Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-146 |
Sentence |
denotes |
TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI. |
TextSentencer_T2 |
147-325 |
Sentence |
denotes |
Neuroblastoma (NB) is the most common extra-cranial pediatric solid tumor with up to 50% of NB patients classified as having high-risk disease with poor long-term survival rates. |
TextSentencer_T3 |
326-536 |
Sentence |
denotes |
The poor clinical outcome and aggressiveness of high-risk NB strongly correlates with enhanced angiogenesis, suggesting anti-angiogenic agents as attractive additions to the currently insufficient therapeutics. |
TextSentencer_T4 |
537-628 |
Sentence |
denotes |
TL-118, a novel drug combination has been recently developed to inhibit tumor angiogenesis. |
TextSentencer_T5 |
629-857 |
Sentence |
denotes |
In the current study, we used the SK-N-BE (2) cell line to generate orthotopic NB tumors in order to study the combinational therapeutic potential of TL-118 with either Gemcitabine (40 mg/kg; IP) or Retinoic acid (40 mg/kg; IP). |
TextSentencer_T6 |
858-1010 |
Sentence |
denotes |
We show that TL-118 treatment (n = 9) significantly inhibited tumor growth, increased cell apoptosis, reduced proliferation and extended mouse survival. |
TextSentencer_T7 |
1011-1130 |
Sentence |
denotes |
Moreover, the reciprocal effect of TL-118 and Gemcitabine treatment (n = 10) demonstrated improved anti-tumor activity. |
TextSentencer_T8 |
1131-1390 |
Sentence |
denotes |
The synergistic effect of these drugs in combination was more effective than either TL or Gemcitabine alone (n = 9), via significantly reduced cell proliferation (p<0.005), increased apoptosis (p<0.05) and significantly prolonged survival (2-fold; p<0.00001). |
TextSentencer_T9 |
1391-1523 |
Sentence |
denotes |
To conclude, we demonstrate that the novel drug combination TL-118 has the ability to suppress the growth of an aggressive NB tumor. |
TextSentencer_T10 |
1524-1677 |
Sentence |
denotes |
The promising results with TL-118 in this aggressive animal model may imply that this drug combination has therapeutic potential in the clinical setting. |
T1 |
0-146 |
Sentence |
denotes |
TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI. |
T2 |
147-325 |
Sentence |
denotes |
Neuroblastoma (NB) is the most common extra-cranial pediatric solid tumor with up to 50% of NB patients classified as having high-risk disease with poor long-term survival rates. |
T3 |
326-536 |
Sentence |
denotes |
The poor clinical outcome and aggressiveness of high-risk NB strongly correlates with enhanced angiogenesis, suggesting anti-angiogenic agents as attractive additions to the currently insufficient therapeutics. |
T4 |
537-628 |
Sentence |
denotes |
TL-118, a novel drug combination has been recently developed to inhibit tumor angiogenesis. |
T5 |
629-857 |
Sentence |
denotes |
In the current study, we used the SK-N-BE (2) cell line to generate orthotopic NB tumors in order to study the combinational therapeutic potential of TL-118 with either Gemcitabine (40 mg/kg; IP) or Retinoic acid (40 mg/kg; IP). |
T6 |
858-1010 |
Sentence |
denotes |
We show that TL-118 treatment (n = 9) significantly inhibited tumor growth, increased cell apoptosis, reduced proliferation and extended mouse survival. |
T7 |
1011-1130 |
Sentence |
denotes |
Moreover, the reciprocal effect of TL-118 and Gemcitabine treatment (n = 10) demonstrated improved anti-tumor activity. |
T8 |
1131-1390 |
Sentence |
denotes |
The synergistic effect of these drugs in combination was more effective than either TL or Gemcitabine alone (n = 9), via significantly reduced cell proliferation (p<0.005), increased apoptosis (p<0.05) and significantly prolonged survival (2-fold; p<0.00001). |
T9 |
1391-1523 |
Sentence |
denotes |
To conclude, we demonstrate that the novel drug combination TL-118 has the ability to suppress the growth of an aggressive NB tumor. |
T10 |
1524-1677 |
Sentence |
denotes |
The promising results with TL-118 in this aggressive animal model may imply that this drug combination has therapeutic potential in the clinical setting. |