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PubMed:24725412 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
24725412_0 701-707 ProteinMutation denotes G2019S rs34637584
24725412_1 640-646 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T2 0-17 GO:0003735 denotes Ribosomal protein
T3 0-21 C036004 denotes Ribosomal protein s15
T8 10-17 SO:0000104 denotes protein
T4 10-17 GO:0003675 denotes protein
T9 10-19 34822 denotes protein s
T10 10-19 P23428 denotes protein s
T11 10-19 P21124 denotes protein s
T12 10-19 P35958 denotes protein s
T14 10-19 Q00844 denotes protein s
T15 10-19 Q01209 denotes protein s
T16 10-19 P21125 denotes protein s
T17 10-19 P16904 denotes protein s
T18 10-19 P22175 denotes protein s
T19 10-19 P23429 denotes protein s
T21 10-19 P27392 denotes protein s
T22 10-19 P03408 denotes protein s
T23 18-21 PR:P07185 denotes s15
T24 18-21 P33192 denotes s15
T25 22-37 GO:0016310 denotes phosphorylation
T26 47-52 PR:Q5S006 denotes LRRK2
T27 47-52 PR:000003033 denotes LRRK2
T28 47-52 PR:Q5S007 denotes LRRK2
T33 74-93 D010300 denotes Parkinson's disease
T34 74-93 D010300 denotes Parkinson's disease
T38 108-115 6308 denotes leucine
T39 108-115 SO:0001437 denotes leucine
T37 108-115 CHEBI:15603 denotes leucine
T40 108-115 D007930 denotes leucine
T41 108-115 CHEBI:25017 denotes leucine
T42 108-115 D007930 denotes leucine
T43 121-127 SO:0001068 denotes repeat
T44 138-143 PR:Q5S006 denotes LRRK2
T45 138-143 PR:000003033 denotes LRRK2
T46 138-143 PR:Q5S007 denotes LRRK2
T51 189-208 D010300 denotes Parkinson's disease
T52 189-208 D010300 denotes Parkinson's disease
T55 224-229 PR:Q5S006 denotes LRRK2
T56 224-229 PR:000003033 denotes LRRK2
T57 224-229 PR:Q5S007 denotes LRRK2
T58 230-245 GO:0016301 denotes kinase activity
T59 319-324 PR:Q5S006 denotes LRRK2
T60 319-324 PR:000003033 denotes LRRK2
T61 319-324 PR:Q5S007 denotes LRRK2
T62 325-340 GO:0016301 denotes kinase activity
T64 395-412 GO:0003735 denotes ribosomal protein
T65 395-416 C036004 denotes ribosomal protein s15
T70 405-412 SO:0000104 denotes protein
T66 405-412 GO:0003675 denotes protein
T71 405-414 34822 denotes protein s
T72 405-414 P23428 denotes protein s
T73 405-414 P21124 denotes protein s
T74 405-414 P35958 denotes protein s
T76 405-414 Q00844 denotes protein s
T77 405-414 Q01209 denotes protein s
T78 405-414 P21125 denotes protein s
T79 405-414 P16904 denotes protein s
T80 405-414 P22175 denotes protein s
T81 405-414 P23429 denotes protein s
T83 405-414 P27392 denotes protein s
T84 405-414 P03408 denotes protein s
T85 413-416 PR:P07185 denotes s15
T86 413-416 P33192 denotes s15
T87 437-442 PR:Q5S006 denotes LRRK2
T88 437-442 PR:000003033 denotes LRRK2
T89 437-442 PR:Q5S007 denotes LRRK2
T90 456-466 2294143 denotes Drosophila
T91 456-466 504603 denotes Drosophila
T92 456-466 2294139 denotes Drosophila
T93 456-466 2294145 denotes Drosophila
T94 456-466 2294141 denotes Drosophila
T95 456-466 2294142 denotes Drosophila
T96 456-466 2294144 denotes Drosophila
T97 456-466 2294140 denotes Drosophila
T98 456-466 D004330 denotes Drosophila
T99 456-466 2080301 denotes Drosophila
T100 471-476 D006801 denotes human
T101 477-483 CL:0000540 denotes neuron
T102 512-515 PR:P07185 denotes s15
T103 512-515 P33192 denotes s15
T105 527-536 10524 denotes threonine
T104 527-536 SO:0001445 denotes threonine
T106 527-536 CHEBI:16857 denotes threonine
T107 527-536 CHEBI:26986 denotes threonine
T108 527-536 D013912 denotes threonine
T109 527-536 D013912 denotes threonine
T114 544-551 426 denotes alanine
T115 544-551 SO:0001435 denotes alanine
T110 544-551 D000409 denotes alanine
T111 544-551 D000409 denotes alanine
T112 544-551 CHEBI:16977 denotes alanine
T113 544-551 CHEBI:46217 denotes alanine
T116 544-551 CHEBI:16449 denotes alanine
T117 552-564 SO:1000002 denotes substitution
T122 573-581 3628 denotes dopamine
T118 573-581 CHEBI:59905 denotes dopamine
T119 573-581 CHEBI:18243 denotes dopamine
T120 573-581 D004298 denotes dopamine
T121 573-581 D004298 denotes dopamine
T123 582-588 CL:0000540 denotes neuron
T124 582-601 D009410 denotes neuron degeneration
T125 582-601 D009410 denotes neuron degeneration
T126 647-652 PR:Q5S006 denotes LRRK2
T127 647-652 PR:000003033 denotes LRRK2
T128 647-652 PR:Q5S007 denotes LRRK2
T129 653-663 SO:0000781 denotes transgenic
T130 664-674 2294143 denotes Drosophila
T131 664-674 504603 denotes Drosophila
T132 664-674 2294139 denotes Drosophila
T133 664-674 2294145 denotes Drosophila
T134 664-674 2294141 denotes Drosophila
T135 664-674 2294142 denotes Drosophila
T136 664-674 2294144 denotes Drosophila
T137 664-674 2294140 denotes Drosophila
T138 664-674 D004330 denotes Drosophila
T139 664-674 2080301 denotes Drosophila
T140 708-713 PR:Q5S006 denotes LRRK2
T141 708-713 PR:000003033 denotes LRRK2
T142 708-713 PR:Q5S007 denotes LRRK2
T143 723-730 GO:0043005 denotes neurite
T144 740-750 GO:0008219 denotes cell death
T145 754-759 D006801 denotes human
T150 760-768 3628 denotes dopamine
T146 760-768 CHEBI:59905 denotes dopamine
T147 760-768 CHEBI:18243 denotes dopamine
T148 760-768 D004298 denotes dopamine
T149 760-768 D004298 denotes dopamine
T151 814-819 PR:Q5S006 denotes LRRK2
T152 814-819 PR:000003033 denotes LRRK2
T153 814-819 PR:Q5S007 denotes LRRK2
T160 836-839 SO:0000581 denotes cap
T154 836-839 PR:P36621 denotes cap
T155 836-839 PR:P0ACJ8 denotes cap
T156 836-839 PR:P54654 denotes cap
T157 836-839 PR:000022333 denotes cap
T158 836-839 PR:P0A2T6 denotes cap
T159 836-839 PR:Q02910 denotes cap
T167 854-857 SO:0000581 denotes cap
T161 854-857 PR:P36621 denotes cap
T162 854-857 PR:P0ACJ8 denotes cap
T163 854-857 PR:P54654 denotes cap
T164 854-857 PR:000022333 denotes cap
T165 854-857 PR:P0A2T6 denotes cap
T166 854-857 PR:Q02910 denotes cap
T170 870-874 SO:0000234 denotes mRNA
T168 870-874 D012333 denotes mRNA
T169 870-874 CHEBI:33699 denotes mRNA
T171 875-886 GO:0006412 denotes translation
T176 918-925 SO:0000104 denotes protein
T175 918-925 PR:000000001 denotes protein
T172 918-925 GO:0003675 denotes protein
T173 918-925 CHEBI:36080 denotes protein
T174 918-925 CHEBI:11122 denotes protein
T177 918-935 GO:0006412 denotes protein synthesis
T179 939-949 2294143 denotes Drosophila
T180 939-949 504603 denotes Drosophila
T181 939-949 2294139 denotes Drosophila
T182 939-949 2294145 denotes Drosophila
T183 939-949 2294141 denotes Drosophila
T184 939-949 2294142 denotes Drosophila
T185 939-949 2294144 denotes Drosophila
T186 939-949 2294140 denotes Drosophila
T187 939-949 D004330 denotes Drosophila
T188 939-949 2080301 denotes Drosophila
T189 1000-1003 PR:P07185 denotes s15
T190 1000-1003 P33192 denotes s15
T191 1050-1062 GO:0009405 denotes pathogenesis
T192 1082-1087 PR:Q5S006 denotes LRRK2
T193 1082-1087 PR:000003033 denotes LRRK2
T194 1082-1087 PR:Q5S007 denotes LRRK2
T195 1088-1103 GO:0016301 denotes kinase activity
T200 1117-1124 SO:0000104 denotes protein
T199 1117-1124 PR:000000001 denotes protein
T196 1117-1124 GO:0003675 denotes protein
T197 1117-1124 CHEBI:36080 denotes protein
T198 1117-1124 CHEBI:11122 denotes protein
T201 1117-1134 GO:0006412 denotes protein synthesis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 189-198 HP_0001300 denotes Parkinson
T2 250-267 HP_0002180 denotes neurodegeneration
T3 344-361 HP_0002180 denotes neurodegeneration

Allie

Id Subject Object Predicate Lexical cue
SS1_24725412_1_0 108-136 expanded denotes leucine-rich repeat kinase 2
SS2_24725412_1_0 138-143 abbr denotes LRRK2
SS1_24725412_1_1 189-208 expanded denotes Parkinson's disease
SS2_24725412_1_1 210-212 abbr denotes PD
AE1_24725412_1_0 SS1_24725412_1_0 SS2_24725412_1_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_24725412_1_1 SS1_24725412_1_1 SS2_24725412_1_1 abbreviatedTo Parkinson's disease,PD

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-94 DRI_Challenge denotes Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
T2 95-214 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and sporadic Parkinson's disease (PD).
T3 215-375 DRI_Background denotes Elevated LRRK2 kinase activity and neurodegeneration are linked, but the phosphosubstrate that connects LRRK2 kinase activity to neurodegeneration is not known.
T4 376-494 DRI_Outcome denotes Here, we show that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron PD models.
T5 495-639 DRI_Outcome denotes Phosphodeficient s15 carrying a threonine 136 to alanine substitution rescues dopamine neuron degeneration and age-related locomotor deficits in
T6 640-652 Token_Label.OUTSIDE denotes G2019S LRRK2
T7 653-700 DRI_Outcome denotes transgenic Drosophila and substantially reduces
T8 701-722 Token_Label.OUTSIDE denotes G2019S LRRK2-mediated
T9 723-790 DRI_Outcome denotes neurite loss and cell death in human dopamine and cortical neurons.
T10 791-976 DRI_Outcome denotes Remarkably, pathogenic LRRK2 stimulates both cap-dependent and cap-independent mRNA translation and induces a bulk increase in protein synthesis in Drosophila, which can be prevented by
T11 977-999 Token_Label.OUTSIDE denotes phosphodeficient T136A
T12 1000-1004 DRI_Outcome denotes s15.
T13 1005-1143 DRI_Background denotes These results reveal a novel mechanism of PD pathogenesis linked to elevated LRRK2 kinase activity and aberrant protein synthesis in vivo.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 95-214 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and sporadic Parkinson's disease (PD).
T2 215-375 DRI_Background denotes Elevated LRRK2 kinase activity and neurodegeneration are linked, but the phosphosubstrate that connects LRRK2 kinase activity to neurodegeneration is not known.
T3 376-494 DRI_Outcome denotes Here, we show that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron PD models.
T4 495-639 DRI_Outcome denotes Phosphodeficient s15 carrying a threonine 136 to alanine substitution rescues dopamine neuron degeneration and age-related locomotor deficits in
T5 653-700 DRI_Outcome denotes transgenic Drosophila and substantially reduces
T6 723-790 DRI_Outcome denotes neurite loss and cell death in human dopamine and cortical neurons.
T7 791-976 DRI_Outcome denotes Remarkably, pathogenic LRRK2 stimulates both cap-dependent and cap-independent mRNA translation and induces a bulk increase in protein synthesis in Drosophila, which can be prevented by
T8 1000-1004 DRI_Outcome denotes s15.
T9 1005-1143 DRI_Background denotes These results reveal a novel mechanism of PD pathogenesis linked to elevated LRRK2 kinase activity and aberrant protein synthesis in vivo.

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 53-70 Phenotype denotes neurodegeneration HP:0002180
T2 250-267 Phenotype denotes neurodegeneration HP:0002180
T3 344-361 Phenotype denotes neurodegeneration HP:0002180

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 74-93 Disease denotes Parkinson's disease http://purl.obolibrary.org/obo/MONDO_0005180
T2 189-208 Disease denotes Parkinson's disease http://purl.obolibrary.org/obo/MONDO_0005180
T3 210-212 Disease denotes PD http://purl.obolibrary.org/obo/MONDO_0005180
T4 484-486 Disease denotes PD http://purl.obolibrary.org/obo/MONDO_0005180
T5 1047-1049 Disease denotes PD http://purl.obolibrary.org/obo/MONDO_0005180

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 456-466 OrganismTaxon denotes Drosophila 2081351|32281|7215
T4 471-476 OrganismTaxon denotes human 9606
T5 664-674 OrganismTaxon denotes Drosophila 2081351|32281|7215
T8 754-759 OrganismTaxon denotes human 9606
T9 939-949 OrganismTaxon denotes Drosophila 2081351|32281|7215

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 477-483 Body_part denotes neuron http://purl.obolibrary.org/obo/CL_0000540
T2 582-588 Body_part denotes neuron http://purl.obolibrary.org/obo/CL_0000540
T3 723-730 Body_part denotes neurite http://purl.obolibrary.org/obo/GO_0043005
T4 773-789 Body_part denotes cortical neurons http://purl.obolibrary.org/obo/CL_0010012

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 477-483 Cell denotes neuron http://purl.obolibrary.org/obo/CL:0000540
T2 582-588 Cell denotes neuron http://purl.obolibrary.org/obo/CL:0000540
T3 773-789 Cell denotes cortical neurons http://purl.obolibrary.org/obo/CL:0010012