PubMed:24817687 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/24817687","sourcedb":"PubMed","sourceid":"24817687","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/24817687","text":"Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome.\nSingle nucleotide polymorphisms (SNPs) in the tachykinin receptor 1 gene (TACR1) are nominally associated with bipolar affective disorder (BPAD) in a genome-wide association study and in several case-control samples of BPAD, alcohol dependence syndrome (ADS) and attention-deficit hyperactivity disorder (ADHD). Eighteen TACR1 SNPs were associated with BPAD in a sample (506 subjects) from University College London (UCL1), the most significant being rs3771829, previously associated with ADHD. To further elucidate the role of TACR1 in affective disorders, rs3771829 was genotyped in a second BPAD sample of 593 subjects (UCL2), in 997 subjects with ADS, and a subsample of 143 individuals diagnosed with BPAD and comorbid alcohol dependence (BPALC). rs3771829 was associated with BPAD (UCL1 and UCL2 combined: P = 2.0 × 10(-3)), ADS (P = 2.0 × 10(-3)) and BPALC (P = 6.0 × 10(-4)) compared with controls screened for the absence of mental illness and alcohol dependence. DNA sequencing in selected cases of BPAD and ADHD who had inherited TACR1-susceptibility haplotypes identified 19 SNPs in the promoter region, 5' UTR, exons, intron/exon junctions and 3' UTR of TACR1 that could increase vulnerability to BPAD, ADS, ADHD, and BPALC. Alternative splicing of TACR1 excludes intron 4 and exon 5, giving rise to two variants of the neurokinin 1 receptor (NK1R) that differ in binding affinity of substance P by 10-fold. A mutation in intron four, rs1106854, was associated with BPAD, although a regulatory role for rs1106854 is unclear. The association with TACR1 and BPAD, ADS, and ADHD suggests a shared molecular pathophysiology between these affective disorders.","tracks":[{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T1","span":{"begin":513,"end":517},"obj":"disease:C2700439"},{"id":"T2","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T3","span":{"begin":649,"end":653},"obj":"disease:C1263846"},{"id":"T4","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T5","span":{"begin":513,"end":517},"obj":"disease:C1852197"},{"id":"T6","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T7","span":{"begin":513,"end":517},"obj":"disease:C2700440"},{"id":"T8","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T9","span":{"begin":513,"end":517},"obj":"disease:C1839839"},{"id":"T10","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T11","span":{"begin":513,"end":517},"obj":"disease:C0005586"},{"id":"T12","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T13","span":{"begin":513,"end":517},"obj":"disease:C1970944"},{"id":"T14","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T15","span":{"begin":513,"end":517},"obj":"disease:C1970945"},{"id":"T16","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T17","span":{"begin":513,"end":517},"obj":"disease:C2700438"},{"id":"T18","span":{"begin":481,"end":486},"obj":"gene:6869"},{"id":"T19","span":{"begin":513,"end":517},"obj":"disease:C1970943"},{"id":"T20","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T21","span":{"begin":811,"end":814},"obj":"disease:C0001973"},{"id":"T22","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T23","span":{"begin":866,"end":870},"obj":"disease:C1970943"},{"id":"T24","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T25","span":{"begin":866,"end":870},"obj":"disease:C2700438"},{"id":"T26","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T27","span":{"begin":866,"end":870},"obj":"disease:C1970945"},{"id":"T28","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T29","span":{"begin":866,"end":870},"obj":"disease:C1970944"},{"id":"T30","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T31","span":{"begin":697,"end":716},"obj":"disease:C0525045"},{"id":"T32","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T33","span":{"begin":866,"end":870},"obj":"disease:C0005586"},{"id":"T34","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T35","span":{"begin":866,"end":870},"obj":"disease:C2700439"},{"id":"T36","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T37","span":{"begin":866,"end":870},"obj":"disease:C1839839"},{"id":"T38","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T39","span":{"begin":866,"end":870},"obj":"disease:C2700440"},{"id":"T40","span":{"begin":688,"end":693},"obj":"gene:6869"},{"id":"T41","span":{"begin":866,"end":870},"obj":"disease:C1852197"},{"id":"T42","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T43","span":{"begin":1807,"end":1826},"obj":"disease:C0525045"},{"id":"T44","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T45","span":{"begin":1729,"end":1733},"obj":"disease:C1852197"},{"id":"T46","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T47","span":{"begin":1729,"end":1733},"obj":"disease:C2700440"},{"id":"T48","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T49","span":{"begin":1729,"end":1733},"obj":"disease:C1839839"},{"id":"T50","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T51","span":{"begin":1729,"end":1733},"obj":"disease:C2700439"},{"id":"T52","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T53","span":{"begin":1729,"end":1733},"obj":"disease:C0005586"},{"id":"T54","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T55","span":{"begin":1729,"end":1733},"obj":"disease:C1970944"},{"id":"T56","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T57","span":{"begin":1729,"end":1733},"obj":"disease:C1970945"},{"id":"T58","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T59","span":{"begin":1729,"end":1733},"obj":"disease:C2700438"},{"id":"T60","span":{"begin":1719,"end":1724},"obj":"gene:6869"},{"id":"T61","span":{"begin":1729,"end":1733},"obj":"disease:C1970943"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"},{"id":"R9","pred":"associated_with","subj":"T16","obj":"T17"},{"id":"R10","pred":"associated_with","subj":"T18","obj":"T19"},{"id":"R11","pred":"associated_with","subj":"T20","obj":"T21"},{"id":"R12","pred":"associated_with","subj":"T22","obj":"T23"},{"id":"R13","pred":"associated_with","subj":"T24","obj":"T25"},{"id":"R14","pred":"associated_with","subj":"T26","obj":"T27"},{"id":"R15","pred":"associated_with","subj":"T28","obj":"T29"},{"id":"R16","pred":"associated_with","subj":"T30","obj":"T31"},{"id":"R17","pred":"associated_with","subj":"T32","obj":"T33"},{"id":"R18","pred":"associated_with","subj":"T34","obj":"T35"},{"id":"R19","pred":"associated_with","subj":"T36","obj":"T37"},{"id":"R20","pred":"associated_with","subj":"T38","obj":"T39"},{"id":"R21","pred":"associated_with","subj":"T40","obj":"T41"},{"id":"R22","pred":"associated_with","subj":"T42","obj":"T43"},{"id":"R23","pred":"associated_with","subj":"T44","obj":"T45"},{"id":"R24","pred":"associated_with","subj":"T46","obj":"T47"},{"id":"R25","pred":"associated_with","subj":"T48","obj":"T49"},{"id":"R26","pred":"associated_with","subj":"T50","obj":"T51"},{"id":"R27","pred":"associated_with","subj":"T52","obj":"T53"},{"id":"R28","pred":"associated_with","subj":"T54","obj":"T55"},{"id":"R29","pred":"associated_with","subj":"T56","obj":"T57"},{"id":"R30","pred":"associated_with","subj":"T58","obj":"T59"},{"id":"R31","pred":"associated_with","subj":"T60","obj":"T61"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"},{"subj":"T12","pred":"source","obj":"DisGeNET"},{"subj":"T13","pred":"source","obj":"DisGeNET"},{"subj":"T14","pred":"source","obj":"DisGeNET"},{"subj":"T15","pred":"source","obj":"DisGeNET"},{"subj":"T16","pred":"source","obj":"DisGeNET"},{"subj":"T17","pred":"source","obj":"DisGeNET"},{"subj":"T18","pred":"source","obj":"DisGeNET"},{"subj":"T19","pred":"source","obj":"DisGeNET"},{"subj":"T20","pred":"source","obj":"DisGeNET"},{"subj":"T21","pred":"source","obj":"DisGeNET"},{"subj":"T22","pred":"source","obj":"DisGeNET"},{"subj":"T23","pred":"source","obj":"DisGeNET"},{"subj":"T24","pred":"source","obj":"DisGeNET"},{"subj":"T25","pred":"source","obj":"DisGeNET"},{"subj":"T26","pred":"source","obj":"DisGeNET"},{"subj":"T27","pred":"source","obj":"DisGeNET"},{"subj":"T28","pred":"source","obj":"DisGeNET"},{"subj":"T29","pred":"source","obj":"DisGeNET"},{"subj":"T30","pred":"source","obj":"DisGeNET"},{"subj":"T31","pred":"source","obj":"DisGeNET"},{"subj":"T32","pred":"source","obj":"DisGeNET"},{"subj":"T33","pred":"source","obj":"DisGeNET"},{"subj":"T34","pred":"source","obj":"DisGeNET"},{"subj":"T35","pred":"source","obj":"DisGeNET"},{"subj":"T36","pred":"source","obj":"DisGeNET"},{"subj":"T37","pred":"source","obj":"DisGeNET"},{"subj":"T38","pred":"source","obj":"DisGeNET"},{"subj":"T39","pred":"source","obj":"DisGeNET"},{"subj":"T40","pred":"source","obj":"DisGeNET"},{"subj":"T41","pred":"source","obj":"DisGeNET"},{"subj":"T42","pred":"source","obj":"DisGeNET"},{"subj":"T43","pred":"source","obj":"DisGeNET"},{"subj":"T44","pred":"source","obj":"DisGeNET"},{"subj":"T45","pred":"source","obj":"DisGeNET"},{"subj":"T46","pred":"source","obj":"DisGeNET"},{"subj":"T47","pred":"source","obj":"DisGeNET"},{"subj":"T48","pred":"source","obj":"DisGeNET"},{"subj":"T49","pred":"source","obj":"DisGeNET"},{"subj":"T50","pred":"source","obj":"DisGeNET"},{"subj":"T51","pred":"source","obj":"DisGeNET"},{"subj":"T52","pred":"source","obj":"DisGeNET"},{"subj":"T53","pred":"source","obj":"DisGeNET"},{"subj":"T54","pred":"source","obj":"DisGeNET"},{"subj":"T55","pred":"source","obj":"DisGeNET"},{"subj":"T56","pred":"source","obj":"DisGeNET"},{"subj":"T57","pred":"source","obj":"DisGeNET"},{"subj":"T58","pred":"source","obj":"DisGeNET"},{"subj":"T59","pred":"source","obj":"DisGeNET"},{"subj":"T60","pred":"source","obj":"DisGeNET"},{"subj":"T61","pred":"source","obj":"DisGeNET"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":271,"end":297},"obj":"HP_0007302"},{"id":"T2","span":{"begin":423,"end":463},"obj":"HP_0007018"},{"id":"T3","span":{"begin":423,"end":440},"obj":"HP_0007018"},{"id":"T4","span":{"begin":441,"end":454},"obj":"HP_0000752"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"}]},{"project":"Allie","denotations":[{"id":"SS1_24817687_1_0","span":{"begin":160,"end":191},"obj":"expanded"},{"id":"SS2_24817687_1_0","span":{"begin":193,"end":197},"obj":"abbr"},{"id":"SS1_24817687_1_1","span":{"begin":206,"end":232},"obj":"expanded"},{"id":"SS2_24817687_1_1","span":{"begin":234,"end":239},"obj":"abbr"},{"id":"SS1_24817687_1_2","span":{"begin":271,"end":297},"obj":"expanded"},{"id":"SS2_24817687_1_2","span":{"begin":299,"end":303},"obj":"abbr"},{"id":"SS1_24817687_1_3","span":{"begin":385,"end":412},"obj":"expanded"},{"id":"SS2_24817687_1_3","span":{"begin":414,"end":417},"obj":"abbr"},{"id":"SS1_24817687_1_4","span":{"begin":423,"end":463},"obj":"expanded"},{"id":"SS2_24817687_1_4","span":{"begin":465,"end":469},"obj":"abbr"},{"id":"SS1_24817687_3_0","span":{"begin":866,"end":902},"obj":"expanded"},{"id":"SS2_24817687_3_0","span":{"begin":904,"end":909},"obj":"abbr"},{"id":"SS1_24817687_5_0","span":{"begin":1493,"end":1514},"obj":"expanded"},{"id":"SS2_24817687_5_0","span":{"begin":1516,"end":1520},"obj":"abbr"}],"relations":[{"id":"AE1_24817687_1_0","pred":"abbreviatedTo","subj":"SS1_24817687_1_0","obj":"SS2_24817687_1_0"},{"id":"AE1_24817687_1_1","pred":"abbreviatedTo","subj":"SS1_24817687_1_1","obj":"SS2_24817687_1_1"},{"id":"AE1_24817687_1_2","pred":"abbreviatedTo","subj":"SS1_24817687_1_2","obj":"SS2_24817687_1_2"},{"id":"AE1_24817687_1_3","pred":"abbreviatedTo","subj":"SS1_24817687_1_3","obj":"SS2_24817687_1_3"},{"id":"AE1_24817687_1_4","pred":"abbreviatedTo","subj":"SS1_24817687_1_4","obj":"SS2_24817687_1_4"},{"id":"AE1_24817687_3_0","pred":"abbreviatedTo","subj":"SS1_24817687_3_0","obj":"SS2_24817687_3_0"},{"id":"AE1_24817687_5_0","pred":"abbreviatedTo","subj":"SS1_24817687_5_0","obj":"SS2_24817687_5_0"}],"attributes":[{"subj":"SS1_24817687_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_24817687_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_24817687_1_1","pred":"source","obj":"Allie"},{"subj":"SS2_24817687_1_1","pred":"source","obj":"Allie"},{"subj":"SS1_24817687_1_2","pred":"source","obj":"Allie"},{"subj":"SS2_24817687_1_2","pred":"source","obj":"Allie"},{"subj":"SS1_24817687_1_3","pred":"source","obj":"Allie"},{"subj":"SS2_24817687_1_3","pred":"source","obj":"Allie"},{"subj":"SS1_24817687_1_4","pred":"source","obj":"Allie"},{"subj":"SS2_24817687_1_4","pred":"source","obj":"Allie"},{"subj":"SS1_24817687_3_0","pred":"source","obj":"Allie"},{"subj":"SS2_24817687_3_0","pred":"source","obj":"Allie"},{"subj":"SS1_24817687_5_0","pred":"source","obj":"Allie"},{"subj":"SS2_24817687_5_0","pred":"source","obj":"Allie"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"24817687-2#139#148#geners3771829","span":{"begin":611,"end":620},"obj":"geners3771829"},{"id":"24817687-2#177#181#diseaseC1263846","span":{"begin":649,"end":653},"obj":"diseaseC1263846"},{"id":"24817687-3#257#266#geners3771829","span":{"begin":912,"end":921},"obj":"geners3771829"},{"id":"24817687-3#63#72#geners3771829","span":{"begin":718,"end":727},"obj":"geners3771829"},{"id":"24817687-3#42#61#diseaseC0525045","span":{"begin":697,"end":716},"obj":"diseaseC0525045"},{"id":"24817687-3#99#103#diseaseC1839839","span":{"begin":754,"end":758},"obj":"diseaseC1839839"},{"id":"24817687-3#99#103#diseaseC0005586","span":{"begin":754,"end":758},"obj":"diseaseC0005586"},{"id":"24817687-3#99#103#diseaseC1970943","span":{"begin":754,"end":758},"obj":"diseaseC1970943"},{"id":"24817687-3#99#103#diseaseC1970945","span":{"begin":754,"end":758},"obj":"diseaseC1970945"},{"id":"24817687-3#99#103#diseaseC1852197","span":{"begin":754,"end":758},"obj":"diseaseC1852197"},{"id":"24817687-3#211#215#diseaseC1839839","span":{"begin":866,"end":870},"obj":"diseaseC1839839"},{"id":"24817687-3#211#215#diseaseC0005586","span":{"begin":866,"end":870},"obj":"diseaseC0005586"},{"id":"24817687-3#211#215#diseaseC1970943","span":{"begin":866,"end":870},"obj":"diseaseC1970943"},{"id":"24817687-3#211#215#diseaseC1970945","span":{"begin":866,"end":870},"obj":"diseaseC1970945"},{"id":"24817687-3#211#215#diseaseC1852197","span":{"begin":866,"end":870},"obj":"diseaseC1852197"},{"id":"24817687-3#287#291#diseaseC1839839","span":{"begin":942,"end":946},"obj":"diseaseC1839839"},{"id":"24817687-3#287#291#diseaseC0005586","span":{"begin":942,"end":946},"obj":"diseaseC0005586"},{"id":"24817687-3#287#291#diseaseC1970943","span":{"begin":942,"end":946},"obj":"diseaseC1970943"},{"id":"24817687-3#287#291#diseaseC1970945","span":{"begin":942,"end":946},"obj":"diseaseC1970945"},{"id":"24817687-3#287#291#diseaseC1852197","span":{"begin":942,"end":946},"obj":"diseaseC1852197"},{"id":"24817687-3#336#339#diseaseC0001973","span":{"begin":991,"end":994},"obj":"diseaseC0001973"},{"id":"24817687-3#439#453#diseaseC0004936","span":{"begin":1094,"end":1108},"obj":"diseaseC0004936"},{"id":"24817687-3#458#476#diseaseC0001973","span":{"begin":1113,"end":1131},"obj":"diseaseC0001973"},{"id":"24817687-3#99#103#diseaseC1839839","span":{"begin":754,"end":758},"obj":"diseaseC1839839"},{"id":"24817687-3#99#103#diseaseC0005586","span":{"begin":754,"end":758},"obj":"diseaseC0005586"},{"id":"24817687-3#99#103#diseaseC1970943","span":{"begin":754,"end":758},"obj":"diseaseC1970943"},{"id":"24817687-3#99#103#diseaseC1970945","span":{"begin":754,"end":758},"obj":"diseaseC1970945"},{"id":"24817687-3#99#103#diseaseC1852197","span":{"begin":754,"end":758},"obj":"diseaseC1852197"},{"id":"24817687-3#211#215#diseaseC1839839","span":{"begin":866,"end":870},"obj":"diseaseC1839839"},{"id":"24817687-3#211#215#diseaseC0005586","span":{"begin":866,"end":870},"obj":"diseaseC0005586"},{"id":"24817687-3#211#215#diseaseC1970943","span":{"begin":866,"end":870},"obj":"diseaseC1970943"},{"id":"24817687-3#211#215#diseaseC1970945","span":{"begin":866,"end":870},"obj":"diseaseC1970945"},{"id":"24817687-3#211#215#diseaseC1852197","span":{"begin":866,"end":870},"obj":"diseaseC1852197"},{"id":"24817687-3#287#291#diseaseC1839839","span":{"begin":942,"end":946},"obj":"diseaseC1839839"},{"id":"24817687-3#287#291#diseaseC0005586","span":{"begin":942,"end":946},"obj":"diseaseC0005586"},{"id":"24817687-3#287#291#diseaseC1970943","span":{"begin":942,"end":946},"obj":"diseaseC1970943"},{"id":"24817687-3#287#291#diseaseC1970945","span":{"begin":942,"end":946},"obj":"diseaseC1970945"},{"id":"24817687-3#287#291#diseaseC1852197","span":{"begin":942,"end":946},"obj":"diseaseC1852197"},{"id":"24817687-3#336#339#diseaseC0001973","span":{"begin":991,"end":994},"obj":"diseaseC0001973"},{"id":"24817687-3#439#453#diseaseC0004936","span":{"begin":1094,"end":1108},"obj":"diseaseC0004936"},{"id":"24817687-3#458#476#diseaseC0001973","span":{"begin":1113,"end":1131},"obj":"diseaseC0001973"},{"id":"24817687-6#95#104#geners1106854","span":{"begin":1676,"end":1685},"obj":"geners1106854"},{"id":"24817687-6#27#36#geners1106854","span":{"begin":1608,"end":1617},"obj":"geners1106854"},{"id":"24817687-6#58#62#diseaseC1839839","span":{"begin":1639,"end":1643},"obj":"diseaseC1839839"},{"id":"24817687-6#58#62#diseaseC0005586","span":{"begin":1639,"end":1643},"obj":"diseaseC0005586"},{"id":"24817687-6#58#62#diseaseC1970943","span":{"begin":1639,"end":1643},"obj":"diseaseC1970943"},{"id":"24817687-6#58#62#diseaseC1970945","span":{"begin":1639,"end":1643},"obj":"diseaseC1970945"},{"id":"24817687-6#58#62#diseaseC1852197","span":{"begin":1639,"end":1643},"obj":"diseaseC1852197"},{"id":"24817687-6#58#62#diseaseC1839839","span":{"begin":1639,"end":1643},"obj":"diseaseC1839839"},{"id":"24817687-6#58#62#diseaseC0005586","span":{"begin":1639,"end":1643},"obj":"diseaseC0005586"},{"id":"24817687-6#58#62#diseaseC1970943","span":{"begin":1639,"end":1643},"obj":"diseaseC1970943"},{"id":"24817687-6#58#62#diseaseC1970945","span":{"begin":1639,"end":1643},"obj":"diseaseC1970945"},{"id":"24817687-6#58#62#diseaseC1852197","span":{"begin":1639,"end":1643},"obj":"diseaseC1852197"}],"relations":[{"id":"139#148#geners3771829177#181#diseaseC1263846","pred":"associated_with","subj":"24817687-2#139#148#geners3771829","obj":"24817687-2#177#181#diseaseC1263846"},{"id":"257#266#geners377182942#61#diseaseC0525045","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#42#61#diseaseC0525045"},{"id":"257#266#geners377182999#103#diseaseC1839839","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC1839839"},{"id":"257#266#geners377182999#103#diseaseC0005586","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC0005586"},{"id":"257#266#geners377182999#103#diseaseC1970943","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC1970943"},{"id":"257#266#geners377182999#103#diseaseC1970945","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC1970945"},{"id":"257#266#geners377182999#103#diseaseC1852197","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC1852197"},{"id":"257#266#geners3771829211#215#diseaseC1839839","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC1839839"},{"id":"257#266#geners3771829211#215#diseaseC0005586","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC0005586"},{"id":"257#266#geners3771829211#215#diseaseC1970943","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC1970943"},{"id":"257#266#geners3771829211#215#diseaseC1970945","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC1970945"},{"id":"257#266#geners3771829211#215#diseaseC1852197","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC1852197"},{"id":"257#266#geners3771829287#291#diseaseC1839839","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC1839839"},{"id":"257#266#geners3771829287#291#diseaseC0005586","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC0005586"},{"id":"257#266#geners3771829287#291#diseaseC1970943","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC1970943"},{"id":"257#266#geners3771829287#291#diseaseC1970945","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC1970945"},{"id":"257#266#geners3771829287#291#diseaseC1852197","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC1852197"},{"id":"257#266#geners3771829336#339#diseaseC0001973","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#336#339#diseaseC0001973"},{"id":"257#266#geners3771829439#453#diseaseC0004936","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#439#453#diseaseC0004936"},{"id":"257#266#geners3771829458#476#diseaseC0001973","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#458#476#diseaseC0001973"},{"id":"257#266#geners377182999#103#diseaseC1839839","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC1839839"},{"id":"257#266#geners377182999#103#diseaseC0005586","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC0005586"},{"id":"257#266#geners377182999#103#diseaseC1970943","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC1970943"},{"id":"257#266#geners377182999#103#diseaseC1970945","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC1970945"},{"id":"257#266#geners377182999#103#diseaseC1852197","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#99#103#diseaseC1852197"},{"id":"257#266#geners3771829211#215#diseaseC1839839","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC1839839"},{"id":"257#266#geners3771829211#215#diseaseC0005586","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC0005586"},{"id":"257#266#geners3771829211#215#diseaseC1970943","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC1970943"},{"id":"257#266#geners3771829211#215#diseaseC1970945","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC1970945"},{"id":"257#266#geners3771829211#215#diseaseC1852197","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#211#215#diseaseC1852197"},{"id":"257#266#geners3771829287#291#diseaseC1839839","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC1839839"},{"id":"257#266#geners3771829287#291#diseaseC0005586","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC0005586"},{"id":"257#266#geners3771829287#291#diseaseC1970943","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC1970943"},{"id":"257#266#geners3771829287#291#diseaseC1970945","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC1970945"},{"id":"257#266#geners3771829287#291#diseaseC1852197","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#287#291#diseaseC1852197"},{"id":"257#266#geners3771829336#339#diseaseC0001973","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#336#339#diseaseC0001973"},{"id":"257#266#geners3771829439#453#diseaseC0004936","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#439#453#diseaseC0004936"},{"id":"257#266#geners3771829458#476#diseaseC0001973","pred":"associated_with","subj":"24817687-3#257#266#geners3771829","obj":"24817687-3#458#476#diseaseC0001973"},{"id":"63#72#geners377182942#61#diseaseC0525045","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#42#61#diseaseC0525045"},{"id":"63#72#geners377182999#103#diseaseC1839839","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC1839839"},{"id":"63#72#geners377182999#103#diseaseC0005586","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC0005586"},{"id":"63#72#geners377182999#103#diseaseC1970943","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC1970943"},{"id":"63#72#geners377182999#103#diseaseC1970945","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC1970945"},{"id":"63#72#geners377182999#103#diseaseC1852197","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC1852197"},{"id":"63#72#geners3771829211#215#diseaseC1839839","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC1839839"},{"id":"63#72#geners3771829211#215#diseaseC0005586","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC0005586"},{"id":"63#72#geners3771829211#215#diseaseC1970943","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC1970943"},{"id":"63#72#geners3771829211#215#diseaseC1970945","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC1970945"},{"id":"63#72#geners3771829211#215#diseaseC1852197","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC1852197"},{"id":"63#72#geners3771829287#291#diseaseC1839839","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC1839839"},{"id":"63#72#geners3771829287#291#diseaseC0005586","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC0005586"},{"id":"63#72#geners3771829287#291#diseaseC1970943","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC1970943"},{"id":"63#72#geners3771829287#291#diseaseC1970945","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC1970945"},{"id":"63#72#geners3771829287#291#diseaseC1852197","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC1852197"},{"id":"63#72#geners3771829336#339#diseaseC0001973","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#336#339#diseaseC0001973"},{"id":"63#72#geners3771829439#453#diseaseC0004936","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#439#453#diseaseC0004936"},{"id":"63#72#geners3771829458#476#diseaseC0001973","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#458#476#diseaseC0001973"},{"id":"63#72#geners377182999#103#diseaseC1839839","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC1839839"},{"id":"63#72#geners377182999#103#diseaseC0005586","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC0005586"},{"id":"63#72#geners377182999#103#diseaseC1970943","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC1970943"},{"id":"63#72#geners377182999#103#diseaseC1970945","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC1970945"},{"id":"63#72#geners377182999#103#diseaseC1852197","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#99#103#diseaseC1852197"},{"id":"63#72#geners3771829211#215#diseaseC1839839","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC1839839"},{"id":"63#72#geners3771829211#215#diseaseC0005586","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC0005586"},{"id":"63#72#geners3771829211#215#diseaseC1970943","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC1970943"},{"id":"63#72#geners3771829211#215#diseaseC1970945","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC1970945"},{"id":"63#72#geners3771829211#215#diseaseC1852197","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#211#215#diseaseC1852197"},{"id":"63#72#geners3771829287#291#diseaseC1839839","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC1839839"},{"id":"63#72#geners3771829287#291#diseaseC0005586","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC0005586"},{"id":"63#72#geners3771829287#291#diseaseC1970943","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC1970943"},{"id":"63#72#geners3771829287#291#diseaseC1970945","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC1970945"},{"id":"63#72#geners3771829287#291#diseaseC1852197","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#287#291#diseaseC1852197"},{"id":"63#72#geners3771829336#339#diseaseC0001973","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#336#339#diseaseC0001973"},{"id":"63#72#geners3771829439#453#diseaseC0004936","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#439#453#diseaseC0004936"},{"id":"63#72#geners3771829458#476#diseaseC0001973","pred":"associated_with","subj":"24817687-3#63#72#geners3771829","obj":"24817687-3#458#476#diseaseC0001973"},{"id":"95#104#geners110685458#62#diseaseC1839839","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC1839839"},{"id":"95#104#geners110685458#62#diseaseC0005586","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC0005586"},{"id":"95#104#geners110685458#62#diseaseC1970943","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC1970943"},{"id":"95#104#geners110685458#62#diseaseC1970945","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC1970945"},{"id":"95#104#geners110685458#62#diseaseC1852197","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC1852197"},{"id":"95#104#geners110685458#62#diseaseC1839839","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC1839839"},{"id":"95#104#geners110685458#62#diseaseC0005586","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC0005586"},{"id":"95#104#geners110685458#62#diseaseC1970943","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC1970943"},{"id":"95#104#geners110685458#62#diseaseC1970945","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC1970945"},{"id":"95#104#geners110685458#62#diseaseC1852197","pred":"associated_with","subj":"24817687-6#95#104#geners1106854","obj":"24817687-6#58#62#diseaseC1852197"},{"id":"27#36#geners110685458#62#diseaseC1839839","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC1839839"},{"id":"27#36#geners110685458#62#diseaseC0005586","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC0005586"},{"id":"27#36#geners110685458#62#diseaseC1970943","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC1970943"},{"id":"27#36#geners110685458#62#diseaseC1970945","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC1970945"},{"id":"27#36#geners110685458#62#diseaseC1852197","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC1852197"},{"id":"27#36#geners110685458#62#diseaseC1839839","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC1839839"},{"id":"27#36#geners110685458#62#diseaseC0005586","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC0005586"},{"id":"27#36#geners110685458#62#diseaseC1970943","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC1970943"},{"id":"27#36#geners110685458#62#diseaseC1970945","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC1970945"},{"id":"27#36#geners110685458#62#diseaseC1852197","pred":"associated_with","subj":"24817687-6#27#36#geners1106854","obj":"24817687-6#58#62#diseaseC1852197"}],"attributes":[{"subj":"24817687-2#139#148#geners3771829","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-2#177#181#diseaseC1263846","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#257#266#geners3771829","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#63#72#geners3771829","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#42#61#diseaseC0525045","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC1839839","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC0005586","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC1970943","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC1970945","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC1852197","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC1839839","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC0005586","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC1970943","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC1970945","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC1852197","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC1839839","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC0005586","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC1970943","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC1970945","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC1852197","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#336#339#diseaseC0001973","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#439#453#diseaseC0004936","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#458#476#diseaseC0001973","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC1839839","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC0005586","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC1970943","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC1970945","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#99#103#diseaseC1852197","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC1839839","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC0005586","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC1970943","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC1970945","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#211#215#diseaseC1852197","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC1839839","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC0005586","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC1970943","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC1970945","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#287#291#diseaseC1852197","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#336#339#diseaseC0001973","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#439#453#diseaseC0004936","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-3#458#476#diseaseC0001973","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#95#104#geners1106854","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#27#36#geners1106854","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC1839839","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC0005586","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC1970943","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC1970945","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC1852197","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC1839839","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC0005586","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC1970943","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC1970945","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"24817687-6#58#62#diseaseC1852197","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"24817687-0#27#48#gene6869","span":{"begin":27,"end":48},"obj":"gene6869"},{"id":"24817687-0#49#54#gene6869","span":{"begin":49,"end":54},"obj":"gene6869"},{"id":"24817687-0#63#79#diseaseC0005586","span":{"begin":63,"end":79},"obj":"diseaseC0005586"},{"id":"24817687-3#33#38#gene6869","span":{"begin":688,"end":693},"obj":"gene6869"},{"id":"24817687-3#42#61#diseaseC0525045","span":{"begin":697,"end":716},"obj":"diseaseC0525045"},{"id":"24817687-3#336#339#diseaseC0001973","span":{"begin":991,"end":994},"obj":"diseaseC0001973"},{"id":"24817687-3#439#453#diseaseC0004936","span":{"begin":1094,"end":1108},"obj":"diseaseC0004936"},{"id":"24817687-3#458#476#diseaseC0001973","span":{"begin":1113,"end":1131},"obj":"diseaseC0001973"},{"id":"24817687-4#68#73#gene6869","span":{"begin":1201,"end":1206},"obj":"gene6869"},{"id":"24817687-4#194#199#gene6869","span":{"begin":1327,"end":1332},"obj":"gene6869"},{"id":"24817687-4#45#49#diseaseC1263846","span":{"begin":1178,"end":1182},"obj":"diseaseC1263846"},{"id":"24817687-7#21#26#gene6869","span":{"begin":1719,"end":1724},"obj":"gene6869"},{"id":"24817687-7#31#35#diseaseC1839839","span":{"begin":1729,"end":1733},"obj":"diseaseC1839839"},{"id":"24817687-7#31#35#diseaseC1970943","span":{"begin":1729,"end":1733},"obj":"diseaseC1970943"},{"id":"24817687-7#31#35#diseaseC1970945","span":{"begin":1729,"end":1733},"obj":"diseaseC1970945"},{"id":"24817687-7#31#35#diseaseC1852197","span":{"begin":1729,"end":1733},"obj":"diseaseC1852197"}],"relations":[{"id":"27#48#gene686963#79#diseaseC0005586","pred":"associated_with","subj":"24817687-0#27#48#gene6869","obj":"24817687-0#63#79#diseaseC0005586"},{"id":"49#54#gene686963#79#diseaseC0005586","pred":"associated_with","subj":"24817687-0#49#54#gene6869","obj":"24817687-0#63#79#diseaseC0005586"},{"id":"33#38#gene686942#61#diseaseC0525045","pred":"associated_with","subj":"24817687-3#33#38#gene6869","obj":"24817687-3#42#61#diseaseC0525045"},{"id":"33#38#gene6869336#339#diseaseC0001973","pred":"associated_with","subj":"24817687-3#33#38#gene6869","obj":"24817687-3#336#339#diseaseC0001973"},{"id":"33#38#gene6869439#453#diseaseC0004936","pred":"associated_with","subj":"24817687-3#33#38#gene6869","obj":"24817687-3#439#453#diseaseC0004936"},{"id":"33#38#gene6869458#476#diseaseC0001973","pred":"associated_with","subj":"24817687-3#33#38#gene6869","obj":"24817687-3#458#476#diseaseC0001973"},{"id":"68#73#gene686945#49#diseaseC1263846","pred":"associated_with","subj":"24817687-4#68#73#gene6869","obj":"24817687-4#45#49#diseaseC1263846"},{"id":"194#199#gene686945#49#diseaseC1263846","pred":"associated_with","subj":"24817687-4#194#199#gene6869","obj":"24817687-4#45#49#diseaseC1263846"},{"id":"21#26#gene686931#35#diseaseC1839839","pred":"associated_with","subj":"24817687-7#21#26#gene6869","obj":"24817687-7#31#35#diseaseC1839839"},{"id":"21#26#gene686931#35#diseaseC1970943","pred":"associated_with","subj":"24817687-7#21#26#gene6869","obj":"24817687-7#31#35#diseaseC1970943"},{"id":"21#26#gene686931#35#diseaseC1970945","pred":"associated_with","subj":"24817687-7#21#26#gene6869","obj":"24817687-7#31#35#diseaseC1970945"},{"id":"21#26#gene686931#35#diseaseC1852197","pred":"associated_with","subj":"24817687-7#21#26#gene6869","obj":"24817687-7#31#35#diseaseC1852197"}],"attributes":[{"subj":"24817687-0#27#48#gene6869","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-0#49#54#gene6869","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-0#63#79#diseaseC0005586","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-3#33#38#gene6869","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-3#42#61#diseaseC0525045","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-3#336#339#diseaseC0001973","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-3#439#453#diseaseC0004936","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-3#458#476#diseaseC0001973","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-4#68#73#gene6869","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-4#194#199#gene6869","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-4#45#49#diseaseC1263846","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-7#21#26#gene6869","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-7#31#35#diseaseC1839839","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-7#31#35#diseaseC1970943","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-7#31#35#diseaseC1970945","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24817687-7#31#35#diseaseC1852197","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET","color":"#eccd93","default":true},{"id":"PubmedHPO","color":"#b393ec"},{"id":"Allie","color":"#93ec99"},{"id":"DisGeNET5_variant_disease","color":"#ec93a6"},{"id":"DisGeNET5_gene_disease","color":"#93c0ec"}]}]}}