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PubMed:24742667 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 721-736 Cell denotes epithelial cell http://purl.obolibrary.org/obo/CL:0000066

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-133 Sentence denotes Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling.
TextSentencer_T2 134-334 Sentence denotes N-Linked glycosylation (N-glycosylation) of proteins has long been associated with oncogenesis, but not until recently have the molecular mechanisms underlying this relationship begun to be unraveled.
TextSentencer_T3 335-455 Sentence denotes Here, we review studies describing how dysregulation of the N-glycosylation-regulating gene, DPAGT1, drives oral cancer.
TextSentencer_T4 456-663 Sentence denotes DPAGT1 encodes the first and rate-limiting enzyme in the assembly of the lipid-linked oligosaccharide precursor in the endoplasmic reticulum and thus mediates N-glycosylation of many cancer-related proteins.
TextSentencer_T5 664-851 Sentence denotes DPAGT1 controls N-glycosylation of E-cadherin, the major epithelial cell-cell adhesion receptor and a tumor suppressor, thereby affecting intercellular adhesion and cytoskeletal dynamics.
TextSentencer_T6 852-999 Sentence denotes DPAGT1 also regulates and is regulated by Wnt/β-catenin signaling, impacting the balance between proliferation and adhesion in homeostatic tissues.
TextSentencer_T7 1000-1166 Sentence denotes Thus, aberrant induction of DPAGT1 promotes a positive feedback network with Wnt/β-catenin that represses E-cadherin-based adhesion and drives tumorigenic phenotypes.
TextSentencer_T8 1167-1415 Sentence denotes Further, modification of receptor tyrosine kinases (RTKs) with N-glycans is known to control their surface presentation via the galectin lattice, and thus increased DPAGT1 expression likely contributes to abnormal activation of RTKs in oral cancer.
TextSentencer_T9 1416-1563 Sentence denotes Collectively, these studies suggest that dysregulation of the DPAGT1/Wnt/E-cadherin network underlies the etiology and pathogenesis of oral cancer.
T1 0-133 Sentence denotes Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling.
T2 134-334 Sentence denotes N-Linked glycosylation (N-glycosylation) of proteins has long been associated with oncogenesis, but not until recently have the molecular mechanisms underlying this relationship begun to be unraveled.
T3 335-455 Sentence denotes Here, we review studies describing how dysregulation of the N-glycosylation-regulating gene, DPAGT1, drives oral cancer.
T4 456-663 Sentence denotes DPAGT1 encodes the first and rate-limiting enzyme in the assembly of the lipid-linked oligosaccharide precursor in the endoplasmic reticulum and thus mediates N-glycosylation of many cancer-related proteins.
T5 664-851 Sentence denotes DPAGT1 controls N-glycosylation of E-cadherin, the major epithelial cell-cell adhesion receptor and a tumor suppressor, thereby affecting intercellular adhesion and cytoskeletal dynamics.
T6 852-999 Sentence denotes DPAGT1 also regulates and is regulated by Wnt/β-catenin signaling, impacting the balance between proliferation and adhesion in homeostatic tissues.
T7 1000-1166 Sentence denotes Thus, aberrant induction of DPAGT1 promotes a positive feedback network with Wnt/β-catenin that represses E-cadherin-based adhesion and drives tumorigenic phenotypes.
T8 1167-1415 Sentence denotes Further, modification of receptor tyrosine kinases (RTKs) with N-glycans is known to control their surface presentation via the galectin lattice, and thus increased DPAGT1 expression likely contributes to abnormal activation of RTKs in oral cancer.
T9 1416-1563 Sentence denotes Collectively, these studies suggest that dysregulation of the DPAGT1/Wnt/E-cadherin network underlies the etiology and pathogenesis of oral cancer.
T1 0-133 Sentence denotes Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling.
T2 134-334 Sentence denotes N-Linked glycosylation (N-glycosylation) of proteins has long been associated with oncogenesis, but not until recently have the molecular mechanisms underlying this relationship begun to be unraveled.
T3 335-455 Sentence denotes Here, we review studies describing how dysregulation of the N-glycosylation-regulating gene, DPAGT1, drives oral cancer.
T4 456-663 Sentence denotes DPAGT1 encodes the first and rate-limiting enzyme in the assembly of the lipid-linked oligosaccharide precursor in the endoplasmic reticulum and thus mediates N-glycosylation of many cancer-related proteins.
T5 664-851 Sentence denotes DPAGT1 controls N-glycosylation of E-cadherin, the major epithelial cell-cell adhesion receptor and a tumor suppressor, thereby affecting intercellular adhesion and cytoskeletal dynamics.
T6 852-999 Sentence denotes DPAGT1 also regulates and is regulated by Wnt/β-catenin signaling, impacting the balance between proliferation and adhesion in homeostatic tissues.
T7 1000-1166 Sentence denotes Thus, aberrant induction of DPAGT1 promotes a positive feedback network with Wnt/β-catenin that represses E-cadherin-based adhesion and drives tumorigenic phenotypes.
T8 1167-1415 Sentence denotes Further, modification of receptor tyrosine kinases (RTKs) with N-glycans is known to control their surface presentation via the galectin lattice, and thus increased DPAGT1 expression likely contributes to abnormal activation of RTKs in oral cancer.
T9 1416-1563 Sentence denotes Collectively, these studies suggest that dysregulation of the DPAGT1/Wnt/E-cadherin network underlies the etiology and pathogenesis of oral cancer.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 443-454 HP_0012290 denotes oral cancer
T2 448-454 HP_0002664 denotes cancer
T3 639-645 HP_0002664 denotes cancer
T4 766-771 HP_0002664 denotes tumor
T5 1403-1414 HP_0012290 denotes oral cancer
T6 1408-1414 HP_0002664 denotes cancer
T7 1551-1562 HP_0012290 denotes oral cancer
T8 1556-1562 HP_0002664 denotes cancer

GlycoBiology-GDGDB

Id Subject Object Predicate Lexical cue
_T1 77-83 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes DPAGT1
_T2 428-434 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes DPAGT1
_T3 456-462 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes DPAGT1
_T4 664-670 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes DPAGT1
_T5 852-858 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes DPAGT1
_T6 1028-1034 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes DPAGT1
_T7 1332-1338 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes DPAGT1
_T8 1478-1484 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00352 denotes DPAGT1

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 0-7 FMAID:165447 denotes Protein
_T2 0-7 FMAID:67257 denotes Protein
_T3 62-70 FMAID:179365 denotes networks
_T4 85-95 FMAID:61792 denotes E-cadherin
_T5 85-95 FMAID:165239 denotes E-cadherin
_T6 85-95 FMAID:165240 denotes E-cadherin
_T7 85-95 FMAID:61793 denotes E-cadherin
_T8 85-95 FMAID:165241 denotes E-cadherin
_T9 85-95 FMAID:61794 denotes E-cadherin
_T10 87-95 FMAID:165235 denotes cadherin
_T11 87-95 FMAID:61790 denotes cadherin
_T12 178-186 FMAID:67257 denotes proteins
_T13 178-186 FMAID:165447 denotes proteins
_T14 422-426 FMAID:198663 denotes gene
_T15 485-489 FMAID:217859 denotes rate
_T16 529-534 FMAID:67264 denotes lipid
_T17 529-534 FMAID:165448 denotes lipid
_T18 542-557 FMAID:196731 denotes oligosaccharide
_T19 542-557 FMAID:82742 denotes oligosaccharide
_T20 575-586 FMAID:165003 denotes endoplasmic
_T21 575-586 FMAID:66856 denotes endoplasmic
_T22 575-596 FMAID:212510 denotes endoplasmic reticulum
_T23 575-596 FMAID:80351 denotes endoplasmic reticulum
_T24 575-596 FMAID:66898 denotes endoplasmic reticulum
_T25 575-596 FMAID:162308 denotes endoplasmic reticulum
_T26 575-596 FMAID:63842 denotes endoplasmic reticulum
_T27 575-596 FMAID:66897 denotes endoplasmic reticulum
_T28 575-596 FMAID:165250 denotes endoplasmic reticulum
_T29 575-596 FMAID:67429 denotes endoplasmic reticulum
_T30 575-596 FMAID:199093 denotes endoplasmic reticulum
_T31 575-596 FMAID:211269 denotes endoplasmic reticulum
_T32 575-596 FMAID:210694 denotes endoplasmic reticulum
_T33 575-596 FMAID:165144 denotes endoplasmic reticulum
_T34 575-596 FMAID:67434 denotes endoplasmic reticulum
_T35 575-596 FMAID:165141 denotes endoplasmic reticulum
_T36 575-596 FMAID:67438 denotes endoplasmic reticulum
_T37 575-596 FMAID:165142 denotes endoplasmic reticulum
_T38 575-596 FMAID:210679 denotes endoplasmic reticulum
_T39 575-596 FMAID:188464 denotes endoplasmic reticulum
_T40 575-596 FMAID:165026 denotes endoplasmic reticulum
_T41 575-596 FMAID:165027 denotes endoplasmic reticulum
_T42 587-596 FMAID:7646 denotes reticulum
_T43 587-596 FMAID:94520 denotes reticulum
_T44 654-662 FMAID:165447 denotes proteins
_T45 654-662 FMAID:67257 denotes proteins
_T46 699-709 FMAID:165239 denotes E-cadherin
_T47 699-709 FMAID:61793 denotes E-cadherin
_T48 699-709 FMAID:61792 denotes E-cadherin
_T49 699-709 FMAID:165241 denotes E-cadherin
_T50 699-709 FMAID:165240 denotes E-cadherin
_T51 699-709 FMAID:61794 denotes E-cadherin
_T52 701-709 FMAID:165235 denotes cadherin
_T53 701-709 FMAID:61790 denotes cadherin
_T54 715-741 FMAID:169654 denotes major epithelial cell-cell
_T55 715-741 FMAID:69076 denotes major epithelial cell-cell
_T56 721-736 FMAID:67559 denotes epithelial cell
_T57 721-736 FMAID:69074 denotes epithelial cell
_T58 721-736 FMAID:165528 denotes epithelial cell
_T59 721-736 FMAID:83514 denotes epithelial cell
_T60 721-736 FMAID:69075 denotes epithelial cell
_T61 721-736 FMAID:164922 denotes epithelial cell
_T62 721-736 FMAID:197786 denotes epithelial cell
_T63 721-736 FMAID:169652 denotes epithelial cell
_T64 721-736 FMAID:165731 denotes epithelial cell
_T65 721-736 FMAID:67799 denotes epithelial cell
_T66 721-736 FMAID:66768 denotes epithelial cell
_T67 721-736 FMAID:169653 denotes epithelial cell
_T68 721-741 FMAID:171393 denotes epithelial cell-cell
_T69 721-741 FMAID:256160 denotes epithelial cell-cell
_T70 721-741 FMAID:213270 denotes epithelial cell-cell
_T71 721-741 FMAID:174281 denotes epithelial cell-cell
_T72 721-741 FMAID:164926 denotes epithelial cell-cell
_T73 721-741 FMAID:256161 denotes epithelial cell-cell
_T74 721-741 FMAID:202186 denotes epithelial cell-cell
_T75 721-741 FMAID:72208 denotes epithelial cell-cell
_T76 721-741 FMAID:66772 denotes epithelial cell-cell
_T77 721-741 FMAID:255871 denotes epithelial cell-cell
_T78 721-741 FMAID:166631 denotes epithelial cell-cell
_T79 721-741 FMAID:174393 denotes epithelial cell-cell
_T80 721-741 FMAID:169655 denotes epithelial cell-cell
_T81 721-741 FMAID:200980 denotes epithelial cell-cell
_T82 721-741 FMAID:72289 denotes epithelial cell-cell
_T83 829-841 FMAID:63834 denotes cytoskeletal
_T84 829-841 FMAID:162297 denotes cytoskeletal
_T85 991-998 FMAID:256050 denotes tissues
_T86 1064-1071 FMAID:179365 denotes network
_T87 1106-1116 FMAID:61794 denotes E-cadherin
_T88 1106-1116 FMAID:165241 denotes E-cadherin
_T89 1106-1116 FMAID:165240 denotes E-cadherin
_T90 1106-1116 FMAID:61793 denotes E-cadherin
_T91 1106-1116 FMAID:61792 denotes E-cadherin
_T92 1106-1116 FMAID:165239 denotes E-cadherin
_T93 1108-1116 FMAID:61790 denotes cadherin
_T94 1108-1116 FMAID:165235 denotes cadherin
_T95 1201-1209 FMAID:82768 denotes tyrosine
_T96 1201-1209 FMAID:196757 denotes tyrosine
_T97 1266-1273 FMAID:146300 denotes surface
_T98 1266-1273 FMAID:50594 denotes surface
_T99 1489-1499 FMAID:165241 denotes E-cadherin
_T100 1489-1499 FMAID:165240 denotes E-cadherin
_T101 1489-1499 FMAID:61792 denotes E-cadherin
_T102 1489-1499 FMAID:165239 denotes E-cadherin
_T103 1489-1499 FMAID:61794 denotes E-cadherin
_T104 1489-1499 FMAID:61793 denotes E-cadherin
_T105 1491-1499 FMAID:165235 denotes cadherin
_T106 1491-1499 FMAID:61790 denotes cadherin
_T107 1500-1507 FMAID:179365 denotes network

uniprot-human

Id Subject Object Predicate Lexical cue
T1 77-83 http://www.uniprot.org/uniprot/Q9H3H5 denotes DPAGT1
T2 428-434 http://www.uniprot.org/uniprot/Q9H3H5 denotes DPAGT1
T3 456-462 http://www.uniprot.org/uniprot/Q9H3H5 denotes DPAGT1
T4 664-670 http://www.uniprot.org/uniprot/Q9H3H5 denotes DPAGT1
T5 852-858 http://www.uniprot.org/uniprot/Q9H3H5 denotes DPAGT1
T6 1028-1034 http://www.uniprot.org/uniprot/Q9H3H5 denotes DPAGT1
T7 1332-1338 http://www.uniprot.org/uniprot/Q9H3H5 denotes DPAGT1
T8 1478-1484 http://www.uniprot.org/uniprot/Q9H3H5 denotes DPAGT1
T9 85-95 http://www.uniprot.org/uniprot/P12830 denotes E-cadherin
T10 699-709 http://www.uniprot.org/uniprot/P12830 denotes E-cadherin
T11 1106-1116 http://www.uniprot.org/uniprot/P12830 denotes E-cadherin
T12 1489-1499 http://www.uniprot.org/uniprot/P12830 denotes E-cadherin
T13 898-907 http://www.uniprot.org/uniprot/P35222 denotes β-catenin
T14 1081-1090 http://www.uniprot.org/uniprot/P35222 denotes β-catenin
T15 1192-1217 http://www.uniprot.org/uniprot/P29322 denotes receptor tyrosine kinases
T16 1192-1217 http://www.uniprot.org/uniprot/Q02763 denotes receptor tyrosine kinases
T17 1192-1217 http://www.uniprot.org/uniprot/Q12866 denotes receptor tyrosine kinases
T18 1192-1217 http://www.uniprot.org/uniprot/P54764 denotes receptor tyrosine kinases
T19 1192-1217 http://www.uniprot.org/uniprot/Q06418 denotes receptor tyrosine kinases
T20 1192-1217 http://www.uniprot.org/uniprot/Q7Z5C3 denotes receptor tyrosine kinases
T21 1192-1217 http://www.uniprot.org/uniprot/P29376 denotes receptor tyrosine kinases
T22 1192-1217 http://www.uniprot.org/uniprot/Q5ST11 denotes receptor tyrosine kinases
T23 1192-1217 http://www.uniprot.org/uniprot/P35916 denotes receptor tyrosine kinases

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 85-95 http://www.uniprot.org/uniprot/P09803 denotes E-cadherin
T2 699-709 http://www.uniprot.org/uniprot/P09803 denotes E-cadherin
T3 1106-1116 http://www.uniprot.org/uniprot/P09803 denotes E-cadherin
T4 1489-1499 http://www.uniprot.org/uniprot/P09803 denotes E-cadherin
T5 898-907 http://www.uniprot.org/uniprot/Q02248 denotes β-catenin
T6 1081-1090 http://www.uniprot.org/uniprot/Q02248 denotes β-catenin

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 32-38 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T2 272-282 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanisms
T3 448-454 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T4 634-638 http://purl.bioontology.org/ontology/NCBITAXON/9973 denotes many
T5 639-645 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T6 646-653 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T7 991-998 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T8 1408-1414 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T9 1556-1562 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer

GO-BP

Id Subject Object Predicate Lexical cue
T1 10-23 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T2 143-156 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T3 160-173 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T4 397-410 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 617-630 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 682-695 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T7 53-61 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T8 123-132 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9 908-917 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T10 158-186 http://purl.obolibrary.org/obo/GO_0006487 denotes N-glycosylation) of proteins
T11 160-186 http://purl.obolibrary.org/obo/GO_0006486 denotes glycosylation) of proteins
T12 411-421 http://purl.obolibrary.org/obo/GO_0065007 denotes regulating
T13 864-873 http://purl.obolibrary.org/obo/GO_0065007 denotes regulates
T14 881-890 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T15 737-750 http://purl.obolibrary.org/obo/GO_0007155 denotes cell adhesion
T16 766-782 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T17 1192-1217 http://purl.obolibrary.org/obo/GO_0038083 denotes receptor tyrosine kinases
T18 1535-1547 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis

GO-CC

Id Subject Object Predicate Lexical cue
T1 575-596 http://purl.obolibrary.org/obo/GO_0005783 denotes endoplasmic reticulum
T2 732-736 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 737-741 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 991-998 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

Allie

Id Subject Object Predicate Lexical cue
SS1_24742667_1_0 134-156 expanded denotes N-Linked glycosylation
SS2_24742667_1_0 158-173 abbr denotes N-glycosylation
SS1_24742667_7_0 1192-1217 expanded denotes receptor tyrosine kinases
SS2_24742667_7_0 1219-1223 abbr denotes RTKs
AE1_24742667_1_0 SS1_24742667_1_0 SS2_24742667_1_0 abbreviatedTo N-Linked glycosylation,N-glycosylation
AE1_24742667_7_0 SS1_24742667_7_0 SS2_24742667_7_0 abbreviatedTo receptor tyrosine kinases,RTKs

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 732-741 http://purl.obolibrary.org/obo/MAT_0000083 denotes cell-cell

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 1230-1239 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycans

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 991-998 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 27-38 Disease denotes oral cancer http://purl.obolibrary.org/obo/MONDO_0023644
T2 443-454 Disease denotes oral cancer http://purl.obolibrary.org/obo/MONDO_0023644
T3 639-645 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 766-771 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 1403-1414 Disease denotes oral cancer http://purl.obolibrary.org/obo/MONDO_0023644
T6 1551-1562 Disease denotes oral cancer http://purl.obolibrary.org/obo/MONDO_0023644

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 32-38 Phenotype denotes cancer HP:0002664
T2 448-454 Phenotype denotes cancer HP:0002664
T3 639-645 Phenotype denotes cancer HP:0002664
T4 766-771 Phenotype denotes tumor HP:0002664
T5 1408-1414 Phenotype denotes cancer HP:0002664
T6 1556-1562 Phenotype denotes cancer HP:0002664

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 587-596 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 721-736 Body_part denotes epithelial cell http://purl.obolibrary.org/obo/CL_0000066