PubMed:24652679 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/24652679","sourcedb":"PubMed","sourceid":"24652679","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/24652679","text":"Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.\nIncreasing evidence suggests that Parkinson's disease (PD)-linked Leucine-rich repeat kinase 2 (LRRK2) has a role in peripheral and brain-resident immune cells. Furthermore, dysregulation of the anti-inflammatory, neurotrophic protein progranulin (PGRN) has been demonstrated in several chronic neurodegenerative diseases. Here we show that PGRN levels are significantly reduced in conditioned medium of LRRK2(R1441G) mutant mouse fibroblasts, leukocytes, and microglia, whereas levels of proinflammatory factors, like interleukin-1β and keratinocyte-derived chemokine, were significantly increased. Decreased PGRN levels were also detected in supernatants of cultured human fibroblasts isolated from presymptomatic LRRK2(G2019S) mutation carriers, while mitochondrial function was unaffected. Furthermore, medium levels of matrix metalloprotease (MMP) 2 increased, whereas MMP 9 decreased in LRRK2(R1441G) mutant microglia. Increased proteolytic cleavage of the MMP substrates ICAM-5 and α-synuclein in synaptoneurosomes from LRRK2(R1441G) mutant mouse brain indicates increased net synaptic MMP activity. PGRN levels were decreased in the cerebrospinal fluid of presymptomatic LRRK2 mutant mice, whereas PGRN levels were increased in aged symptomatic mutant mice. Notably, PGRN levels were also increased in the cerebrospinal fluid of PD patients carrying LRRK2 mutations, but not in idiopathic PD patients and in healthy control donors. Our data suggest that proinflammatory activity of peripheral and brain-resident immune cells may particularly contribute to the early stages of Parkinson's disease caused by LRRK2 mutations.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_24652679_1_0","span":{"begin":190,"end":209},"obj":"expanded"},{"id":"SS2_24652679_1_0","span":{"begin":211,"end":213},"obj":"abbr"},{"id":"SS1_24652679_1_1","span":{"begin":222,"end":250},"obj":"expanded"},{"id":"SS2_24652679_1_1","span":{"begin":252,"end":257},"obj":"abbr"},{"id":"SS1_24652679_2_0","span":{"begin":391,"end":402},"obj":"expanded"},{"id":"SS2_24652679_2_0","span":{"begin":404,"end":408},"obj":"abbr"},{"id":"SS1_24652679_5_0","span":{"begin":980,"end":1002},"obj":"expanded"},{"id":"SS2_24652679_5_0","span":{"begin":1004,"end":1007},"obj":"abbr"}],"relations":[{"id":"AE1_24652679_1_0","pred":"abbreviatedTo","subj":"SS1_24652679_1_0","obj":"SS2_24652679_1_0"},{"id":"AE1_24652679_1_1","pred":"abbreviatedTo","subj":"SS1_24652679_1_1","obj":"SS2_24652679_1_1"},{"id":"AE1_24652679_2_0","pred":"abbreviatedTo","subj":"SS1_24652679_2_0","obj":"SS2_24652679_2_0"},{"id":"AE1_24652679_5_0","pred":"abbreviatedTo","subj":"SS1_24652679_5_0","obj":"SS2_24652679_5_0"}],"attributes":[{"subj":"SS1_24652679_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_24652679_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_24652679_1_1","pred":"source","obj":"Allie"},{"subj":"SS2_24652679_1_1","pred":"source","obj":"Allie"},{"subj":"SS1_24652679_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_24652679_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_24652679_5_0","pred":"source","obj":"Allie"},{"subj":"SS2_24652679_5_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":190,"end":199},"obj":"HP_0001300"},{"id":"T2","span":{"begin":911,"end":924},"obj":"HP_0001427"},{"id":"T3","span":{"begin":1740,"end":1749},"obj":"HP_0001300"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":391,"end":402},"obj":"gene:2896"},{"id":"T1","span":{"begin":451,"end":477},"obj":"disease:C0524851"},{"id":"T2","span":{"begin":404,"end":408},"obj":"gene:2896"},{"id":"T3","span":{"begin":451,"end":477},"obj":"disease:C0524851"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"24652679-1#66#94#gene120892","span":{"begin":222,"end":250},"obj":"gene120892"},{"id":"24652679-1#96#101#gene120892","span":{"begin":252,"end":257},"obj":"gene120892"},{"id":"24652679-1#34#53#diseaseC0030567","span":{"begin":190,"end":209},"obj":"diseaseC0030567"},{"id":"24652679-1#55#57#diseaseC0030567","span":{"begin":211,"end":213},"obj":"diseaseC0030567"},{"id":"24652679-1#34#53#diseaseC0030567","span":{"begin":190,"end":209},"obj":"diseaseC0030567"},{"id":"24652679-1#55#57#diseaseC0030567","span":{"begin":211,"end":213},"obj":"diseaseC0030567"},{"id":"24652679-2#74#85#gene2896","span":{"begin":391,"end":402},"obj":"gene2896"},{"id":"24652679-2#87#91#gene2896","span":{"begin":404,"end":408},"obj":"gene2896"},{"id":"24652679-2#134#160#diseaseC0524851","span":{"begin":451,"end":477},"obj":"diseaseC0524851"}],"relations":[{"id":"66#94#gene12089234#53#diseaseC0030567","pred":"associated_with","subj":"24652679-1#66#94#gene120892","obj":"24652679-1#34#53#diseaseC0030567"},{"id":"66#94#gene12089255#57#diseaseC0030567","pred":"associated_with","subj":"24652679-1#66#94#gene120892","obj":"24652679-1#55#57#diseaseC0030567"},{"id":"66#94#gene12089234#53#diseaseC0030567","pred":"associated_with","subj":"24652679-1#66#94#gene120892","obj":"24652679-1#34#53#diseaseC0030567"},{"id":"66#94#gene12089255#57#diseaseC0030567","pred":"associated_with","subj":"24652679-1#66#94#gene120892","obj":"24652679-1#55#57#diseaseC0030567"},{"id":"96#101#gene12089234#53#diseaseC0030567","pred":"associated_with","subj":"24652679-1#96#101#gene120892","obj":"24652679-1#34#53#diseaseC0030567"},{"id":"96#101#gene12089255#57#diseaseC0030567","pred":"associated_with","subj":"24652679-1#96#101#gene120892","obj":"24652679-1#55#57#diseaseC0030567"},{"id":"96#101#gene12089234#53#diseaseC0030567","pred":"associated_with","subj":"24652679-1#96#101#gene120892","obj":"24652679-1#34#53#diseaseC0030567"},{"id":"96#101#gene12089255#57#diseaseC0030567","pred":"associated_with","subj":"24652679-1#96#101#gene120892","obj":"24652679-1#55#57#diseaseC0030567"},{"id":"74#85#gene2896134#160#diseaseC0524851","pred":"associated_with","subj":"24652679-2#74#85#gene2896","obj":"24652679-2#134#160#diseaseC0524851"},{"id":"87#91#gene2896134#160#diseaseC0524851","pred":"associated_with","subj":"24652679-2#87#91#gene2896","obj":"24652679-2#134#160#diseaseC0524851"}],"attributes":[{"subj":"24652679-1#66#94#gene120892","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24652679-1#96#101#gene120892","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24652679-1#34#53#diseaseC0030567","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24652679-1#55#57#diseaseC0030567","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24652679-1#34#53#diseaseC0030567","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24652679-1#55#57#diseaseC0030567","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24652679-2#74#85#gene2896","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24652679-2#87#91#gene2896","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24652679-2#134#160#diseaseC0524851","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":155},"obj":"DRI_Background"},{"id":"T2","span":{"begin":156,"end":316},"obj":"DRI_Background"},{"id":"T3","span":{"begin":317,"end":478},"obj":"DRI_Background"},{"id":"T4","span":{"begin":479,"end":755},"obj":"DRI_Outcome"},{"id":"T5","span":{"begin":756,"end":856},"obj":"DRI_Background"},{"id":"T6","span":{"begin":857,"end":877},"obj":"Token_Label.OUTSIDE"},{"id":"T7","span":{"begin":877,"end":949},"obj":"DRI_Background"},{"id":"T8","span":{"begin":950,"end":1080},"obj":"DRI_Background"},{"id":"T9","span":{"begin":1081,"end":1262},"obj":"DRI_Outcome"},{"id":"T10","span":{"begin":1263,"end":1319},"obj":"DRI_Background"},{"id":"T11","span":{"begin":1320,"end":1340},"obj":"Token_Label.OUTSIDE"},{"id":"T12","span":{"begin":1341,"end":1421},"obj":"DRI_Background"},{"id":"T13","span":{"begin":1422,"end":1595},"obj":"DRI_Background"},{"id":"T14","span":{"begin":1596,"end":1786},"obj":"DRI_Outcome"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T13","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T14","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":156,"end":316},"obj":"DRI_Background"},{"id":"T2","span":{"begin":317,"end":478},"obj":"DRI_Background"},{"id":"T3","span":{"begin":479,"end":755},"obj":"DRI_Outcome"},{"id":"T4","span":{"begin":756,"end":856},"obj":"DRI_Background"},{"id":"T5","span":{"begin":877,"end":949},"obj":"DRI_Background"},{"id":"T6","span":{"begin":950,"end":1080},"obj":"DRI_Background"},{"id":"T7","span":{"begin":1081,"end":1262},"obj":"DRI_Outcome"},{"id":"T8","span":{"begin":1263,"end":1319},"obj":"DRI_Background"},{"id":"T9","span":{"begin":1341,"end":1421},"obj":"DRI_Background"},{"id":"T10","span":{"begin":1422,"end":1595},"obj":"DRI_Background"},{"id":"T11","span":{"begin":1596,"end":1786},"obj":"DRI_Outcome"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T10","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T11","pred":"source","obj":"PubMed_ArguminSci"}]},{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":11,"end":17},"obj":"UBERON:0027368"},{"id":"T2","span":{"begin":18,"end":42},"obj":"GO:0008237"},{"id":"T3","span":{"begin":47,"end":58},"obj":"P28798"},{"id":"T4","span":{"begin":47,"end":58},"obj":"P28799"},{"id":"T6","span":{"begin":47,"end":58},"obj":"PR:000008271"},{"id":"T7","span":{"begin":47,"end":58},"obj":"P28797"},{"id":"T9","span":{"begin":47,"end":58},"obj":"P23785"},{"id":"T5","span":{"begin":47,"end":58},"obj":"D000077153"},{"id":"T8","span":{"begin":47,"end":58},"obj":"D000077153"},{"id":"T11","span":{"begin":126,"end":133},"obj":"6308"},{"id":"T12","span":{"begin":126,"end":133},"obj":"SO:0001437"},{"id":"T10","span":{"begin":126,"end":133},"obj":"CHEBI:15603"},{"id":"T13","span":{"begin":126,"end":133},"obj":"D007930"},{"id":"T14","span":{"begin":126,"end":133},"obj":"CHEBI:25017"},{"id":"T15","span":{"begin":126,"end":133},"obj":"D007930"},{"id":"T16","span":{"begin":139,"end":145},"obj":"SO:0001068"},{"id":"T21","span":{"begin":190,"end":209},"obj":"D010300"},{"id":"T22","span":{"begin":190,"end":209},"obj":"D010300"},{"id":"T26","span":{"begin":222,"end":229},"obj":"6308"},{"id":"T27","span":{"begin":222,"end":229},"obj":"SO:0001437"},{"id":"T25","span":{"begin":222,"end":229},"obj":"CHEBI:15603"},{"id":"T28","span":{"begin":222,"end":229},"obj":"D007930"},{"id":"T29","span":{"begin":222,"end":229},"obj":"CHEBI:25017"},{"id":"T30","span":{"begin":222,"end":229},"obj":"D007930"},{"id":"T31","span":{"begin":235,"end":241},"obj":"SO:0001068"},{"id":"T32","span":{"begin":252,"end":257},"obj":"PR:Q5S006"},{"id":"T33","span":{"begin":252,"end":257},"obj":"PR:000003033"},{"id":"T34","span":{"begin":252,"end":257},"obj":"PR:Q5S007"},{"id":"T35","span":{"begin":288,"end":293},"obj":"UBERON:6110636"},{"id":"T36","span":{"begin":288,"end":293},"obj":"UBERON:0000955"},{"id":"T37","span":{"begin":370,"end":390},"obj":"D009414"},{"id":"T38","span":{"begin":370,"end":390},"obj":"D009414"},{"id":"T42","span":{"begin":383,"end":390},"obj":"PR:000000001"},{"id":"T39","span":{"begin":383,"end":390},"obj":"GO:0003675"},{"id":"T43","span":{"begin":383,"end":390},"obj":"SO:0000104"},{"id":"T44","span":{"begin":391,"end":402},"obj":"P28798"},{"id":"T45","span":{"begin":391,"end":402},"obj":"P28799"},{"id":"T47","span":{"begin":391,"end":402},"obj":"PR:000008271"},{"id":"T48","span":{"begin":391,"end":402},"obj":"P28797"},{"id":"T50","span":{"begin":391,"end":402},"obj":"P23785"},{"id":"T46","span":{"begin":391,"end":402},"obj":"D000077153"},{"id":"T49","span":{"begin":391,"end":402},"obj":"D000077153"},{"id":"T51","span":{"begin":404,"end":408},"obj":"P28798"},{"id":"T52","span":{"begin":404,"end":408},"obj":"P28799"},{"id":"T53","span":{"begin":404,"end":408},"obj":"PR:000008271"},{"id":"T54","span":{"begin":404,"end":408},"obj":"P28797"},{"id":"T55","span":{"begin":404,"end":408},"obj":"P23785"},{"id":"T58","span":{"begin":451,"end":477},"obj":"D019636"},{"id":"T59","span":{"begin":451,"end":477},"obj":"D019636"},{"id":"T60","span":{"begin":497,"end":501},"obj":"P28798"},{"id":"T61","span":{"begin":497,"end":501},"obj":"P28799"},{"id":"T62","span":{"begin":497,"end":501},"obj":"PR:000008271"},{"id":"T63","span":{"begin":497,"end":501},"obj":"P28797"},{"id":"T64","span":{"begin":497,"end":501},"obj":"P23785"},{"id":"T65","span":{"begin":538,"end":556},"obj":"D017077"},{"id":"T66","span":{"begin":560,"end":565},"obj":"PR:Q5S006"},{"id":"T67","span":{"begin":560,"end":565},"obj":"PR:000003033"},{"id":"T68","span":{"begin":560,"end":565},"obj":"PR:Q5S007"},{"id":"T69","span":{"begin":581,"end":586},"obj":"10090"},{"id":"T70","span":{"begin":581,"end":586},"obj":"D051379"},{"id":"T71","span":{"begin":616,"end":625},"obj":"CL:0000129"},{"id":"T75","span":{"begin":675,"end":688},"obj":"PR:000001091"},{"id":"T74","span":{"begin":675,"end":688},"obj":"D007375"},{"id":"T76","span":{"begin":675,"end":688},"obj":"D007375"},{"id":"T77","span":{"begin":694,"end":706},"obj":"CL:0000312"},{"id":"T78","span":{"begin":766,"end":770},"obj":"P28798"},{"id":"T79","span":{"begin":766,"end":770},"obj":"P28799"},{"id":"T80","span":{"begin":766,"end":770},"obj":"PR:000008271"},{"id":"T81","span":{"begin":766,"end":770},"obj":"P28797"},{"id":"T82","span":{"begin":766,"end":770},"obj":"P23785"},{"id":"T83","span":{"begin":825,"end":830},"obj":"D006801"},{"id":"T84","span":{"begin":857,"end":871},"obj":"D058070"},{"id":"T85","span":{"begin":857,"end":871},"obj":"D058070"},{"id":"T86","span":{"begin":872,"end":877},"obj":"PR:Q5S006"},{"id":"T87","span":{"begin":872,"end":877},"obj":"PR:000003033"},{"id":"T88","span":{"begin":872,"end":877},"obj":"PR:Q5S007"},{"id":"T89","span":{"begin":886,"end":894},"obj":"SO:0000109"},{"id":"T90","span":{"begin":895,"end":903},"obj":"CHEBI:78059"},{"id":"T91","span":{"begin":980,"end":986},"obj":"UBERON:0027368"},{"id":"T92","span":{"begin":1004,"end":1007},"obj":"CHEBI:340824"},{"id":"T95","span":{"begin":1004,"end":1007},"obj":"CHEBI:59761"},{"id":"T96","span":{"begin":1004,"end":1010},"obj":"PR:P08253"},{"id":"T97","span":{"begin":1004,"end":1010},"obj":"Q9GLE5"},{"id":"T98","span":{"begin":1004,"end":1010},"obj":"P08253"},{"id":"T99","span":{"begin":1004,"end":1010},"obj":"Q90611"},{"id":"T101","span":{"begin":1004,"end":1010},"obj":"PR:Q8MPP3"},{"id":"T102","span":{"begin":1004,"end":1010},"obj":"P33436"},{"id":"T103","span":{"begin":1004,"end":1010},"obj":"PR:Q90611"},{"id":"T104","span":{"begin":1004,"end":1010},"obj":"PR:P33436"},{"id":"T105","span":{"begin":1004,"end":1010},"obj":"PR:000010479"},{"id":"T106","span":{"begin":1004,"end":1010},"obj":"PR:P33434"},{"id":"T107","span":{"begin":1004,"end":1010},"obj":"P33434"},{"id":"T108","span":{"begin":1004,"end":1010},"obj":"P50757"},{"id":"T100","span":{"begin":1004,"end":1010},"obj":"GO:0004228"},{"id":"T109","span":{"begin":1030,"end":1033},"obj":"CHEBI:340824"},{"id":"T112","span":{"begin":1030,"end":1033},"obj":"CHEBI:59761"},{"id":"T113","span":{"begin":1030,"end":1035},"obj":"PR:P50282"},{"id":"T114","span":{"begin":1030,"end":1035},"obj":"PR:P14780"},{"id":"T115","span":{"begin":1030,"end":1035},"obj":"P14780"},{"id":"T116","span":{"begin":1030,"end":1035},"obj":"PR:P41245"},{"id":"T117","span":{"begin":1030,"end":1035},"obj":"P41246"},{"id":"T118","span":{"begin":1030,"end":1035},"obj":"P41245"},{"id":"T119","span":{"begin":1030,"end":1035},"obj":"PR:P52176"},{"id":"T120","span":{"begin":1030,"end":1035},"obj":"P50282"},{"id":"T122","span":{"begin":1030,"end":1035},"obj":"PR:000010491"},{"id":"T123","span":{"begin":1030,"end":1035},"obj":"P52176"},{"id":"T124","span":{"begin":1030,"end":1035},"obj":"O18733"},{"id":"T121","span":{"begin":1030,"end":1035},"obj":"GO:0004229"},{"id":"T125","span":{"begin":1049,"end":1054},"obj":"PR:Q5S006"},{"id":"T126","span":{"begin":1049,"end":1054},"obj":"PR:000003033"},{"id":"T127","span":{"begin":1049,"end":1054},"obj":"PR:Q5S007"},{"id":"T128","span":{"begin":1070,"end":1079},"obj":"CL:0000129"},{"id":"T131","span":{"begin":1119,"end":1122},"obj":"PR:O04529"},{"id":"T129","span":{"begin":1119,"end":1122},"obj":"CHEBI:340824"},{"id":"T132","span":{"begin":1119,"end":1122},"obj":"CHEBI:59761"},{"id":"T130","span":{"begin":1119,"end":1122},"obj":"GO:0004235"},{"id":"T134","span":{"begin":1134,"end":1140},"obj":"PR:000001360"},{"id":"T135","span":{"begin":1134,"end":1140},"obj":"Q9UMF0"},{"id":"T136","span":{"begin":1134,"end":1140},"obj":"Q60625"},{"id":"T137","span":{"begin":1134,"end":1140},"obj":"PR:Q60625"},{"id":"T138","span":{"begin":1134,"end":1140},"obj":"Q28730"},{"id":"T139","span":{"begin":1134,"end":1140},"obj":"PR:Q9UMF0"},{"id":"T141","span":{"begin":1147,"end":1156},"obj":"P37379"},{"id":"T140","span":{"begin":1147,"end":1156},"obj":"D051843"},{"id":"T142","span":{"begin":1183,"end":1188},"obj":"PR:Q5S006"},{"id":"T143","span":{"begin":1183,"end":1188},"obj":"PR:000003033"},{"id":"T144","span":{"begin":1183,"end":1188},"obj":"PR:Q5S007"},{"id":"T145","span":{"begin":1204,"end":1209},"obj":"10090"},{"id":"T146","span":{"begin":1204,"end":1209},"obj":"D051379"},{"id":"T147","span":{"begin":1210,"end":1215},"obj":"UBERON:6110636"},{"id":"T148","span":{"begin":1210,"end":1215},"obj":"UBERON:0000955"},{"id":"T151","span":{"begin":1249,"end":1252},"obj":"PR:O04529"},{"id":"T149","span":{"begin":1249,"end":1252},"obj":"CHEBI:340824"},{"id":"T152","span":{"begin":1249,"end":1252},"obj":"CHEBI:59761"},{"id":"T150","span":{"begin":1249,"end":1252},"obj":"GO:0004235"},{"id":"T153","span":{"begin":1263,"end":1267},"obj":"P28798"},{"id":"T154","span":{"begin":1263,"end":1267},"obj":"P28799"},{"id":"T155","span":{"begin":1263,"end":1267},"obj":"PR:000008271"},{"id":"T156","span":{"begin":1263,"end":1267},"obj":"P28797"},{"id":"T157","span":{"begin":1263,"end":1267},"obj":"P23785"},{"id":"T158","span":{"begin":1297,"end":1316},"obj":"UBERON:0001359"},{"id":"T160","span":{"begin":1320,"end":1334},"obj":"D058070"},{"id":"T161","span":{"begin":1320,"end":1334},"obj":"D058070"},{"id":"T162","span":{"begin":1335,"end":1340},"obj":"PR:Q5S006"},{"id":"T163","span":{"begin":1335,"end":1340},"obj":"PR:000003033"},{"id":"T164","span":{"begin":1335,"end":1340},"obj":"PR:Q5S007"},{"id":"T165","span":{"begin":1348,"end":1352},"obj":"PR:000005054"},{"id":"T167","span":{"begin":1348,"end":1352},"obj":"O89094"},{"id":"T166","span":{"begin":1348,"end":1352},"obj":"D051379"},{"id":"T168","span":{"begin":1348,"end":1352},"obj":"10095"},{"id":"T169","span":{"begin":1362,"end":1366},"obj":"P28798"},{"id":"T170","span":{"begin":1362,"end":1366},"obj":"P28799"},{"id":"T171","span":{"begin":1362,"end":1366},"obj":"PR:000008271"},{"id":"T172","span":{"begin":1362,"end":1366},"obj":"P28797"},{"id":"T173","span":{"begin":1362,"end":1366},"obj":"P23785"},{"id":"T174","span":{"begin":1416,"end":1420},"obj":"PR:000005054"},{"id":"T176","span":{"begin":1416,"end":1420},"obj":"O89094"},{"id":"T175","span":{"begin":1416,"end":1420},"obj":"D051379"},{"id":"T177","span":{"begin":1416,"end":1420},"obj":"10095"},{"id":"T178","span":{"begin":1431,"end":1435},"obj":"P28798"},{"id":"T179","span":{"begin":1431,"end":1435},"obj":"P28799"},{"id":"T180","span":{"begin":1431,"end":1435},"obj":"PR:000008271"},{"id":"T181","span":{"begin":1431,"end":1435},"obj":"P28797"},{"id":"T182","span":{"begin":1431,"end":1435},"obj":"P23785"},{"id":"T183","span":{"begin":1470,"end":1489},"obj":"UBERON:0001359"},{"id":"T185","span":{"begin":1514,"end":1519},"obj":"PR:Q5S006"},{"id":"T186","span":{"begin":1514,"end":1519},"obj":"PR:000003033"},{"id":"T187","span":{"begin":1514,"end":1519},"obj":"PR:Q5S007"},{"id":"T188","span":{"begin":1661,"end":1666},"obj":"UBERON:6110636"},{"id":"T189","span":{"begin":1661,"end":1666},"obj":"UBERON:0000955"},{"id":"T194","span":{"begin":1740,"end":1759},"obj":"D010300"},{"id":"T195","span":{"begin":1740,"end":1759},"obj":"D010300"},{"id":"T198","span":{"begin":1770,"end":1775},"obj":"PR:Q5S006"},{"id":"T199","span":{"begin":1770,"end":1775},"obj":"PR:000003033"},{"id":"T200","span":{"begin":1770,"end":1775},"obj":"PR:Q5S007"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T12","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T14","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T45","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T151","pred":"source","obj":"c_corpus"},{"subj":"T149","pred":"source","obj":"c_corpus"},{"subj":"T152","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T153","pred":"source","obj":"c_corpus"},{"subj":"T154","pred":"source","obj":"c_corpus"},{"subj":"T155","pred":"source","obj":"c_corpus"},{"subj":"T156","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T168","pred":"source","obj":"c_corpus"},{"subj":"T169","pred":"source","obj":"c_corpus"},{"subj":"T170","pred":"source","obj":"c_corpus"},{"subj":"T171","pred":"source","obj":"c_corpus"},{"subj":"T172","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T179","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T182","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T185","pred":"source","obj":"c_corpus"},{"subj":"T186","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T194","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T198","pred":"source","obj":"c_corpus"},{"subj":"T199","pred":"source","obj":"c_corpus"},{"subj":"T200","pred":"source","obj":"c_corpus"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":155},"obj":"Sentence"},{"id":"T2","span":{"begin":156,"end":316},"obj":"Sentence"},{"id":"T3","span":{"begin":317,"end":478},"obj":"Sentence"},{"id":"T4","span":{"begin":479,"end":755},"obj":"Sentence"},{"id":"T5","span":{"begin":756,"end":949},"obj":"Sentence"},{"id":"T6","span":{"begin":950,"end":1080},"obj":"Sentence"},{"id":"T7","span":{"begin":1081,"end":1262},"obj":"Sentence"},{"id":"T8","span":{"begin":1263,"end":1421},"obj":"Sentence"},{"id":"T9","span":{"begin":1422,"end":1595},"obj":"Sentence"},{"id":"T10","span":{"begin":1596,"end":1786},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":155},"obj":"Sentence"},{"id":"T2","span":{"begin":156,"end":316},"obj":"Sentence"},{"id":"T3","span":{"begin":317,"end":478},"obj":"Sentence"},{"id":"T4","span":{"begin":479,"end":755},"obj":"Sentence"},{"id":"T5","span":{"begin":756,"end":949},"obj":"Sentence"},{"id":"T6","span":{"begin":950,"end":1080},"obj":"Sentence"},{"id":"T7","span":{"begin":1081,"end":1262},"obj":"Sentence"},{"id":"T8","span":{"begin":1263,"end":1421},"obj":"Sentence"},{"id":"T9","span":{"begin":1422,"end":1595},"obj":"Sentence"},{"id":"T10","span":{"begin":1596,"end":1786},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#93ec9b","default":true},{"id":"PubmedHPO","color":"#ec93a4"},{"id":"DisGeNET","color":"#93beec"},{"id":"DisGeNET5_gene_disease","color":"#d8ec93"},{"id":"UseCases_ArguminSci_Discourse","color":"#e693ec"},{"id":"PubMed_ArguminSci","color":"#93eccc"},{"id":"c_corpus","color":"#ecb293"},{"id":"Inflammaging","color":"#9893ec"}]}]}}