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c_corpus

Id Subject Object Predicate Lexical cue
T1 9-14 PR:Q5S006 denotes LRRK2
T2 9-14 PR:000003033 denotes LRRK2
T3 9-14 PR:Q5S007 denotes LRRK2
T4 49-53 PR:Q9U9R7 denotes SNpc
T5 49-53 UBERON:0001965 denotes SNpc
T6 109-129 GO:0060292 denotes long-term depression
T7 114-118 original_id denotes term
T8 119-129 UBERON:0004704 denotes depression
T9 140-150 SO:0000781 denotes transgenic
T10 140-156 D008822 denotes transgenic mouse
T13 196-201 PR:Q5S006 denotes LRRK2
T14 196-201 PR:000003033 denotes LRRK2
T15 196-201 PR:Q5S007 denotes LRRK2
T16 202-212 SO:0000781 denotes transgenic
T17 202-217 10090 denotes transgenic mice
T18 202-217 D008822 denotes transgenic mice
T19 213-217 PR:000005054 denotes mice
T21 213-217 O89094 denotes mice
T24 273-303 UBERON:0001966 denotes substantia nigra pars compacta
T25 273-303 UBERON:0001965 denotes substantia nigra pars compacta
T26 290-294 PR:P07814 denotes pars
T27 290-294 PR:000007144 denotes pars
T29 305-309 PR:Q9U9R7 denotes SNpc
T30 305-309 UBERON:0001965 denotes SNpc
T32 405-409 PR:Q9U9R7 denotes SNpc
T33 405-409 UBERON:0001965 denotes SNpc
T34 441-446 PR:Q5S006 denotes LRRK2
T35 441-446 PR:000003033 denotes LRRK2
T36 441-446 PR:Q5S007 denotes LRRK2
T37 498-502 PR:Q9U9R7 denotes SNpc
T38 498-502 UBERON:0001965 denotes SNpc
T42 538-549 MGI:1913975 denotes LRRK2 mouse
T43 544-549 10090 denotes mouse
T44 544-549 D051379 denotes mouse
T45 584-589 PR:Q5S006 denotes LRRK2
T46 584-589 PR:000003033 denotes LRRK2
T47 584-589 PR:Q5S007 denotes LRRK2
T48 590-600 SO:0000781 denotes transgenic
T49 590-605 10090 denotes transgenic mice
T50 590-605 D008822 denotes transgenic mice
T51 601-605 PR:000005054 denotes mice
T53 601-605 O89094 denotes mice
T55 682-686 PR:Q9U9R7 denotes SNpc
T56 682-686 UBERON:0001965 denotes SNpc
T57 768-773 PR:Q99JL1 denotes clamp
T58 768-773 PR:Q9JJ40 denotes clamp
T59 788-792 PR:Q9U9R7 denotes SNpc
T60 788-792 UBERON:0001965 denotes SNpc
T61 815-820 UBERON:6110636 denotes brain
T62 815-820 UBERON:0000955 denotes brain
T63 899-903 PR:Q9U9R7 denotes SNpc
T64 899-903 UBERON:0001965 denotes SNpc
T65 949-954 PR:Q5S006 denotes LRRK2
T66 949-954 PR:000003033 denotes LRRK2
T67 949-954 PR:Q5S007 denotes LRRK2
T68 955-959 PR:000005054 denotes mice
T70 955-959 O89094 denotes mice
T69 955-959 D051379 denotes mice
T71 955-959 10095 denotes mice
T75 961-973 D000077482 denotes Carbon fiber
T76 961-973 D000077482 denotes Carbon fiber
T77 1049-1054 PR:Q5S006 denotes LRRK2
T78 1049-1054 PR:000003033 denotes LRRK2
T79 1049-1054 PR:Q5S007 denotes LRRK2
T80 1055-1065 SO:0000781 denotes transgenic
T81 1055-1070 10090 denotes transgenic mice
T82 1055-1070 D008822 denotes transgenic mice
T83 1066-1070 PR:000005054 denotes mice
T85 1066-1070 O89094 denotes mice
T92 1125-1133 3628 denotes dopamine
T88 1125-1133 CHEBI:59905 denotes dopamine
T89 1125-1133 CHEBI:18243 denotes dopamine
T90 1125-1133 D004298 denotes dopamine
T91 1125-1133 D004298 denotes dopamine
T93 1162-1170 UBERON:0002435 denotes striatum
T94 1162-1170 UBERON:0005383 denotes striatum
T95 1257-1261 original_id denotes term
T96 1387-1392 PR:Q99JL1 denotes clamp
T97 1387-1392 PR:Q9JJ40 denotes clamp
T99 1472-1481 SO:0000817 denotes wild-type
T100 1482-1486 PR:000005054 denotes mice
T102 1482-1486 O89094 denotes mice
T101 1482-1486 D051379 denotes mice
T103 1482-1486 10095 denotes mice
T104 1561-1581 GO:0060292 denotes long-term depression
T105 1566-1570 original_id denotes term
T106 1571-1581 UBERON:0004704 denotes depression
T109 1583-1586 GO:0060292 denotes LTD
T107 1583-1586 CHEBI:73573 denotes LTD
T108 1583-1586 PR:Q8VY88 denotes LTD
T110 1649-1654 PR:Q5S006 denotes LRRK2
T111 1649-1654 PR:000003033 denotes LRRK2
T112 1649-1654 PR:Q5S007 denotes LRRK2
T113 1655-1659 PR:000005054 denotes mice
T115 1655-1659 O89094 denotes mice
T114 1655-1659 D051379 denotes mice
T116 1655-1659 10095 denotes mice
T117 1730-1735 PR:Q5S006 denotes LRRK2
T118 1730-1735 PR:000003033 denotes LRRK2
T119 1730-1735 PR:Q5S007 denotes LRRK2
T120 1771-1775 PR:Q9U9R7 denotes SNpc
T121 1771-1775 UBERON:0001965 denotes SNpc
T122 1852-1861 MOP:0000569 denotes reduction
T127 1872-1880 3628 denotes dopamine
T123 1872-1880 CHEBI:59905 denotes dopamine
T124 1872-1880 CHEBI:18243 denotes dopamine
T125 1872-1880 D004298 denotes dopamine
T126 1872-1880 D004298 denotes dopamine
T130 1924-1927 GO:0060292 denotes LTD
T129 1924-1927 PR:Q8VY88 denotes LTD
T128 1924-1927 CHEBI:73573 denotes LTD
T131 1944-1949 PR:Q5S006 denotes LRRK2
T132 1944-1949 PR:000003033 denotes LRRK2
T133 1944-1949 PR:Q5S007 denotes LRRK2
T134 1950-1960 SO:0000781 denotes transgenic
T135 1950-1966 D008822 denotes transgenic mouse

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1571-1581 HP_0000716 denotes depression

Allie

Id Subject Object Predicate Lexical cue
SS1_24830390_1_0 273-303 expanded denotes substantia nigra pars compacta
SS2_24830390_1_0 305-309 abbr denotes SNpc
SS1_24830390_7_0 1561-1581 expanded denotes long-term depression
SS2_24830390_7_0 1583-1586 abbr denotes LTD
AE1_24830390_1_0 SS1_24830390_1_0 SS2_24830390_1_0 abbreviatedTo substantia nigra pars compacta,SNpc
AE1_24830390_7_0 SS1_24830390_7_0 SS2_24830390_7_0 abbreviatedTo long-term depression,LTD

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-157 DRI_Challenge denotes (G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse.
T2 158-330 DRI_Background denotes Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive neuronal death of substantia nigra pars compacta (SNpc) dopaminergic cells.
T3 331-550 DRI_Challenge denotes In the present study, we hypothesized that prior to a late-phase death of SNpc dopaminergic neurons, (G2019S) LRRK2 also causes an early-phase neuronal dysfunction of SNpc dopaminergic cells in the (G2019S) LRRK2 mouse.
T4 551-748 DRI_Outcome denotes Eight to nine-month-old (G2019S) LRRK2 transgenic mice exhibited the symptom of hypoactivity in the absence of the degeneration of SNpc dopaminergic neurons or nigrostriatal dopaminergic terminals.
T5 749-759 REPLACED denotes Whole-cell
T6 760-773 Token_Label.OUTSIDE denotes current-clamp
T7 774-960 DRI_Background denotes recordings of SNpc dopaminergic cells in brain slices demonstrated a significant decrease in spontaneous firing frequency of SNpc dopaminergic neurons of 8-month-old (G2019S) LRRK2 mice.
T8 961-1171 DRI_Approach denotes Carbon fiber electrode amperometry recording using striatal slices showed that (G2019S) LRRK2 transgenic mice at the age of 8 to 9months display an impaired evoked dopamine release in the dorsolateral striatum.
T9 1172-1367 DRI_Background denotes Normal nigrostriatal dopaminergic transmission is required for the induction of long-term synaptic plasticity expressed at corticostriatal glutamatergic synapses of striatal medium spiny neurons.
T10 1368-1378 REPLACED denotes Whole-cell
T11 1379-1392 Token_Label.OUTSIDE denotes voltage-clamp
T12 1393-1590 DRI_Background denotes recordings showed that in contrast to medium spiny neurons of 8 to 9-month-old wild-type mice, high-frequency stimulation of corticostriatal afferents failed to induce long-term depression (LTD) of
T13 1591-1612 Token_Label.OUTSIDE denotes corticostriatal EPSCs
T14 1613-1676 DRI_Background denotes in medium spiny neurons of (G2019S) LRRK2 mice at the same age.
T15 1677-1967 DRI_Outcome denotes Our study provides the evidence that mutant (G2019S) LRRK2 causes early-phase dysfunctions of SNpc dopaminergic neurons, including a decrease in spontaneous firing rate and a reduction in evoked dopamine release, and impairment of corticostriatal LTD in the (G2019S) LRRK2 transgenic mouse.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 158-330 DRI_Background denotes Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive neuronal death of substantia nigra pars compacta (SNpc) dopaminergic cells.
T2 331-550 DRI_Challenge denotes In the present study, we hypothesized that prior to a late-phase death of SNpc dopaminergic neurons, (G2019S) LRRK2 also causes an early-phase neuronal dysfunction of SNpc dopaminergic cells in the (G2019S) LRRK2 mouse.
T3 551-748 DRI_Outcome denotes Eight to nine-month-old (G2019S) LRRK2 transgenic mice exhibited the symptom of hypoactivity in the absence of the degeneration of SNpc dopaminergic neurons or nigrostriatal dopaminergic terminals.
T4 749-759 REPLACED denotes Whole-cell
T5 774-960 DRI_Background denotes recordings of SNpc dopaminergic cells in brain slices demonstrated a significant decrease in spontaneous firing frequency of SNpc dopaminergic neurons of 8-month-old (G2019S) LRRK2 mice.
T6 961-1171 DRI_Approach denotes Carbon fiber electrode amperometry recording using striatal slices showed that (G2019S) LRRK2 transgenic mice at the age of 8 to 9months display an impaired evoked dopamine release in the dorsolateral striatum.
T7 1172-1367 DRI_Background denotes Normal nigrostriatal dopaminergic transmission is required for the induction of long-term synaptic plasticity expressed at corticostriatal glutamatergic synapses of striatal medium spiny neurons.
T8 1368-1378 REPLACED denotes Whole-cell
T9 1393-1590 DRI_Background denotes recordings showed that in contrast to medium spiny neurons of 8 to 9-month-old wild-type mice, high-frequency stimulation of corticostriatal afferents failed to induce long-term depression (LTD) of
T10 1613-1676 DRI_Background denotes in medium spiny neurons of (G2019S) LRRK2 mice at the same age.
T11 1677-1967 DRI_Outcome denotes Our study provides the evidence that mutant (G2019S) LRRK2 causes early-phase dysfunctions of SNpc dopaminergic neurons, including a decrease in spontaneous firing rate and a reduction in evoked dopamine release, and impairment of corticostriatal LTD in the (G2019S) LRRK2 transgenic mouse.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
24830390-0#1#7#geners34637584 433-439 geners34637584 denotes G2019S
24830390-0#34#45#diseaseC3887505 483-494 diseaseC3887505 denotes dysfunction
1#7#geners3463758434#45#diseaseC3887505 24830390-0#1#7#geners34637584 24830390-0#34#45#diseaseC3887505 associated_with G2019S,dysfunction

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24830390-0#9#14#gene120892 441-446 gene120892 denotes LRRK2
24830390-0#34#45#diseaseC3887505 483-494 diseaseC3887505 denotes dysfunction
9#14#gene12089234#45#diseaseC3887505 24830390-0#9#14#gene120892 24830390-0#34#45#diseaseC3887505 associated_with LRRK2,dysfunction