PubMed:24824948
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-164 | Sentence | denotes | Hydrogen sulfide inhibits opioid withdrawal-induced pain sensitization in rats by down-regulation of spinal calcitonin gene-related peptide expression in the spine. |
| TextSentencer_T2 | 165-229 | Sentence | denotes | Hyperalgesia often occurs in opioid-induced withdrawal syndrome. |
| TextSentencer_T3 | 230-491 | Sentence | denotes | In the present study, we found that three hourly injections of DAMGO (a μ-opioid receptor agonist) followed by naloxone administration at the fourth hour significantly decreased rat paw nociceptive threshold, indicating the induction of withdrawal hyperalgesia. |
| TextSentencer_T4 | 492-634 | Sentence | denotes | Application of NaHS (a hydrogen sulfide donor) together with each injection of DAMGO attenuated naloxone-precipitated withdrawal hyperalgesia. |
| TextSentencer_T5 | 635-830 | Sentence | denotes | RT-PCR and Western blot analysis showed that NaHS significantly reversed the gene and protein expression of up-regulated spinal calcitonin gene-related peptide (CGRP) in naloxone-treated animals. |
| TextSentencer_T6 | 831-965 | Sentence | denotes | NaHS also inhibited naloxone-induced cAMP rebound and cAMP response element-binding protein (CREB) phosphorylation in rat spinal cord. |
| TextSentencer_T7 | 966-1081 | Sentence | denotes | In SH-SY5Y neuronal cells, NaHS inhibited forskolin-stimulated cAMP production and adenylate cyclase (AC) activity. |
| TextSentencer_T8 | 1082-1260 | Sentence | denotes | Moreover, NaHS pre-treatment suppressed naloxone-stimulated activation of protein kinase C (PKC) α, Raf-1, and extracellular signal-regulated kinase (ERK) 1/2 in rat spinal cord. |
| TextSentencer_T9 | 1261-1457 | Sentence | denotes | Our data suggest that H2S prevents the development of opioid withdrawal-induced hyperalgesia via suppression of synthesis of CGRP in spine through inhibition of AC/cAMP and PKC/Raf-1/ERK pathways. |
| T1 | 0-164 | Sentence | denotes | Hydrogen sulfide inhibits opioid withdrawal-induced pain sensitization in rats by down-regulation of spinal calcitonin gene-related peptide expression in the spine. |
| T2 | 165-229 | Sentence | denotes | Hyperalgesia often occurs in opioid-induced withdrawal syndrome. |
| T3 | 230-491 | Sentence | denotes | In the present study, we found that three hourly injections of DAMGO (a μ-opioid receptor agonist) followed by naloxone administration at the fourth hour significantly decreased rat paw nociceptive threshold, indicating the induction of withdrawal hyperalgesia. |
| T4 | 492-634 | Sentence | denotes | Application of NaHS (a hydrogen sulfide donor) together with each injection of DAMGO attenuated naloxone-precipitated withdrawal hyperalgesia. |
| T5 | 635-830 | Sentence | denotes | RT-PCR and Western blot analysis showed that NaHS significantly reversed the gene and protein expression of up-regulated spinal calcitonin gene-related peptide (CGRP) in naloxone-treated animals. |
| T6 | 831-965 | Sentence | denotes | NaHS also inhibited naloxone-induced cAMP rebound and cAMP response element-binding protein (CREB) phosphorylation in rat spinal cord. |
| T7 | 966-1081 | Sentence | denotes | In SH-SY5Y neuronal cells, NaHS inhibited forskolin-stimulated cAMP production and adenylate cyclase (AC) activity. |
| T8 | 1082-1260 | Sentence | denotes | Moreover, NaHS pre-treatment suppressed naloxone-stimulated activation of protein kinase C (PKC) α, Raf-1, and extracellular signal-regulated kinase (ERK) 1/2 in rat spinal cord. |
| T9 | 1261-1457 | Sentence | denotes | Our data suggest that H2S prevents the development of opioid withdrawal-induced hyperalgesia via suppression of synthesis of CGRP in spine through inhibition of AC/cAMP and PKC/Raf-1/ERK pathways. |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24824948_4_0 | 763-794 | expanded | denotes | calcitonin gene-related peptide |
| SS2_24824948_4_0 | 796-800 | abbr | denotes | CGRP |
| SS1_24824948_5_0 | 885-922 | expanded | denotes | cAMP response element-binding protein |
| SS2_24824948_5_0 | 924-928 | abbr | denotes | CREB |
| SS1_24824948_6_0 | 1049-1066 | expanded | denotes | adenylate cyclase |
| SS2_24824948_6_0 | 1068-1070 | abbr | denotes | AC |
| SS1_24824948_7_0 | 1156-1172 | expanded | denotes | protein kinase C |
| SS2_24824948_7_0 | 1174-1177 | abbr | denotes | PKC |
| SS1_24824948_7_1 | 1193-1230 | expanded | denotes | extracellular signal-regulated kinase |
| SS2_24824948_7_1 | 1232-1235 | abbr | denotes | ERK |
| AE1_24824948_4_0 | SS1_24824948_4_0 | SS2_24824948_4_0 | abbreviatedTo | calcitonin gene-related peptide,CGRP |
| AE1_24824948_5_0 | SS1_24824948_5_0 | SS2_24824948_5_0 | abbreviatedTo | cAMP response element-binding protein,CREB |
| AE1_24824948_6_0 | SS1_24824948_6_0 | SS2_24824948_6_0 | abbreviatedTo | adenylate cyclase,AC |
| AE1_24824948_7_0 | SS1_24824948_7_0 | SS2_24824948_7_0 | abbreviatedTo | protein kinase C,PKC |
| AE1_24824948_7_1 | SS1_24824948_7_1 | SS2_24824948_7_1 | abbreviatedTo | extracellular signal-regulated kinase,ERK |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24824948-2#72#89#gene4988 | 302-319 | gene4988 | denotes | μ-opioid receptor |
| 24824948-2#248#260#diseaseC0020429 | 478-490 | diseaseC0020429 | denotes | hyperalgesia |
| 24824948-8#177#182#gene5894 | 1438-1443 | gene5894 | denotes | Raf-1 |
| 24824948-8#177#182#gene6037 | 1438-1443 | gene6037 | denotes | Raf-1 |
| 24824948-8#177#182#gene5894 | 1438-1443 | gene5894 | denotes | Raf-1 |
| 24824948-8#177#182#gene6037 | 1438-1443 | gene6037 | denotes | Raf-1 |
| 24824948-8#54#71#diseaseC0029104 | 1315-1332 | diseaseC0029104 | denotes | opioid withdrawal |
| 24824948-8#80#92#diseaseC0020429 | 1341-1353 | diseaseC0020429 | denotes | hyperalgesia |
| 72#89#gene4988248#260#diseaseC0020429 | 24824948-2#72#89#gene4988 | 24824948-2#248#260#diseaseC0020429 | associated_with | μ-opioid receptor,hyperalgesia |
| 177#182#gene589454#71#diseaseC0029104 | 24824948-8#177#182#gene5894 | 24824948-8#54#71#diseaseC0029104 | associated_with | Raf-1,opioid withdrawal |
| 177#182#gene589480#92#diseaseC0020429 | 24824948-8#177#182#gene5894 | 24824948-8#80#92#diseaseC0020429 | associated_with | Raf-1,hyperalgesia |
| 177#182#gene603754#71#diseaseC0029104 | 24824948-8#177#182#gene6037 | 24824948-8#54#71#diseaseC0029104 | associated_with | Raf-1,opioid withdrawal |
| 177#182#gene603780#92#diseaseC0020429 | 24824948-8#177#182#gene6037 | 24824948-8#80#92#diseaseC0020429 | associated_with | Raf-1,hyperalgesia |
| 177#182#gene589454#71#diseaseC0029104 | 24824948-8#177#182#gene5894 | 24824948-8#54#71#diseaseC0029104 | associated_with | Raf-1,opioid withdrawal |
| 177#182#gene589480#92#diseaseC0020429 | 24824948-8#177#182#gene5894 | 24824948-8#80#92#diseaseC0020429 | associated_with | Raf-1,hyperalgesia |
| 177#182#gene603754#71#diseaseC0029104 | 24824948-8#177#182#gene6037 | 24824948-8#54#71#diseaseC0029104 | associated_with | Raf-1,opioid withdrawal |
| 177#182#gene603780#92#diseaseC0020429 | 24824948-8#177#182#gene6037 | 24824948-8#80#92#diseaseC0020429 | associated_with | Raf-1,hyperalgesia |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2668 | 1438-1443 | gene:5894 | denotes | Raf-1 |
| T2669 | 1315-1332 | disease:C0029104 | denotes | opioid withdrawal |
| T2670 | 1341-1353 | disease:C0020429 | denotes | hyperalgesia |
| R1 | T2668 | T2669 | associated_with | Raf-1,opioid withdrawal |
| R2 | T2668 | T2669 | associated_with | Raf-1,opioid withdrawal |
| R3 | T2668 | T2670 | associated_with | Raf-1,hyperalgesia |
| R4 | T2668 | T2670 | associated_with | Raf-1,hyperalgesia |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 953-964 | http://purl.obolibrary.org/obo/UBERON_0002240 | denotes | spinal cord |
| PD-UBERON-AE-B_T2 | 1248-1259 | http://purl.obolibrary.org/obo/UBERON_0002240 | denotes | spinal cord |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 977-985 | http://purl.obolibrary.org/obo/UBERON_2000602 | denotes | neuronal |
| PD-UBERON-AE-B_T2 | 953-964 | http://purl.obolibrary.org/obo/UBERON_0002240 | denotes | spinal cord |
| PD-UBERON-AE-B_T3 | 1248-1259 | http://purl.obolibrary.org/obo/UBERON_0002240 | denotes | spinal cord |