PubMed:24628819
Annnotations
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-150 | Sentence | denotes | IL10 single nucleotide polymorphisms are related to upregulation of constitutive IL-10 production and susceptibility to Helicobacter pylori infection. |
| T2 | 151-162 | Sentence | denotes | BACKGROUND: |
| T3 | 163-325 | Sentence | denotes | Helicobacter pylori infection is a strong risk factor for gastric cancer, likely due to the extensive inflammation in the stomach mucosa caused by these bacteria. |
| T4 | 326-445 | Sentence | denotes | Many studies have reported an association between IL10 polymorphisms, the risk of gastric cancer, and IL-10 production. |
| T5 | 446-625 | Sentence | denotes | The aim of the study was to evaluate the association between IL10 genetic variants, Helicobacter pylori infection, and IL-10 production by peripheral blood leukocytes in children. |
| T6 | 626-648 | Sentence | denotes | MATERIALS AND METHODS: |
| T7 | 649-872 | Sentence | denotes | We genotyped a total of 12 single nucleotide polymorphisms in IL10 in 1259 children aged 4-11 years living in a poor urban area in Salvador, Brazil, using TaqMan probe based, 5' nuclease assay minor groove binder chemistry. |
| T8 | 873-1146 | Sentence | denotes | Association tests were performed by logistic regression for Helicobacter pylori infection and linear regression for IL-10 spontaneous production (whole-blood cultures) including sex, age, and principal components for informative ancestry markers as covariates, using PLINK. |
| T9 | 1147-1155 | Sentence | denotes | RESULTS: |
| T10 | 1156-1453 | Sentence | denotes | Our results shown that IL10 single nucleotide polymorphisms rs1800896 (OR = 1.63; 95% CI = 1.11-2.39), rs3024491 (OR = 1.71; 95% CI = 1.14-2.57), rs1878672 (OR = 1.79; 95% CI = 1.19-2.68), and rs3024496 (OR = 1.48; 95% CI = 1.05-2.08) were positively associated with Helicobacter pylori infection. |
| T11 | 1454-1690 | Sentence | denotes | Eight single nucleotide polymorphisms were associated with spontaneous production of IL-10 in culture, of which three (rs1800896 and rs1878672, p = .04; rs3024491, p = .01) were strongly associated with infection by Helicobacter pylori. |
| T12 | 1691-1703 | Sentence | denotes | CONCLUSIONS: |
| T13 | 1704-1906 | Sentence | denotes | Our results indicate that IL10 variants rs1800896, rs3024491, rs1878672, and rs3024496 are more consistently associated with the presence of anti-H. pylori IgG by inducing increased production of IL-10. |
| T14 | 1907-2057 | Sentence | denotes | Further studies are underway to elucidate the role of additional genetic variants and to investigate their impact on the occurrence of gastric cancer. |
| T1 | 0-150 | Sentence | denotes | IL10 single nucleotide polymorphisms are related to upregulation of constitutive IL-10 production and susceptibility to Helicobacter pylori infection. |
| T2 | 151-162 | Sentence | denotes | BACKGROUND: |
| T3 | 163-325 | Sentence | denotes | Helicobacter pylori infection is a strong risk factor for gastric cancer, likely due to the extensive inflammation in the stomach mucosa caused by these bacteria. |
| T4 | 326-445 | Sentence | denotes | Many studies have reported an association between IL10 polymorphisms, the risk of gastric cancer, and IL-10 production. |
| T5 | 446-625 | Sentence | denotes | The aim of the study was to evaluate the association between IL10 genetic variants, Helicobacter pylori infection, and IL-10 production by peripheral blood leukocytes in children. |
| T6 | 626-648 | Sentence | denotes | MATERIALS AND METHODS: |
| T7 | 649-872 | Sentence | denotes | We genotyped a total of 12 single nucleotide polymorphisms in IL10 in 1259 children aged 4-11 years living in a poor urban area in Salvador, Brazil, using TaqMan probe based, 5' nuclease assay minor groove binder chemistry. |
| T8 | 873-1146 | Sentence | denotes | Association tests were performed by logistic regression for Helicobacter pylori infection and linear regression for IL-10 spontaneous production (whole-blood cultures) including sex, age, and principal components for informative ancestry markers as covariates, using PLINK. |
| T9 | 1147-1155 | Sentence | denotes | RESULTS: |
| T10 | 1156-1453 | Sentence | denotes | Our results shown that IL10 single nucleotide polymorphisms rs1800896 (OR = 1.63; 95% CI = 1.11-2.39), rs3024491 (OR = 1.71; 95% CI = 1.14-2.57), rs1878672 (OR = 1.79; 95% CI = 1.19-2.68), and rs3024496 (OR = 1.48; 95% CI = 1.05-2.08) were positively associated with Helicobacter pylori infection. |
| T11 | 1454-1690 | Sentence | denotes | Eight single nucleotide polymorphisms were associated with spontaneous production of IL-10 in culture, of which three (rs1800896 and rs1878672, p = .04; rs3024491, p = .01) were strongly associated with infection by Helicobacter pylori. |
| T12 | 1691-1703 | Sentence | denotes | CONCLUSIONS: |
| T13 | 1704-1906 | Sentence | denotes | Our results indicate that IL10 variants rs1800896, rs3024491, rs1878672, and rs3024496 are more consistently associated with the presence of anti-H. pylori IgG by inducing increased production of IL-10. |
| T14 | 1907-2057 | Sentence | denotes | Further studies are underway to elucidate the role of additional genetic variants and to investigate their impact on the occurrence of gastric cancer. |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 163-192 | HP_0005202 | denotes | Helicobacter pylori infection |
| T2 | 221-235 | HP_0012126 | denotes | gastric cancer |
| T3 | 229-235 | HP_0002664 | denotes | cancer |
| T4 | 408-422 | HP_0012126 | denotes | gastric cancer |
| T5 | 416-422 | HP_0002664 | denotes | cancer |
| T6 | 530-559 | HP_0005202 | denotes | Helicobacter pylori infection |
DisGeNET5_variant_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24628819-6#146#155#geners1878672 | 1302-1311 | geners1878672 | denotes | rs1878672 |
| 24628819-6#103#112#geners3024491 | 1259-1268 | geners3024491 | denotes | rs3024491 |
| 24628819-6#193#202#geners3024496 | 1349-1358 | geners3024496 | denotes | rs3024496 |
| 24628819-6#60#69#geners1800896 | 1216-1225 | geners1800896 | denotes | rs1800896 |
| 24628819-6#267#296#diseaseC0850666 | 1423-1452 | diseaseC0850666 | denotes | Helicobacter pylori infection |
| 24628819-7#119#128#geners1800896 | 1573-1582 | geners1800896 | denotes | rs1800896 |
| 24628819-7#133#142#geners1878672 | 1587-1596 | geners1878672 | denotes | rs1878672 |
| 24628819-7#153#162#geners3024491 | 1607-1616 | geners3024491 | denotes | rs3024491 |
| 24628819-7#216#235#diseaseC0374997 | 1670-1689 | diseaseC0374997 | denotes | Helicobacter pylori |
| 146#155#geners1878672267#296#diseaseC0850666 | 24628819-6#146#155#geners1878672 | 24628819-6#267#296#diseaseC0850666 | associated_with | rs1878672,Helicobacter pylori infection |
| 103#112#geners3024491267#296#diseaseC0850666 | 24628819-6#103#112#geners3024491 | 24628819-6#267#296#diseaseC0850666 | associated_with | rs3024491,Helicobacter pylori infection |
| 193#202#geners3024496267#296#diseaseC0850666 | 24628819-6#193#202#geners3024496 | 24628819-6#267#296#diseaseC0850666 | associated_with | rs3024496,Helicobacter pylori infection |
| 60#69#geners1800896267#296#diseaseC0850666 | 24628819-6#60#69#geners1800896 | 24628819-6#267#296#diseaseC0850666 | associated_with | rs1800896,Helicobacter pylori infection |
| 119#128#geners1800896216#235#diseaseC0374997 | 24628819-7#119#128#geners1800896 | 24628819-7#216#235#diseaseC0374997 | associated_with | rs1800896,Helicobacter pylori |
| 133#142#geners1878672216#235#diseaseC0374997 | 24628819-7#133#142#geners1878672 | 24628819-7#216#235#diseaseC0374997 | associated_with | rs1878672,Helicobacter pylori |
| 153#162#geners3024491216#235#diseaseC0374997 | 24628819-7#153#162#geners3024491 | 24628819-7#216#235#diseaseC0374997 | associated_with | rs3024491,Helicobacter pylori |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24628819-0#0#4#gene3586 | 0-4 | gene3586 | denotes | IL10 |
| 24628819-0#81#86#gene3586 | 81-86 | gene3586 | denotes | IL-10 |
| 24628819-0#120#149#diseaseC0850666 | 120-149 | diseaseC0850666 | denotes | Helicobacter pylori infection |
| 24628819-7#85#90#gene3586 | 1539-1544 | gene3586 | denotes | IL-10 |
| 24628819-7#216#235#diseaseC0374997 | 1670-1689 | diseaseC0374997 | denotes | Helicobacter pylori |
| 0#4#gene3586120#149#diseaseC0850666 | 24628819-0#0#4#gene3586 | 24628819-0#120#149#diseaseC0850666 | associated_with | IL10,Helicobacter pylori infection |
| 81#86#gene3586120#149#diseaseC0850666 | 24628819-0#81#86#gene3586 | 24628819-0#120#149#diseaseC0850666 | associated_with | IL-10,Helicobacter pylori infection |
| 85#90#gene3586216#235#diseaseC0374997 | 24628819-7#85#90#gene3586 | 24628819-7#216#235#diseaseC0374997 | associated_with | IL-10,Helicobacter pylori |
PubTator4TogoVar
| Id | Subject | Object | Predicate | Lexical cue | resolved_to |
|---|---|---|---|---|---|
| 51 | 1216-1225 | SNP | denotes | rs1800896 | tmVar:rs1800896;VariantGroup:0;CorrespondingGene:3586;RS#:1800896;CorrespondingSpecies:9606 |
| 52 | 1259-1268 | SNP | denotes | rs3024491 | tmVar:rs3024491;VariantGroup:2;CorrespondingGene:3586;RS#:3024491;CorrespondingSpecies:9606 |
| 53 | 1302-1311 | SNP | denotes | rs1878672 | tmVar:rs1878672;VariantGroup:3;CorrespondingGene:3586;RS#:1878672;CorrespondingSpecies:9606 |
| 54 | 1349-1358 | SNP | denotes | rs3024496 | tmVar:rs3024496;VariantGroup:1;CorrespondingGene:3586;RS#:3024496;CorrespondingSpecies:9606 |
| 57 | 1573-1582 | SNP | denotes | rs1800896 | tmVar:rs1800896;VariantGroup:0;CorrespondingGene:3586;RS#:1800896;CorrespondingSpecies:9606 |
| 58 | 1587-1596 | SNP | denotes | rs1878672 | tmVar:rs1878672;VariantGroup:3;CorrespondingGene:3586;RS#:1878672;CorrespondingSpecies:9606 |
| 59 | 1607-1616 | SNP | denotes | rs3024491 | tmVar:rs3024491;VariantGroup:2;CorrespondingGene:3586;RS#:3024491;CorrespondingSpecies:9606 |
| 63 | 1744-1753 | SNP | denotes | rs1800896 | tmVar:rs1800896;VariantGroup:0;CorrespondingGene:3586;RS#:1800896;CorrespondingSpecies:9606 |
| 64 | 1755-1764 | SNP | denotes | rs3024491 | tmVar:rs3024491;VariantGroup:2;CorrespondingGene:3586;RS#:3024491;CorrespondingSpecies:9606 |
| 65 | 1766-1775 | SNP | denotes | rs1878672 | tmVar:rs1878672;VariantGroup:3;CorrespondingGene:3586;RS#:1878672;CorrespondingSpecies:9606 |
| 66 | 1781-1790 | SNP | denotes | rs3024496 | tmVar:rs3024496;VariantGroup:1;CorrespondingGene:3586;RS#:3024496;CorrespondingSpecies:9606 |
PubTatorOnTogoVar
| Id | Subject | Object | Predicate | Lexical cue | resolved_to |
|---|---|---|---|---|---|
| 51 | 1216-1225 | SNP | denotes | rs1800896 | tmVar:rs1800896;VariantGroup:0;CorrespondingGene:3586;RS#:1800896;CorrespondingSpecies:9606 |
| 52 | 1259-1268 | SNP | denotes | rs3024491 | tmVar:rs3024491;VariantGroup:2;CorrespondingGene:3586;RS#:3024491;CorrespondingSpecies:9606 |
| 53 | 1302-1311 | SNP | denotes | rs1878672 | tmVar:rs1878672;VariantGroup:3;CorrespondingGene:3586;RS#:1878672;CorrespondingSpecies:9606 |
| 54 | 1349-1358 | SNP | denotes | rs3024496 | tmVar:rs3024496;VariantGroup:1;CorrespondingGene:3586;RS#:3024496;CorrespondingSpecies:9606 |
| 57 | 1573-1582 | SNP | denotes | rs1800896 | tmVar:rs1800896;VariantGroup:0;CorrespondingGene:3586;RS#:1800896;CorrespondingSpecies:9606 |
| 58 | 1587-1596 | SNP | denotes | rs1878672 | tmVar:rs1878672;VariantGroup:3;CorrespondingGene:3586;RS#:1878672;CorrespondingSpecies:9606 |
| 59 | 1607-1616 | SNP | denotes | rs3024491 | tmVar:rs3024491;VariantGroup:2;CorrespondingGene:3586;RS#:3024491;CorrespondingSpecies:9606 |
| 63 | 1744-1753 | SNP | denotes | rs1800896 | tmVar:rs1800896;VariantGroup:0;CorrespondingGene:3586;RS#:1800896;CorrespondingSpecies:9606 |
| 64 | 1755-1764 | SNP | denotes | rs3024491 | tmVar:rs3024491;VariantGroup:2;CorrespondingGene:3586;RS#:3024491;CorrespondingSpecies:9606 |
| 65 | 1766-1775 | SNP | denotes | rs1878672 | tmVar:rs1878672;VariantGroup:3;CorrespondingGene:3586;RS#:1878672;CorrespondingSpecies:9606 |
| 66 | 1781-1790 | SNP | denotes | rs3024496 | tmVar:rs3024496;VariantGroup:1;CorrespondingGene:3586;RS#:3024496;CorrespondingSpecies:9606 |
| T1 | 1216-1225 | SNP | denotes | rs1800896 | tmVar:rs1800896;VariantGroup:0;CorrespondingGene:3586;RS#:1800896;CorrespondingSpecies:9606 |
| T2 | 1259-1268 | SNP | denotes | rs3024491 | tmVar:rs3024491;VariantGroup:2;CorrespondingGene:3586;RS#:3024491;CorrespondingSpecies:9606 |
| T3 | 1302-1311 | SNP | denotes | rs1878672 | tmVar:rs1878672;VariantGroup:3;CorrespondingGene:3586;RS#:1878672;CorrespondingSpecies:9606 |
| T4 | 1349-1358 | SNP | denotes | rs3024496 | tmVar:rs3024496;VariantGroup:1;CorrespondingGene:3586;RS#:3024496;CorrespondingSpecies:9606 |
| T5 | 1573-1582 | SNP | denotes | rs1800896 | tmVar:rs1800896;VariantGroup:0;CorrespondingGene:3586;RS#:1800896;CorrespondingSpecies:9606 |
| T6 | 1587-1596 | SNP | denotes | rs1878672 | tmVar:rs1878672;VariantGroup:3;CorrespondingGene:3586;RS#:1878672;CorrespondingSpecies:9606 |
| T7 | 1607-1616 | SNP | denotes | rs3024491 | tmVar:rs3024491;VariantGroup:2;CorrespondingGene:3586;RS#:3024491;CorrespondingSpecies:9606 |
| T8 | 1744-1753 | SNP | denotes | rs1800896 | tmVar:rs1800896;VariantGroup:0;CorrespondingGene:3586;RS#:1800896;CorrespondingSpecies:9606 |
| T9 | 1755-1764 | SNP | denotes | rs3024491 | tmVar:rs3024491;VariantGroup:2;CorrespondingGene:3586;RS#:3024491;CorrespondingSpecies:9606 |
| T10 | 1766-1775 | SNP | denotes | rs1878672 | tmVar:rs1878672;VariantGroup:3;CorrespondingGene:3586;RS#:1878672;CorrespondingSpecies:9606 |
| T11 | 1781-1790 | SNP | denotes | rs3024496 | tmVar:rs3024496;VariantGroup:1;CorrespondingGene:3586;RS#:3024496;CorrespondingSpecies:9606 |