-1584 ChemicalEntity denotes metformin D008687|http://purl.obolibrary.org/obo/CHEBI_6801
T25 1655-1664 ChemicalEntity denotes metformin D008687|http://purl.obolibrary.org/obo/CHEBI_6801

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T25 1655-1664 ChemicalEntity denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801|D008687
T23 1575-1584 ChemicalEntity denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801|D008687
T21 1150-1163 ChemicalEntity denotes isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T20 1123-1132 ChemicalEntity denotes Metfromin ChemicalEntity
T18 1112-1121 ChemicalEntity denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801|D008687
T16 878-891 ChemicalEntity denotes Isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T14 760-773 ChemicalEntity denotes Isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T12 725-734 ChemicalEntity denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801|D008687
T10 652-665 ChemicalEntity denotes isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T8 394-403 ChemicalEntity denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801|D008687
T5 294-297 ChemicalEntity denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T3 173-182 ChemicalEntity denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801|D008687
T1 23-32 ChemicalEntity denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801|D008687
T15 1790-1794 GeneOrGeneProduct denotes TLR4
T32093 1510-1514 GeneOrGeneProduct denotes AMPK
T13 1501-1505 GeneOrGeneProduct denotes AMPK
T56352 1402-1406 GeneOrGeneProduct denotes IL-6
T11 1310-1314 GeneOrGeneProduct denotes IL-6
T67352 1295-1308 GeneOrGeneProduct denotes interleukin 6
T9 1254-1281 GeneOrGeneProduct denotes tumor necrosis factor-alpha
T42378 1246-1251 GeneOrGeneProduct denotes MyD88
T7 1199-1203 GeneOrGeneProduct denotes TLR4
T6 526-530 GeneOrGeneProduct denotes AMPK
T26590 453-457 GeneOrGeneProduct denotes TLR4
T4 431-451 GeneOrGeneProduct denotes toll-like receptor 4
T41938 324-328 GeneOrGeneProduct denotes AMPK
T2 294-322 GeneOrGeneProduct denotes AMP-activated protein kinase
T77880 44-64 GeneOrGeneProduct denotes toll-like receptor 4
T56093 1700-1719 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T90309 1678-1699 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T69817 1254-1259 DiseaseOrPhenotypicFeature denotes tumor D009369
T70515 1014-1042 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction D018487
T69606 855-876 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T79201 480-501 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T27842 407-426 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T58729 210-231 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T46779 129-150 DiseaseOrPhenotypicFeature denotes myocardial infarction D009203
T1904 90-118 DiseaseOrPhenotypicFeature denotes left ventricular dysfunction D018487
T51445 558-562 OrganismTaxon denotes rats

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-151 Sentence denotes Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.
T2 152-330 Sentence denotes Acute treatment with metformin has a protective effect in myocardial infarction by suppression of inflammatory responses due to activation of AMP-activated protein kinase (AMPK).
T3 331-545 Sentence denotes In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation with AMPK were assessed.
T4 546-759 Sentence denotes Male Wistar rats were randomly assigned to one of 5 groups (n=6): normal control and groups were injected isoproterenol after chronic pre-treatment with 0, 25, 50, or 100mg/kg of metformin twice daily for 14 days.
T5 760-877 Sentence denotes Isoproterenol (100mg/kg) was injected subcutaneously on the 13th and 14th days to induce acute myocardial infarction.
T6 878-1009 Sentence denotes Isoproterenol alone decreased left ventricular systolic pressure and myocardial contractility indexed as LVdp/dtmax and LVdp/dtmin.
T7 1010-1122 Sentence denotes The left ventricular dysfunction was significantly lower in the groups treated with 25 and 50mg/kg of metformin.
T8 1123-1337 Sentence denotes Metfromin markedly lowered isoproterenol-induced elevation in the levels of TLR4 mRNA, myeloid differentiation protein 88 (MyD88), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) in the heart tissues.
T9 1338-1407 Sentence denotes Similar changes were also seen in the serum levels of TNF-α and IL-6.
T10 1408-1485 Sentence denotes However, the lower doses of 25 and 50mg/kg were more effective than 100mg/kg.
T11 1486-1627 Sentence denotes Phosphorylated AMPKα (p-AMPK) in the myocardium was significantly elevated by 25mg/kg of metformin, slightly by 50mg/kg, but not by 100mg/kg.
T12 1628-1806 Sentence denotes Chronic pre-treatment with metformin reduces post-myocardial infarction cardiac dysfunction and suppresses inflammatory responses, possibly through inhibition of TLR4 activities.
T13 1807-1884 Sentence denotes This mechanism can be considered as a target to protect infarcted myocardium.
T1 0-151 Sentence denotes Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.
T2 152-330 Sentence denotes Acute treatment with metformin has a protective effect in myocardial infarction by suppression of inflammatory responses due to activation of AMP-activated protein kinase (AMPK).
T3 331-545 Sentence denotes In the present study, the effect of chronic pre-treatment with metformin on cardiac dysfunction and toll-like receptor 4 (TLR4) activities following myocardial infarction and their relation with AMPK were assessed.
T4 546-759 Sentence denotes Male Wistar rats were randomly assigned to one of 5 groups (n=6): normal control and groups were injected isoproterenol after chronic pre-treatment with 0, 25, 50, or 100mg/kg of metformin twice daily for 14 days.
T5 760-877 Sentence denotes Isoproterenol (100mg/kg) was injected subcutaneously on the 13th and 14th days to induce acute myocardial infarction.
T6 878-1009 Sentence denotes Isoproterenol alone decreased left ventricular systolic pressure and myocardial contractility indexed as LVdp/dtmax and LVdp/dtmin.
T7 1010-1122 Sentence denotes The left ventricular dysfunction was significantly lower in the groups treated with 25 and 50mg/kg of metformin.
T8 1123-1337 Sentence denotes Metfromin markedly lowered isoproterenol-induced elevation in the levels of TLR4 mRNA, myeloid differentiation protein 88 (MyD88), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) in the heart tissues.
T9 1338-1407 Sentence denotes Similar changes were also seen in the serum levels of TNF-α and IL-6.
T10 1408-1485 Sentence denotes However, the lower doses of 25 and 50mg/kg were more effective than 100mg/kg.
T11 1486-1627 Sentence denotes Phosphorylated AMPKα (p-AMPK) in the myocardium was significantly elevated by 25mg/kg of metformin, slightly by 50mg/kg, but not by 100mg/kg.
T12 1628-1806 Sentence denotes Chronic pre-treatment with metformin reduces post-myocardial infarction cardiac dysfunction and suppresses inflammatory responses, possibly through inhibition of TLR4 activities.
T13 1807-1884 Sentence denotes This mechanism can be considered as a target to protect infarcted myocardium.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 210-231 HP_0001658 denotes myocardial infarction
T2 480-501 HP_0001658 denotes myocardial infarction
T3 855-876 HP_0001658 denotes myocardial infarction
T4 958-971 HP_0001371 denotes contractility
T5 1254-1259 HP_0002664 denotes tumor
T6 1678-1699 HP_0001658 denotes myocardial infarction
T7 1863-1883 HP_0001658 denotes infarcted myocardium

Allie

Id Subject Object Predicate Lexical cue
SS1_24842192_1_0 294-322 expanded denotes AMP-activated protein kinase
SS2_24842192_1_0 324-328 abbr denotes AMPK
SS1_24842192_2_0 431-451 expanded denotes toll-like receptor 4
SS2_24842192_2_0 453-457 abbr denotes TLR4
SS1_24842192_7_0 1210-1244 expanded denotes myeloid differentiation protein 88
SS2_24842192_7_0 1246-1251 abbr denotes MyD88
SS1_24842192_7_1 1254-1281 expanded denotes tumor necrosis factor-alpha
SS2_24842192_7_1 1283-1288 abbr denotes TNF-α
SS1_24842192_7_2 1295-1308 expanded denotes interleukin 6
SS2_24842192_7_2 1310-1314 abbr denotes IL-6
SS1_24842192_10_0 1486-1506 expanded denotes Phosphorylated AMPKα
SS2_24842192_10_0 1508-1514 abbr denotes p-AMPK
AE1_24842192_1_0 SS1_24842192_1_0 SS2_24842192_1_0 abbreviatedTo AMP-activated protein kinase,AMPK
AE1_24842192_2_0 SS1_24842192_2_0 SS2_24842192_2_0 abbreviatedTo toll-like receptor 4,TLR4
AE1_24842192_7_0 SS1_24842192_7_0 SS2_24842192_7_0 abbreviatedTo myeloid differentiation protein 88,MyD88
AE1_24842192_7_1 SS1_24842192_7_1 SS2_24842192_7_1 abbreviatedTo tumor necrosis factor-alpha,TNF-α
AE1_24842192_7_2 SS1_24842192_7_2 SS2_24842192_7_2 abbreviatedTo interleukin 6,IL-6
AE1_24842192_10_0 SS1_24842192_10_0 SS2_24842192_10_0 abbreviatedTo Phosphorylated AMPKα,p-AMPK