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PubMed:24709919 JSONTXT

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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 58-62 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T3 397-404 OrganismTaxon denotes ginseng NCBItxid:4054
T4 434-438 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T6 569-573 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T8 670-674 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-63 Sentence denotes Effects of ginsenosides on opioid-induced hyperalgesia in mice.
T2 64-190 Sentence denotes Opioid-induced hyperalgesia (OIH) is characterized by nociceptive sensitization caused by the cessation of chronic opioid use.
T3 191-291 Sentence denotes OIH can limit the clinical use of opioid analgesics and complicate withdrawal from opioid addiction.
T4 292-413 Sentence denotes In this study, we investigated the effects of Re, Rg1, and Rb1 ginsenosides, the bioactive components of ginseng, on OIH.
T5 414-528 Sentence denotes OIH was achieved in mice after subcutaneous administration of morphine for 7 consecutive days three times per day.
T6 529-643 Sentence denotes During withdrawal (days 8 and 9), these mice were administered Re, Rg1, or Rb1 intragastrically two times per day.
T7 644-764 Sentence denotes On the test day (day 10), mice were subjected to the thermal sensitivity test and the acetic acid-induced writhing test.
T8 765-873 Sentence denotes Re (300 mg/kg) inhibited OIH in both the thermal sensitivity test and the acetic acid-induced writhing test.
T9 874-949 Sentence denotes However, the Rg1 and Rb1 ginsenosides failed to prevent OIH in either test.
T10 950-1043 Sentence denotes Furthermore, Rg1 showed a tendency to aggravate OIH in the acetic acid-induced writhing test.
T11 1044-1146 Sentence denotes Our data suggested that the ginsenoside Re, but not Rg1 or Rb1, may contribute toward reversal of OIH.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9843 11-23 ChemicalEntity denotes ginsenosides MESH:D036145
9844 27-33 ChemicalEntity denotes opioid MESH:D000701
9845 42-54 DiseaseOrPhenotypicFeature denotes hyperalgesia MESH:D006930
9846 58-62 OrganismTaxon denotes mice NCBITaxon:10090
9847 64-70 ChemicalEntity denotes Opioid MESH:D000701
9848 79-91 DiseaseOrPhenotypicFeature denotes hyperalgesia MESH:D006930
9849 93-96 DiseaseOrPhenotypicFeature denotes OIH MESH:D006930
9850 179-185 ChemicalEntity denotes opioid MESH:D000701
9851 191-194 DiseaseOrPhenotypicFeature denotes OIH MESH:D006930
9852 225-231 ChemicalEntity denotes opioid MESH:D000701
9853 274-290 DiseaseOrPhenotypicFeature denotes opioid addiction MESH:D009293
9854 338-367 ChemicalEntity denotes Re, Rg1, and Rb1 ginsenosides MESH:C035054|MESH:C049864|MESH:C442759
9855 397-404 OrganismTaxon denotes ginseng NCBITaxon:4054
9856 409-412 DiseaseOrPhenotypicFeature denotes OIH MESH:D006930
9857 414-417 DiseaseOrPhenotypicFeature denotes OIH MESH:D006930
9858 434-438 OrganismTaxon denotes mice NCBITaxon:10090
9859 476-484 ChemicalEntity denotes morphine MESH:D009020
9860 569-573 OrganismTaxon denotes mice NCBITaxon:10090
9861 592-594 ChemicalEntity denotes Re MESH:C049864
9862 596-599 ChemicalEntity denotes Rg1 MESH:C035054
9863 604-607 ChemicalEntity denotes Rb1 MESH:C442759
9864 670-674 OrganismTaxon denotes mice NCBITaxon:10090
9865 730-741 ChemicalEntity denotes acetic acid MESH:D019342
9866 765-767 ChemicalEntity denotes Re MESH:C049864
9867 790-793 DiseaseOrPhenotypicFeature denotes OIH MESH:D006930
9868 839-850 ChemicalEntity denotes acetic acid MESH:D019342
9869 887-911 ChemicalEntity denotes Rg1 and Rb1 ginsenosides MESH:C035054|MESH:C442759
9870 930-933 DiseaseOrPhenotypicFeature denotes OIH MESH:D006930
9871 963-966 ChemicalEntity denotes Rg1 MESH:C035054
9872 998-1001 DiseaseOrPhenotypicFeature denotes OIH MESH:D006930
9873 1009-1020 ChemicalEntity denotes acetic acid MESH:D019342
9874 1072-1086 ChemicalEntity denotes ginsenoside Re MESH:C049864
9875 1096-1099 ChemicalEntity denotes Rg1 MESH:C035054
9876 1103-1106 ChemicalEntity denotes Rb1 MESH:C442759
9877 1142-1145 DiseaseOrPhenotypicFeature denotes OIH MESH:D006930

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 351-354 GeneOrGeneProduct denotes Rb1
T2 604-607 GeneOrGeneProduct denotes Rb1
T3 737-741 GeneOrGeneProduct denotes acid
T4 846-850 GeneOrGeneProduct denotes acid
T5 895-898 GeneOrGeneProduct denotes Rb1
T6 1016-1020 GeneOrGeneProduct denotes acid
T7 1103-1106 GeneOrGeneProduct denotes Rb1

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 34-41 GeneOrGeneProduct denotes induced
T2 58-62 GeneOrGeneProduct denotes mice
T3 71-78 GeneOrGeneProduct denotes induced
T4 199-204 GeneOrGeneProduct denotes limit
T5 351-354 GeneOrGeneProduct denotes Rb1
T6 434-438 GeneOrGeneProduct denotes mice
T7 514-519 GeneOrGeneProduct denotes times
T8 520-523 GeneOrGeneProduct denotes per
T9 569-573 GeneOrGeneProduct denotes mice
T10 604-607 GeneOrGeneProduct denotes Rb1
T11 629-634 GeneOrGeneProduct denotes times
T12 635-638 GeneOrGeneProduct denotes per
T13 651-655 GeneOrGeneProduct denotes test
T14 670-674 GeneOrGeneProduct denotes mice
T15 717-721 GeneOrGeneProduct denotes test
T16 730-736 GeneOrGeneProduct denotes acetic
T17 737-741 GeneOrGeneProduct denotes acid
T18 742-749 GeneOrGeneProduct denotes induced
T19 759-763 GeneOrGeneProduct denotes test
T20 773-775 GeneOrGeneProduct denotes mg
T21 826-830 GeneOrGeneProduct denotes test
T22 839-845 GeneOrGeneProduct denotes acetic
T23 846-850 GeneOrGeneProduct denotes acid
T24 851-858 GeneOrGeneProduct denotes induced
T25 868-872 GeneOrGeneProduct denotes test
T26 895-898 GeneOrGeneProduct denotes Rb1
T27 944-948 GeneOrGeneProduct denotes test
T28 1009-1015 GeneOrGeneProduct denotes acetic
T29 1016-1020 GeneOrGeneProduct denotes acid
T30 1021-1028 GeneOrGeneProduct denotes induced
T31 1038-1042 GeneOrGeneProduct denotes test
T32 1103-1106 GeneOrGeneProduct denotes Rb1

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 42-54 DiseaseOrPhenotypicFeature denotes hyperalgesia D006930
T2 79-91 DiseaseOrPhenotypicFeature denotes hyperalgesia D006930
T3 274-290 DiseaseOrPhenotypicFeature denotes opioid addiction D009293

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 351-354 GeneOrGeneProduct denotes Rb1
T2 604-607 GeneOrGeneProduct denotes Rb1
T3 895-898 GeneOrGeneProduct denotes Rb1
T4 1103-1106 GeneOrGeneProduct denotes Rb1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 195-198 DiseaseOrPhenotypicFeature denotes can 0012833
T2 705-716 DiseaseOrPhenotypicFeature denotes sensitivity 0000605
T3 814-825 DiseaseOrPhenotypicFeature denotes sensitivity 0000605

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 42-54 DiseaseOrPhenotypicFeature denotes hyperalgesia D006930
T2 79-91 DiseaseOrPhenotypicFeature denotes hyperalgesia D006930
T3 93-96 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T4 191-194 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T5 274-290 DiseaseOrPhenotypicFeature denotes opioid addiction D009293
T6 409-412 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T7 414-417 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T8 790-793 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T9 930-933 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T10 998-1001 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T11 1142-1145 DiseaseOrPhenotypicFeature denotes OIH DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 42-54 DiseaseOrPhenotypicFeature denotes hyperalgesia D006930
T2 79-91 DiseaseOrPhenotypicFeature denotes hyperalgesia D006930
T3 93-96 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T4 191-194 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T5 274-290 DiseaseOrPhenotypicFeature denotes opioid addiction D009293
T6 409-412 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T7 414-417 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T8 790-793 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T9 930-933 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T10 998-1001 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T11 1142-1145 DiseaseOrPhenotypicFeature denotes OIH DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 11-23 ChemicalEntity denotes ginsenosides D036145|http://purl.obolibrary.org/obo/CHEBI_74978
T3 27-33 ChemicalEntity denotes opioid ChemicalEntity
T4 64-70 ChemicalEntity denotes Opioid ChemicalEntity
T5 179-185 ChemicalEntity denotes opioid ChemicalEntity
T6 225-231 ChemicalEntity denotes opioid ChemicalEntity
T7 274-280 ChemicalEntity denotes opioid ChemicalEntity
T8 338-367 ChemicalEntity denotes Re, Rg1, and Rb1 ginsenosides ChemicalEntity
T9 476-484 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T12 596-599 ChemicalEntity denotes Rg1 http://purl.obolibrary.org/obo/CHEBI_67987
T13 604-607 ChemicalEntity denotes Rb1 ChemicalEntity
T14 730-741 ChemicalEntity denotes acetic acid D019342|http://purl.obolibrary.org/obo/CHEBI_15366
T16 839-850 ChemicalEntity denotes acetic acid D019342|http://purl.obolibrary.org/obo/CHEBI_15366
T18 887-911 ChemicalEntity denotes Rg1 and Rb1 ginsenosides ChemicalEntity
T19 963-966 ChemicalEntity denotes Rg1 http://purl.obolibrary.org/obo/CHEBI_67987
T20 1009-1020 ChemicalEntity denotes acetic acid D019342|http://purl.obolibrary.org/obo/CHEBI_15366
T22 1072-1086 ChemicalEntity denotes ginsenoside Re http://purl.obolibrary.org/obo/CHEBI_77148
T23 1096-1099 ChemicalEntity denotes Rg1 http://purl.obolibrary.org/obo/CHEBI_67987
T24 1103-1106 ChemicalEntity denotes Rb1 ChemicalEntity

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 58-62 OrganismTaxon denotes mice
T2 397-404 OrganismTaxon denotes ginseng
T3 434-438 OrganismTaxon denotes mice
T4 569-573 OrganismTaxon denotes mice
T5 670-674 OrganismTaxon denotes mice

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T24 1103-1106 ChemicalEntity denotes Rb1 ChemicalEntity
T23 1096-1099 ChemicalEntity denotes Rg1 http://purl.obolibrary.org/obo/CHEBI_67987
T22 1072-1086 ChemicalEntity denotes ginsenoside Re http://purl.obolibrary.org/obo/CHEBI_77148
T20 1009-1020 ChemicalEntity denotes acetic acid http://purl.obolibrary.org/obo/CHEBI_15366|D019342
T19 963-966 ChemicalEntity denotes Rg1 http://purl.obolibrary.org/obo/CHEBI_67987
T18 887-911 ChemicalEntity denotes Rg1 and Rb1 ginsenosides ChemicalEntity
T16 839-850 ChemicalEntity denotes acetic acid http://purl.obolibrary.org/obo/CHEBI_15366|D019342
T14 730-741 ChemicalEntity denotes acetic acid http://purl.obolibrary.org/obo/CHEBI_15366|D019342
T13 604-607 ChemicalEntity denotes Rb1 ChemicalEntity
T12 596-599 ChemicalEntity denotes Rg1 http://purl.obolibrary.org/obo/CHEBI_67987
T9 476-484 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T8 338-367 ChemicalEntity denotes Re, Rg1, and Rb1 ginsenosides ChemicalEntity
T7 274-280 ChemicalEntity denotes opioid ChemicalEntity
T6 225-231 ChemicalEntity denotes opioid ChemicalEntity
T5 179-185 ChemicalEntity denotes opioid ChemicalEntity
T4 64-70 ChemicalEntity denotes Opioid ChemicalEntity
T3 27-33 ChemicalEntity denotes opioid ChemicalEntity
T1 11-23 ChemicalEntity denotes ginsenosides http://purl.obolibrary.org/obo/CHEBI_74978|D036145
T78096 1103-1106 GeneOrGeneProduct denotes Rb1
T63650 895-898 GeneOrGeneProduct denotes Rb1
T2 604-607 GeneOrGeneProduct denotes Rb1
T42266 351-354 GeneOrGeneProduct denotes Rb1
T11 1142-1145 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T10 998-1001 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T43260 930-933 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T94231 790-793 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T62912 414-417 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T31780 409-412 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T30606 274-290 DiseaseOrPhenotypicFeature denotes opioid addiction D009293
T21247 191-194 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T13038 93-96 DiseaseOrPhenotypicFeature denotes OIH DISEASE
T66095 79-91 DiseaseOrPhenotypicFeature denotes hyperalgesia D006930
T79788 42-54 DiseaseOrPhenotypicFeature denotes hyperalgesia D006930
T23936 670-674 OrganismTaxon denotes mice
T73352 569-573 OrganismTaxon denotes mice
T78190 434-438 OrganismTaxon denotes mice
T7484 397-404 OrganismTaxon denotes ginseng
T40401 58-62 OrganismTaxon denotes mice

Allie

Id Subject Object Predicate Lexical cue
SS1_24709919_1_0 64-91 expanded denotes Opioid-induced hyperalgesia
SS2_24709919_1_0 93-96 abbr denotes OIH
AE1_24709919_1_0 SS1_24709919_1_0 SS2_24709919_1_0 abbreviatedTo Opioid-induced hyperalgesia,OIH