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PubMed:24695522 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-101 Sentence denotes Association of genetic variants in Wnt signaling pathway with tuberculosis in Chinese Han population.
T2 102-348 Sentence denotes Compelling studies have implicated that the Wnt signaling pathway plays an important role in the development and progression of tuberculosis, however, there is little literature addressing the role of polymorphisms in Wnt pathway on tuberculosis.
T3 349-494 Sentence denotes We took a pathway based candidate gene approach to investigate the possible correlation between genetic variants in Wnt pathway and tuberculosis.
T4 495-796 Sentence denotes Three single nucleotide polymorphisms (SNPs) in Wnt pathway (rs4135385 in CTNNB1 gene, rs7832767 in SFRP1 gene, and rs11079571 in AXIN2 gene) were genotyped in 422 Chinese Han tuberculosis patients and 402 frequency matched (age, gender, and ethnicity) controls using high-resolution melting analysis.
T5 797-918 Sentence denotes The genotype and allelic frequencies of rs4135385 and rs7832767 were significantly different among patients and controls.
T6 919-1079 Sentence denotes The dominant model of rs4135385 was significantly associated with an increased risk of tuberculosis (AG/GG versus AA: OR = 1.49, 95% CI = 1.06-2.09, p = 0.019).
T7 1080-1222 Sentence denotes The recessive model of rs7832767 posed a significant higher risk for tuberculosis (TT versus TC/CC, OR = 2.70, 95% CI = 1.41-5.18, p = 0.002).
T8 1223-1354 Sentence denotes These SNPs were further evaluated whether they were correlated with the site of tuberculosis and the level of inflammatory markers.
T9 1355-1546 Sentence denotes Rs7832767 was significantly associated with the level of CRP (p = 0.014), and the patients carrying T allele might present with elevated CRP values (OR = 1.90, 95% CI = 1.21-2.96, p = 0.005).
T10 1547-1786 Sentence denotes Our study provided the first evidence that rs4135385 and rs7832767 were associated with tuberculosis risk, and genetic variants in Wnt signaling pathway might participate in genetic susceptibility to tuberculosis in Chinese Han population.
T11 1787-1892 Sentence denotes Further epidemiological and functional studies in larger populations are warranted to verify our results.
T1 0-101 Sentence denotes Association of genetic variants in Wnt signaling pathway with tuberculosis in Chinese Han population.
T2 102-348 Sentence denotes Compelling studies have implicated that the Wnt signaling pathway plays an important role in the development and progression of tuberculosis, however, there is little literature addressing the role of polymorphisms in Wnt pathway on tuberculosis.
T3 349-494 Sentence denotes We took a pathway based candidate gene approach to investigate the possible correlation between genetic variants in Wnt pathway and tuberculosis.
T4 495-796 Sentence denotes Three single nucleotide polymorphisms (SNPs) in Wnt pathway (rs4135385 in CTNNB1 gene, rs7832767 in SFRP1 gene, and rs11079571 in AXIN2 gene) were genotyped in 422 Chinese Han tuberculosis patients and 402 frequency matched (age, gender, and ethnicity) controls using high-resolution melting analysis.
T5 797-918 Sentence denotes The genotype and allelic frequencies of rs4135385 and rs7832767 were significantly different among patients and controls.
T6 919-1079 Sentence denotes The dominant model of rs4135385 was significantly associated with an increased risk of tuberculosis (AG/GG versus AA: OR = 1.49, 95% CI = 1.06-2.09, p = 0.019).
T7 1080-1222 Sentence denotes The recessive model of rs7832767 posed a significant higher risk for tuberculosis (TT versus TC/CC, OR = 2.70, 95% CI = 1.41-5.18, p = 0.002).
T8 1223-1354 Sentence denotes These SNPs were further evaluated whether they were correlated with the site of tuberculosis and the level of inflammatory markers.
T9 1355-1546 Sentence denotes Rs7832767 was significantly associated with the level of CRP (p = 0.014), and the patients carrying T allele might present with elevated CRP values (OR = 1.90, 95% CI = 1.21-2.96, p = 0.005).
T10 1547-1786 Sentence denotes Our study provided the first evidence that rs4135385 and rs7832767 were associated with tuberculosis risk, and genetic variants in Wnt signaling pathway might participate in genetic susceptibility to tuberculosis in Chinese Han population.
T11 1787-1892 Sentence denotes Further epidemiological and functional studies in larger populations are warranted to verify our results.

NEUROSES

Id Subject Object Predicate Lexical cue
T1 187-191 CHEBI_50906 denotes role
T2 295-299 CHEBI_50906 denotes role
T3 508-518 CHEBI_36976 denotes nucleotide
T4 701-710 PATO_0000044 denotes frequency
T5 720-723 CHEBI_84123 denotes age
T6 720-723 PATO_0000011 denotes age
T7 763-767 PATO_0000469 denotes high
T11 988-997 PATO_0000470 denotes increased
T12 1333-1345 PATO_0002104 denotes inflammatory
T13 1470-1477 PATO_0000467 denotes present
T14 1483-1491 PATO_0001688 denotes elevated
T15 1729-1743 PATO_0001043 denotes susceptibility
T16 1815-1825 PATO_0001510 denotes functional

Allie

Id Subject Object Predicate Lexical cue
SS1_24695522_3_0 501-532 expanded denotes single nucleotide polymorphisms
SS2_24695522_3_0 534-538 abbr denotes SNPs
AE1_24695522_3_0 SS1_24695522_3_0 SS2_24695522_3_0 abbreviatedTo single nucleotide polymorphisms,SNPs

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
24695522-9#43#52#geners4135385 1590-1599 geners4135385 denotes rs4135385
24695522-9#57#66#geners7832767 1604-1613 geners7832767 denotes rs7832767
24695522-9#88#100#diseaseC0041296 1635-1647 diseaseC0041296 denotes tuberculosis
24695522-9#200#212#diseaseC0041296 1747-1759 diseaseC0041296 denotes tuberculosis
24695522-9#88#100#diseaseC0041296 1635-1647 diseaseC0041296 denotes tuberculosis
24695522-9#200#212#diseaseC0041296 1747-1759 diseaseC0041296 denotes tuberculosis
43#52#geners413538588#100#diseaseC0041296 24695522-9#43#52#geners4135385 24695522-9#88#100#diseaseC0041296 associated_with rs4135385,tuberculosis
43#52#geners4135385200#212#diseaseC0041296 24695522-9#43#52#geners4135385 24695522-9#200#212#diseaseC0041296 associated_with rs4135385,tuberculosis
43#52#geners413538588#100#diseaseC0041296 24695522-9#43#52#geners4135385 24695522-9#88#100#diseaseC0041296 associated_with rs4135385,tuberculosis
43#52#geners4135385200#212#diseaseC0041296 24695522-9#43#52#geners4135385 24695522-9#200#212#diseaseC0041296 associated_with rs4135385,tuberculosis
57#66#geners783276788#100#diseaseC0041296 24695522-9#57#66#geners7832767 24695522-9#88#100#diseaseC0041296 associated_with rs7832767,tuberculosis
57#66#geners7832767200#212#diseaseC0041296 24695522-9#57#66#geners7832767 24695522-9#200#212#diseaseC0041296 associated_with rs7832767,tuberculosis
57#66#geners783276788#100#diseaseC0041296 24695522-9#57#66#geners7832767 24695522-9#88#100#diseaseC0041296 associated_with rs7832767,tuberculosis
57#66#geners7832767200#212#diseaseC0041296 24695522-9#57#66#geners7832767 24695522-9#200#212#diseaseC0041296 associated_with rs7832767,tuberculosis