PubMed:24719110
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-101 | Sentence | denotes | Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. |
| TextSentencer_T2 | 102-286 | Sentence | denotes | This study aims to identify the inhibitory role of the spinal glucagon like peptide-1 receptor (GLP-1R) signaling in pain hypersensitivity and its mechanism of action in rats and mice. |
| TextSentencer_T3 | 287-451 | Sentence | denotes | First, GLP-1Rs were identified to be specifically expressed on microglial cells in the spinal dorsal horn, and profoundly upregulated after peripheral nerve injury. |
| TextSentencer_T4 | 452-692 | Sentence | denotes | In addition, intrathecal GLP-1R agonists GLP-1(7-36) and exenatide potently alleviated formalin-, peripheral nerve injury-, bone cancer-, and diabetes-induced hypersensitivity states by 60-90%, without affecting acute nociceptive responses. |
| TextSentencer_T5 | 693-820 | Sentence | denotes | The antihypersensitive effects of exenatide and GLP-1 were completely prevented by GLP-1R antagonism and GLP-1R gene knockdown. |
| TextSentencer_T6 | 821-920 | Sentence | denotes | Furthermore, exenatide evoked β-endorphin release from both the spinal cord and cultured microglia. |
| TextSentencer_T7 | 921-1074 | Sentence | denotes | Exenatide antiallodynia was completely prevented by the microglial inhibitor minocycline, β-endorphin antiserum, and opioid receptor antagonist naloxone. |
| TextSentencer_T8 | 1075-1219 | Sentence | denotes | Our results illustrate a novel spinal dorsal horn microglial GLP-1R/β-endorphin inhibitory pathway in a variety of pain hypersensitivity states. |
| T1 | 0-101 | Sentence | denotes | Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. |
| T2 | 102-286 | Sentence | denotes | This study aims to identify the inhibitory role of the spinal glucagon like peptide-1 receptor (GLP-1R) signaling in pain hypersensitivity and its mechanism of action in rats and mice. |
| T3 | 287-451 | Sentence | denotes | First, GLP-1Rs were identified to be specifically expressed on microglial cells in the spinal dorsal horn, and profoundly upregulated after peripheral nerve injury. |
| T4 | 452-692 | Sentence | denotes | In addition, intrathecal GLP-1R agonists GLP-1(7-36) and exenatide potently alleviated formalin-, peripheral nerve injury-, bone cancer-, and diabetes-induced hypersensitivity states by 60-90%, without affecting acute nociceptive responses. |
| T5 | 693-820 | Sentence | denotes | The antihypersensitive effects of exenatide and GLP-1 were completely prevented by GLP-1R antagonism and GLP-1R gene knockdown. |
| T6 | 821-920 | Sentence | denotes | Furthermore, exenatide evoked β-endorphin release from both the spinal cord and cultured microglia. |
| T7 | 921-1074 | Sentence | denotes | Exenatide antiallodynia was completely prevented by the microglial inhibitor minocycline, β-endorphin antiserum, and opioid receptor antagonist naloxone. |
| T8 | 1075-1219 | Sentence | denotes | Our results illustrate a novel spinal dorsal horn microglial GLP-1R/β-endorphin inhibitory pathway in a variety of pain hypersensitivity states. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 477-483 | gene:2740 | denotes | GLP-1R |
| T1 | 594-602 | disease:C0011847 | denotes | diabetes |
| T2 | 477-483 | gene:2740 | denotes | GLP-1R |
| T3 | 594-602 | disease:C0011849 | denotes | diabetes |
| T4 | 493-498 | gene:100125288 | denotes | GLP-1 |
| T5 | 594-602 | disease:C0011847 | denotes | diabetes |
| T6 | 493-498 | gene:100125288 | denotes | GLP-1 |
| T7 | 594-602 | disease:C0011849 | denotes | diabetes |
| T8 | 493-498 | gene:79813 | denotes | GLP-1 |
| T9 | 594-602 | disease:C0011847 | denotes | diabetes |
| T10 | 493-498 | gene:79813 | denotes | GLP-1 |
| T11 | 594-602 | disease:C0011849 | denotes | diabetes |
| T12 | 493-498 | gene:2641 | denotes | GLP-1 |
| T13 | 594-602 | disease:C0011847 | denotes | diabetes |
| T14 | 493-498 | gene:2641 | denotes | GLP-1 |
| T15 | 594-602 | disease:C0011849 | denotes | diabetes |
| R1 | T0 | T1 | associated_with | GLP-1R,diabetes |
| R2 | T2 | T3 | associated_with | GLP-1R,diabetes |
| R3 | T4 | T5 | associated_with | GLP-1,diabetes |
| R4 | T6 | T7 | associated_with | GLP-1,diabetes |
| R5 | T8 | T9 | associated_with | GLP-1,diabetes |
| R6 | T10 | T11 | associated_with | GLP-1,diabetes |
| R7 | T12 | T13 | associated_with | GLP-1,diabetes |
| R8 | T14 | T15 | associated_with | GLP-1,diabetes |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 219-223 | HP_0012531 | denotes | pain |
| T2 | 581-587 | HP_0002664 | denotes | cancer |
| T3 | 1190-1194 | HP_0012531 | denotes | pain |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24719110_1_0 | 164-196 | expanded | denotes | glucagon like peptide-1 receptor |
| SS2_24719110_1_0 | 198-204 | abbr | denotes | GLP-1R |
| AE1_24719110_1_0 | SS1_24719110_1_0 | SS2_24719110_1_0 | abbreviatedTo | glucagon like peptide-1 receptor,GLP-1R |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24719110-0#21#44#gene2641 | 21-44 | gene2641 | denotes | glucagon-like peptide-1 |
| 24719110-0#79#83#diseaseC0030193 | 79-83 | diseaseC0030193 | denotes | pain |
| 24719110-1#62#94#gene2740 | 164-196 | gene2740 | denotes | glucagon like peptide-1 receptor |
| 24719110-1#117#121#diseaseC0030193 | 219-223 | diseaseC0030193 | denotes | pain |
| 24719110-3#41#46#gene79813 | 493-498 | gene79813 | denotes | GLP-1 |
| 24719110-3#41#46#gene2641 | 493-498 | gene2641 | denotes | GLP-1 |
| 24719110-3#41#46#gene2740 | 493-498 | gene2740 | denotes | GLP-1 |
| 24719110-3#41#46#gene100125288 | 493-498 | gene100125288 | denotes | GLP-1 |
| 24719110-3#142#150#diseaseC0011847 | 594-602 | diseaseC0011847 | denotes | diabetes |
| 24719110-3#142#150#diseaseC0011849 | 594-602 | diseaseC0011849 | denotes | diabetes |
| 24719110-3#142#150#diseaseC0011847 | 594-602 | diseaseC0011847 | denotes | diabetes |
| 24719110-3#142#150#diseaseC0011849 | 594-602 | diseaseC0011849 | denotes | diabetes |
| 24719110-3#142#150#diseaseC0011847 | 594-602 | diseaseC0011847 | denotes | diabetes |
| 24719110-3#142#150#diseaseC0011849 | 594-602 | diseaseC0011849 | denotes | diabetes |
| 24719110-3#142#150#diseaseC0011847 | 594-602 | diseaseC0011847 | denotes | diabetes |
| 24719110-3#142#150#diseaseC0011849 | 594-602 | diseaseC0011849 | denotes | diabetes |
| 24719110-7#68#79#gene5443 | 1143-1154 | gene5443 | denotes | β-endorphin |
| 24719110-7#115#119#diseaseC0030193 | 1190-1194 | diseaseC0030193 | denotes | pain |
| 21#44#gene264179#83#diseaseC0030193 | 24719110-0#21#44#gene2641 | 24719110-0#79#83#diseaseC0030193 | associated_with | glucagon-like peptide-1,pain |
| 62#94#gene2740117#121#diseaseC0030193 | 24719110-1#62#94#gene2740 | 24719110-1#117#121#diseaseC0030193 | associated_with | glucagon like peptide-1 receptor,pain |
| 41#46#gene79813142#150#diseaseC0011847 | 24719110-3#41#46#gene79813 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene79813142#150#diseaseC0011849 | 24719110-3#41#46#gene79813 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene79813142#150#diseaseC0011847 | 24719110-3#41#46#gene79813 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene79813142#150#diseaseC0011849 | 24719110-3#41#46#gene79813 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene79813142#150#diseaseC0011847 | 24719110-3#41#46#gene79813 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene79813142#150#diseaseC0011849 | 24719110-3#41#46#gene79813 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene79813142#150#diseaseC0011847 | 24719110-3#41#46#gene79813 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene79813142#150#diseaseC0011849 | 24719110-3#41#46#gene79813 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene2641142#150#diseaseC0011847 | 24719110-3#41#46#gene2641 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene2641142#150#diseaseC0011849 | 24719110-3#41#46#gene2641 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene2641142#150#diseaseC0011847 | 24719110-3#41#46#gene2641 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene2641142#150#diseaseC0011849 | 24719110-3#41#46#gene2641 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene2641142#150#diseaseC0011847 | 24719110-3#41#46#gene2641 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene2641142#150#diseaseC0011849 | 24719110-3#41#46#gene2641 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene2641142#150#diseaseC0011847 | 24719110-3#41#46#gene2641 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene2641142#150#diseaseC0011849 | 24719110-3#41#46#gene2641 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene2740142#150#diseaseC0011847 | 24719110-3#41#46#gene2740 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene2740142#150#diseaseC0011849 | 24719110-3#41#46#gene2740 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene2740142#150#diseaseC0011847 | 24719110-3#41#46#gene2740 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene2740142#150#diseaseC0011849 | 24719110-3#41#46#gene2740 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene2740142#150#diseaseC0011847 | 24719110-3#41#46#gene2740 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene2740142#150#diseaseC0011849 | 24719110-3#41#46#gene2740 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene2740142#150#diseaseC0011847 | 24719110-3#41#46#gene2740 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene2740142#150#diseaseC0011849 | 24719110-3#41#46#gene2740 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene100125288142#150#diseaseC0011847 | 24719110-3#41#46#gene100125288 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene100125288142#150#diseaseC0011849 | 24719110-3#41#46#gene100125288 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene100125288142#150#diseaseC0011847 | 24719110-3#41#46#gene100125288 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene100125288142#150#diseaseC0011849 | 24719110-3#41#46#gene100125288 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene100125288142#150#diseaseC0011847 | 24719110-3#41#46#gene100125288 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene100125288142#150#diseaseC0011849 | 24719110-3#41#46#gene100125288 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 41#46#gene100125288142#150#diseaseC0011847 | 24719110-3#41#46#gene100125288 | 24719110-3#142#150#diseaseC0011847 | associated_with | GLP-1,diabetes |
| 41#46#gene100125288142#150#diseaseC0011849 | 24719110-3#41#46#gene100125288 | 24719110-3#142#150#diseaseC0011849 | associated_with | GLP-1,diabetes |
| 68#79#gene5443115#119#diseaseC0030193 | 24719110-7#68#79#gene5443 | 24719110-7#115#119#diseaseC0030193 | associated_with | β-endorphin,pain |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2712 | 493-498 | gene:79813 | denotes | GLP-1 |
| T2713 | 594-602 | disease:C0011847 | denotes | diabetes |
| R1 | T2712 | T2713 | associated_with | GLP-1,diabetes |
| R2 | T2712 | T2713 | associated_with | GLP-1,diabetes |
| R3 | T2712 | T2713 | associated_with | GLP-1,diabetes |
| R4 | T2712 | T2713 | associated_with | GLP-1,diabetes |
| R5 | T2712 | T2713 | associated_with | GLP-1,diabetes |
| R6 | T2712 | T2713 | associated_with | GLP-1,diabetes |
| R7 | T2712 | T2713 | associated_with | GLP-1,diabetes |
| R8 | T2712 | T2713 | associated_with | GLP-1,diabetes |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 388-392 | http://purl.obolibrary.org/obo/UBERON_0006967 | denotes | horn |
| PD-UBERON-AE-B_T2 | 1120-1124 | http://purl.obolibrary.org/obo/UBERON_0006967 | denotes | horn |
| PD-UBERON-AE-B_T3 | 438-443 | http://purl.obolibrary.org/obo/UBERON_0001021 | denotes | nerve |
| PD-UBERON-AE-B_T4 | 561-566 | http://purl.obolibrary.org/obo/UBERON_0001021 | denotes | nerve |
| PD-UBERON-AE-B_T5 | 885-896 | http://purl.obolibrary.org/obo/UBERON_0002240 | denotes | spinal cord |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 438-443 | http://purl.obolibrary.org/obo/UBERON_0001021 | denotes | nerve |
| PD-UBERON-AE-B_T2 | 561-566 | http://purl.obolibrary.org/obo/UBERON_0001021 | denotes | nerve |
| PD-UBERON-AE-B_T3 | 388-392 | http://purl.obolibrary.org/obo/UBERON_0006967 | denotes | horn |
| PD-UBERON-AE-B_T4 | 1120-1124 | http://purl.obolibrary.org/obo/UBERON_0006967 | denotes | horn |
| PD-UBERON-AE-B_T5 | 885-896 | http://purl.obolibrary.org/obo/UBERON_0002240 | denotes | spinal cord |