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PubMed:24796628 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Tumor necrosis factor-β Nco1 polymorphism and susceptibility to sepsis following major elective surgery.
T2 105-116 Sentence denotes BACKGROUND:
T3 117-194 Sentence denotes Post-operative sepsis remains a substantial cause of morbidity and mortality.
T4 195-330 Sentence denotes In injured patients, that a polymorphism of the gene for tumor necrosis factor-β (TNF-β) has been related to the development of sepsis.
T5 331-417 Sentence denotes Genetic factors may also have a role in etio-pathogenesis of sepsis following surgery.
T6 418-588 Sentence denotes We investigated the relationship of the polymorphism of the gene for TNF-β and the serum concentration of TNF-α to the development of sepsis after elective major surgery.
T7 589-597 Sentence denotes METHODS:
T8 598-679 Sentence denotes The study population consisted of 211 patients undergoing major elective surgery.
T9 680-846 Sentence denotes The NcoI polymorphism of TNF-β was studied in genomic DNA through the analysis of restriction fragments of Nco1-digested DNA with the polymerase chain reaction (PCR).
T10 847-924 Sentence denotes All patients were followed for 1 mo after surgery for any evidence of sepsis.
T11 925-1040 Sentence denotes Serum concentrations of TNF-α were measured pre- and post-operatively by enzyme linked immunosorbent assay (ELISA).
T12 1041-1129 Sentence denotes Genotypes of TNF-β and the production of TNF-α were related to the occurrence of sepsis.
T13 1130-1138 Sentence denotes RESULTS:
T14 1139-1203 Sentence denotes Post-operative sepsis developed in 21.8% (n=46) of the patients.
T15 1204-1241 Sentence denotes The overall mortality was 4.2% (n=9).
T16 1242-1331 Sentence denotes The overall allele frequency of the TNF-β genotype was 0.32 for TNFB1 and 0.68 for TNFB2.
T17 1332-1530 Sentence denotes Within the TNF-β genotype, 11.84% (n=25) of the patients were homozygous recessive for TNFB1, 41.23% (n=87) were heterozygous, with TNFB1/TNFB2, and 46.91% (n=99) were homozygous dominant for TNFB2.
T18 1531-1648 Sentence denotes The incidence of post-operative sepsis was significantly (p=0.01) higher in patients homozygous for the TNFB2 allele.
T19 1649-1893 Sentence denotes When compared with patients carrying at least one TNFB1 allele (TNFB1 homozygous and heterozygous genotype), the TNFB2 homozygous genotype was associated with an odds ratio (OR) of 2.60 (p=0.005; 95% CI 1.32-5.15) for the development of sepsis.
T20 1894-2025 Sentence denotes As compared with that for the heterozygous genotype, the OR for the homozygous TNFB2 genotype was 3.00 (p=0.003; 95% CI 1.39-6.44).
T21 2026-2221 Sentence denotes In patients with post-operative sepsis, serum concentrations of TNF-α were significantly higher (p=0.02) in TNFB2 homozygous individuals than in those of individuals of the other TNF-β genotypes.
T22 2222-2233 Sentence denotes CONCLUSION:
T23 2234-2330 Sentence denotes The development of sepsis was associated with a greater capacity to produce TNF-α after surgery.
T24 2331-2479 Sentence denotes The Nco1 polymorphism of the TNF-β gene was associated with the development of post-operative sepsis with an increased serum concentration of TNF-α.
T25 2480-2610 Sentence denotes In patients without post-operative sepsis, polymorphism of the TNF-β gene was not related to different levels of TNF-α production.
T26 2611-2815 Sentence denotes This indicates an association between polymorphism of the TNF-β gene and post-operative sepsis, suggesting the TNFB2/B2 genotype as a high-risk factor for the development of sepsis after elective surgery.
T1 0-104 Sentence denotes Tumor necrosis factor-β Nco1 polymorphism and susceptibility to sepsis following major elective surgery.
T2 105-116 Sentence denotes BACKGROUND:
T3 117-194 Sentence denotes Post-operative sepsis remains a substantial cause of morbidity and mortality.
T4 195-330 Sentence denotes In injured patients, that a polymorphism of the gene for tumor necrosis factor-β (TNF-β) has been related to the development of sepsis.
T5 331-417 Sentence denotes Genetic factors may also have a role in etio-pathogenesis of sepsis following surgery.
T6 418-588 Sentence denotes We investigated the relationship of the polymorphism of the gene for TNF-β and the serum concentration of TNF-α to the development of sepsis after elective major surgery.
T7 589-597 Sentence denotes METHODS:
T8 598-679 Sentence denotes The study population consisted of 211 patients undergoing major elective surgery.
T9 680-846 Sentence denotes The NcoI polymorphism of TNF-β was studied in genomic DNA through the analysis of restriction fragments of Nco1-digested DNA with the polymerase chain reaction (PCR).
T10 847-924 Sentence denotes All patients were followed for 1 mo after surgery for any evidence of sepsis.
T11 925-1040 Sentence denotes Serum concentrations of TNF-α were measured pre- and post-operatively by enzyme linked immunosorbent assay (ELISA).
T12 1041-1129 Sentence denotes Genotypes of TNF-β and the production of TNF-α were related to the occurrence of sepsis.
T13 1130-1138 Sentence denotes RESULTS:
T14 1139-1203 Sentence denotes Post-operative sepsis developed in 21.8% (n=46) of the patients.
T15 1204-1241 Sentence denotes The overall mortality was 4.2% (n=9).
T16 1242-1331 Sentence denotes The overall allele frequency of the TNF-β genotype was 0.32 for TNFB1 and 0.68 for TNFB2.
T17 1332-1530 Sentence denotes Within the TNF-β genotype, 11.84% (n=25) of the patients were homozygous recessive for TNFB1, 41.23% (n=87) were heterozygous, with TNFB1/TNFB2, and 46.91% (n=99) were homozygous dominant for TNFB2.
T18 1531-1648 Sentence denotes The incidence of post-operative sepsis was significantly (p=0.01) higher in patients homozygous for the TNFB2 allele.
T19 1649-1893 Sentence denotes When compared with patients carrying at least one TNFB1 allele (TNFB1 homozygous and heterozygous genotype), the TNFB2 homozygous genotype was associated with an odds ratio (OR) of 2.60 (p=0.005; 95% CI 1.32-5.15) for the development of sepsis.
T20 1894-2025 Sentence denotes As compared with that for the heterozygous genotype, the OR for the homozygous TNFB2 genotype was 3.00 (p=0.003; 95% CI 1.39-6.44).
T21 2026-2221 Sentence denotes In patients with post-operative sepsis, serum concentrations of TNF-α were significantly higher (p=0.02) in TNFB2 homozygous individuals than in those of individuals of the other TNF-β genotypes.
T22 2222-2233 Sentence denotes CONCLUSION:
T23 2234-2330 Sentence denotes The development of sepsis was associated with a greater capacity to produce TNF-α after surgery.
T24 2331-2479 Sentence denotes The Nco1 polymorphism of the TNF-β gene was associated with the development of post-operative sepsis with an increased serum concentration of TNF-α.
T25 2480-2610 Sentence denotes In patients without post-operative sepsis, polymorphism of the TNF-β gene was not related to different levels of TNF-α production.
T26 2611-2815 Sentence denotes This indicates an association between polymorphism of the TNF-β gene and post-operative sepsis, suggesting the TNFB2/B2 genotype as a high-risk factor for the development of sepsis after elective surgery.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 2310-2315 gene:7124 denotes TNF-α
T1 2253-2259 disease:C0036690 denotes sepsis
T2 2310-2315 gene:7124 denotes TNF-α
T3 2253-2259 disease:C0243026 denotes sepsis
R1 T0 T1 associated_with TNF-α,sepsis
R2 T2 T3 associated_with TNF-α,sepsis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 132-138 HP_0100806 denotes sepsis
T2 252-257 HP_0002664 denotes tumor
T3 323-329 HP_0100806 denotes sepsis
T4 392-398 HP_0100806 denotes sepsis
T5 552-558 HP_0100806 denotes sepsis

Allie

Id Subject Object Predicate Lexical cue
SS1_24796628_3_0 252-275 expanded denotes tumor necrosis factor-β
SS2_24796628_3_0 277-282 abbr denotes TNF-β
SS1_24796628_8_0 814-839 expanded denotes polymerase chain reaction
SS2_24796628_8_0 841-844 abbr denotes PCR
SS1_24796628_10_0 998-1031 expanded denotes enzyme linked immunosorbent assay
SS2_24796628_10_0 1033-1038 abbr denotes ELISA
SS1_24796628_18_0 1811-1821 expanded denotes odds ratio
SS2_24796628_18_0 1823-1825 abbr denotes OR
AE1_24796628_3_0 SS1_24796628_3_0 SS2_24796628_3_0 abbreviatedTo tumor necrosis factor-β,TNF-β
AE1_24796628_8_0 SS1_24796628_8_0 SS2_24796628_8_0 abbreviatedTo polymerase chain reaction,PCR
AE1_24796628_10_0 SS1_24796628_10_0 SS2_24796628_10_0 abbreviatedTo enzyme linked immunosorbent assay,ELISA
AE1_24796628_18_0 SS1_24796628_18_0 SS2_24796628_18_0 abbreviatedTo odds ratio,OR

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24796628-0#0#23#gene4049 0-23 gene4049 denotes Tumor necrosis factor-β
24796628-0#64#70#diseaseC0243026 64-70 diseaseC0243026 denotes sepsis
24796628-18#142#147#gene7124 2473-2478 gene7124 denotes TNF-α
24796628-18#94#100#diseaseC0243026 2425-2431 diseaseC0243026 denotes sepsis
0#23#gene404964#70#diseaseC0243026 24796628-0#0#23#gene4049 24796628-0#64#70#diseaseC0243026 associated_with Tumor necrosis factor-β,sepsis
142#147#gene712494#100#diseaseC0243026 24796628-18#142#147#gene7124 24796628-18#94#100#diseaseC0243026 associated_with TNF-α,sepsis