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sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Vitamin D3 metabolites modulate dihydropyridine-sensitive calcium currents in clonal rat osteosarcoma cells.
T2 109-282 Sentence denotes A slowly inactivating inward calcium current was identified in the rat osteosarcoma cell line ROS 17/2.8 using a combination of ion flux and electrophysiological techniques.
T3 283-461 Sentence denotes Voltage dependence, dihydropyridine sensitivity, divalent cation selectivity, and single channel properties identified this current as a high threshold, "L-type" calcium current.
T4 462-617 Sentence denotes Ion flux experiments using 45Ca2+ confirmed that calcium uptake through these channel represents a major pathway for calcium entry into osteosarcoma cells.
T5 618-816 Sentence denotes In resting cells, i.e. at negative membrane potentials, stimulation of both calcium current and rapid 45Ca2+ influx could be elicited by concentrations of 1,25-(OH)2-vitamin D3 between 0.1 and 3 nM.
T6 817-955 Sentence denotes At these concentrations, 1,25-(OH)2-vitamin D3 shifted the threshold for activation of inward calcium current to more negative potentials.
T7 956-1030 Sentence denotes At higher concentrations (5-10 nM), inhibitory effects became predominant.
T8 1031-1122 Sentence denotes These opposing effects are functionally similar to those of the dihydropyridine BAY K 8644.
T9 1123-1287 Sentence denotes Other vitamin D3 metabolites (25-(OH)-D3 and 24,25-(OH)2-D3) exhibited less potent stimulatory effects and greater inhibition of calcium current than 1,25-(OH)2-D3.
T10 1288-1548 Sentence denotes These results suggest that (i) vitamin D3 acts as a potent modulator of calcium channel function in osteosarcoma cells, and (ii) intracellular Ca2+-dependent signaling processes may be affected acutely by physiological concentrations of vitamin D3 metabolites.
T1 0-108 Sentence denotes Vitamin D3 metabolites modulate dihydropyridine-sensitive calcium currents in clonal rat osteosarcoma cells.
T2 109-282 Sentence denotes A slowly inactivating inward calcium current was identified in the rat osteosarcoma cell line ROS 17/2.8 using a combination of ion flux and electrophysiological techniques.
T3 283-461 Sentence denotes Voltage dependence, dihydropyridine sensitivity, divalent cation selectivity, and single channel properties identified this current as a high threshold, "L-type" calcium current.
T4 462-617 Sentence denotes Ion flux experiments using 45Ca2+ confirmed that calcium uptake through these channel represents a major pathway for calcium entry into osteosarcoma cells.
T5 618-816 Sentence denotes In resting cells, i.e. at negative membrane potentials, stimulation of both calcium current and rapid 45Ca2+ influx could be elicited by concentrations of 1,25-(OH)2-vitamin D3 between 0.1 and 3 nM.
T6 817-955 Sentence denotes At these concentrations, 1,25-(OH)2-vitamin D3 shifted the threshold for activation of inward calcium current to more negative potentials.
T7 956-1030 Sentence denotes At higher concentrations (5-10 nM), inhibitory effects became predominant.
T8 1031-1122 Sentence denotes These opposing effects are functionally similar to those of the dihydropyridine BAY K 8644.
T9 1123-1287 Sentence denotes Other vitamin D3 metabolites (25-(OH)-D3 and 24,25-(OH)2-D3) exhibited less potent stimulatory effects and greater inhibition of calcium current than 1,25-(OH)2-D3.
T10 1288-1548 Sentence denotes These results suggest that (i) vitamin D3 acts as a potent modulator of calcium channel function in osteosarcoma cells, and (ii) intracellular Ca2+-dependent signaling processes may be affected acutely by physiological concentrations of vitamin D3 metabolites.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 180-192 HP_0002669 denotes osteosarcoma
T2 598-610 HP_0002669 denotes osteosarcoma
T3 1388-1400 HP_0002669 denotes osteosarcoma

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 89-101 Disease denotes osteosarcoma http://purl.obolibrary.org/obo/MONDO_0002623|http://purl.obolibrary.org/obo/MONDO_0009807
T3 180-192 Disease denotes osteosarcoma http://purl.obolibrary.org/obo/MONDO_0002623|http://purl.obolibrary.org/obo/MONDO_0009807
T5 598-610 Disease denotes osteosarcoma http://purl.obolibrary.org/obo/MONDO_0002623|http://purl.obolibrary.org/obo/MONDO_0009807
T7 1388-1400 Disease denotes osteosarcoma http://purl.obolibrary.org/obo/MONDO_0002623|http://purl.obolibrary.org/obo/MONDO_0009807

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 85-88 OrganismTaxon denotes rat 10114|10116
T3 176-179 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 653-661 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 1417-1430 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 89-101 Phenotype denotes osteosarcoma HP:0002669
T2 180-192 Phenotype denotes osteosarcoma HP:0002669
T3 598-610 Phenotype denotes osteosarcoma HP:0002669
T4 1388-1400 Phenotype denotes osteosarcoma HP:0002669