PubMed:24616092
Annnotations
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 5-12 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
T2 | 521-528 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
T3 | 535-542 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
T4 | 567-575 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
T6 | 649-656 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
T7 | 760-768 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
T9 | 849-857 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
T11 | 922-930 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-202 | Sentence | denotes | High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathy. |
T2 | 203-337 | Sentence | denotes | Carbohydrate response element-binding protein (ChREBP) is a transcription factor responsible for carbohydrate metabolism in the liver. |
T3 | 338-414 | Sentence | denotes | However, the role of ChREBP in diabetic nephropathy has not been elucidated. |
T4 | 415-499 | Sentence | denotes | Thus, we investigated the role of ChREBP in mesangial cells in diabetic nephropathy. |
T5 | 500-657 | Sentence | denotes | Treatment with 25 mM glucose (high glucose; HG) increased cellular O-GlcNAc and O-GlcNAcylated ChREBP in mesangial cells compared with normal 5.5 mM glucose. |
T6 | 658-921 | Sentence | denotes | O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenylcarbamate (PUGNAc), a drug that increases O-GlcNAc, augmented the expression of ChREBP targets, whereas DON, a drug that decreases O-GlcNAc and O-GlcNAcase overexpression, mitigated the increase with HG. |
T7 | 922-1026 | Sentence | denotes | O-GlcNAc augmented the protein stability, transcriptional activity, and nuclear translocation of ChREBP. |
T8 | 1027-1143 | Sentence | denotes | HG treatment also stimulated lipid accumulation and the contents of triglyceride and cholesterol in mesangial cells. |
T9 | 1144-1313 | Sentence | denotes | In addition, HG triggered expression of hypoxia-inducible factor 1-α, vascular endothelial growth factor, and extracellular matrix components related to nephrosclerosis. |
T10 | 1314-1518 | Sentence | denotes | The ChREBP mutant, W130A, did not exhibit HG-induced lipid accumulation and fibrotic proteins, suggesting that the Trp-130 residue in the MCR3 domain is important in the development of glomerulosclerosis. |
T11 | 1519-1613 | Sentence | denotes | O-GlcNAcylated ChREBP was elevated in mesangium cells of streptozotocin-induced diabetic rats. |
T12 | 1614-1770 | Sentence | denotes | In conclusion, HG increased the O-GlcNAcylated ChREBP level, which resulted in lipid accumulation and up-regulation of fibrotic proteins in mesangial cells. |
T13 | 1771-1846 | Sentence | denotes | These effects may lead mesangial cells to an ultimately pathological state. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 5-12 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
T2 | 521-528 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
T3 | 535-542 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
T4 | 567-575 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
T5 | 567-575 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
T6 | 649-656 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
T7 | 760-768 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
T8 | 760-768 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
T9 | 849-857 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
T10 | 849-857 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
T11 | 922-930 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
T12 | 922-930 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
---|---|---|---|---|---|
T1 | 567-575 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T2 | 760-768 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T3 | 849-857 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T4 | 922-930 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 331-336 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 83-89 | gene:51085 | denotes | ChREBP |
T1 | 181-201 | disease:C0011881 | denotes | diabetic nephropathy |
T2 | 36-81 | gene:51085 | denotes | carbohydrate response element-binding protein |
T3 | 181-201 | disease:C0011881 | denotes | diabetic nephropathy |
T4 | 359-365 | gene:51085 | denotes | ChREBP |
T5 | 369-389 | disease:C0011881 | denotes | diabetic nephropathy |
T6 | 449-455 | gene:51085 | denotes | ChREBP |
T7 | 478-498 | disease:C0011881 | denotes | diabetic nephropathy |
T8 | 1214-1248 | gene:7422 | denotes | vascular endothelial growth factor |
T9 | 1297-1312 | disease:C0027719 | denotes | nephrosclerosis |
T10 | 1184-1212 | gene:3091 | denotes | hypoxia-inducible factor 1-α |
T11 | 1297-1312 | disease:C0027719 | denotes | nephrosclerosis |
T12 | 1318-1324 | gene:51085 | denotes | ChREBP |
T13 | 1499-1517 | disease:C0178664 | denotes | glomerulosclerosis |
R1 | T0 | T1 | associated_with | ChREBP,diabetic nephropathy |
R2 | T2 | T3 | associated_with | carbohydrate response element-binding protein,diabetic nephropathy |
R3 | T4 | T5 | associated_with | ChREBP,diabetic nephropathy |
R4 | T6 | T7 | associated_with | ChREBP,diabetic nephropathy |
R5 | T8 | T9 | associated_with | vascular endothelial growth factor,nephrosclerosis |
R6 | T10 | T11 | associated_with | hypoxia-inducible factor 1-α,nephrosclerosis |
R7 | T12 | T13 | associated_with | ChREBP,glomerulosclerosis |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 378-389 | HP_0000112 | denotes | nephropathy |
T2 | 487-498 | HP_0000112 | denotes | nephropathy |
T3 | 1297-1312 | HP_0009741 | denotes | nephrosclerosis |
T4 | 1499-1517 | HP_0000096 | denotes | glomerulosclerosis |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_24616092_0_0 | 36-81 | expanded | denotes | carbohydrate response element-binding protein |
SS2_24616092_0_0 | 83-89 | abbr | denotes | ChREBP |
SS1_24616092_1_0 | 203-248 | expanded | denotes | Carbohydrate response element-binding protein |
SS2_24616092_1_0 | 250-256 | abbr | denotes | ChREBP |
AE1_24616092_0_0 | SS1_24616092_0_0 | SS2_24616092_0_0 | abbreviatedTo | carbohydrate response element-binding protein,ChREBP |
AE1_24616092_1_0 | SS1_24616092_1_0 | SS2_24616092_1_0 | abbreviatedTo | Carbohydrate response element-binding protein,ChREBP |
NGLY1-deficiency
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-NGLY1-deficiency-B_T1 | 569-575 | chem:24139 | denotes | GlcNAc |
PD-NGLY1-deficiency-B_T2 | 762-768 | chem:24139 | denotes | GlcNAc |
PD-NGLY1-deficiency-B_T3 | 851-857 | chem:24139 | denotes | GlcNAc |
PD-NGLY1-deficiency-B_T4 | 924-930 | chem:24139 | denotes | GlcNAc |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
24616092-0#36#81#gene51085 | 36-81 | gene51085 | denotes | carbohydrate response element-binding protein |
24616092-0#83#89#gene51085 | 83-89 | gene51085 | denotes | ChREBP |
24616092-0#181#201#diseaseC0011881 | 181-201 | diseaseC0011881 | denotes | diabetic nephropathy |
24616092-8#40#68#gene3091 | 1184-1212 | gene3091 | denotes | hypoxia-inducible factor 1-α |
24616092-8#70#104#gene7422 | 1214-1248 | gene7422 | denotes | vascular endothelial growth factor |
24616092-8#153#168#diseaseC0027719 | 1297-1312 | diseaseC0027719 | denotes | nephrosclerosis |
24616092-9#4#10#gene51085 | 1318-1324 | gene51085 | denotes | ChREBP |
24616092-9#185#203#diseaseC0178664 | 1499-1517 | diseaseC0178664 | denotes | glomerulosclerosis |
36#81#gene51085181#201#diseaseC0011881 | 24616092-0#36#81#gene51085 | 24616092-0#181#201#diseaseC0011881 | associated_with | carbohydrate response element-binding protein,diabetic nephropathy |
83#89#gene51085181#201#diseaseC0011881 | 24616092-0#83#89#gene51085 | 24616092-0#181#201#diseaseC0011881 | associated_with | ChREBP,diabetic nephropathy |
40#68#gene3091153#168#diseaseC0027719 | 24616092-8#40#68#gene3091 | 24616092-8#153#168#diseaseC0027719 | associated_with | hypoxia-inducible factor 1-α,nephrosclerosis |
70#104#gene7422153#168#diseaseC0027719 | 24616092-8#70#104#gene7422 | 24616092-8#153#168#diseaseC0027719 | associated_with | vascular endothelial growth factor,nephrosclerosis |
4#10#gene51085185#203#diseaseC0178664 | 24616092-9#4#10#gene51085 | 24616092-9#185#203#diseaseC0178664 | associated_with | ChREBP,glomerulosclerosis |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 181-201 | Disease | denotes | diabetic nephropathy | http://purl.obolibrary.org/obo/MONDO_0005016 |
T2 | 369-389 | Disease | denotes | diabetic nephropathy | http://purl.obolibrary.org/obo/MONDO_0005016 |
T3 | 478-498 | Disease | denotes | diabetic nephropathy | http://purl.obolibrary.org/obo/MONDO_0005016 |
T4 | 822-825 | Disease | denotes | DON | http://purl.obolibrary.org/obo/MONDO_0000840 |
T5 | 1297-1312 | Disease | denotes | nephrosclerosis | http://purl.obolibrary.org/obo/MONDO_0006044 |
T6 | 1499-1517 | Disease | denotes | glomerulosclerosis | http://purl.obolibrary.org/obo/MONDO_0000490 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 190-201 | Phenotype | denotes | nephropathy | HP:0000112 |
T2 | 378-389 | Phenotype | denotes | nephropathy | HP:0000112 |
T3 | 487-498 | Phenotype | denotes | nephropathy | HP:0000112 |
T4 | 1184-1191 | Phenotype | denotes | hypoxia | HP:0012418 |
T5 | 1297-1312 | Phenotype | denotes | nephrosclerosis | HP:0009741 |
T6 | 1499-1517 | Phenotype | denotes | glomerulosclerosis | HP:0000096 |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 567-575 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
T2 | 760-768 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
T3 | 849-857 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
T4 | 922-930 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 567-575 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T2 | 760-768 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T3 | 849-857 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T4 | 922-930 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 190-201 | Phenotype | denotes | nephropathy | HP:0000112 |
T2 | 378-389 | Phenotype | denotes | nephropathy | HP:0000112 |
T3 | 487-498 | Phenotype | denotes | nephropathy | HP:0000112 |
T4 | 1184-1191 | Phenotype | denotes | hypoxia | HP:0012418 |
T5 | 1297-1312 | Phenotype | denotes | nephrosclerosis | HP:0009741 |
T6 | 1499-1517 | Phenotype | denotes | glomerulosclerosis | HP:0000096 |
GlyCosmos15-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 181-201 | Disease | denotes | diabetic nephropathy | http://purl.obolibrary.org/obo/MONDO_0005016 |
T2 | 369-389 | Disease | denotes | diabetic nephropathy | http://purl.obolibrary.org/obo/MONDO_0005016 |
T3 | 478-498 | Disease | denotes | diabetic nephropathy | http://purl.obolibrary.org/obo/MONDO_0005016 |
T4 | 822-825 | Disease | denotes | DON | http://purl.obolibrary.org/obo/MONDO_0000840 |
T5 | 1297-1312 | Disease | denotes | nephrosclerosis | http://purl.obolibrary.org/obo/MONDO_0006044 |
T6 | 1499-1517 | Disease | denotes | glomerulosclerosis | http://purl.obolibrary.org/obo/MONDO_0000490 |
GlyCosmos15-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 1608-1612 | OrganismTaxon | denotes | rats | 10114|10116 |
GlyCosmos15-CL
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 100-114 | Cell | denotes | mesangial cell | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T3 | 459-474 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T5 | 605-620 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T7 | 1127-1142 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T9 | 1754-1769 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T11 | 1794-1809 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
GlyCosmos15-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 100-114 | Body_part | denotes | mesangial cell | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T3 | 331-336 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
T4 | 459-474 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T6 | 605-620 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T8 | 1127-1142 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T10 | 1254-1274 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T11 | 1557-1566 | Body_part | denotes | mesangium | http://purl.obolibrary.org/obo/UBERON_0002319 |
T12 | 1754-1769 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T14 | 1794-1809 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
GlyCosmos15-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 331-336 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-202 | Sentence | denotes | High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathy. |
T2 | 203-337 | Sentence | denotes | Carbohydrate response element-binding protein (ChREBP) is a transcription factor responsible for carbohydrate metabolism in the liver. |
T3 | 338-414 | Sentence | denotes | However, the role of ChREBP in diabetic nephropathy has not been elucidated. |
T4 | 415-499 | Sentence | denotes | Thus, we investigated the role of ChREBP in mesangial cells in diabetic nephropathy. |
T5 | 500-657 | Sentence | denotes | Treatment with 25 mM glucose (high glucose; HG) increased cellular O-GlcNAc and O-GlcNAcylated ChREBP in mesangial cells compared with normal 5.5 mM glucose. |
T6 | 658-921 | Sentence | denotes | O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenylcarbamate (PUGNAc), a drug that increases O-GlcNAc, augmented the expression of ChREBP targets, whereas DON, a drug that decreases O-GlcNAc and O-GlcNAcase overexpression, mitigated the increase with HG. |
T7 | 922-1026 | Sentence | denotes | O-GlcNAc augmented the protein stability, transcriptional activity, and nuclear translocation of ChREBP. |
T8 | 1027-1143 | Sentence | denotes | HG treatment also stimulated lipid accumulation and the contents of triglyceride and cholesterol in mesangial cells. |
T9 | 1144-1313 | Sentence | denotes | In addition, HG triggered expression of hypoxia-inducible factor 1-α, vascular endothelial growth factor, and extracellular matrix components related to nephrosclerosis. |
T10 | 1314-1518 | Sentence | denotes | The ChREBP mutant, W130A, did not exhibit HG-induced lipid accumulation and fibrotic proteins, suggesting that the Trp-130 residue in the MCR3 domain is important in the development of glomerulosclerosis. |
T11 | 1519-1613 | Sentence | denotes | O-GlcNAcylated ChREBP was elevated in mesangium cells of streptozotocin-induced diabetic rats. |
T12 | 1614-1770 | Sentence | denotes | In conclusion, HG increased the O-GlcNAcylated ChREBP level, which resulted in lipid accumulation and up-regulation of fibrotic proteins in mesangial cells. |
T13 | 1771-1846 | Sentence | denotes | These effects may lead mesangial cells to an ultimately pathological state. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-202 | Sentence | denotes | High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathy. |
T2 | 203-337 | Sentence | denotes | Carbohydrate response element-binding protein (ChREBP) is a transcription factor responsible for carbohydrate metabolism in the liver. |
T3 | 338-414 | Sentence | denotes | However, the role of ChREBP in diabetic nephropathy has not been elucidated. |
T4 | 415-499 | Sentence | denotes | Thus, we investigated the role of ChREBP in mesangial cells in diabetic nephropathy. |
T5 | 500-657 | Sentence | denotes | Treatment with 25 mM glucose (high glucose; HG) increased cellular O-GlcNAc and O-GlcNAcylated ChREBP in mesangial cells compared with normal 5.5 mM glucose. |
T6 | 658-921 | Sentence | denotes | O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenylcarbamate (PUGNAc), a drug that increases O-GlcNAc, augmented the expression of ChREBP targets, whereas DON, a drug that decreases O-GlcNAc and O-GlcNAcase overexpression, mitigated the increase with HG. |
T7 | 922-1026 | Sentence | denotes | O-GlcNAc augmented the protein stability, transcriptional activity, and nuclear translocation of ChREBP. |
T8 | 1027-1143 | Sentence | denotes | HG treatment also stimulated lipid accumulation and the contents of triglyceride and cholesterol in mesangial cells. |
T9 | 1144-1313 | Sentence | denotes | In addition, HG triggered expression of hypoxia-inducible factor 1-α, vascular endothelial growth factor, and extracellular matrix components related to nephrosclerosis. |
T10 | 1314-1518 | Sentence | denotes | The ChREBP mutant, W130A, did not exhibit HG-induced lipid accumulation and fibrotic proteins, suggesting that the Trp-130 residue in the MCR3 domain is important in the development of glomerulosclerosis. |
T11 | 1519-1613 | Sentence | denotes | O-GlcNAcylated ChREBP was elevated in mesangium cells of streptozotocin-induced diabetic rats. |
T12 | 1614-1770 | Sentence | denotes | In conclusion, HG increased the O-GlcNAcylated ChREBP level, which resulted in lipid accumulation and up-regulation of fibrotic proteins in mesangial cells. |
T13 | 1771-1846 | Sentence | denotes | These effects may lead mesangial cells to an ultimately pathological state. |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 567-575 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
T2 | 760-768 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
T3 | 849-857 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
T4 | 922-930 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 567-575 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T2 | 760-768 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T3 | 849-857 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
T4 | 922-930 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 1608-1612 | OrganismTaxon | denotes | rats | 10114|10116 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 100-114 | Body_part | denotes | mesangial cell | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T3 | 331-336 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
T4 | 459-474 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T6 | 605-620 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T8 | 1127-1142 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T10 | 1254-1274 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
T11 | 1557-1566 | Body_part | denotes | mesangium | http://purl.obolibrary.org/obo/UBERON_0002319 |
T12 | 1754-1769 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
T14 | 1794-1809 | Body_part | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL_0000650|http://purl.obolibrary.org/obo/CL_0000777 |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 331-336 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 100-114 | Cell | denotes | mesangial cell | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T3 | 459-474 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T5 | 605-620 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T7 | 1127-1142 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T9 | 1754-1769 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |
T11 | 1794-1809 | Cell | denotes | mesangial cells | http://purl.obolibrary.org/obo/CL:0000650|http://purl.obolibrary.org/obo/CL:0000777 |