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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis.
T2 103-114 Sentence denotes UNLABELLED:
T3 115-338 Sentence denotes Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often poorly managed with current treatments.
T4 339-467 Sentence denotes Arthritic disease is usually characterized by high levels of the chemokine CCL2 and a prodigious monocyte/macrophage infiltrate.
T5 468-654 Sentence denotes Several inhibitors of CCL2 and its receptor CCR2 are in development and may find application for treatment of certain inflammatory conditions, including autoimmune and viral arthritides.
T6 655-759 Sentence denotes Here we used CCR2(-/-) mice to determine the effect of CCR2 deficiency on CHIKV infection and arthritis.
T7 760-990 Sentence denotes Although there were no significant changes in viral load or RNA persistence and only marginal changes in antiviral immunity, arthritic disease was substantially increased and prolonged in CCR2(-/-) mice compared to wild-type mice.
T8 991-1318 Sentence denotes The monocyte/macrophage infiltrate was replaced in CCR2(-/-) mice by a severe neutrophil (followed by an eosinophil) infiltrate and was associated with changes in the expression levels of multiple inflammatory mediators (including CXCL1, CXCL2, granulocyte colony-stimulating factor [G-CSF], interleukin-1β [IL-1β], and IL-10).
T9 1319-1452 Sentence denotes The loss of anti-inflammatory macrophages and their activities (e.g., efferocytosis) was also implicated in exacerbated inflammation.
T10 1453-1598 Sentence denotes Clear evidence of cartilage damage was also seen in CHIKV-infected CCR2(-/-) mice, a feature not normally associated with alphaviral arthritides.
T11 1599-1809 Sentence denotes Although recruitment of CCR2(+) monocytes/macrophages can contribute to inflammation, it also appears to be critical for preventing excessive pathology and resolving inflammation following alphavirus infection.
T12 1810-1938 Sentence denotes Caution might thus be warranted when considering therapeutic targeting of CCR2/CCL2 for the treatment of alphaviral arthritides.
T13 1939-1950 Sentence denotes IMPORTANCE:
T14 1951-2056 Sentence denotes Here we describe the first analysis of viral arthritis in mice deficient for the chemokine receptor CCR2.
T15 2057-2238 Sentence denotes CCR2 is thought to be central to the monocyte/macrophage-dominated inflammatory arthritic infiltrates seen after infection with arthritogenic alphaviruses such as chikungunya virus.
T16 2239-2466 Sentence denotes Surprisingly, the viral arthritis caused by chikungunya virus in CCR2-deficient mice was more severe, prolonged, and erosive and was neutrophil dominated, with viral replication and persistence not being significantly affected.
T17 2467-2646 Sentence denotes Monocytes/macrophages recruited by CCL2 thus also appear to be important for both preventing even worse pathology mediated by neutrophils and promoting resolution of inflammation.
T18 2647-2856 Sentence denotes Caution might thus be warranted when considering the use of therapeutic agents that target CCR2/CCL2 or inflammatory monocytes/macrophages for the treatment of alphaviral (and perhaps other viral) arthritides.
T19 2857-3025 Sentence denotes Individuals with diminished CCR2 responses (due to drug treatment or other reasons) may also be at risk of exacerbated arthritic disease following alphaviral infection.
T1 0-102 Sentence denotes CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis.
T2 103-114 Sentence denotes UNLABELLED:
T3 115-338 Sentence denotes Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often poorly managed with current treatments.
T4 339-467 Sentence denotes Arthritic disease is usually characterized by high levels of the chemokine CCL2 and a prodigious monocyte/macrophage infiltrate.
T5 468-654 Sentence denotes Several inhibitors of CCL2 and its receptor CCR2 are in development and may find application for treatment of certain inflammatory conditions, including autoimmune and viral arthritides.
T6 655-759 Sentence denotes Here we used CCR2(-/-) mice to determine the effect of CCR2 deficiency on CHIKV infection and arthritis.
T7 760-990 Sentence denotes Although there were no significant changes in viral load or RNA persistence and only marginal changes in antiviral immunity, arthritic disease was substantially increased and prolonged in CCR2(-/-) mice compared to wild-type mice.
T8 991-1318 Sentence denotes The monocyte/macrophage infiltrate was replaced in CCR2(-/-) mice by a severe neutrophil (followed by an eosinophil) infiltrate and was associated with changes in the expression levels of multiple inflammatory mediators (including CXCL1, CXCL2, granulocyte colony-stimulating factor [G-CSF], interleukin-1β [IL-1β], and IL-10).
T9 1319-1452 Sentence denotes The loss of anti-inflammatory macrophages and their activities (e.g., efferocytosis) was also implicated in exacerbated inflammation.
T10 1453-1598 Sentence denotes Clear evidence of cartilage damage was also seen in CHIKV-infected CCR2(-/-) mice, a feature not normally associated with alphaviral arthritides.
T11 1599-1809 Sentence denotes Although recruitment of CCR2(+) monocytes/macrophages can contribute to inflammation, it also appears to be critical for preventing excessive pathology and resolving inflammation following alphavirus infection.
T12 1810-1938 Sentence denotes Caution might thus be warranted when considering therapeutic targeting of CCR2/CCL2 for the treatment of alphaviral arthritides.
T13 1939-1950 Sentence denotes IMPORTANCE:
T14 1951-2056 Sentence denotes Here we describe the first analysis of viral arthritis in mice deficient for the chemokine receptor CCR2.
T15 2057-2238 Sentence denotes CCR2 is thought to be central to the monocyte/macrophage-dominated inflammatory arthritic infiltrates seen after infection with arthritogenic alphaviruses such as chikungunya virus.
T16 2239-2466 Sentence denotes Surprisingly, the viral arthritis caused by chikungunya virus in CCR2-deficient mice was more severe, prolonged, and erosive and was neutrophil dominated, with viral replication and persistence not being significantly affected.
T17 2467-2646 Sentence denotes Monocytes/macrophages recruited by CCL2 thus also appear to be important for both preventing even worse pathology mediated by neutrophils and promoting resolution of inflammation.
T18 2647-2856 Sentence denotes Caution might thus be warranted when considering the use of therapeutic agents that target CCR2/CCL2 or inflammatory monocytes/macrophages for the treatment of alphaviral (and perhaps other viral) arthritides.
T19 2857-3025 Sentence denotes Individuals with diminished CCR2 responses (due to drug treatment or other reasons) may also be at risk of exacerbated arthritic disease following alphaviral infection.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1520-1524 gene:729230 denotes CCR2
T1 1586-1597 disease:C0003864 denotes arthritides
T2 1623-1627 gene:729230 denotes CCR2
T3 1788-1808 disease:C0206752 denotes alphavirus infection
R1 T0 T1 associated_with CCR2,arthritides
R2 T2 T3 associated_with CCR2,alphavirus infection

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 272-282 HP_0002829 denotes arthralgia
T2 339-348 HP_0001369 denotes Arthritic
T3 621-631 HP_0002960 denotes autoimmune
T4 642-653 HP_0001369 denotes arthritides
T5 749-758 HP_0001369 denotes arthritis
T6 885-894 HP_0001369 denotes arthritic
T7 1586-1597 HP_0001369 denotes arthritides
T8 1926-1937 HP_0001369 denotes arthritides

Allie

Id Subject Object Predicate Lexical cue
SS1_24696480_2_0 115-132 expanded denotes Chikungunya virus
SS2_24696480_2_0 134-139 abbr denotes CHIKV
SS1_24696480_7_0 1236-1273 expanded denotes granulocyte colony-stimulating factor
SS2_24696480_7_0 1275-1280 abbr denotes G-CSF
SS1_24696480_7_1 1283-1297 expanded denotes interleukin-1β
SS2_24696480_7_1 1299-1304 abbr denotes IL-1β
AE1_24696480_2_0 SS1_24696480_2_0 SS2_24696480_2_0 abbreviatedTo Chikungunya virus,CHIKV
AE1_24696480_7_0 SS1_24696480_7_0 SS2_24696480_7_0 abbreviatedTo granulocyte colony-stimulating factor,G-CSF
AE1_24696480_7_1 SS1_24696480_7_1 SS2_24696480_7_1 abbreviatedTo interleukin-1β,IL-1β

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24696480-0#0#4#gene729230 0-4 gene729230 denotes CCR2
24696480-0#74#85#diseaseC0008055 74-85 diseaseC0008055 denotes chikungunya
24696480-0#92#101#diseaseC0003864 92-101 diseaseC0003864 denotes arthritis
24696480-11#81#99#gene7852 2032-2050 gene7852 denotes chemokine receptor
24696480-11#100#104#gene729230 2051-2055 gene729230 denotes CCR2
24696480-11#39#54#diseaseC0003875 1990-2005 diseaseC0003875 denotes viral arthritis
24696480-15#96#100#gene6347 2743-2747 gene6347 denotes CCL2
24696480-15#197#208#diseaseC0003864 2844-2855 diseaseC0003864 denotes arthritides
24696480-9#24#28#gene729230 1623-1627 gene729230 denotes CCR2
24696480-9#189#209#diseaseC0206752 1788-1808 diseaseC0206752 denotes alphavirus infection
0#4#gene72923074#85#diseaseC0008055 24696480-0#0#4#gene729230 24696480-0#74#85#diseaseC0008055 associated_with CCR2,chikungunya
0#4#gene72923092#101#diseaseC0003864 24696480-0#0#4#gene729230 24696480-0#92#101#diseaseC0003864 associated_with CCR2,arthritis
81#99#gene785239#54#diseaseC0003875 24696480-11#81#99#gene7852 24696480-11#39#54#diseaseC0003875 associated_with chemokine receptor,viral arthritis
100#104#gene72923039#54#diseaseC0003875 24696480-11#100#104#gene729230 24696480-11#39#54#diseaseC0003875 associated_with CCR2,viral arthritis
96#100#gene6347197#208#diseaseC0003864 24696480-15#96#100#gene6347 24696480-15#197#208#diseaseC0003864 associated_with CCL2,arthritides
24#28#gene729230189#209#diseaseC0206752 24696480-9#24#28#gene729230 24696480-9#189#209#diseaseC0206752 associated_with CCR2,alphavirus infection