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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 178-667 OBJECTIVE denotes NADPH oxidase-generated reactive oxygen species (ROS) are implicated in angiogenesis. Isoforms of NADPH oxidase NOX1, NOX2, and NOX4 are reported to be expressed in endothelial cells (ECs). Of these, NOX1 and NOX2 have been reported to contribute to intravitreal neovascularization (IVNV) in oxygen-induced retinopathy (OIR) models. In this study, we tested the hypothesis that the isoform NOX4 in ECs contributed to vascular endothelial growth factor (VEGF)-induced angiogenesis and IVNV.
T2 677-2064 METHODS denotes Isoforms of NADPH oxidase MRNA were measured in several types of cultured vascular ecs: human retinal microvascular ECs (hRMVECs), choroidal ECs (CECs), and human umbilical vascular ECs (HUVECs) using real-time PCR. Newborn rat pups and dams were placed into an OIR model that cycled oxygen concentration between 50% and 10% every 24 h for 14 days, and then were placed in room air (RA) for an additional 4 days (rat OIR model). NOX4 expression in retinal lysates from the RA-raised pups at postnatal day 0 (P0), P14, and P18 was determined with western blots. STAT3 activation was determined as the ratio of phosphorylated STAT3 to total STAT3 with western blot analysis of retinal lysates from pups raised in RA or from the rat OIR model at P18. Semiquantitative assessment of the density of NOX4 colabeling with lectin-stained retinal ECs was determined by immunolabeling of retinal cryosections from P18 pups in OIR or in RA. In hRMVECs transfected with NOX4 siRNA and treated with VEGF or control, 1) ROS generation was measured using the 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate, acetyl ester fluorescence assay and 2) phosphorylated VEGF receptor 2 and STAT3, and total VEGFR2 and STAT3 were measured in western blot analyses. VEGF-stimulated hRMVEC proliferation was measured following transfection with NOX4 siRNA or STAT3 siRNA, or respective controls.
T3 2074-2902 RESULTS denotes NOX4 was the most prevalent isoform of NADPH oxidase in vascular ECs. NOX4 expression in retinal lysates was significantly decreased during development in RA. Compared to RA, the expression of retinal NOX4 increased at P18. At p18 OIR, semiquantitative assessment of the density of lectin and NOX4 colabeling in retinal vascular ECs was greater in retinal cryosections and activated STAT3 was greater in retinal lysates when compared to the RA-raised pups. In cultured hRMVECs, knockdown of NOX4 by siRNA transfection inhibited VEGF-induced ROS generation. VEGF induced a physical interaction of phosphorylated-VEGFR2 and NOX4. Knockdown of NOX4: 1) reduced VEGFR2 activation but did not abolish it and 2) abolished STAT3 activation in response to VEGF. Knockdown of either NOX4 or STAT3 inhibited VEGF-induced EC proliferation.
T4 2916-3294 CONCLUSIONS denotes Our data suggest that in a model representative of human retinopathy of prematurity, NOX4 was increased at a time point when IVNV developed. VEGF-activated NOX4 led to an interaction between VEGF-activated VEGFR2 and NOX4 that mediated EC proliferation via activation of STAT3. Altogether, our results suggest that NOX4 may regulate VEGFR2-mediated IVNV through activated STAT3.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9704 12-27 GeneOrGeneProduct denotes NADPH oxidase 4 NCBIGene:85431
9705 37-82 GeneOrGeneProduct denotes vascular endothelial growth factor receptor 2 NCBIGene:25589
9706 128-131 OrganismTaxon denotes rat NCBITaxon:10116
9707 141-167 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity MESH:D012178
9708 178-191 GeneOrGeneProduct denotes NADPH oxidase NCBIGene:114243|NCBIGene:50507|NCBIGene:66021|NCBIGene:85431
9709 202-225 ChemicalEntity denotes reactive oxygen species MESH:D017382
9710 227-230 ChemicalEntity denotes ROS MESH:D017382
9711 276-289 GeneOrGeneProduct denotes NADPH oxidase NCBIGene:114243|NCBIGene:50507|NCBIGene:66021|NCBIGene:85431
9712 290-294 GeneOrGeneProduct denotes NOX1 NCBIGene:114243
9713 296-300 GeneOrGeneProduct denotes NOX2 NCBIGene:66021
9714 306-310 GeneOrGeneProduct denotes NOX4 NCBIGene:85431
9715 378-382 GeneOrGeneProduct denotes NOX1 NCBIGene:114243
9716 387-391 GeneOrGeneProduct denotes NOX2 NCBIGene:66021
9717 470-476 ChemicalEntity denotes oxygen MESH:D010100
9718 485-496 DiseaseOrPhenotypicFeature denotes retinopathy MESH:D012164
9719 498-501 DiseaseOrPhenotypicFeature denotes OIR MESH:D012164
9720 568-572 GeneOrGeneProduct denotes NOX4 NCBIGene:85431
9721 595-629 GeneOrGeneProduct denotes vascular endothelial growth factor NCBIGene:83785
9722 631-635 GeneOrGeneProduct denotes VEGF NCBIGene:83785
9723 689-702 GeneOrGeneProduct denotes NADPH oxidase NCBIGene:114243|NCBIGene:50507|NCBIGene:66021|NCBIGene:85431
9724 765-770 OrganismTaxon denotes human NCBITaxon:9606
9725 834-839 OrganismTaxon denotes human NCBITaxon:9606
9726 901-904 OrganismTaxon denotes rat NCBITaxon:10116
9727 939-942 DiseaseOrPhenotypicFeature denotes OIR MESH:D012164
9728 961-967 ChemicalEntity denotes oxygen MESH:D010100
9729 1090-1093 OrganismTaxon denotes rat NCBITaxon:10116
9730 1094-1097 DiseaseOrPhenotypicFeature denotes OIR MESH:D012164
9731 1106-1110 GeneOrGeneProduct denotes NOX4 NCBIGene:85431
9732 1238-1243 GeneOrGeneProduct denotes STAT3 NCBIGene:25125
9733 1301-1306 GeneOrGeneProduct denotes STAT3 NCBIGene:25125
9734 1316-1321 GeneOrGeneProduct denotes STAT3 NCBIGene:25125
9735 1403-1406 OrganismTaxon denotes rat NCBITaxon:10116
9736 1407-1410 DiseaseOrPhenotypicFeature denotes OIR MESH:D012164
9737 1471-1475 GeneOrGeneProduct denotes NOX4 NCBIGene:85431
9738 1492-1498 GeneOrGeneProduct denotes lectin
9739 1593-1596 DiseaseOrPhenotypicFeature denotes OIR MESH:D012164
9740 1635-1639 GeneOrGeneProduct denotes NOX4 NCBIGene:50507
9741 1663-1667 GeneOrGeneProduct denotes VEGF NCBIGene:7422
9742 1683-1686 ChemicalEntity denotes ROS MESH:D017382
9743 1721-1800 ChemicalEntity denotes 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate, acetyl ester
9744 1842-1857 GeneOrGeneProduct denotes VEGF receptor 2 NCBIGene:3791
9745 1862-1867 GeneOrGeneProduct denotes STAT3 NCBIGene:6774
9746 1879-1885 GeneOrGeneProduct denotes VEGFR2 NCBIGene:3791
9747 1890-1895 GeneOrGeneProduct denotes STAT3 NCBIGene:6774
9748 1936-1940 GeneOrGeneProduct denotes VEGF NCBIGene:7422
9749 2014-2018 GeneOrGeneProduct denotes NOX4 NCBIGene:50507
9750 2028-2033 GeneOrGeneProduct denotes STAT3 NCBIGene:6774
9751 2074-2078 GeneOrGeneProduct denotes NOX4 NCBIGene:50507
9752 2113-2126 GeneOrGeneProduct denotes NADPH oxidase NCBIGene:114243|NCBIGene:50507|NCBIGene:66021|NCBIGene:85431
9753 2144-2148 GeneOrGeneProduct denotes NOX4 NCBIGene:85431
9754 2275-2279 GeneOrGeneProduct denotes NOX4 NCBIGene:85431
9755 2305-2308 DiseaseOrPhenotypicFeature denotes OIR MESH:D012164
9756 2356-2362 GeneOrGeneProduct denotes lectin
9757 2367-2371 GeneOrGeneProduct denotes NOX4 NCBIGene:85431
9758 2457-2462 GeneOrGeneProduct denotes STAT3 NCBIGene:25125
9759 2565-2569 GeneOrGeneProduct denotes NOX4 NCBIGene:50507
9760 2602-2606 GeneOrGeneProduct denotes VEGF NCBIGene:7422
9761 2615-2618 ChemicalEntity denotes ROS MESH:D017382
9762 2631-2635 GeneOrGeneProduct denotes VEGF NCBIGene:7422
9763 2685-2691 GeneOrGeneProduct denotes VEGFR2 NCBIGene:3791
9764 2696-2700 GeneOrGeneProduct denotes NOX4 NCBIGene:50507
9765 2715-2719 GeneOrGeneProduct denotes NOX4 NCBIGene:50507
9766 2732-2738 GeneOrGeneProduct denotes VEGFR2 NCBIGene:3791
9767 2790-2795 GeneOrGeneProduct denotes STAT3 NCBIGene:6774
9768 2822-2826 GeneOrGeneProduct denotes VEGF NCBIGene:7422
9769 2848-2852 GeneOrGeneProduct denotes NOX4 NCBIGene:50507
9770 2856-2861 GeneOrGeneProduct denotes STAT3 NCBIGene:6774
9771 2872-2876 GeneOrGeneProduct denotes VEGF NCBIGene:7422
9772 2967-2972 OrganismTaxon denotes human NCBITaxon:9606
9773 2973-2999 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity MESH:D012178
9774 3001-3005 GeneOrGeneProduct denotes NOX4 NCBIGene:85431
9775 3057-3061 GeneOrGeneProduct denotes VEGF NCBIGene:7422
9776 3072-3076 GeneOrGeneProduct denotes NOX4 NCBIGene:50507
9777 3107-3111 GeneOrGeneProduct denotes VEGF NCBIGene:7422
9778 3122-3128 GeneOrGeneProduct denotes VEGFR2 NCBIGene:3791
9779 3133-3137 GeneOrGeneProduct denotes NOX4 NCBIGene:50507
9780 3187-3192 GeneOrGeneProduct denotes STAT3 NCBIGene:6774
9781 3231-3235 GeneOrGeneProduct denotes NOX4 NCBIGene:85431
9782 3249-3255 GeneOrGeneProduct denotes VEGFR2 NCBIGene:25589
9783 3288-3293 GeneOrGeneProduct denotes STAT3 NCBIGene:25125

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 128-131 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T3 765-770 OrganismTaxon denotes human NCBItxid:9606
T4 834-839 OrganismTaxon denotes human NCBItxid:9606
T5 901-904 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T7 1090-1093 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T9 1403-1406 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T11 2967-2972 OrganismTaxon denotes human NCBItxid:9606

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-168 Sentence denotes Endothelial NADPH oxidase 4 mediates vascular endothelial growth factor receptor 2-induced intravitreal neovascularization in a rat model of retinopathy of prematurity.
T2 169-263 Sentence denotes PURPOSE: NADPH oxidase-generated reactive oxygen species (ROS) are implicated in angiogenesis.
T3 264-367 Sentence denotes Isoforms of NADPH oxidase NOX1, NOX2, and NOX4 are reported to be expressed in endothelial cells (ECs).
T4 368-510 Sentence denotes Of these, NOX1 and NOX2 have been reported to contribute to intravitreal neovascularization (IVNV) in oxygen-induced retinopathy (OIR) models.
T5 511-667 Sentence denotes In this study, we tested the hypothesis that the isoform NOX4 in ECs contributed to vascular endothelial growth factor (VEGF)-induced angiogenesis and IVNV.
T6 668-676 Sentence denotes METHODS:
T7 677-892 Sentence denotes Isoforms of NADPH oxidase MRNA were measured in several types of cultured vascular ecs: human retinal microvascular ECs (hRMVECs), choroidal ECs (CECs), and human umbilical vascular ECs (HUVECs) using real-time PCR.
T8 893-1105 Sentence denotes Newborn rat pups and dams were placed into an OIR model that cycled oxygen concentration between 50% and 10% every 24 h for 14 days, and then were placed in room air (RA) for an additional 4 days (rat OIR model).
T9 1106-1237 Sentence denotes NOX4 expression in retinal lysates from the RA-raised pups at postnatal day 0 (P0), P14, and P18 was determined with western blots.
T10 1238-1424 Sentence denotes STAT3 activation was determined as the ratio of phosphorylated STAT3 to total STAT3 with western blot analysis of retinal lysates from pups raised in RA or from the rat OIR model at P18.
T11 1425-1606 Sentence denotes Semiquantitative assessment of the density of NOX4 colabeling with lectin-stained retinal ECs was determined by immunolabeling of retinal cryosections from P18 pups in OIR or in RA.
T12 1607-1935 Sentence denotes In hRMVECs transfected with NOX4 siRNA and treated with VEGF or control, 1) ROS generation was measured using the 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate, acetyl ester fluorescence assay and 2) phosphorylated VEGF receptor 2 and STAT3, and total VEGFR2 and STAT3 were measured in western blot analyses.
T13 1936-2064 Sentence denotes VEGF-stimulated hRMVEC proliferation was measured following transfection with NOX4 siRNA or STAT3 siRNA, or respective controls.
T14 2065-2143 Sentence denotes RESULTS: NOX4 was the most prevalent isoform of NADPH oxidase in vascular ECs.
T15 2144-2232 Sentence denotes NOX4 expression in retinal lysates was significantly decreased during development in RA.
T16 2233-2297 Sentence denotes Compared to RA, the expression of retinal NOX4 increased at P18.
T17 2298-2530 Sentence denotes At p18 OIR, semiquantitative assessment of the density of lectin and NOX4 colabeling in retinal vascular ECs was greater in retinal cryosections and activated STAT3 was greater in retinal lysates when compared to the RA-raised pups.
T18 2531-2630 Sentence denotes In cultured hRMVECs, knockdown of NOX4 by siRNA transfection inhibited VEGF-induced ROS generation.
T19 2631-2701 Sentence denotes VEGF induced a physical interaction of phosphorylated-VEGFR2 and NOX4.
T20 2702-2720 Sentence denotes Knockdown of NOX4:
T21 2721-2827 Sentence denotes 1) reduced VEGFR2 activation but did not abolish it and 2) abolished STAT3 activation in response to VEGF.
T22 2828-2902 Sentence denotes Knockdown of either NOX4 or STAT3 inhibited VEGF-induced EC proliferation.
T23 2903-2915 Sentence denotes CONCLUSIONS:
T24 2916-3056 Sentence denotes Our data suggest that in a model representative of human retinopathy of prematurity, NOX4 was increased at a time point when IVNV developed.
T25 3057-3193 Sentence denotes VEGF-activated NOX4 led to an interaction between VEGF-activated VEGFR2 and NOX4 that mediated EC proliferation via activation of STAT3.
T26 3194-3294 Sentence denotes Altogether, our results suggest that NOX4 may regulate VEGFR2-mediated IVNV through activated STAT3.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 0-11 DiseaseOrPhenotypicFeature denotes Endothelial 0015292
T2 46-57 DiseaseOrPhenotypicFeature denotes endothelial 0015292
T3 141-167 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity 0006952
T4 343-354 DiseaseOrPhenotypicFeature denotes endothelial 0015292
T5 604-615 DiseaseOrPhenotypicFeature denotes endothelial 0015292
T6 771-778 DiseaseOrPhenotypicFeature denotes retinal 0002708
T7 808-817 DiseaseOrPhenotypicFeature denotes choroidal 0001280
T8 1125-1132 DiseaseOrPhenotypicFeature denotes retinal 0002708
T9 1352-1359 DiseaseOrPhenotypicFeature denotes retinal 0002708
T10 1507-1514 DiseaseOrPhenotypicFeature denotes retinal 0002708
T11 1555-1562 DiseaseOrPhenotypicFeature denotes retinal 0002708
T12 2163-2170 DiseaseOrPhenotypicFeature denotes retinal 0002708
T13 2267-2274 DiseaseOrPhenotypicFeature denotes retinal 0002708
T14 2386-2393 DiseaseOrPhenotypicFeature denotes retinal 0002708
T15 2422-2429 DiseaseOrPhenotypicFeature denotes retinal 0002708
T16 2478-2485 DiseaseOrPhenotypicFeature denotes retinal 0002708
T17 2973-2999 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity 0006952

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T29 1013-1019 GeneOrGeneProduct denotes for 14
T30 1055-1058 GeneOrGeneProduct denotes air
T31 1106-1110 GeneOrGeneProduct denotes NOX4
T32 1122-1132 GeneOrGeneProduct denotes in retinal
T33 1153-1159 GeneOrGeneProduct denotes raised
T34 1207-1217 GeneOrGeneProduct denotes determined
T35 1231-1236 GeneOrGeneProduct denotes blots
T36 1238-1243 GeneOrGeneProduct denotes STAT3
T37 1244-1254 GeneOrGeneProduct denotes activation
T38 1259-1269 GeneOrGeneProduct denotes determined
T39 1301-1306 GeneOrGeneProduct denotes STAT3
T40 1310-1315 GeneOrGeneProduct denotes total
T41 1316-1321 GeneOrGeneProduct denotes STAT3
T42 1335-1339 GeneOrGeneProduct denotes blot
T43 1352-1359 GeneOrGeneProduct denotes retinal
T44 1378-1384 GeneOrGeneProduct denotes raised
T45 1471-1475 GeneOrGeneProduct denotes NOX4
T46 1492-1498 GeneOrGeneProduct denotes lectin
T47 1507-1514 GeneOrGeneProduct denotes retinal
T14 378-382 GeneOrGeneProduct denotes NOX1
T69 2367-2371 GeneOrGeneProduct denotes NOX4
T1 0-11 GeneOrGeneProduct denotes Endothelial
T2 12-27 GeneOrGeneProduct denotes NADPH oxidase 4
T3 28-36 GeneOrGeneProduct denotes mediates
T4 37-82 GeneOrGeneProduct denotes vascular endothelial growth factor receptor 2
T5 83-90 GeneOrGeneProduct denotes induced
T6 126-131 GeneOrGeneProduct denotes a rat
T7 178-191 GeneOrGeneProduct denotes NADPH oxidase
T8 276-289 GeneOrGeneProduct denotes NADPH oxidase
T9 290-294 GeneOrGeneProduct denotes NOX1
T10 296-300 GeneOrGeneProduct denotes NOX2
T11 306-310 GeneOrGeneProduct denotes NOX4
T12 343-354 GeneOrGeneProduct denotes endothelial
T13 355-360 GeneOrGeneProduct denotes cells
T15 387-391 GeneOrGeneProduct denotes NOX2
T16 477-484 GeneOrGeneProduct denotes induced
T17 529-535 GeneOrGeneProduct denotes tested
T18 568-572 GeneOrGeneProduct denotes NOX4
T19 595-629 GeneOrGeneProduct denotes vascular endothelial growth factor
T20 631-635 GeneOrGeneProduct denotes VEGF
T21 637-644 GeneOrGeneProduct denotes induced
T22 668-675 GeneOrGeneProduct denotes METHODS
T23 689-702 GeneOrGeneProduct denotes NADPH oxidase
T24 703-707 GeneOrGeneProduct denotes MRNA
T25 771-778 GeneOrGeneProduct denotes retinal
T26 878-887 GeneOrGeneProduct denotes real-time
T27 914-918 GeneOrGeneProduct denotes dams
T28 954-960 GeneOrGeneProduct denotes cycled
T57 1890-1895 GeneOrGeneProduct denotes STAT3
T58 1921-1925 GeneOrGeneProduct denotes blot
T59 1936-1940 GeneOrGeneProduct denotes VEGF
T60 2014-2018 GeneOrGeneProduct denotes NOX4
T61 2028-2033 GeneOrGeneProduct denotes STAT3
T62 2074-2078 GeneOrGeneProduct denotes NOX4
T63 2113-2126 GeneOrGeneProduct denotes NADPH oxidase
T64 2144-2148 GeneOrGeneProduct denotes NOX4
T65 2160-2170 GeneOrGeneProduct denotes in retinal
T66 2267-2274 GeneOrGeneProduct denotes retinal
T67 2275-2279 GeneOrGeneProduct denotes NOX4
T68 2356-2362 GeneOrGeneProduct denotes lectin
T70 2383-2393 GeneOrGeneProduct denotes in retinal
T71 2419-2429 GeneOrGeneProduct denotes in retinal
T72 2447-2456 GeneOrGeneProduct denotes activated
T73 2457-2462 GeneOrGeneProduct denotes STAT3
T74 2475-2485 GeneOrGeneProduct denotes in retinal
T75 2518-2524 GeneOrGeneProduct denotes raised
T76 2552-2561 GeneOrGeneProduct denotes knockdown
T77 2565-2569 GeneOrGeneProduct denotes NOX4
T78 2602-2606 GeneOrGeneProduct denotes VEGF
T79 2607-2614 GeneOrGeneProduct denotes induced
T80 2631-2635 GeneOrGeneProduct denotes VEGF
T81 2636-2643 GeneOrGeneProduct denotes induced
T87 2732-2738 GeneOrGeneProduct denotes VEGFR2
T82 2685-2691 GeneOrGeneProduct denotes VEGFR2
T83 2696-2700 GeneOrGeneProduct denotes NOX4
T84 2702-2711 GeneOrGeneProduct denotes Knockdown
T85 2715-2719 GeneOrGeneProduct denotes NOX4
T86 2724-2731 GeneOrGeneProduct denotes reduced
T88 2739-2749 GeneOrGeneProduct denotes activation
T89 2773-2778 GeneOrGeneProduct denotes and 2
T90 2790-2795 GeneOrGeneProduct denotes STAT3
T91 2796-2806 GeneOrGeneProduct denotes activation
T92 2822-2826 GeneOrGeneProduct denotes VEGF
T93 2828-2837 GeneOrGeneProduct denotes Knockdown
T94 2848-2852 GeneOrGeneProduct denotes NOX4
T95 2856-2861 GeneOrGeneProduct denotes STAT3
T96 2872-2876 GeneOrGeneProduct denotes VEGF
T97 2877-2884 GeneOrGeneProduct denotes induced
T98 2938-2942 GeneOrGeneProduct denotes in a
T99 3001-3005 GeneOrGeneProduct denotes NOX4
T100 3025-3029 GeneOrGeneProduct denotes time
T101 3030-3035 GeneOrGeneProduct denotes point
T102 3057-3061 GeneOrGeneProduct denotes VEGF
T103 3062-3071 GeneOrGeneProduct denotes activated
T104 3072-3076 GeneOrGeneProduct denotes NOX4
T105 3107-3111 GeneOrGeneProduct denotes VEGF
T106 3112-3121 GeneOrGeneProduct denotes activated
T107 3122-3128 GeneOrGeneProduct denotes VEGFR2
T108 3133-3137 GeneOrGeneProduct denotes NOX4
T109 3143-3151 GeneOrGeneProduct denotes mediated
T110 3173-3183 GeneOrGeneProduct denotes activation
T111 3187-3192 GeneOrGeneProduct denotes STAT3
T112 3231-3235 GeneOrGeneProduct denotes NOX4
T113 3240-3248 GeneOrGeneProduct denotes regulate
T114 3249-3255 GeneOrGeneProduct denotes VEGFR2
T115 3256-3264 GeneOrGeneProduct denotes mediated
T116 3278-3287 GeneOrGeneProduct denotes activated
T117 3288-3293 GeneOrGeneProduct denotes STAT3
T48 1523-1533 GeneOrGeneProduct denotes determined
T49 1555-1562 GeneOrGeneProduct denotes retinal
T50 1635-1639 GeneOrGeneProduct denotes NOX4
T51 1663-1667 GeneOrGeneProduct denotes VEGF
T52 1820-1825 GeneOrGeneProduct denotes and 2
T53 1842-1855 GeneOrGeneProduct denotes VEGF receptor
T54 1862-1867 GeneOrGeneProduct denotes STAT3
T55 1873-1878 GeneOrGeneProduct denotes total
T56 1879-1885 GeneOrGeneProduct denotes VEGFR2

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-11 GeneOrGeneProduct denotes Endothelial
T2 12-27 GeneOrGeneProduct denotes NADPH oxidase 4
T3 37-82 GeneOrGeneProduct denotes vascular endothelial growth factor receptor 2
T4 178-191 GeneOrGeneProduct denotes NADPH oxidase
T5 276-289 GeneOrGeneProduct denotes NADPH oxidase
T6 290-294 GeneOrGeneProduct denotes NOX1
T7 296-300 GeneOrGeneProduct denotes NOX2
T8 306-310 GeneOrGeneProduct denotes NOX4
T9 343-354 GeneOrGeneProduct denotes endothelial
T10 378-382 GeneOrGeneProduct denotes NOX1
T11 387-391 GeneOrGeneProduct denotes NOX2
T12 568-572 GeneOrGeneProduct denotes NOX4
T13 595-629 GeneOrGeneProduct denotes vascular endothelial growth factor
T14 631-635 GeneOrGeneProduct denotes VEGF
T15 689-702 GeneOrGeneProduct denotes NADPH oxidase
T16 878-887 GeneOrGeneProduct denotes real-time
T17 1106-1110 GeneOrGeneProduct denotes NOX4
T18 1153-1159 GeneOrGeneProduct denotes raised
T19 1238-1243 GeneOrGeneProduct denotes STAT3
T20 1301-1306 GeneOrGeneProduct denotes STAT3
T21 1316-1321 GeneOrGeneProduct denotes STAT3
T22 1335-1339 GeneOrGeneProduct denotes blot
T23 1378-1384 GeneOrGeneProduct denotes raised
T24 1471-1475 GeneOrGeneProduct denotes NOX4
T25 1492-1498 GeneOrGeneProduct denotes lectin
T26 1635-1639 GeneOrGeneProduct denotes NOX4
T27 1663-1667 GeneOrGeneProduct denotes VEGF
T28 1842-1855 GeneOrGeneProduct denotes VEGF receptor
T29 1862-1867 GeneOrGeneProduct denotes STAT3
T30 1879-1885 GeneOrGeneProduct denotes VEGFR2
T31 1890-1895 GeneOrGeneProduct denotes STAT3
T32 1921-1925 GeneOrGeneProduct denotes blot
T33 1936-1940 GeneOrGeneProduct denotes VEGF
T34 2014-2018 GeneOrGeneProduct denotes NOX4
T35 2028-2033 GeneOrGeneProduct denotes STAT3
T36 2074-2078 GeneOrGeneProduct denotes NOX4
T37 2113-2126 GeneOrGeneProduct denotes NADPH oxidase
T38 2144-2148 GeneOrGeneProduct denotes NOX4
T39 2275-2279 GeneOrGeneProduct denotes NOX4
T40 2356-2362 GeneOrGeneProduct denotes lectin
T41 2367-2371 GeneOrGeneProduct denotes NOX4
T42 2457-2462 GeneOrGeneProduct denotes STAT3
T43 2518-2524 GeneOrGeneProduct denotes raised
T44 2552-2561 GeneOrGeneProduct denotes knockdown
T45 2565-2569 GeneOrGeneProduct denotes NOX4
T46 2602-2606 GeneOrGeneProduct denotes VEGF
T47 2631-2635 GeneOrGeneProduct denotes VEGF
T48 2685-2691 GeneOrGeneProduct denotes VEGFR2
T49 2696-2700 GeneOrGeneProduct denotes NOX4
T50 2702-2711 GeneOrGeneProduct denotes Knockdown
T51 2715-2719 GeneOrGeneProduct denotes NOX4
T52 2724-2731 GeneOrGeneProduct denotes reduced
T53 2732-2738 GeneOrGeneProduct denotes VEGFR2
T54 2790-2795 GeneOrGeneProduct denotes STAT3
T55 2822-2826 GeneOrGeneProduct denotes VEGF
T56 2828-2837 GeneOrGeneProduct denotes Knockdown
T57 2848-2852 GeneOrGeneProduct denotes NOX4
T58 2856-2861 GeneOrGeneProduct denotes STAT3
T59 2872-2876 GeneOrGeneProduct denotes VEGF
T60 3001-3005 GeneOrGeneProduct denotes NOX4
T61 3057-3061 GeneOrGeneProduct denotes VEGF
T62 3072-3076 GeneOrGeneProduct denotes NOX4
T63 3107-3111 GeneOrGeneProduct denotes VEGF
T64 3122-3128 GeneOrGeneProduct denotes VEGFR2
T65 3133-3137 GeneOrGeneProduct denotes NOX4
T66 3187-3192 GeneOrGeneProduct denotes STAT3
T67 3231-3235 GeneOrGeneProduct denotes NOX4
T68 3249-3255 GeneOrGeneProduct denotes VEGFR2
T69 3288-3293 GeneOrGeneProduct denotes STAT3

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 141-167 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity D012178
T2 2973-2999 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity D012178

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 141-167 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity 0007589|0006952
T3 485-496 DiseaseOrPhenotypicFeature denotes retinopathy 0005283
T4 1060-1062 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T6 1150-1152 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T8 1388-1390 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T10 1603-1605 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T12 2229-2231 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T14 2245-2247 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T16 2515-2517 DiseaseOrPhenotypicFeature denotes RA 0008383|0005272
T18 2973-2999 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity 0007589|0006952

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 141-167 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity D012178
T2 485-496 DiseaseOrPhenotypicFeature denotes retinopathy DISEASE
T3 498-501 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T4 939-942 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T5 1094-1097 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T6 1407-1410 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T7 1593-1596 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T8 2305-2308 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T9 2973-2999 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity D012178

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 141-167 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity D012178
T2 485-496 DiseaseOrPhenotypicFeature denotes retinopathy DISEASE
T3 498-501 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T4 939-942 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T5 1094-1097 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T6 1407-1410 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T7 1593-1596 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T8 2305-2308 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T9 2973-2999 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity D012178

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 12-17 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_57783|http://purl.obolibrary.org/obo/CHEBI_16474
T3 18-25 ChemicalEntity denotes oxidase D010088
T4 178-183 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_57783|http://purl.obolibrary.org/obo/CHEBI_16474
T6 184-191 ChemicalEntity denotes oxidase D010088
T7 202-225 ChemicalEntity denotes reactive oxygen species D017382|http://purl.obolibrary.org/obo/CHEBI_26523
T9 227-230 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T10 276-281 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_57783|http://purl.obolibrary.org/obo/CHEBI_16474
T12 282-289 ChemicalEntity denotes oxidase D010088
T13 470-476 ChemicalEntity denotes oxygen D010100|http://purl.obolibrary.org/obo/CHEBI_25805
T15 689-694 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_57783|http://purl.obolibrary.org/obo/CHEBI_16474
T17 695-702 ChemicalEntity denotes oxidase D010088
T18 771-778 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T20 961-967 ChemicalEntity denotes oxygen D010100|http://purl.obolibrary.org/obo/CHEBI_25805
T22 1125-1132 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T24 1352-1359 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T26 1507-1514 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T28 1555-1562 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T30 1683-1686 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T31 1744-1786 ChemicalEntity denotes 2',7'-dichlorodihydrofluorescein diacetate C110400
T32 1788-1800 ChemicalEntity denotes acetyl ester http://purl.obolibrary.org/obo/CHEBI_47622|http://purl.obolibrary.org/obo/CHEBI_27750
T34 2113-2118 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_57783|http://purl.obolibrary.org/obo/CHEBI_16474
T36 2119-2126 ChemicalEntity denotes oxidase D010088
T37 2163-2170 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T39 2267-2274 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T41 2386-2393 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T43 2422-2429 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T45 2478-2485 ChemicalEntity denotes retinal D012172|http://purl.obolibrary.org/obo/CHEBI_15035
T47 2615-2618 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 128-131 OrganismTaxon denotes rat
T2 765-770 OrganismTaxon denotes human
T3 834-839 OrganismTaxon denotes human
T4 901-904 OrganismTaxon denotes rat
T5 1090-1093 OrganismTaxon denotes rat
T6 1403-1406 OrganismTaxon denotes rat
T7 2967-2972 OrganismTaxon denotes human

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 12-27 GeneOrGeneProduct denotes NADPH oxidase 4
T2 37-82 GeneOrGeneProduct denotes vascular endothelial growth factor receptor 2
T3 178-191 GeneOrGeneProduct denotes NADPH oxidase
T4 276-289 GeneOrGeneProduct denotes NADPH oxidase
T5 290-294 GeneOrGeneProduct denotes NOX1
T6 296-300 GeneOrGeneProduct denotes NOX2
T7 306-310 GeneOrGeneProduct denotes NOX4
T8 378-382 GeneOrGeneProduct denotes NOX1
T9 387-391 GeneOrGeneProduct denotes NOX2
T10 568-572 GeneOrGeneProduct denotes NOX4
T11 595-629 GeneOrGeneProduct denotes vascular endothelial growth factor
T12 631-635 GeneOrGeneProduct denotes VEGF
T13 689-702 GeneOrGeneProduct denotes NADPH oxidase
T14 1106-1110 GeneOrGeneProduct denotes NOX4
T15 1238-1243 GeneOrGeneProduct denotes STAT3
T16 1301-1306 GeneOrGeneProduct denotes STAT3
T17 1316-1321 GeneOrGeneProduct denotes STAT3
T18 1471-1475 GeneOrGeneProduct denotes NOX4
T19 1492-1498 GeneOrGeneProduct denotes lectin
T20 1635-1639 GeneOrGeneProduct denotes NOX4
T21 1663-1667 GeneOrGeneProduct denotes VEGF
T22 1842-1855 GeneOrGeneProduct denotes VEGF receptor
T24 1862-1867 GeneOrGeneProduct denotes STAT3
T25 1879-1885 GeneOrGeneProduct denotes VEGFR2
T26 1890-1895 GeneOrGeneProduct denotes STAT3
T27 1936-1940 GeneOrGeneProduct denotes VEGF
T28 2014-2018 GeneOrGeneProduct denotes NOX4
T29 2028-2033 GeneOrGeneProduct denotes STAT3
T30 2074-2078 GeneOrGeneProduct denotes NOX4
T31 2113-2126 GeneOrGeneProduct denotes NADPH oxidase
T32 2144-2148 GeneOrGeneProduct denotes NOX4
T33 2275-2279 GeneOrGeneProduct denotes NOX4
T34 2356-2362 GeneOrGeneProduct denotes lectin
T35 2367-2371 GeneOrGeneProduct denotes NOX4
T36 2457-2462 GeneOrGeneProduct denotes STAT3
T37 2565-2569 GeneOrGeneProduct denotes NOX4
T38 2602-2606 GeneOrGeneProduct denotes VEGF
T39 2631-2635 GeneOrGeneProduct denotes VEGF
T40 2685-2691 GeneOrGeneProduct denotes VEGFR2
T41 2696-2700 GeneOrGeneProduct denotes NOX4
T42 2715-2719 GeneOrGeneProduct denotes NOX4
T43 2732-2738 GeneOrGeneProduct denotes VEGFR2
T44 2790-2795 GeneOrGeneProduct denotes STAT3
T45 2822-2826 GeneOrGeneProduct denotes VEGF
T46 2848-2852 GeneOrGeneProduct denotes NOX4
T47 2856-2861 GeneOrGeneProduct denotes STAT3
T48 2872-2876 GeneOrGeneProduct denotes VEGF
T49 3001-3005 GeneOrGeneProduct denotes NOX4
T50 3057-3061 GeneOrGeneProduct denotes VEGF
T51 3072-3076 GeneOrGeneProduct denotes NOX4
T52 3107-3111 GeneOrGeneProduct denotes VEGF
T53 3122-3128 GeneOrGeneProduct denotes VEGFR2
T54 3133-3137 GeneOrGeneProduct denotes NOX4
T55 3187-3192 GeneOrGeneProduct denotes STAT3
T56 3231-3235 GeneOrGeneProduct denotes NOX4
T57 3249-3255 GeneOrGeneProduct denotes VEGFR2
T58 3288-3293 GeneOrGeneProduct denotes STAT3

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T47 2615-2618 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T45 2478-2485 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T43 2422-2429 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T41 2386-2393 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T39 2267-2274 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T37 2163-2170 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T36 2119-2126 ChemicalEntity denotes oxidase D010088
T34 2113-2118 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783
T32 1788-1800 ChemicalEntity denotes acetyl ester http://purl.obolibrary.org/obo/CHEBI_27750|http://purl.obolibrary.org/obo/CHEBI_47622
T31 1744-1786 ChemicalEntity denotes 2',7'-dichlorodihydrofluorescein diacetate C110400
T30 1683-1686 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T28 1555-1562 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T26 1507-1514 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T24 1352-1359 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T22 1125-1132 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T20 961-967 ChemicalEntity denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805|D010100
T18 771-778 ChemicalEntity denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035|D012172
T17 695-702 ChemicalEntity denotes oxidase D010088
T15 689-694 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783
T13 470-476 ChemicalEntity denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805|D010100
T12 282-289 ChemicalEntity denotes oxidase D010088
T10 276-281 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783
T9 227-230 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T7 202-225 ChemicalEntity denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523|D017382
T6 184-191 ChemicalEntity denotes oxidase D010088
T4 178-183 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783
T3 18-25 ChemicalEntity denotes oxidase D010088
T1 12-17 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783
T58 3288-3293 GeneOrGeneProduct denotes STAT3
T57 3249-3255 GeneOrGeneProduct denotes VEGFR2
T56 3231-3235 GeneOrGeneProduct denotes NOX4
T55 3187-3192 GeneOrGeneProduct denotes STAT3
T54 3133-3137 GeneOrGeneProduct denotes NOX4
T53 3122-3128 GeneOrGeneProduct denotes VEGFR2
T52 3107-3111 GeneOrGeneProduct denotes VEGF
T51 3072-3076 GeneOrGeneProduct denotes NOX4
T50 3057-3061 GeneOrGeneProduct denotes VEGF
T49 3001-3005 GeneOrGeneProduct denotes NOX4
T48 2872-2876 GeneOrGeneProduct denotes VEGF
T53088 2856-2861 GeneOrGeneProduct denotes STAT3
T46 2848-2852 GeneOrGeneProduct denotes NOX4
T83340 2822-2826 GeneOrGeneProduct denotes VEGF
T44 2790-2795 GeneOrGeneProduct denotes STAT3
T17066 2732-2738 GeneOrGeneProduct denotes VEGFR2
T42 2715-2719 GeneOrGeneProduct denotes NOX4
T13691 2696-2700 GeneOrGeneProduct denotes NOX4
T40 2685-2691 GeneOrGeneProduct denotes VEGFR2
T85879 2631-2635 GeneOrGeneProduct denotes VEGF
T38 2602-2606 GeneOrGeneProduct denotes VEGF
T67465 2565-2569 GeneOrGeneProduct denotes NOX4
T70544 2457-2462 GeneOrGeneProduct denotes STAT3
T35 2367-2371 GeneOrGeneProduct denotes NOX4
T8697 2356-2362 GeneOrGeneProduct denotes lectin
T33 2275-2279 GeneOrGeneProduct denotes NOX4
T69672 2144-2148 GeneOrGeneProduct denotes NOX4
T85541 2113-2126 GeneOrGeneProduct denotes NADPH oxidase
T98376 2074-2078 GeneOrGeneProduct denotes NOX4
T29 2028-2033 GeneOrGeneProduct denotes STAT3
T26989 2014-2018 GeneOrGeneProduct denotes NOX4
T27 1936-1940 GeneOrGeneProduct denotes VEGF
T39153 1890-1895 GeneOrGeneProduct denotes STAT3
T25 1879-1885 GeneOrGeneProduct denotes VEGFR2
T30295 1862-1867 GeneOrGeneProduct denotes STAT3
T55747 1842-1855 GeneOrGeneProduct denotes VEGF receptor
T21 1663-1667 GeneOrGeneProduct denotes VEGF
T27383 1635-1639 GeneOrGeneProduct denotes NOX4
T19 1492-1498 GeneOrGeneProduct denotes lectin
T95323 1471-1475 GeneOrGeneProduct denotes NOX4
T12299 1316-1321 GeneOrGeneProduct denotes STAT3
T16 1301-1306 GeneOrGeneProduct denotes STAT3
T48182 1238-1243 GeneOrGeneProduct denotes STAT3
T14 1106-1110 GeneOrGeneProduct denotes NOX4
T35861 689-702 GeneOrGeneProduct denotes NADPH oxidase
T94072 631-635 GeneOrGeneProduct denotes VEGF
T11 595-629 GeneOrGeneProduct denotes vascular endothelial growth factor
T40063 568-572 GeneOrGeneProduct denotes NOX4
T82382 387-391 GeneOrGeneProduct denotes NOX2
T8 378-382 GeneOrGeneProduct denotes NOX1
T83379 306-310 GeneOrGeneProduct denotes NOX4
T72254 296-300 GeneOrGeneProduct denotes NOX2
T5 290-294 GeneOrGeneProduct denotes NOX1
T85246 276-289 GeneOrGeneProduct denotes NADPH oxidase
T24523 178-191 GeneOrGeneProduct denotes NADPH oxidase
T2 37-82 GeneOrGeneProduct denotes vascular endothelial growth factor receptor 2
T6423 12-27 GeneOrGeneProduct denotes NADPH oxidase 4
T42442 2973-2999 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity D012178
T31734 2305-2308 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T87165 1593-1596 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T26679 1407-1410 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T5726 1094-1097 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T79285 939-942 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T70805 498-501 DiseaseOrPhenotypicFeature denotes OIR DISEASE
T15999 485-496 DiseaseOrPhenotypicFeature denotes retinopathy DISEASE
T12778 141-167 DiseaseOrPhenotypicFeature denotes retinopathy of prematurity D012178
T48568 2967-2972 OrganismTaxon denotes human
T86665 1403-1406 OrganismTaxon denotes rat
T60183 1090-1093 OrganismTaxon denotes rat
T10349 901-904 OrganismTaxon denotes rat
T25895 834-839 OrganismTaxon denotes human
T48766 765-770 OrganismTaxon denotes human
T79316 128-131 OrganismTaxon denotes rat

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 485-496 HP_0000488 denotes retinopathy

Allie

Id Subject Object Predicate Lexical cue
SS1_24623966_2_0 202-225 expanded denotes reactive oxygen species
SS2_24623966_2_0 227-230 abbr denotes ROS
SS1_24623966_3_0 343-360 expanded denotes endothelial cells
SS2_24623966_3_0 362-365 abbr denotes ECs
SS1_24623966_4_0 428-459 expanded denotes intravitreal neovascularization
SS2_24623966_4_0 461-465 abbr denotes IVNV
SS1_24623966_4_1 470-496 expanded denotes oxygen-induced retinopathy
SS2_24623966_4_1 498-501 abbr denotes OIR
SS1_24623966_5_0 595-629 expanded denotes vascular endothelial growth factor
SS2_24623966_5_0 631-635 abbr denotes VEGF
SS1_24623966_7_0 765-796 expanded denotes human retinal microvascular ECs
SS2_24623966_7_0 798-805 abbr denotes hRMVECs
SS1_24623966_7_1 808-821 expanded denotes choroidal ECs
SS2_24623966_7_1 823-827 abbr denotes CECs
SS1_24623966_7_2 834-862 expanded denotes human umbilical vascular ECs
SS2_24623966_7_2 864-870 abbr denotes HUVECs
SS1_24623966_8_0 1050-1058 expanded denotes room air
SS2_24623966_8_0 1060-1062 abbr denotes RA
SS1_24623966_9_0 1168-1183 expanded denotes postnatal day 0
SS2_24623966_9_0 1185-1187 abbr denotes P0
AE1_24623966_2_0 SS1_24623966_2_0 SS2_24623966_2_0 abbreviatedTo reactive oxygen species,ROS
AE1_24623966_3_0 SS1_24623966_3_0 SS2_24623966_3_0 abbreviatedTo endothelial cells,ECs
AE1_24623966_4_0 SS1_24623966_4_0 SS2_24623966_4_0 abbreviatedTo intravitreal neovascularization,IVNV
AE1_24623966_4_1 SS1_24623966_4_1 SS2_24623966_4_1 abbreviatedTo oxygen-induced retinopathy,OIR
AE1_24623966_5_0 SS1_24623966_5_0 SS2_24623966_5_0 abbreviatedTo vascular endothelial growth factor,VEGF
AE1_24623966_7_0 SS1_24623966_7_0 SS2_24623966_7_0 abbreviatedTo human retinal microvascular ECs,hRMVECs
AE1_24623966_7_1 SS1_24623966_7_1 SS2_24623966_7_1 abbreviatedTo choroidal ECs,CECs
AE1_24623966_7_2 SS1_24623966_7_2 SS2_24623966_7_2 abbreviatedTo human umbilical vascular ECs,HUVECs
AE1_24623966_8_0 SS1_24623966_8_0 SS2_24623966_8_0 abbreviatedTo room air,RA
AE1_24623966_9_0 SS1_24623966_9_0 SS2_24623966_9_0 abbreviatedTo postnatal day 0,P0