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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 80-136 DRI_Background denotes Many animals show left-right (LR) asymmetric morphology.
T2 137-252 DRI_Background denotes The mechanisms of LR asymmetric development are evolutionarily divergent, and they remain elusive in invertebrates.
T3 253-354 DRI_Background denotes Various organs in Drosophila melanogaster show stereotypic LR asymmetry, including the embryonic gut.
T4 355-458 DRI_Approach denotes The Drosophila embryonic hindgut twists 90° left-handedly, thereby generating directional LR asymmetry.
T5 459-597 DRI_Background denotes We recently revealed that the hindgut epithelial cell is chiral in shape and other properties; this is termed planar cell chirality (PCC).
T6 598-694 DRI_Approach denotes We previously showed by computer modeling that PCC is sufficient to induce the hindgut rotation.
T7 695-804 DRI_Outcome denotes In addition, both the PCC and the direction of hindgut twisting are reversed in Myosin31DF (Myo31DF) mutants.
T8 805-947 DRI_Background denotes Myo31DF encodes Drosophila MyosinID, an actin-based motor protein, whose molecular functions in LR asymmetric development are largely unknown.
T9 948-1146 DRI_Outcome denotes Here, to understand how PCC directs the asymmetric cell-shape, we analyzed PCC in genetic mosaics composed of cells homozygous for mutant Myo31DF, some of which also overexpressed wild-type Myo31DF.
T10 1147-1320 DRI_Background denotes Wild-type cell-shape chirality only formed in the Myo31DF-overexpressing cells, suggesting that cell-shape chirality was established in each cell and reflects intrinsic PCC.
T11 1321-1499 DRI_Background denotes A computer model recapitulating the development of this genetic mosaic suggested that mechanical interactions between cells are required for the cell-shape behavior seen in vivo.
T12 1500-1732 DRI_Outcome denotes Our mosaic analysis also suggested that during hindgut rotation in vivo, wild-type Myo31DF suppresses the elongation of cell boundaries, supporting the idea that cell-shape chirality is an intrinsic property determined in each cell.
T13 1733-2079 DRI_Background denotes However, the amount and distribution of F-actin and Myosin II, which are known to help generate the contraction force on cell boundaries, did not show differences between Myo31DF mutant cells and wild-type cells, suggesting that the static amount and distribution of these proteins are not involved in the suppression of cell-boundary elongation.
T14 2080-2286 DRI_Outcome denotes Taken together, our results suggest that cell-shape chirality is intrinsically formed in each cell, and that mechanical force from intercellular interactions contributes to its formation and/or maintenance.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1833-1844 HP_0001371 denotes contraction