PubMed:24807871 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/24807871","sourcedb":"PubMed","sourceid":"24807871","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/24807871","text":"Maintenance tocolysis with oral micronized progesterone for prevention of preterm birth after arrested preterm labor.\nOBJECTIVE: To evaluate the efficacy of maintenance therapy with oral micronized progesterone (OMP) for prolongation of pregnancy in cases of arrested preterm labor.\nMETHODS: Ninety women at 24-34weeks of singleton pregnancy with intact membranes and arrested preterm labor were randomly allocated to receive OMP (n=45) or placebo (n=45) daily until 37weeks or delivery, whichever was earlier. Outcome parameters were compared using Student t test, χ(2) test, Fisher exact test, and log-rank χ(2) test.\nRESULTS: OMP significantly prolonged the latency period (33.29±22.16 vs 23.07±15.42days; P=0.013). Log-rank analysis revealed a significant difference in mean time to delivery between the 2 groups (P=0.014). There were significantly fewer preterm births (33% vs 58%; P=0.034) and low birth weight neonates (37% vs 64%; P=0.017), and significantly higher mean birth weight (2.44±0.58 vs 2.14±0.47kg; P=0.009) in the OMP group. Perinatal outcomes and adverse effects were similar in the 2 groups.\nCONCLUSION: Maintenance tocolysis with OMP significantly prolonged pregnancy and decreased the number of preterm births. Clinical Trial Registry of India: CTRI/2011/10/002043.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_24807871_2_0","span":{"begin":182,"end":210},"obj":"expanded"},{"id":"SS2_24807871_2_0","span":{"begin":212,"end":215},"obj":"abbr"}],"relations":[{"id":"AE1_24807871_2_0","pred":"abbreviatedTo","subj":"SS1_24807871_2_0","obj":"SS2_24807871_2_0"}],"attributes":[{"subj":"SS1_24807871_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_24807871_2_0","pred":"source","obj":"Allie"}]},{"project":"maxiaofeng52_800_3","denotations":[{"id":"T1","span":{"begin":198,"end":210},"obj":"CI"},{"id":"T2","span":{"begin":43,"end":55},"obj":"CI"},{"id":"T3","span":{"begin":212,"end":215},"obj":"CI"},{"id":"T4","span":{"begin":426,"end":429},"obj":"CI"},{"id":"T5","span":{"begin":629,"end":632},"obj":"CI"},{"id":"T6","span":{"begin":1035,"end":1038},"obj":"CI"},{"id":"T7","span":{"begin":1154,"end":1157},"obj":"CI"},{"id":"T8","span":{"begin":440,"end":447},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T2","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T3","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T4","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T5","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T6","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T7","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T8","pred":"source","obj":"maxiaofeng52_800_3"}]},{"project":"wangzhuo19_800_3","denotations":[{"id":"T3","span":{"begin":212,"end":215},"obj":"CI"},{"id":"T4","span":{"begin":426,"end":429},"obj":"CI"},{"id":"T5","span":{"begin":629,"end":632},"obj":"CI"},{"id":"T6","span":{"begin":1035,"end":1038},"obj":"CI"},{"id":"T7","span":{"begin":1154,"end":1157},"obj":"CI"},{"id":"T8","span":{"begin":440,"end":447},"obj":"CI"},{"id":"T9","span":{"begin":43,"end":55},"obj":"CI"},{"id":"T10","span":{"begin":198,"end":210},"obj":"CI"}],"attributes":[{"subj":"T3","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T4","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T5","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T6","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T7","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T8","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T9","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T10","pred":"source","obj":"wangzhuo19_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#ecd893","default":true},{"id":"maxiaofeng52_800_3","color":"#be93ec"},{"id":"wangzhuo19_800_3","color":"#93eca4"}]}]}}