PubMed:24590455
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-80 | Sentence | denotes | Systemic GLIPR1-ΔTM protein as a novel therapeutic approach for prostate cancer. |
| TextSentencer_T2 | 81-356 | Sentence | denotes | GLIPR1 is a p53 target gene known to be downregulated in prostate cancer, and increased endogenous GLIPR1 expression has been associated with increased production of reactive oxygen species, increased apoptosis, decreased c-Myc protein levels and increased cell cycle arrest. |
| TextSentencer_T3 | 357-569 | Sentence | denotes | Recently, we found that upregulation of GLIPR1 in prostate cancer cells increases mitotic catastrophe through interaction with heat shock cognate protein 70 (Hsc70) and downregulation of Aurora kinase A and TPX2. |
| TextSentencer_T4 | 570-855 | Sentence | denotes | In this study, we evaluated the mechanisms of recombinant GLIPR1 protein (glioma pathogenesis-related protein 1-transmembrane domain deleted [GLIPR1-ΔTM]) uptake by prostate cancer cells and the efficacy of systemic GLIPR1-ΔTM administration in a prostate cancer xenograft mouse model. |
| TextSentencer_T5 | 856-1034 | Sentence | denotes | GLIPR1-ΔTM was selectively internalized by prostate cancer cells, leading to increased apoptosis through reactive oxygen species production and to decreased c-Myc protein levels. |
| TextSentencer_T6 | 1035-1142 | Sentence | denotes | Interestingly, GLIPR1-ΔTM was internalized through clathrin-mediated endocytosis in association with Hsc70. |
| TextSentencer_T7 | 1143-1227 | Sentence | denotes | Systemic administration of GLIPR1-ΔTM significantly inhibited VCaP xenograft growth. |
| TextSentencer_T8 | 1228-1331 | Sentence | denotes | GLIPR1-ΔTM showed no evidence of toxicity following elimination from mouse models 8 hr after injection. |
| TextSentencer_T9 | 1332-1603 | Sentence | denotes | Our results demonstrate that GLIPR1-ΔTM is selectively endocytosed by prostate cancer cells, leading to increased reactive oxygen species production and apoptosis, and that systemic GLIPR1-ΔTM significantly inhibits growth of VCaP xenografts without substantial toxicity. |
| T1 | 0-80 | Sentence | denotes | Systemic GLIPR1-ΔTM protein as a novel therapeutic approach for prostate cancer. |
| T2 | 81-356 | Sentence | denotes | GLIPR1 is a p53 target gene known to be downregulated in prostate cancer, and increased endogenous GLIPR1 expression has been associated with increased production of reactive oxygen species, increased apoptosis, decreased c-Myc protein levels and increased cell cycle arrest. |
| T3 | 357-569 | Sentence | denotes | Recently, we found that upregulation of GLIPR1 in prostate cancer cells increases mitotic catastrophe through interaction with heat shock cognate protein 70 (Hsc70) and downregulation of Aurora kinase A and TPX2. |
| T4 | 570-855 | Sentence | denotes | In this study, we evaluated the mechanisms of recombinant GLIPR1 protein (glioma pathogenesis-related protein 1-transmembrane domain deleted [GLIPR1-ΔTM]) uptake by prostate cancer cells and the efficacy of systemic GLIPR1-ΔTM administration in a prostate cancer xenograft mouse model. |
| T5 | 856-1034 | Sentence | denotes | GLIPR1-ΔTM was selectively internalized by prostate cancer cells, leading to increased apoptosis through reactive oxygen species production and to decreased c-Myc protein levels. |
| T6 | 1035-1142 | Sentence | denotes | Interestingly, GLIPR1-ΔTM was internalized through clathrin-mediated endocytosis in association with Hsc70. |
| T7 | 1143-1227 | Sentence | denotes | Systemic administration of GLIPR1-ΔTM significantly inhibited VCaP xenograft growth. |
| T8 | 1228-1331 | Sentence | denotes | GLIPR1-ΔTM showed no evidence of toxicity following elimination from mouse models 8 hr after injection. |
| T9 | 1332-1603 | Sentence | denotes | Our results demonstrate that GLIPR1-ΔTM is selectively endocytosed by prostate cancer cells, leading to increased reactive oxygen species production and apoptosis, and that systemic GLIPR1-ΔTM significantly inhibits growth of VCaP xenografts without substantial toxicity. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 628-634 | gene:11010 | denotes | GLIPR1 |
| T1 | 817-832 | disease:C0376358 | denotes | prostate cancer |
| T2 | 628-634 | gene:11010 | denotes | GLIPR1 |
| T3 | 817-832 | disease:C0600139 | denotes | prostate cancer |
| T4 | 644-681 | gene:11010 | denotes | glioma pathogenesis-related protein 1 |
| T5 | 817-832 | disease:C0376358 | denotes | prostate cancer |
| T6 | 644-681 | gene:11010 | denotes | glioma pathogenesis-related protein 1 |
| T7 | 817-832 | disease:C0600139 | denotes | prostate cancer |
| T8 | 712-718 | gene:11010 | denotes | GLIPR1 |
| T9 | 735-750 | disease:C0376358 | denotes | prostate cancer |
| T10 | 712-718 | gene:11010 | denotes | GLIPR1 |
| T11 | 735-750 | disease:C0600139 | denotes | prostate cancer |
| T12 | 712-718 | gene:11010 | denotes | GLIPR1 |
| T13 | 817-832 | disease:C0376358 | denotes | prostate cancer |
| T14 | 712-718 | gene:11010 | denotes | GLIPR1 |
| T15 | 817-832 | disease:C0600139 | denotes | prostate cancer |
| T16 | 786-792 | gene:11010 | denotes | GLIPR1 |
| T17 | 817-832 | disease:C0376358 | denotes | prostate cancer |
| T18 | 786-792 | gene:11010 | denotes | GLIPR1 |
| T19 | 817-832 | disease:C0600139 | denotes | prostate cancer |
| R1 | T0 | T1 | associated_with | GLIPR1,prostate cancer |
| R2 | T2 | T3 | associated_with | GLIPR1,prostate cancer |
| R3 | T4 | T5 | associated_with | glioma pathogenesis-related protein 1,prostate cancer |
| R4 | T6 | T7 | associated_with | glioma pathogenesis-related protein 1,prostate cancer |
| R5 | T8 | T9 | associated_with | GLIPR1,prostate cancer |
| R6 | T10 | T11 | associated_with | GLIPR1,prostate cancer |
| R7 | T12 | T13 | associated_with | GLIPR1,prostate cancer |
| R8 | T14 | T15 | associated_with | GLIPR1,prostate cancer |
| R9 | T16 | T17 | associated_with | GLIPR1,prostate cancer |
| R10 | T18 | T19 | associated_with | GLIPR1,prostate cancer |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 138-153 | HP_0012125 | denotes | prostate cancer |
| T2 | 147-153 | HP_0002664 | denotes | cancer |
| T3 | 407-422 | HP_0012125 | denotes | prostate cancer |
| T4 | 416-422 | HP_0002664 | denotes | cancer |
| T5 | 644-650 | HP_0009733 | denotes | glioma |
| T6 | 735-750 | HP_0012125 | denotes | prostate cancer |
| T7 | 744-750 | HP_0002664 | denotes | cancer |
| T8 | 817-832 | HP_0012125 | denotes | prostate cancer |
| T9 | 826-832 | HP_0002664 | denotes | cancer |
| T10 | 899-914 | HP_0012125 | denotes | prostate cancer |
| T11 | 908-914 | HP_0002664 | denotes | cancer |
| T12 | 1402-1417 | HP_0012125 | denotes | prostate cancer |
| T13 | 1411-1417 | HP_0002664 | denotes | cancer |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24590455_2_0 | 484-513 | expanded | denotes | heat shock cognate protein 70 |
| SS2_24590455_2_0 | 515-520 | abbr | denotes | Hsc70 |
| SS1_24590455_3_0 | 644-710 | expanded | denotes | glioma pathogenesis-related protein 1-transmembrane domain deleted |
| SS2_24590455_3_0 | 712-722 | abbr | denotes | GLIPR1-ΔTM |
| AE1_24590455_2_0 | SS1_24590455_2_0 | SS2_24590455_2_0 | abbreviatedTo | heat shock cognate protein 70,Hsc70 |
| AE1_24590455_3_0 | SS1_24590455_3_0 | SS2_24590455_3_0 | abbreviatedTo | glioma pathogenesis-related protein 1-transmembrane domain deleted,GLIPR1-ΔTM |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24590455-0#9#15#gene11010 | 9-15 | gene11010 | denotes | GLIPR1 |
| 24590455-0#64#79#diseaseC0376358 | 64-79 | diseaseC0376358 | denotes | prostate cancer |
| 24590455-0#64#79#diseaseC0600139 | 64-79 | diseaseC0600139 | denotes | prostate cancer |
| 24590455-1#12#15#gene7157 | 93-96 | gene7157 | denotes | p53 |
| 24590455-1#57#72#diseaseC0376358 | 138-153 | diseaseC0376358 | denotes | prostate cancer |
| 24590455-1#57#72#diseaseC0600139 | 138-153 | diseaseC0600139 | denotes | prostate cancer |
| 24590455-2#158#163#gene3312 | 515-520 | gene3312 | denotes | Hsc70 |
| 24590455-2#187#202#gene6790 | 544-559 | gene6790 | denotes | Aurora kinase A |
| 24590455-2#207#211#gene22974 | 564-568 | gene22974 | denotes | TPX2 |
| 24590455-2#50#65#diseaseC0376358 | 407-422 | diseaseC0376358 | denotes | prostate cancer |
| 24590455-2#50#65#diseaseC0600139 | 407-422 | diseaseC0600139 | denotes | prostate cancer |
| 24590455-2#50#65#diseaseC0376358 | 407-422 | diseaseC0376358 | denotes | prostate cancer |
| 24590455-2#50#65#diseaseC0600139 | 407-422 | diseaseC0600139 | denotes | prostate cancer |
| 24590455-2#50#65#diseaseC0376358 | 407-422 | diseaseC0376358 | denotes | prostate cancer |
| 24590455-2#50#65#diseaseC0600139 | 407-422 | diseaseC0600139 | denotes | prostate cancer |
| 24590455-4#157#162#gene4609 | 1013-1018 | gene4609 | denotes | c-Myc |
| 24590455-4#43#58#diseaseC0376358 | 899-914 | diseaseC0376358 | denotes | prostate cancer |
| 24590455-4#43#58#diseaseC0600139 | 899-914 | diseaseC0600139 | denotes | prostate cancer |
| 9#15#gene1101064#79#diseaseC0376358 | 24590455-0#9#15#gene11010 | 24590455-0#64#79#diseaseC0376358 | associated_with | GLIPR1,prostate cancer |
| 9#15#gene1101064#79#diseaseC0600139 | 24590455-0#9#15#gene11010 | 24590455-0#64#79#diseaseC0600139 | associated_with | GLIPR1,prostate cancer |
| 12#15#gene715757#72#diseaseC0376358 | 24590455-1#12#15#gene7157 | 24590455-1#57#72#diseaseC0376358 | associated_with | p53,prostate cancer |
| 12#15#gene715757#72#diseaseC0600139 | 24590455-1#12#15#gene7157 | 24590455-1#57#72#diseaseC0600139 | associated_with | p53,prostate cancer |
| 158#163#gene331250#65#diseaseC0376358 | 24590455-2#158#163#gene3312 | 24590455-2#50#65#diseaseC0376358 | associated_with | Hsc70,prostate cancer |
| 158#163#gene331250#65#diseaseC0600139 | 24590455-2#158#163#gene3312 | 24590455-2#50#65#diseaseC0600139 | associated_with | Hsc70,prostate cancer |
| 158#163#gene331250#65#diseaseC0376358 | 24590455-2#158#163#gene3312 | 24590455-2#50#65#diseaseC0376358 | associated_with | Hsc70,prostate cancer |
| 158#163#gene331250#65#diseaseC0600139 | 24590455-2#158#163#gene3312 | 24590455-2#50#65#diseaseC0600139 | associated_with | Hsc70,prostate cancer |
| 158#163#gene331250#65#diseaseC0376358 | 24590455-2#158#163#gene3312 | 24590455-2#50#65#diseaseC0376358 | associated_with | Hsc70,prostate cancer |
| 158#163#gene331250#65#diseaseC0600139 | 24590455-2#158#163#gene3312 | 24590455-2#50#65#diseaseC0600139 | associated_with | Hsc70,prostate cancer |
| 187#202#gene679050#65#diseaseC0376358 | 24590455-2#187#202#gene6790 | 24590455-2#50#65#diseaseC0376358 | associated_with | Aurora kinase A,prostate cancer |
| 187#202#gene679050#65#diseaseC0600139 | 24590455-2#187#202#gene6790 | 24590455-2#50#65#diseaseC0600139 | associated_with | Aurora kinase A,prostate cancer |
| 187#202#gene679050#65#diseaseC0376358 | 24590455-2#187#202#gene6790 | 24590455-2#50#65#diseaseC0376358 | associated_with | Aurora kinase A,prostate cancer |
| 187#202#gene679050#65#diseaseC0600139 | 24590455-2#187#202#gene6790 | 24590455-2#50#65#diseaseC0600139 | associated_with | Aurora kinase A,prostate cancer |
| 187#202#gene679050#65#diseaseC0376358 | 24590455-2#187#202#gene6790 | 24590455-2#50#65#diseaseC0376358 | associated_with | Aurora kinase A,prostate cancer |
| 187#202#gene679050#65#diseaseC0600139 | 24590455-2#187#202#gene6790 | 24590455-2#50#65#diseaseC0600139 | associated_with | Aurora kinase A,prostate cancer |
| 207#211#gene2297450#65#diseaseC0376358 | 24590455-2#207#211#gene22974 | 24590455-2#50#65#diseaseC0376358 | associated_with | TPX2,prostate cancer |
| 207#211#gene2297450#65#diseaseC0600139 | 24590455-2#207#211#gene22974 | 24590455-2#50#65#diseaseC0600139 | associated_with | TPX2,prostate cancer |
| 207#211#gene2297450#65#diseaseC0376358 | 24590455-2#207#211#gene22974 | 24590455-2#50#65#diseaseC0376358 | associated_with | TPX2,prostate cancer |
| 207#211#gene2297450#65#diseaseC0600139 | 24590455-2#207#211#gene22974 | 24590455-2#50#65#diseaseC0600139 | associated_with | TPX2,prostate cancer |
| 207#211#gene2297450#65#diseaseC0376358 | 24590455-2#207#211#gene22974 | 24590455-2#50#65#diseaseC0376358 | associated_with | TPX2,prostate cancer |
| 207#211#gene2297450#65#diseaseC0600139 | 24590455-2#207#211#gene22974 | 24590455-2#50#65#diseaseC0600139 | associated_with | TPX2,prostate cancer |
| 157#162#gene460943#58#diseaseC0376358 | 24590455-4#157#162#gene4609 | 24590455-4#43#58#diseaseC0376358 | associated_with | c-Myc,prostate cancer |
| 157#162#gene460943#58#diseaseC0600139 | 24590455-4#157#162#gene4609 | 24590455-4#43#58#diseaseC0600139 | associated_with | c-Myc,prostate cancer |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1221 | 9-15 | gene:11010 | denotes | GLIPR1 |
| T1222 | 64-79 | disease:C0376358 | denotes | prostate cancer |
| T1223 | 93-96 | gene:7157 | denotes | p53 |
| T1224 | 138-153 | disease:C0376358 | denotes | prostate cancer |
| T1225 | 515-520 | gene:3312 | denotes | Hsc70 |
| T1226 | 407-422 | disease:C0376358 | denotes | prostate cancer |
| T1227 | 544-559 | gene:6790 | denotes | Aurora kinase A |
| T1228 | 564-568 | gene:22974 | denotes | TPX2 |
| T1229 | 1013-1018 | gene:4609 | denotes | c-Myc |
| T1230 | 899-914 | disease:C0376358 | denotes | prostate cancer |
| R1 | T1221 | T1222 | associated_with | GLIPR1,prostate cancer |
| R2 | T1221 | T1222 | associated_with | GLIPR1,prostate cancer |
| R3 | T1223 | T1224 | associated_with | p53,prostate cancer |
| R4 | T1223 | T1224 | associated_with | p53,prostate cancer |
| R5 | T1225 | T1226 | associated_with | Hsc70,prostate cancer |
| R6 | T1225 | T1226 | associated_with | Hsc70,prostate cancer |
| R7 | T1227 | T1226 | associated_with | Aurora kinase A,prostate cancer |
| R8 | T1227 | T1226 | associated_with | Aurora kinase A,prostate cancer |
| R9 | T1228 | T1226 | associated_with | TPX2,prostate cancer |
| R10 | T1228 | T1226 | associated_with | TPX2,prostate cancer |
| R11 | T1229 | T1230 | associated_with | c-Myc,prostate cancer |
| R12 | T1229 | T1230 | associated_with | c-Myc,prostate cancer |