PubMed:24751681 JSONTXT

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":21,"end":27},"obj":"gene:80332"},{"id":"T1","span":{"begin":72,"end":89},"obj":"disease:C2607914"},{"id":"T2","span":{"begin":131,"end":137},"obj":"gene:80332"},{"id":"T3","span":{"begin":292,"end":318},"obj":"disease:C0018621"},{"id":"T4","span":{"begin":131,"end":137},"obj":"gene:80332"},{"id":"T5","span":{"begin":281,"end":287},"obj":"disease:C0004096"},{"id":"T6","span":{"begin":131,"end":137},"obj":"gene:80332"},{"id":"T7","span":{"begin":190,"end":196},"obj":"disease:C0004096"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.\nBACKGROUND: The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis.\nOBJECTIVE: To assess whether the ADAM33 polymorphisms are associated with persistent allergic rhinitis (PER) due to house dust mites in a Chinese population.\nMETHODS: In a hospital-based case-control study of 515 patients with mite-sensitized PER and 495 healthy controls, we genotyped seven single nucleotide polymorphisms (SNPs) in ADAM33. Serum levels of eosinophil cationic protein, total IgE and allergen-specific IgE against Dermatophagoides pteronyssinus and Dermatophagoides farinae were measured by the ImmunoCAP assays.\nRESULTS: In the single-locus analysis, three polymorphisms, rs3918392 (F1), rs528557 (S2) and rs2787093, were significantly associated with mite-sensitized PER. SNP S2 was associated with significantly increased risk both of asthmatic and nonasthmatic mite-sensitized PER. In the combined genotypes analysis, individuals with 2-4 risk alleles had a significantly higher risk of mite-sensitized PER (adjusted OR = 1.99, 95% CI = 1.50-2.62) than those with 0-1 risk alleles. Haplotype-based association analysis revealed that the ACAGCCT haplotype might have potential to protect against mite-sensitized PER (adjusted OR = 0.67; 95% CI = 0.49-0.90).\nCONCLUSIONS: Polymorphisms in the ADAM33 gene may contribute to susceptibility of mite-sensitized PER in this Chinese population."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":190,"end":196},"obj":"HP_0002099"},{"id":"T2","span":{"begin":281,"end":287},"obj":"HP_0002099"},{"id":"T3","span":{"begin":301,"end":318},"obj":"HP_0003193"},{"id":"T4","span":{"begin":310,"end":318},"obj":"HP_0012384"}],"text":"Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.\nBACKGROUND: The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis.\nOBJECTIVE: To assess whether the ADAM33 polymorphisms are associated with persistent allergic rhinitis (PER) due to house dust mites in a Chinese population.\nMETHODS: In a hospital-based case-control study of 515 patients with mite-sensitized PER and 495 healthy controls, we genotyped seven single nucleotide polymorphisms (SNPs) in ADAM33. Serum levels of eosinophil cationic protein, total IgE and allergen-specific IgE against Dermatophagoides pteronyssinus and Dermatophagoides farinae were measured by the ImmunoCAP assays.\nRESULTS: In the single-locus analysis, three polymorphisms, rs3918392 (F1), rs528557 (S2) and rs2787093, were significantly associated with mite-sensitized PER. SNP S2 was associated with significantly increased risk both of asthmatic and nonasthmatic mite-sensitized PER. In the combined genotypes analysis, individuals with 2-4 risk alleles had a significantly higher risk of mite-sensitized PER (adjusted OR = 1.99, 95% CI = 1.50-2.62) than those with 0-1 risk alleles. Haplotype-based association analysis revealed that the ACAGCCT haplotype might have potential to protect against mite-sensitized PER (adjusted OR = 0.67; 95% CI = 0.49-0.90).\nCONCLUSIONS: Polymorphisms in the ADAM33 gene may contribute to susceptibility of mite-sensitized PER in this Chinese population."}

{"project":"Allie","denotations":[{"id":"SS1_24751681_4_0","span":{"begin":394,"end":422},"obj":"expanded"},{"id":"SS2_24751681_4_0","span":{"begin":424,"end":427},"obj":"abbr"},{"id":"SS1_24751681_6_0","span":{"begin":612,"end":643},"obj":"expanded"},{"id":"SS2_24751681_6_0","span":{"begin":645,"end":649},"obj":"abbr"}],"relations":[{"id":"AE1_24751681_4_0","pred":"abbreviatedTo","subj":"SS1_24751681_4_0","obj":"SS2_24751681_4_0"},{"id":"AE1_24751681_6_0","pred":"abbreviatedTo","subj":"SS1_24751681_6_0","obj":"SS2_24751681_6_0"}],"text":"Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.\nBACKGROUND: The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis.\nOBJECTIVE: To assess whether the ADAM33 polymorphisms are associated with persistent allergic rhinitis (PER) due to house dust mites in a Chinese population.\nMETHODS: In a hospital-based case-control study of 515 patients with mite-sensitized PER and 495 healthy controls, we genotyped seven single nucleotide polymorphisms (SNPs) in ADAM33. Serum levels of eosinophil cationic protein, total IgE and allergen-specific IgE against Dermatophagoides pteronyssinus and Dermatophagoides farinae were measured by the ImmunoCAP assays.\nRESULTS: In the single-locus analysis, three polymorphisms, rs3918392 (F1), rs528557 (S2) and rs2787093, were significantly associated with mite-sensitized PER. SNP S2 was associated with significantly increased risk both of asthmatic and nonasthmatic mite-sensitized PER. In the combined genotypes analysis, individuals with 2-4 risk alleles had a significantly higher risk of mite-sensitized PER (adjusted OR = 1.99, 95% CI = 1.50-2.62) than those with 0-1 risk alleles. Haplotype-based association analysis revealed that the ACAGCCT haplotype might have potential to protect against mite-sensitized PER (adjusted OR = 0.67; 95% CI = 0.49-0.90).\nCONCLUSIONS: Polymorphisms in the ADAM33 gene may contribute to susceptibility of mite-sensitized PER in this Chinese population."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"24751681-0#21#27#gene80332","span":{"begin":21,"end":27},"obj":"gene80332"},{"id":"24751681-0#61#71#diseaseC0332996","span":{"begin":61,"end":71},"obj":"diseaseC0332996"},{"id":"24751681-0#72#89#diseaseC2607914","span":{"begin":72,"end":89},"obj":"diseaseC2607914"},{"id":"24751681-1#4#10#gene80332","span":{"begin":131,"end":137},"obj":"gene80332"},{"id":"24751681-1#63#69#diseaseC0004096","span":{"begin":190,"end":196},"obj":"diseaseC0004096"},{"id":"24751681-1#154#160#diseaseC0004096","span":{"begin":281,"end":287},"obj":"diseaseC0004096"},{"id":"24751681-1#165#191#diseaseC0018621","span":{"begin":292,"end":318},"obj":"diseaseC0018621"}],"relations":[{"id":"21#27#gene8033261#71#diseaseC0332996","pred":"associated_with","subj":"24751681-0#21#27#gene80332","obj":"24751681-0#61#71#diseaseC0332996"},{"id":"21#27#gene8033272#89#diseaseC2607914","pred":"associated_with","subj":"24751681-0#21#27#gene80332","obj":"24751681-0#72#89#diseaseC2607914"},{"id":"4#10#gene8033263#69#diseaseC0004096","pred":"associated_with","subj":"24751681-1#4#10#gene80332","obj":"24751681-1#63#69#diseaseC0004096"},{"id":"4#10#gene80332154#160#diseaseC0004096","pred":"associated_with","subj":"24751681-1#4#10#gene80332","obj":"24751681-1#154#160#diseaseC0004096"},{"id":"4#10#gene80332165#191#diseaseC0018621","pred":"associated_with","subj":"24751681-1#4#10#gene80332","obj":"24751681-1#165#191#diseaseC0018621"}],"text":"Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.\nBACKGROUND: The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis.\nOBJECTIVE: To assess whether the ADAM33 polymorphisms are associated with persistent allergic rhinitis (PER) due to house dust mites in a Chinese population.\nMETHODS: In a hospital-based case-control study of 515 patients with mite-sensitized PER and 495 healthy controls, we genotyped seven single nucleotide polymorphisms (SNPs) in ADAM33. Serum levels of eosinophil cationic protein, total IgE and allergen-specific IgE against Dermatophagoides pteronyssinus and Dermatophagoides farinae were measured by the ImmunoCAP assays.\nRESULTS: In the single-locus analysis, three polymorphisms, rs3918392 (F1), rs528557 (S2) and rs2787093, were significantly associated with mite-sensitized PER. SNP S2 was associated with significantly increased risk both of asthmatic and nonasthmatic mite-sensitized PER. In the combined genotypes analysis, individuals with 2-4 risk alleles had a significantly higher risk of mite-sensitized PER (adjusted OR = 1.99, 95% CI = 1.50-2.62) than those with 0-1 risk alleles. Haplotype-based association analysis revealed that the ACAGCCT haplotype might have potential to protect against mite-sensitized PER (adjusted OR = 0.67; 95% CI = 0.49-0.90).\nCONCLUSIONS: Polymorphisms in the ADAM33 gene may contribute to susceptibility of mite-sensitized PER in this Chinese population."}