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PubMed:24688094 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 74-87 https://glytoucan.org/Structures/Glycans/G00023MO denotes peptidoglycan
T2 137-150 https://glytoucan.org/Structures/Glycans/G00023MO denotes peptidoglycan
T3 152-154 https://glytoucan.org/Structures/Glycans/G00023MO denotes PG
T4 315-317 https://glytoucan.org/Structures/Glycans/G00023MO denotes PG
T5 360-362 https://glytoucan.org/Structures/Glycans/G00023MO denotes PG
T6 440-460 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetyl glucosamine
T7 746-748 https://glytoucan.org/Structures/Glycans/G00023MO denotes PG
T8 1251-1253 https://glytoucan.org/Structures/Glycans/G00023MO denotes PG
T9 1463-1465 https://glytoucan.org/Structures/Glycans/G00023MO denotes PG
T10 1869-1871 https://glytoucan.org/Structures/Glycans/G00023MO denotes PG

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 74-87 Glycan_Motif denotes peptidoglycan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T2 137-150 Glycan_Motif denotes peptidoglycan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T3 152-154 Glycan_Motif denotes PG https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T4 315-317 Glycan_Motif denotes PG https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T5 360-362 Glycan_Motif denotes PG https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T6 440-460 Glycan_Motif denotes N-acetyl glucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T7 746-748 Glycan_Motif denotes PG https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T8 1251-1253 Glycan_Motif denotes PG https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T9 1463-1465 Glycan_Motif denotes PG https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T10 1869-1871 Glycan_Motif denotes PG https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes A Burkholderia cenocepacia MurJ (MviN) homolog is essential for cell wall peptidoglycan synthesis and bacterial viability.
TextSentencer_T2 123-243 Sentence denotes The cell wall peptidoglycan (PG) of Burkholderia cenocepacia, an opportunistic pathogen, has not yet been characterized.
TextSentencer_T3 244-359 Sentence denotes However, the B. cenocepacia genome contains homologs of genes encoding PG biosynthetic functions in other bacteria.
TextSentencer_T4 360-574 Sentence denotes PG biosynthesis involves the formation of the undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide, known as lipid II, which is built on the cytosolic face of the cell membrane.
TextSentencer_T5 575-759 Sentence denotes Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh; this translocation step is critical to PG synthesis.
TextSentencer_T6 760-846 Sentence denotes We have investigated candidate flippase homologs of the MurJ family in B. cenocepacia.
TextSentencer_T7 847-940 Sentence denotes Our results show that BCAL2764, herein referred to as murJBc, is indispensable for viability.
TextSentencer_T8 941-1098 Sentence denotes Viable B. cenocepacia could only be obtained through a conditional mutagenesis strategy by placing murJBc under the control of a rhamnose-inducible promoter.
TextSentencer_T9 1099-1264 Sentence denotes Under rhamnose depletion, the conditional strain stopped growing and individual cells displayed morphological abnormalities consistent with a defect in PG synthesis.
TextSentencer_T10 1265-1419 Sentence denotes Bacterial cells unable to express MurJBc underwent cell lysis, while partial MurJBc depletion sensitized the mutant to the action of β-lactam antibiotics.
TextSentencer_T11 1420-1587 Sentence denotes Depletion of MurJBc caused accumulation of PG precursors consistent with the notion that this protein plays a role in lipid II flipping to the periplasmic compartment.
TextSentencer_T12 1588-1798 Sentence denotes Reciprocal complementation experiments of conditional murJ mutants in B. cenocepacia and Escherichia coli with plasmids expressing MurJ from each strain indicated that MurJBc and MurJEc are functional homologs.
TextSentencer_T13 1799-1908 Sentence denotes Together, our results are consistent with the notion that MurJBc is a PG lipid II flippase in B. cenocepacia.
T1 0-122 Sentence denotes A Burkholderia cenocepacia MurJ (MviN) homolog is essential for cell wall peptidoglycan synthesis and bacterial viability.
T2 123-243 Sentence denotes The cell wall peptidoglycan (PG) of Burkholderia cenocepacia, an opportunistic pathogen, has not yet been characterized.
T3 244-359 Sentence denotes However, the B. cenocepacia genome contains homologs of genes encoding PG biosynthetic functions in other bacteria.
T4 360-574 Sentence denotes PG biosynthesis involves the formation of the undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide, known as lipid II, which is built on the cytosolic face of the cell membrane.
T5 575-759 Sentence denotes Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh; this translocation step is critical to PG synthesis.
T6 760-846 Sentence denotes We have investigated candidate flippase homologs of the MurJ family in B. cenocepacia.
T7 847-940 Sentence denotes Our results show that BCAL2764, herein referred to as murJBc, is indispensable for viability.
T8 941-1098 Sentence denotes Viable B. cenocepacia could only be obtained through a conditional mutagenesis strategy by placing murJBc under the control of a rhamnose-inducible promoter.
T9 1099-1264 Sentence denotes Under rhamnose depletion, the conditional strain stopped growing and individual cells displayed morphological abnormalities consistent with a defect in PG synthesis.
T10 1265-1419 Sentence denotes Bacterial cells unable to express MurJBc underwent cell lysis, while partial MurJBc depletion sensitized the mutant to the action of β-lactam antibiotics.
T11 1420-1587 Sentence denotes Depletion of MurJBc caused accumulation of PG precursors consistent with the notion that this protein plays a role in lipid II flipping to the periplasmic compartment.
T12 1588-1798 Sentence denotes Reciprocal complementation experiments of conditional murJ mutants in B. cenocepacia and Escherichia coli with plasmids expressing MurJ from each strain indicated that MurJBc and MurJEc are functional homologs.
T13 1799-1908 Sentence denotes Together, our results are consistent with the notion that MurJBc is a PG lipid II flippase in B. cenocepacia.
T1 0-122 Sentence denotes A Burkholderia cenocepacia MurJ (MviN) homolog is essential for cell wall peptidoglycan synthesis and bacterial viability.
T2 123-243 Sentence denotes The cell wall peptidoglycan (PG) of Burkholderia cenocepacia, an opportunistic pathogen, has not yet been characterized.
T3 244-359 Sentence denotes However, the B. cenocepacia genome contains homologs of genes encoding PG biosynthetic functions in other bacteria.
T4 360-574 Sentence denotes PG biosynthesis involves the formation of the undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide, known as lipid II, which is built on the cytosolic face of the cell membrane.
T5 575-759 Sentence denotes Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh; this translocation step is critical to PG synthesis.
T6 760-846 Sentence denotes We have investigated candidate flippase homologs of the MurJ family in B. cenocepacia.
T7 847-940 Sentence denotes Our results show that BCAL2764, herein referred to as murJBc, is indispensable for viability.
T8 941-1098 Sentence denotes Viable B. cenocepacia could only be obtained through a conditional mutagenesis strategy by placing murJBc under the control of a rhamnose-inducible promoter.
T9 1099-1264 Sentence denotes Under rhamnose depletion, the conditional strain stopped growing and individual cells displayed morphological abnormalities consistent with a defect in PG synthesis.
T10 1265-1419 Sentence denotes Bacterial cells unable to express MurJBc underwent cell lysis, while partial MurJBc depletion sensitized the mutant to the action of β-lactam antibiotics.
T11 1420-1587 Sentence denotes Depletion of MurJBc caused accumulation of PG precursors consistent with the notion that this protein plays a role in lipid II flipping to the periplasmic compartment.
T12 1588-1798 Sentence denotes Reciprocal complementation experiments of conditional murJ mutants in B. cenocepacia and Escherichia coli with plasmids expressing MurJ from each strain indicated that MurJBc and MurJEc are functional homologs.
T13 1799-1908 Sentence denotes Together, our results are consistent with the notion that MurJBc is a PG lipid II flippase in B. cenocepacia.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 74-87 https://glytoucan.org/Structures/Glycans/G00023MO denotes peptidoglycan
T2 137-150 https://glytoucan.org/Structures/Glycans/G00023MO denotes peptidoglycan
T3 440-460 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetyl glucosamine

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T1 2-26 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC347 denotes Burkholderia cenocepacia
_T2 2-26 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC372 denotes Burkholderia cenocepacia
_T3 2-26 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC096 denotes Burkholderia cenocepacia
_T4 2-26 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC464 denotes Burkholderia cenocepacia
_T5 2-26 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC385 denotes Burkholderia cenocepacia
_T6 2-26 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC420 denotes Burkholderia cenocepacia
_T7 2-26 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC065 denotes Burkholderia cenocepacia
_T8 159-183 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC065 denotes Burkholderia cenocepacia
_T9 159-183 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC385 denotes Burkholderia cenocepacia
_T10 159-183 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC420 denotes Burkholderia cenocepacia
_T11 159-183 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC096 denotes Burkholderia cenocepacia
_T12 159-183 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC372 denotes Burkholderia cenocepacia
_T13 159-183 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC347 denotes Burkholderia cenocepacia
_T14 159-183 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC464 denotes Burkholderia cenocepacia
_T15 1677-1693 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC002,LEC056,LEC062,LEC069,LEC081,LEC111,LEC133,LEC171,LEC177,LEC187,LEC211,LEC242,LEC252,LEC258,LEC259,LEC260,LEC262,LEC369,LEC377,LEC422,LEC442,LEC448,LEC450,LEC451,LEC454,LEC472,LEC492,LEC620 denotes Escherichia coli
_T16 1677-1693 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC157,LEC407 denotes Escherichia coli
_T17 1677-1693 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC754 denotes Escherichia coli
_T18 1677-1693 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC243,LEC640 denotes Escherichia coli
_T19 1677-1693 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC295,LEC417 denotes Escherichia coli
_T20 1677-1693 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC487 denotes Escherichia coli
_T21 1677-1693 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC244,LEC256,LEC354 denotes Escherichia coli
_T22 1677-1693 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC054,LEC058,LEC073,LEC082,LEC091,LEC103,LEC109,LEC110,LEC123,LEC158,LEC179,LEC198,LEC205,LEC222,LEC223,LEC224,LEC225,LEC232,LEC298,LEC357,LEC378,LEC383,LEC388,LEC389,LEC397,LEC401,LEC410,LEC452 denotes Escherichia coli
_T23 1677-1693 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC636 denotes Escherichia coli

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 74-87 FMAID:196777 denotes peptidoglycan
_T2 74-87 FMAID:82783 denotes peptidoglycan
_T3 137-150 FMAID:196777 denotes peptidoglycan
_T4 137-150 FMAID:82783 denotes peptidoglycan
_T5 272-278 FMAID:198062 denotes genome
_T6 272-278 FMAID:84116 denotes genome
_T7 300-305 FMAID:198663 denotes genes
_T8 440-460 FMAID:196781 denotes N-acetyl glucosamine
_T9 440-460 FMAID:82787 denotes N-acetyl glucosamine
_T10 449-460 FMAID:82797 denotes glucosamine
_T11 449-460 FMAID:196792 denotes glucosamine
_T12 506-511 FMAID:67264 denotes lipid
_T13 506-511 FMAID:165448 denotes lipid
_T14 548-552 FMAID:117356 denotes face
_T15 548-552 FMAID:24728 denotes face
_T16 560-573 FMAID:200943 denotes cell membrane
_T17 560-573 FMAID:162305 denotes cell membrane
_T18 575-580 FMAID:67264 denotes Lipid
_T19 575-580 FMAID:165448 denotes Lipid
_T20 633-645 FMAID:82784 denotes glycopeptide
_T21 633-645 FMAID:196778 denotes glycopeptide
_T22 1070-1078 FMAID:196798 denotes rhamnose
_T23 1070-1078 FMAID:82803 denotes rhamnose
_T24 1105-1113 FMAID:82803 denotes rhamnose
_T25 1105-1113 FMAID:196798 denotes rhamnose
_T26 1179-1184 FMAID:68646 denotes cells
_T27 1179-1184 FMAID:169002 denotes cells
_T28 1179-1208 FMAID:171489 denotes cells displayed morphological
_T29 1179-1208 FMAID:70631 denotes cells displayed morphological
_T30 1275-1280 FMAID:169002 denotes cells
_T31 1275-1280 FMAID:68646 denotes cells
_T32 1514-1521 FMAID:67257 denotes protein
_T33 1514-1521 FMAID:165447 denotes protein
_T34 1538-1543 FMAID:67264 denotes lipid
_T35 1538-1543 FMAID:165448 denotes lipid
_T36 1575-1586 FMAID:76700 denotes compartment
_T37 1575-1586 FMAID:183399 denotes compartment
_T38 1575-1586 FMAID:183854 denotes compartment
_T39 1872-1877 FMAID:165448 denotes lipid
_T40 1872-1877 FMAID:67264 denotes lipid

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 2-14 http://purl.bioontology.org/ontology/NCBITAXON/337 denotes Burkholderia
T2 2-14 http://purl.bioontology.org/ontology/NCBITAXON/311230 denotes Burkholderia
T3 2-14 http://purl.bioontology.org/ontology/NCBITAXON/32008 denotes Burkholderia
T4 2-14 http://purl.bioontology.org/ontology/NCBITAXON/948107 denotes Burkholderia
T5 2-14 http://purl.bioontology.org/ontology/NCBITAXON/634127 denotes Burkholderia
T6 2-14 http://purl.bioontology.org/ontology/NCBITAXON/219649 denotes Burkholderia
T7 2-14 http://purl.bioontology.org/ontology/NCBITAXON/386056 denotes Burkholderia
T8 2-14 http://purl.bioontology.org/ontology/NCBITAXON/482957 denotes Burkholderia
T9 2-26 http://purl.bioontology.org/ontology/NCBITAXON/215535 denotes Burkholderia cenocepacia
T10 2-26 http://purl.bioontology.org/ontology/NCBITAXON/292 denotes Burkholderia cenocepacia
T11 159-171 http://purl.bioontology.org/ontology/NCBITAXON/634127 denotes Burkholderia
T12 159-171 http://purl.bioontology.org/ontology/NCBITAXON/337 denotes Burkholderia
T13 159-171 http://purl.bioontology.org/ontology/NCBITAXON/386056 denotes Burkholderia
T14 159-171 http://purl.bioontology.org/ontology/NCBITAXON/311230 denotes Burkholderia
T15 159-171 http://purl.bioontology.org/ontology/NCBITAXON/219649 denotes Burkholderia
T16 159-171 http://purl.bioontology.org/ontology/NCBITAXON/948107 denotes Burkholderia
T17 159-171 http://purl.bioontology.org/ontology/NCBITAXON/32008 denotes Burkholderia
T18 159-171 http://purl.bioontology.org/ontology/NCBITAXON/482957 denotes Burkholderia
T19 159-183 http://purl.bioontology.org/ontology/NCBITAXON/292 denotes Burkholderia cenocepacia
T20 159-183 http://purl.bioontology.org/ontology/NCBITAXON/215535 denotes Burkholderia cenocepacia
T21 350-358 http://purl.bioontology.org/ontology/NCBITAXON/2 denotes bacteria
T22 350-358 http://purl.bioontology.org/ontology/NCBITAXON/629395 denotes bacteria
T23 548-552 http://purl.bioontology.org/ontology/NCBITAXON/1240355 denotes face
T24 1179-1184 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T25 1275-1280 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T26 1677-1688 http://purl.bioontology.org/ontology/NCBITAXON/561 denotes Escherichia

GO-BP

Id Subject Object Predicate Lexical cue
T1 74-97 http://purl.obolibrary.org/obo/GO_0009252 denotes peptidoglycan synthesis
T2 88-97 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T3 749-758 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T4 1254-1263 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T5 363-375 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T6 389-398 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T7 791-799 http://purl.obolibrary.org/obo/GO_0034203 denotes flippase
T8 791-799 http://purl.obolibrary.org/obo/GO_0045332 denotes flippase
T9 1881-1889 http://purl.obolibrary.org/obo/GO_0034203 denotes flippase
T10 1881-1889 http://purl.obolibrary.org/obo/GO_0045332 denotes flippase
T11 1321-1326 http://purl.obolibrary.org/obo/GO_0043870 denotes lysis
T12 1321-1326 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T13 1359-1369 http://purl.obolibrary.org/obo/GO_0046960 denotes sensitized

GO-CC

Id Subject Object Predicate Lexical cue
T1 64-68 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 127-131 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 560-564 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 691-695 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 1179-1184 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 1275-1280 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 64-73 http://purl.obolibrary.org/obo/GO_0005618 denotes cell wall
T8 127-136 http://purl.obolibrary.org/obo/GO_0005618 denotes cell wall
T9 691-700 http://purl.obolibrary.org/obo/GO_0005618 denotes cell wall
T10 74-87 http://purl.obolibrary.org/obo/GO_0009274 denotes peptidoglycan
T11 137-150 http://purl.obolibrary.org/obo/GO_0009274 denotes peptidoglycan
T12 152-154 http://purl.obolibrary.org/obo/GO_0010287 denotes PG
T13 315-317 http://purl.obolibrary.org/obo/GO_0010287 denotes PG
T14 360-362 http://purl.obolibrary.org/obo/GO_0010287 denotes PG
T15 746-748 http://purl.obolibrary.org/obo/GO_0010287 denotes PG
T16 1251-1253 http://purl.obolibrary.org/obo/GO_0010287 denotes PG
T17 1463-1465 http://purl.obolibrary.org/obo/GO_0010287 denotes PG
T18 1869-1871 http://purl.obolibrary.org/obo/GO_0010287 denotes PG
T19 538-547 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosolic
T20 560-573 http://purl.obolibrary.org/obo/GO_0005886 denotes cell membrane
T21 565-573 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T22 616-624 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T23 1563-1574 http://purl.obolibrary.org/obo/GO_0042597 denotes periplasmic

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 548-552 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face

Allie

Id Subject Object Predicate Lexical cue
SS1_24688094_1_0 137-150 expanded denotes peptidoglycan
SS2_24688094_1_0 152-154 abbr denotes PG
AE1_24688094_1_0 SS1_24688094_1_0 SS2_24688094_1_0 abbreviatedTo peptidoglycan,PG

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 74-87 http://rdf.glycoinfo.org/glycan/G00023MO denotes peptidoglycan
T2 137-150 http://rdf.glycoinfo.org/glycan/G00023MO denotes peptidoglycan

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 548-552 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 2-26 OrganismTaxon denotes Burkholderia cenocepacia 95486
T2 159-183 OrganismTaxon denotes Burkholderia cenocepacia 95486
T3 350-358 OrganismTaxon denotes bacteria 2|629395
T5 1677-1693 OrganismTaxon denotes Escherichia coli 562

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 69-73 Body_part denotes wall http://purl.obolibrary.org/obo/UBERON_0000060
T2 132-136 Body_part denotes wall http://purl.obolibrary.org/obo/UBERON_0000060
T3 548-552 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T4 560-573 Body_part denotes cell membrane http://purl.obolibrary.org/obo/GO_0005886
T5 616-624 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T8 696-700 Body_part denotes wall http://purl.obolibrary.org/obo/UBERON_0000060